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    EAPP E2F-associated phosphoprotein [ Homo sapiens ]

    Gene ID: 55837, updated on 11-May-2012
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    Summary

    Official Symbol
    EAPPprovided by HGNC
    Official Full Name
    E2F-associated phosphoproteinprovided by HGNC
    Primary source
    HGNC:19312
    Locus tag
    BM-036
    See related
    Ensembl:ENSG00000129518; HPRD:12631; MIM:609486; Vega:OTTHUMG00000170621
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BM036; C14orf11; MGC4957; FLJ20578
    Summary
    This gene encodes a phosphoprotein that interacts with several members of the E2F family of proteins. The protein localizes to the nucleus, and is present throughout the cell cycle except during mitosis. It functions to modulate E2F-regulated transcription and stimulate proliferation. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    14q13.1
    Sequence :
    Chromosome: 14; NC_000014.8 (34985135..35008943, complement)
    See EAPP in Epigenomics, MapViewer

    Chromosome 14 - NC_000014.8Genomic Context describing neighboring genes Neighboring gene serine palmitoyltransferase, small subunit A Neighboring gene ribosomal protein L23a pseudogene 71 Neighboring gene uncharacterized LOC100506143 Neighboring gene RNA, U1 small nuclear 7

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    2. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    3. EAPP: gatekeeper at the crossroad of apoptosis and p21-mediated cell-cycle arrest. Andorfer P, et al. Oncogene, 2011 Jun 9. PMID 21258403.
    4. Systematic analysis of human protein complexes identifies chromosome segregation proteins. Hutchins JR, et al. Science, 2010 Apr 30. PMID 20360068.
    5. Regulation of the E2F-associated phosphoprotein promoter by GC-box binding proteins. Schwarzmayr L, et al. Int J Biochem Cell Biol, 2008. PMID 18588995.

    See all (18) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. results indicate that the level of EAPP is critical for cellular homeostasis
      Title: EAPP: gatekeeper at the crossroad of apoptosis and p21-mediated cell-cycle arrest.
    2. Regulation of the EAPP promoter by GC-box binding proteins is reported.
      Title: Regulation of the E2F-associated phosphoprotein promoter by GC-box binding proteins.
    3. EAPP modulates E2F-regulated transcription, stimulates proliferation, and may be involved in the malignant transformation of cells.
      Title: EAPP, a novel E2F binding protein that modulates E2F-dependent transcription.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    AAX63200.1 NP_005216.1 E2F1    BIND  PubMed E2F1 interacts with EAPP. 
    AAX63200.1 NP_004082.1 E2F2    BIND  PubMed E2F2 interacts with EAPP. 
    AAX63200.1 NP_001940.1 E2F3    BIND  PubMed E2F3 interacts with EAPP. 
    Q56P03 Q9Y312 C20orf4    HPRD  PubMed  
    Q56P03 Q05086 UBE3A    HPRD  PubMed  
    Q56P03 Q9NRR5 UBQLN4    HPRD  PubMed  
    BioGRID:120941 BioGRID:117464 C20orf4    BioGRID  PubMed Two-hybrid 
    BioGRID:120941 BioGRID:228650 Prpf8    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:120941 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    negative regulation of transcription elongation from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of cell proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of transcription elongation from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    E2F-associated phosphoprotein
    Names
    E2F-associated phosphoprotein
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_018453.3 → NP_060923.2  E2F-associated phosphoprotein

      Status: REVIEWED

      Source sequence(s)
      AL445363, BC001245, CD702290
      Consensus CDS
      CCDS41941.1
      UniProtKB/Swiss-Prot
      Q56P03
      Related
      ENSP00000250454, OTTHUMP00000244146, ENST00000250454, OTTHUMT00000409847
      Conserved Domains (1) summary
      pfam10238
      Location:138 – 283
      Blast Score: 486
      Eapp_C; E2F-associated phosphoprotein

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000014.8 Reference GRCh37.p5 Primary Assembly

      Range
      34985135..35008943, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000146.1 Alternate HuRef

      Range
      15103161..15127041, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL445363.7 (87773..111554) None
    genomic CH471078.2 EAW65920.1
      EAW65921.1
      EAW65922.1
    mRNA AF217512.1 AAF67623.1
    mRNA AK000585.1 BAA91271.1
    mRNA AK225467.1 None
    mRNA AK225477.1 None
    mRNA AK225991.1 None
    mRNA AY157300.1 AAO17041.1
    mRNA AY157301.1 AAO17042.1
    mRNA AY869694.1 AAX63200.1
    mRNA BC001245.1 AAH01245.1
    mRNA CD702290.1 None
    other-genetic HQ447367.1 ADQ31853.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q56P03.4 GenPept UniProtKB/Swiss-Prot:Q56P03
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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