My NCBISign In

Display Settings:

Format

Send to:

Choose Destination

    CAND1 cullin-associated and neddylation-dissociated 1 [ Homo sapiens ]

    Gene ID: 55832, updated on 11-May-2012
    Help top of page

    Summary

    Official Symbol
    CAND1provided by HGNC
    Official Full Name
    cullin-associated and neddylation-dissociated 1provided by HGNC
    Primary source
    HGNC:30688
    See related
    Ensembl:ENSG00000111530; HPRD:06983; MIM:607727; Vega:OTTHUMG00000169060
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TIP120; TIP120A; FLJ10114; FLJ10929; FLJ38691; FLJ90441; KIAA0829; DKFZp434M1414
    Help top of page

    Genomic context

    Location :
    12q14
    Sequence :
    Chromosome: 12; NC_000012.11 (67663061..67708388)
    See CAND1 in Epigenomics, MapViewer

    Chromosome 12 - NC_000012.11Genomic Context describing neighboring genes Neighboring gene glutamate receptor interacting protein 1 Neighboring gene oxysterol binding protein-like 9 pseudogene Neighboring gene glycoprotein, alpha-galactosyltransferase 2, pseudogene Neighboring gene mitochondrial ribosomal protein L40 pseudogene Neighboring gene N-terminal asparagine amidase pseudogene

    Help top of page

    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
    Helptop of page

    Bibliography

    Related articles in PubMed

    1. Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration. Martins-de-Souza D, et al. J Proteome Res, 2012 Apr 6. PMID 22360420.
    2. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    3. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    4. COMMD1 (copper metabolism MURR1 domain-containing protein 1) regulates Cullin RING ligases by preventing CAND1 (Cullin-associated Nedd8-dissociated protein 1) binding. Mao X, et al. J Biol Chem, 2011 Sep 16. PMID 21778237.
    5. Purification and identification of endogenous polySUMO conjugates. Bruderer R, et al. EMBO Rep, 2011 Feb. PMID 21252943.

    See all (39) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. A protein encoded by this locus was found to be differentially expressed in postmortem brains from patients with atypical frontotemporal lobar degeneration.
      Title: Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration.
    2. COMMD1 (copper metabolism MURR1 domain-containing protein 1) regulates Cullin RING ligases by preventing CAND1 (Cullin-associated Nedd8-dissociated protein 1) binding.
      Title: COMMD1 (copper metabolism MURR1 domain-containing protein 1) regulates Cullin RING ligases by preventing CAND1 (Cullin-associated Nedd8-dissociated protein 1) binding.
    3. CAND1 does not function by sequestering cullins in vivo to prevent substrate receptor autoubiquitination and is likely to regulate cullin RING ligase activity via alternative mechanisms
      Title: Regulation of cullin RING E3 ubiquitin ligases by CAND1 in vivo.
    4. miR-148a is an androgen-responsive microRNA that promotes LNCaP prostate cell growth by repressing its target CAND1 expression.
      Title: miR-148a is an androgen-responsive microRNA that promotes LNCaP prostate cell growth by repressing its target CAND1 expression.
    5. SCCRO recruits Ubc12 approximately NEDD8 to the CAND1-Cul1-ROC1 complex but that this is not sufficient to dissociate or overcome the inhibitory effects of CAND1 on cullin neddylation
      Title: SCCRO (DCUN1D1) is an essential component of the E3 complex for neddylation.
    6. TIP120A functions as a negative regulator of SCF E3 ubiquitin ligases and may modulate other cullin ligases in a similar fashion.
      Title: TIP120A associates with cullins and modulates ubiquitin ligase activity.
    7. CAND1 & COP9 signalosome (CSN), major deneddylase of cullins, bind to unneddylated CUL1 in mutually exclusive way. Suppression of CAND1 expression by siRNA enhanced interaction between CUL1 & CSN, suggesting that CAND1 inhibited binding of CSN to CUL1.
      Title: CAND1 enhances deneddylation of CUL1 by COP9 signalosome.
    8. binds to unneddylated CUL1 and regulates the formation of SCF ubiquitin E3 ligase complex
      Title: CAND1 binds to unneddylated CUL1 and regulates the formation of SCF ubiquitin E3 ligase complex.
    9. selectively binds to unneddylated CUL1 and is dissociated by CUL1 neddylation
      Title: NEDD8 modification of CUL1 dissociates p120(CAND1), an inhibitor of CUL1-SKP1 binding and SCF ligases.
    Submit: New GeneRIF Correction
    Help top of page

    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Hippocampal atrophy as a quantitative trait in a genome-wide association study identifying novel susceptibility genes for Alzheimer's disease.

