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    PRKCI protein kinase C, iota [ Homo sapiens ]

    Gene ID: 5584, updated on 21-Feb-2012
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    Summary

    Official Symbol
    PRKCIprovided by HGNC
    Official Full Name
    protein kinase C, iotaprovided by HGNC
    Primary source
    HGNC:9404
    See related
    Ensembl:ENSG00000163558; HPRD:02105; MIM:600539; Vega:OTTHUMG00000150214
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PKCI; DXS1179E; nPKC-iota
    Summary
    This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. There is a single exon pseudogene mapped on chromosome X. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    3q26.3
    Sequence :
    Chromosome: 3; NC_000003.11 (169940220..170023770)
    See PRKCI in Epigenomics, MapViewer

    Chromosome 3 - NC_000003.11Genomic Context describing neighboring genes Neighboring gene SET domain containing (lysine methyltransferase) 8 pseudogene Neighboring gene G protein-coupled receptor 160 Neighboring gene polyhomeotic homolog 3 (Drosophila) Neighboring gene RNA, U7 small nuclear 32 pseudogene Neighboring gene SKI-like oncogene Neighboring gene claudin 11

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Regulation of Cdk7 activity through a phosphatidylinositol (3)-kinase/PKC-ι-mediated signaling cascade in glioblastoma. Desai SR, et al. Carcinogenesis, 2012 Jan. PMID 22021906.
    2. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. Lee KA, et al. J Biol Chem, 2011 Dec 2. PMID 21987572.
    3. A directed protein interaction network for investigating intracellular signal transduction. Vinayagam A, et al. Sci Signal, 2011 Sep 6. PMID 21900206.
    4. Numb controls E-cadherin endocytosis through p120 catenin with aPKC. Sato K, et al. Mol Biol Cell, 2011 Sep. PMID 21775625.
    5. Willin and Par3 cooperatively regulate epithelial apical constriction through aPKC-mediated ROCK phosphorylation. Ishiuchi T, et al. Nat Cell Biol, 2011 Jun 19. PMID 21685893.

