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BRK1 BRICK1, SCAR/WAVE actin nucleating complex subunit [ Homo sapiens (human) ]

Gene ID: 55845, updated on 12-May-2016
Official Symbol
BRK1provided by HGNC
Official Full Name
BRICK1, SCAR/WAVE actin nucleating complex subunitprovided by HGNC
Primary source
HGNC:HGNC:23057
See related
Ensembl:ENSG00000254999 HPRD:12818; MIM:611183; Vega:OTTHUMG00000155400
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MDS027; hHBrk1; C3orf10; HSPC300
Orthologs
Location:
3p25.3
Exon count:
3
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 3 NC_000003.12 (10115649..10127190)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (10157333..10168874)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene Fanconi anemia complementation group D2 Neighboring gene cytochrome c, somatic pseudogene 11 Neighboring gene FANCD2 opposite strand Neighboring gene von Hippel-Lindau tumor suppressor Neighboring gene interleukin 1 receptor associated kinase 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to Rac GTPase binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein complex binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
Fc-gamma receptor signaling pathway involved in phagocytosis TAS
Traceable Author Statement
more info
 
Rac protein signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
actin filament organization IEA
Inferred from Electronic Annotation
more info
 
cell motility IEA
Inferred from Electronic Annotation
more info
 
in utero embryonic development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of Arp2/3 complex-mediated actin nucleation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of lamellipodium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein homotrimerization IDA
Inferred from Direct Assay
more info
PubMed 
vascular endothelial growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
SCAR complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
lamellipodium ISS
Inferred from Sequence or Structural Similarity
more info
 
Preferred Names
protein BRICK1
Names
BRICK1, SCAR/WAVE actin-nucleating complex subunit
BRICK1, SCAR/WAVE actin-nucleating complex subunit, homolog
haematopoietic stem/progenitor cell protein 300
probable protein BRICK1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018462.4NP_060932.2  protein BRICK1

    See identical proteins and their annotated locations for NP_060932.2

    Status: VALIDATED

    Source sequence(s)
    AY148219
    Consensus CDS
    CCDS54553.1
    UniProtKB/Swiss-Prot
    Q8WUW1
    Related
    ENSP00000432472, OTTHUMP00000230721, ENST00000530758, OTTHUMT00000339900

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p2 Primary Assembly

    Range
    10115649..10127190
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018914.2 Alternate CHM1_1.1

    Range
    10107444..10118867
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)