    Help top of page

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q86VP6 O75175 CNOT3    HPRD  PubMed  
    Q86VP6 Q13616 CUL1    HPRD  PubMed  
    Q86VP6 Q13617 CUL2    HPRD  PubMed  
    Q86VP6 Q13618 CUL3    HPRD  PubMed  
    Q86VP6 Q13619 CUL4A    HPRD  PubMed  
    Q86VP6 Q13620 CUL4B    HPRD  PubMed  
    Q86VP6 P62877 RBX1    HPRD  PubMed  
    BioGRID:120937 BioGRID:122599 BRCC3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:120937 BioGRID:120937 CAND1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:120937 BioGRID:107612 CLN3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:120937 BioGRID:114032 CUL1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:120937 BioGRID:114031 CUL2    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:120937 BioGRID:114030 CUL3    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:120937 BioGRID:114029 CUL4A    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:120937 BioGRID:114028 CUL4B    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:120937 BioGRID:113743 CUL5    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:120937 BioGRID:119920 DCUN1D1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:120937 BioGRID:122485 DDA1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:120937 BioGRID:108009 DDB1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:120937 BioGRID:115331 HDAC5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:120937 BioGRID:121122 MEPCE    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:120937 BioGRID:115301 RBX1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:120937 BioGRID:113188 SUMO1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:120937 BioGRID:112497 SUMO2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:120937 BioGRID:112781 TCEA2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:120937 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:120937 BioGRID:1205541 tat    BioGRID  PubMed Reconstituted Complex 
    Help top of page

    General gene information

    Markers

    Genotypes

    Homology

    • Homologs of the CAND1 gene: The CAND1 gene is conserved in chimpanzee, , dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, , and N.crassa.
    • Map Viewer (Mouse, Rat)

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    cell differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of catalytic activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    regulation of transcription, DNA-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Help top of page

    General protein information

    Preferred Names
    cullin-associated NEDD8-dissociated protein 1
    Names
    cullin-associated NEDD8-dissociated protein 1
    p120 CAND1
    TBP interacting protein
    TBP-interacting protein 120A
    TBP-interacting protein of 120 kDa A
    cullin-associated and neddylation-dissociated protein 1
    Help top of page

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_018448.3 → NP_060918.2  cullin-associated NEDD8-dissociated protein 1

      Status: VALIDATED

      Source sequence(s)
      AL136810, AL833880, DB064887, DB098973
      Consensus CDS
      CCDS8977.1
      UniProtKB/Swiss-Prot
      Q86VP6
      Related
      ENSP00000442318, OTTHUMP00000240019, ENST00000545606, OTTHUMT00000402105
      Conserved Domains (2) summary
      pfam08623
      Location:1039 – 1205
      Blast Score: 659
      TIP120; TATA-binding protein interacting (TIP20)
      pfam13513
      Location:149 – 202
      Blast Score: 100
      HEAT_EZ; HEAT-like repeat

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000012.11 Reference GRCh37.p5 Primary Assembly

      Range
      67663061..67708388
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000144.1 Alternate HuRef

      Range
      64713845..64759496
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC012518.19 (78789..106399) None
    genomic AC078983.17 (144455..161617) None
    genomic CH471054.1 EAW97171.1
      EAW97172.1
    mRNA AB020636.2 BAA74852.2
    mRNA AF157326.1 AAF67492.1
    mRNA AK000976.1 BAG50842.1
    mRNA AK001791.1 BAG50975.1
    mRNA AK027404.1 BAB55090.1
    mRNA AK027783.1 BAB55365.1
    mRNA AK074922.1 None
    mRNA AK096010.1 None
    mRNA AK129780.1 None
    mRNA AK292456.1 BAF85145.1
    mRNA AK314358.1 BAG36990.1
    mRNA AL133560.1 CAB63714.1
    mRNA AL136810.1 CAB66744.1
    mRNA AL833880.2 CAD38737.1
    mRNA BC004232.1 AAH04232.1
    mRNA BC026220.2 AAH26220.1
    mRNA BC050341.1 AAH50341.1
    mRNA DB064887.1 None
    mRNA DB098973.1 None
    other-genetic EU832277.1 ACE87534.1
    other-genetic EU832362.1 ACE86847.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86VP6.2 GenPept UniProtKB/Swiss-Prot:Q86VP6
    Help top of page

    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Links

      Links to other resources

      General information

      Related sites

      Feedback

      Subscription

      Recent activity

      Clear Turn Off Turn On

      Your browsing activity is empty.

      Activity recording is turned off.

      Turn recording back on

      See more...