    See all (130) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. glioma cells may be proliferating through a novel PI (3)-kinase-/PKC-iota/Cdk7/cdk2-mediated pathway.
      Title: Regulation of Cdk7 activity through a phosphatidylinositol (3)-kinase/PKC-ι-mediated signaling cascade in glioblastoma.
    2. atypical protein kinase C phosphorylates Numb to prevent its binding to p120 and alpha-adaptin, thereby attenuating E-cadherin endocytosis to maintain apicobasal polarity
      Title: Numb controls E-cadherin endocytosis through p120 catenin with aPKC.
    3. Changes in PKC iota, PKC zeta, and non-muscle MyoIIA expression are likely to participate in pathogenesis of epithelial barrier function in response to local pro-inflammatory signals.
      Title: Aberrant expression of the polarity complex atypical PKC and non-muscle myosin IIA in active and inactive inflammatory bowel disease.
    4. aPKClambda/iota-IL-6 axis is a reliable prognostic factor for the biochemical recurrence of this cancer.
      Title: Coexpression of aPKCλ/ι and IL-6 in prostate cancer tissue correlates with biochemical recurrence.
    5. Report a willin(FRMD6)/Par3-aPKC-ROCK pathway that controls epithelial apical morphology.
      Title: Willin and Par3 cooperatively regulate epithelial apical constriction through aPKC-mediated ROCK phosphorylation.
    6. An association with prostate cancer risk for two SNPs belonging to PRKCI, a gene which is frequently overexpressed in various neoplasms, including prostate cancer.
      Title: Genetic variability of the mTOR pathway and prostate cancer risk in the European Prospective Investigation on Cancer (EPIC).
    7. The results strongly support the notion that KIBRA regulates epithelial cell polarity by suppressing apical exocytosis through direct inhibition of aPKC kinase activity in the PAR3-aPKC-PAR6 complex.
      Title: KIBRA suppresses apical exocytosis through inhibition of aPKC kinase activity in epithelial cells.
    8. PKCiota promotes tumorigenicity and metastasis of human esophageal cancer and that SKP2 is a candidate downstream effector of PKCiota signaling in ESCC.
      Title: Atypical protein kinase Cι (PKCι) promotes metastasis of esophageal squamous cell carcinoma by enhancing resistance to Anoikis via PKCι-SKP2-AKT pathway.
    9. Data suggest that glioma cell survival occurs through a PI(3)-kinase/PDK1/PKC-iota/BAD mediated pathway.
      Title: PKC-ι promotes glioblastoma cell survival by phosphorylating and inhibiting BAD through a phosphatidylinositol 3-kinase pathway.
    10. Data conclude that Par6B and aPKC control mitotic spindle orientation in polarized epithelia and, furthermore, that aPKC coordinately regulates multiple processes to promote morphogenesis.
      Title: Par6B and atypical PKC regulate mitotic spindle orientation during epithelial morphogenesis.
    Submit: New GeneRIF Correction See all (58)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Pre-treatment of endothelial cells with fibroblast growth factor 2 (FGF2) protects cells from HIV-1 gp120 angiotoxicity; this protection is regulated by crosstalk among the ERK, PI3K-AKT and PKC signaling pathways PubMed
    env Induction of apoptosis in cell cultures through binding of HIV-1 gp120 or gp160 to CXCR4 involves protein kinase C, basic fibroblast growth factor, caspase-3, and the pro-apoptotic molecule Bax PubMed
    env A specific interaction between CD4 and HIV-1 gp120 is required for phosphorylation of CD4, which could involve protein kinase C PubMed
    env HIV-1 gp120 increases the levels of calcium-dependent and -independent PKC isozymes; the most striking change is observed in PKC-zeta isozyme levels PubMed
    env Downmodulation of the interaction between HIV-1 gp120 and CD4 by TPA is blocked by protein kinase C (PKC) inhibitors, suggesting PKC may play an important role in HIV-1 infection PubMed
    env IL-16 induces rapid translocation of PKC from the cytosol to the membrane in CD4+ cells; PKC inhibitors completely block IL-16-induced lymphocyte migration as well as the motile response induced by HIV-1 gp120 and anti-CD4 antibody binding to CD4 PubMed
    Envelope surface glycoprotein gp160, precursor env HIV-1 gp160-induced AP-1 complex formation is dependent upon protein tyrosine phosphorylation and is abolished by inhibitors of protein kinase C, but it is unaffected by calcium channel blockers or cyclosporine A PubMed
    Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to cytoplasmic domain residues 828-848 of HIV-1 gp41 inhibits pKC-catalysed phosphorylation of a protein substrate PubMed
    env A synthetic peptide containing residues 581-597 from HIV-1 gp41 inhibits protein kinase C (pkC)-mediated phosphorylation of the CD3 gamma-chain in intact cells and directly inhibits partially purified pkC PubMed
    Tat tat Protein kinase C is required for HIV-1 Tat-mediated transactivation of the viral LTR promoter, indicating protein kinase C regulates the process of HIV-1 transactivation and may play a role in the transition of HIV from latency to productive growth PubMed
    tat Protein kinase C phosphorylates HIV-1 Tat on serine residue 46 PubMed
    tat HIV-1 Tat activates protein kinase C, resulting in the induction of TNF-alpha, IL-6 and IL-10 expression and the secretion of MCP-1 PubMed
    retropepsin gag-pol Phosphorylation of human recombinant vimentin by PKC inhibits the proteolytic processing of the vimentin head domain by HIV-1 protease PubMed
    reverse transcriptase gag-pol HIV-1 RT heterodimer expressed in bacteria can be phosphorylated in vitro by several purified mammalian protein kinases including auto-activated protein kinase (PK), CKII, cytosolic protamine kinase (CPK), myelin basic protein kinase 1 (MBPK1), and PRKC PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_002731.2 NP_002574.1 PAWR    BIND  PubMed Par-4 interacts with PKC-lambda/iota. This interaction was modelled on a demonstrated interaction between human Par-4 and Xenopus laevis PKC-lambda/iota. 
