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    DCAF6 DDB1 and CUL4 associated factor 6 [ Homo sapiens ]

    Gene ID: 55827, updated on 11-May-2012
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    Summary

    Official Symbol
    DCAF6provided by HGNC
    Official Full Name
    DDB1 and CUL4 associated factor 6provided by HGNC
    Primary source
    HGNC:30002
    Locus tag
    RP4-745I14.1
    See related
    Ensembl:ENSG00000143164; HPRD:17156; MIM:610494; Vega:OTTHUMG00000034572
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NRIP; ARCAP; IQWD1; PC326; MSTP055; RP4-745I14.1; 1200006M05Rik; FLJ23798
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    Genomic context

    Location :
    1q24.2
    Sequence :
    Chromosome: 1; NC_000001.10 (167905797..168045081)
    See DCAF6 in Epigenomics, MapViewer

    Chromosome 1 - NC_000001.10Genomic Context describing neighboring genes Neighboring gene myelin protein zero-like 1 Neighboring gene adenylate cyclase 10 (soluble) Neighboring gene brain protein 44 Neighboring gene microRNA 1255b-2 Neighboring gene glycine cleavage system protein H pseudogene Neighboring gene G protein-coupled receptor 161 Neighboring gene TIP41, TOR signaling pathway regulator-like (S. cerevisiae)

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. NRIP enhances HPV gene expression via interaction with either GR or E2. Chang SW, et al. Virology, 2012 Feb 5. PMID 22177699.
    2. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    3. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    4. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, et al. Mol Cell Proteomics, 2011 Mar. PMID 21139048.
    5. Systematic analysis of human protein complexes identifies chromosome segregation proteins. Hutchins JR, et al. Science, 2010 Apr 30. PMID 20360068.

    See all (18) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. NRIP enhances HPV 16 gene expression via interaction with either GR or viral E2.
      Title: NRIP enhances HPV gene expression via interaction with either GR or E2.
    2. Observational study of gene-disease association. (HuGE Navigator)
      Title: Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study.
    3. A survey results showed that ten cancer cases were revealed to express the NRIP in six malignancies, but not all of these specific tumor types consistently showed positive NRIP expression.
      Title: Nuclear Receptor Interaction Protein (NRIP) expression assay using human tissue microarray and immunohistochemistry technology confirming nuclear localization.
    4. NRIP plays a feed-forward role enhancing androgen receptor (AR)-driven NRIP promoter activity via NRIP forming a complex with AR to protect AR protein from proteasome degradation.
      Title: Nuclear receptor interaction protein, a coactivator of androgen receptors (AR), is regulated by AR and Sp1 to feed forward and activate its own gene expression through AR protein stability.
    5. NRIP interacts with either androgen or glucocorticoid receptors
      Title: NRIP, a novel nuclear receptor interaction protein, enhances the transcriptional activity of nuclear receptors.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    IQ motif and WD repeats 1 Q04771 ACVR1    HPRD  PubMed  
    IQ motif and WD repeats 1 P10275 AR    HPRD  PubMed  
    IQ motif and WD repeats 1 O00238 BMPR1B    HPRD  PubMed  
    IQ motif and WD repeats 1 P04150 NR3C1    HPRD  PubMed  
    IQ motif and WD repeats 1 Q15796 SMAD2    HPRD  PubMed  
    IQ motif and WD repeats 1 O00267 SUPT5H    HPRD  PubMed  
    IQ motif and WD repeats 1 P36897 TGFBR1    HPRD  PubMed  
    BioGRID:120933 BioGRID:198236 Atm    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:120933 BioGRID:114029 CUL4A    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:120933 BioGRID:114028 CUL4B    BioGRID  PubMed Reconstituted Complex 
    BioGRID:120933 BioGRID:108009 DDB1    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:120933 BioGRID:199074 Ddb1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:120933 BioGRID:112550 SP1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:120933 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ligand-dependent nuclear receptor transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    positive regulation of transcription from RNA polymerase II promoter IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    protein ubiquitination IC
    Inferred by Curator
    more info
    		 PubMed 
    Component Evidence Code Pubs
    CUL4 RING ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    DDB1- and CUL4-associated factor 6
    Names
    DDB1- and CUL4-associated factor 6
    IQ motif and WD repeats 1
    nuclear receptor interaction protein
    IQ motif and WD repeat-containing protein 1
    androgen receptor complex-associated protein
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001017977.2 → NP_001017977.1  DDB1- and CUL4-associated factor 6 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two consecutive exons and a downstream single exon in the CDS compared to variant 3. The reading frame is not changed and the resulting isoform (b) lacks two internal segments compared to isoform c.
      Source sequence(s)
      AY766164, CA310484, DA128283
      Consensus CDS
      CCDS30933.1
      UniProtKB/Swiss-Prot
      Q58WW2
      Related
      ENSP00000311949, OTTHUMP00000032524, ENST00000312263, OTTHUMT00000083661
      Conserved Domains (1) summary
      cl02567
      Location:43 – 286
      Blast Score: 231
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. NM_001198956.1 → NP_001185885.1  DDB1- and CUL4-associated factor 6 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) is the longest transcript and encodes the longest isoform (c).
      Source sequence(s)
      AF116725, CA310484, DA128283
      Consensus CDS
      CCDS55657.1
      UniProtKB/Swiss-Prot
      Q58WW2
      Related
      ENSP00000356814, OTTHUMP00000032522, ENST00000367840, OTTHUMT00000083659
      Conserved Domains (1) summary
      cl02567
      Location:43 – 286
      Blast Score: 230
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    3. NM_001198957.1 → NP_001185886.1  DDB1- and CUL4-associated factor 6 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an in-frame exon in the CDS compared to variant 3. The resulting isoform (d) lacks an internal segment compared to isoform c.
      Source sequence(s)
      AF116725, AK297847, CA310484, DA128283
      Consensus CDS
      CCDS55658.1
      UniProtKB/Swiss-Prot
      Q58WW2
      Related
      ENSP00000396238, ENST00000432587
      Conserved Domains (1) summary
      cl02567
      Location:48 – 261
      Blast Score: 167
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    4. NM_018442.3 → NP_060912.2  DDB1- and CUL4-associated factor 6 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) lacks two in-frame exons in the CDS compared to variant 3. The resulting isoform (a) lacks two internal segments compared to isoform c.
      Source sequence(s)
      AF116725, AL136738, CA310484, DA128283
      Consensus CDS
      CCDS1267.2
      UniProtKB/Swiss-Prot
      Q58WW2
      Related
      ENSP00000356817, OTTHUMP00000082621, ENST00000367843, OTTHUMT00000157115
      Conserved Domains (1) summary
      cl02567
      Location:43 – 286
      Blast Score: 231
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000001.10 Reference GRCh37.p5 Primary Assembly