    NP_002731.2 AAA86535.2 SMG1    BIND  PubMed PKC-lambda/iota interacts with LIP. 
    NP_002731.3 NP_006644.1 FRS3    BIND  PubMed SNT2 interacts with PKC-lambda. 
    NP_002731.3 NP_002376.1 MBP    BIND  PubMed PKC-lambda phosphorylates and interacts with MBP. This interaction was modeled on a demonstrated interaction between PKC-lambda and MBP, both from unspecified species. 
    NP_002731.3 NP_000646.1 SELL    BIND  PubMed L-selectin interacts with PKC-iota. 
    NP_002731.3 NP_003891.1 SQSTM1    BIND  PubMed lamdaPKC interacts with p62. This interaction was modelled on a demonstrated interaction between mouse lamdaPKC and human p62. 
    P41743 O75689 ADAP1    HPRD  PubMed  
    P41743 P04083 ANXA1    HPRD  PubMed  
    P41743 P60953 CDC42    HPRD  PubMed  
    P41743 O15111 CHUK    HPRD  PubMed  
    P41743 Q8WU20 FRS2    HPRD  PubMed  
    P41743 O43559 FRS3    HPRD  PubMed  
    P41743 P04406 GAPDH    HPRD  PubMed  
    P41743 P01112 HRAS    HPRD  PubMed  
    P41743 P51617 IRAK1    HPRD  PubMed  
    P41743 Q02750 MAP2K1    HPRD  PubMed  
    P41743 Q13163 MAP2K5    HPRD  PubMed  
    P41743 Q96L34 MARK4    HPRD  PubMed  
    P41743 P02686 MBP    HPRD  PubMed  
    P41743 P25963 NFKBIA    HPRD  PubMed  
    P41743 Q8TEW0 PARD3    HPRD  PubMed  
    P41743 Q9NPB6 PARD6A    HPRD  PubMed  
    P41743 Q9BYG5 PARD6B    HPRD  PubMed  
    P41743 Q9BYG4 PARD6G    HPRD  PubMed  
    P41743 O15530 PDPK1    HPRD  PubMed  
    P41743 Q8ND90 PNMA1    HPRD  PubMed  
    P41743 P61019 RAB2A    HPRD  PubMed  
    P41743 P20338 RAB4A    HPRD  PubMed  
    P41743 P63000 RAC1    HPRD  PubMed  
    P41743 P17081 RHOQ    HPRD  PubMed  
    P41743 PI3 kinase related kinase SMG1 SMG1    HPRD  PubMed  
    P41743 Q13501 SQSTM1    HPRD  PubMed  
    P41743 P12931 SRC    HPRD  PubMed  
    P41743 Q9Y2K6 USP20    HPRD  PubMed  
    P41743 Q04917 YWHAH    HPRD  PubMed  
    P41743 P63104 YWHAZ    HPRD  PubMed  
    BioGRID:111570 BioGRID:116222 ADAP1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111570 BioGRID:107048 BAD    BioGRID  PubMed Reconstituted Complex 
    BioGRID:111570 BioGRID:116312 CDC37    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111570 BioGRID:107569 CHUK    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111570 BioGRID:108176 DUSP1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111570 BioGRID:108465 FABP4    BioGRID  PubMed Two-hybrid 
    BioGRID:111570 BioGRID:116031 FRS2    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:111570 BioGRID:236497 Frs2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:111570 BioGRID:117223 GABARAPL1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111570 BioGRID:116473 GABARAPL2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111570 BioGRID:108868 GAPDH    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:111570 BioGRID:108901 GBAS    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111570 BioGRID:109552 HSP90AA1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111570 BioGRID:109767 IKBKB    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111570 BioGRID:110183 LLGL1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111570 BioGRID:110181 LLGL2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111570 BioGRID:124137 MAP1LC3A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111570 BioGRID:123565 MAP1LC3B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111570 BioGRID:108326 MARK2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111570 BioGRID:121760 MARK4    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:111570 BioGRID:110735 MYO10    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111570 BioGRID:114080 NIPSNAP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111570 BioGRID:121134 PARD3    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111570 BioGRID:119157 PARD6A    BioGRID  PubMed Affinity Capture-MS; Two-hybrid 
    BioGRID:111570 BioGRID:124145 PARD6B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111570 BioGRID:124135 PARD6G    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111570 BioGRID:111196 PDPK1    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:111570 BioGRID:114667 PNMA1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111570 BioGRID:111805 RAB4A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111570 BioGRID:115045 RAPGEF2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111570 BioGRID:112319 SFPQ    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111570 BioGRID:116687 SMG1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:111570 BioGRID:114397 SQSTM1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-fractionation; Reconstituted Complex; Two-hybrid 
    BioGRID:111570 BioGRID:114374 TSC22D1    BioGRID  PubMed Two-hybrid 
    BioGRID:111570 BioGRID:113127 TTR    BioGRID  PubMed Two-hybrid 
    BioGRID:111570 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Biochemical Activity 
    BioGRID:111570 BioGRID:117950 USP21    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111570 BioGRID:113269 VHL    BioGRID  PubMed Biochemical Activity 
    BioGRID:111570 BioGRID:113365 YWHAH    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:111570 BioGRID:113366 YWHAZ    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Cell junction organization, organism-specific biosystem (from REACTOME)
      Cell junction organization, organism-specific biosystem
      Cell junction organization
    • Cell-Cell communication, organism-specific biosystem (from REACTOME)
      Cell-Cell communication, organism-specific biosystemCell-to-Cell communication is crucial for multicellular organisms because it allows organisms to coordinate the activity of their cells. Some cell-to-cell communication requires direct cell-cell cont...
    • Cell-cell junction organization, organism-specific biosystem (from REACTOME)
      Cell-cell junction organization, organism-specific biosystemEpithelial cell-cell contacts consist of three major adhesion systems: adherens junctions (AJs), tight junctions (TJs), and desmosomes. These adhesion systems differ in their function and compositio...
    • EGFR1 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      EGFR1 Signaling Pathway, organism-specific biosystemThe androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among ot...
    • Endocytosis, organism-specific biosystem (from KEGG)
      Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Endocytosis, conserved biosystem (from KEGG)
      Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • G Protein Signaling Pathways, organism-specific biosystem (from WikiPathways)
      G Protein Signaling Pathways, organism-specific biosystemG proteins, short for guanine nucleotide-binding proteins, are a family of proteins involved in second messenger cascades. G proteins are so called because they function as "molecular switches". They...
    • IL-4 signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-4 signaling Pathway, organism-specific biosystemInterleukin-4 belongs to the IL-2 family of cytokines, which includes IL-2, IL-7, IL-9, IL-15 and IL-21. It signals through 2 different receptor complexes; Receptor complex 1 comprises of IL-4 recept...
    • IL1-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
      IL1-mediated signaling events, organism-specific biosystem
      IL1-mediated signaling events
    • Insulin Pathway, organism-specific biosystem (from Pathway Interaction Database)
      Insulin Pathway, organism-specific biosystem
      Insulin Pathway
    • Insulin Signaling, organism-specific biosystem (from WikiPathways)
      Insulin Signaling, organism-specific biosystem
      Insulin Signaling
    • Insulin signaling pathway, organism-specific biosystem (from KEGG)
      Insulin signaling pathway, organism-specific biosystemInsulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the r...
    • Insulin signaling pathway, conserved biosystem (from KEGG)
      Insulin signaling pathway, conserved biosystemInsulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the r...
    • Insulin-mediated glucose transport, organism-specific biosystem (from Pathway Interaction Database)
      Insulin-mediated glucose transport, organism-specific biosystem
      Insulin-mediated glucose transport
    • Neurotrophic factor-mediated Trk receptor signaling, organism-specific biosystem (from Pathway Interaction Database)
      Neurotrophic factor-mediated Trk receptor signaling, organism-specific biosystem
      Neurotrophic factor-mediated Trk receptor signaling
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signalling by NGF, organism-specific biosystem (from REACTOME)
      Signalling by NGF, organism-specific biosystemNeurotrophins (NGF, BDNF, NT-3, NT-4/5) play pivotal roles in survival, differentiation, and plasticity of neurons in the peripheral and central nervous system. They are produced, and secreted in mi...
    • TNF receptor signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      TNF receptor signaling pathway, organism-specific biosystem
      TNF receptor signaling pathway
    • Tight junction, organism-specific biosystem (from KEGG)
      Tight junction, organism-specific biosystemEpithelial tight junctions (TJs) are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of ma...
    • Tight junction, conserved biosystem (from KEGG)
      Tight junction, conserved biosystemEpithelial tight junctions (TJs) are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of ma...
    • Tight junction interactions, organism-specific biosystem (from REACTOME)
      Tight junction interactions, organism-specific biosystemTight junctions (TJs) are the most apical component of the epithelial junctional complex forming a belt-like structure at the cellular junction. When visualized by freeze-fracture electron microscopy...
    • Wnt Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Wnt Signaling Pathway, organism-specific biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
    • Wnt Signaling Pathway and Pluripotency, organism-specific biosystem (from WikiPathways)
      Wnt Signaling Pathway and Pluripotency, organism-specific biosystemThis pathway was adapted from several resources and is designed to provide a theoretical frame-work for examining Wnt signaling and interacting components in the context of embryonic stem-cell pluri...
    • p75 NTR receptor-mediated signalling, organism-specific biosystem (from REACTOME)
      p75 NTR receptor-mediated signalling, organism-specific biosystemBesides signalling through the tyrosine kinase receptors TRK A, B, and C, the mature neurotrophins NGF, BDNF, and NT3/4 signal through their common receptor p75NTR. NGF binding to p75NTR activates a ...
    • p75(NTR)-mediated signaling, organism-specific biosystem (from Pathway Interaction Database)
      p75(NTR)-mediated signaling, organism-specific biosystem
      p75(NTR)-mediated signaling
    • p75NTR recruits signalling complexes, organism-specific biosystem (from REACTOME)
      p75NTR recruits signalling complexes, organism-specific biosystemNF-kB activation involves recruitment at the cell membrane of several proteins such as RIP2, MYD88, IRAK1, TRAF6, p62 and atypical PKC by the NGF:p75NTR complex.
    • p75NTR signals via NF-kB, organism-specific biosystem (from REACTOME)
      p75NTR signals via NF-kB, organism-specific biosystemThe NF-kB pathway is an important pro-survival signalling pathway activated by mature NGF, but not BDNF or NT-3, through p75NTR. It is unclear whether TRKA activity also affects NF-kB activation.