      Range
      167905797..168045081
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000133.1 Alternate HuRef

      Range
      139151436..139289686
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL031287.3 CAI22480.1
      CAI22481.1
      CAI22482.1
      CAI22484.1
      CAM28293.1
    genomic AL033531.10 CAI22478.1
      CAI22479.1
      CAM28292.1
    genomic AL033531.10 CAI22478.1
      CAI22479.1
      CAM28292.1
    genomic AL033532.36 CAI22625.1
      CAM28303.1
    genomic AL033532.36 CAI22625.1
      CAM28303.1
    genomic CH471067.1 EAW90808.1
      EAW90809.1
      EAW90810.1
      EAW90811.1
      EAW90812.1
    genomic Z97876.1 CAI20077.1
      CAI20078.1
      CAI20079.1
      CAI20081.1
      CAM28213.1
    genomic Z97876.1 CAI20077.1
      CAI20078.1
      CAI20079.1
      CAI20081.1
      CAM28213.1
    mRNA AF116725.1 AAO15301.1
    mRNA AF124434.1 None
    mRNA AF150734.1 AAF67474.1
    mRNA AK000984.1 None
    mRNA AK093970.1 None
    mRNA AK226181.1 None
    mRNA AK297847.1 BAG60180.1
    mRNA AL136738.1 CAB66672.2
    mRNA AY766164.1 AAX09330.1
    mRNA BC025262.1 AAH25262.2
    mRNA BM822167.1 None
    mRNA BQ028917.1 None
    mRNA CA310484.1 None
    mRNA DA128283.1 None
    mRNA DQ768089.1 ABG76793.1
    other-genetic DQ892143.2 ABM83069.1
    other-genetic DQ895337.2 ABM86263.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q58WW2.1 GenPept UniProtKB/Swiss-Prot:Q58WW2
    Q9P0U0 GenPept UniProtKB/TrEMBL:Q9P0U0
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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