    Clone Names

    • MGC26534

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    phospholipid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein kinase C activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
    		  
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    Golgi vesicle budding IEA
    Inferred from Electronic Annotation
    more info
    		  
    actin filament organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    anti-apoptosis TAS
    Traceable Author Statement
    more info
    		  
    cell junction assembly TAS
    Traceable Author Statement
    more info
    		  
    cell-cell junction organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    cell-cell junction organization TAS
    Traceable Author Statement
    more info
    		  
    cellular membrane organization NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    cellular response to insulin stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    cytoskeleton organization NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    establishment of apical/basal cell polarity IEA
    Inferred from Electronic Annotation
    more info
    		  
    establishment or maintenance of epithelial cell apical/basal polarity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    eye photoreceptor cell development IEA
    Inferred from Electronic Annotation
    more info
    		  
    intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of glial cell apoptosis IMP
    Inferred from Mutant Phenotype
    more info
    		  
    negative regulation of neuron apoptosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nerve growth factor receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    positive regulation of NF-kappaB transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of endothelial cell apoptosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of establishment of protein localization in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    positive regulation of glial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		  
    positive regulation of glucose import ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    positive regulation of neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein targeting to membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    response to interleukin-1 IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to peptide hormone stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    secretion NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    tight junction assembly TAS
    Traceable Author Statement
    more info
    		  
    vesicle-mediated transport TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    Schmidt-Lanterman incisure IEA
    Inferred from Electronic Annotation
    more info
    		  
    apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
    		  
    endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    membrane fraction IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    polarisome TAS
    Traceable Author Statement
    more info
    		 PubMed 
    soluble fraction IEA
    Inferred from Electronic Annotation
    more info
    		  
    tight junction IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    protein kinase C iota type
    Names
    protein kinase C iota type
    PRKC-lambda/iota
    aPKC-lambda/iota
    atypical protein kinase C-lambda/iota
    NP_002731.4
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002740.5 → NP_002731.4  protein kinase C iota type

      Status: REVIEWED

      Source sequence(s)
      AC073288, BC022016, CN412350, L33881
      Consensus CDS
      CCDS3212.2
      UniProtKB/Swiss-Prot
      P41743
      Related
      ENSP00000295797, OTTHUMP00000196630, ENST00000295797, OTTHUMT00000316866
      Conserved Domains (4) summary
      cd00029
      Location:141 – 173
      Blast Score: 99
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd06404
      Location:26 – 108
      Blast Score: 453
      PB1_aPKC; PB1 domain is an essential modular domain of the atypical protein kinase C (aPKC) which in complex with Par6 and Par3 proteins is crucial for establishment of apical-basal polarity of animal cells. PB1 domain is a modular domain mediating specific ...
      cd05588
      Location:258 – 586
      Blast Score: 1862
      STKc_aPKC; Catalytic domain of the Protein Serine/Threonine Kinase, Atypical Protein Kinase C
      smart00220
      Location:254 – 522
      Blast Score: 763
      S_TKc; Serine/Threonine protein kinases, catalytic domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000003.11 Reference GRCh37.p5 Primary Assembly

      Range
      169940220..170023770
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000135.1 Alternate HuRef

      Range
      167310436..167393660
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC023891.28 (120961..144188) None
    genomic AC073288.27 (2000..62318) None
    genomic CH471052.2 EAW78513.1
      EAW78514.1
      EAW78515.1
    mRNA AB451443.1 BAG70257.1
    mRNA AI521422.1 None
    mRNA AK315342.1 BAG37741.1
    mRNA BC022016.2 AAH22016.3
    mRNA BC042405.1 None
    mRNA BM767350.1 None
    mRNA BQ014217.1 None
    mRNA CN412350.1 None
    mRNA L18964.1 AAA60171.1
    mRNA L33881.1 AAB17011.1
    Protein Accession Links
    GenePept Link UniProtKB Link
    P41743.2 GenPept UniProtKB/Swiss-Prot:P41743
    Help top of page

    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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