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AXL AXL receptor tyrosine kinase [ Homo sapiens (human) ]

Gene ID: 558, updated on 12-Apr-2015
Official Symbol
AXLprovided by HGNC
Official Full Name
AXL receptor tyrosine kinaseprovided by HGNC
Primary source
HGNC:HGNC:905
See related
Ensembl:ENSG00000167601; HPRD:00171; MIM:109135; Vega:OTTHUMG00000182727
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARK; UFO; JTK11; Tyro7
Summary
The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]
Orthologs
See AXL in MapViewer
Location:
19q13.1
Exon count:
21
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 19 NC_000019.10 (41219199..41261767)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (41725104..41767672)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376908 Neighboring gene ribosomal protein L36 pseudogene 16 Neighboring gene cytochrome P450, family 2, subfamily S, polypeptide 1 Neighboring gene transfer RNA-Lys (TTT) 10-1 Neighboring gene uncharacterized LOC105372402 Neighboring gene heterogeneous nuclear ribonucleoprotein U-like 1 Neighboring gene uncharacterized LOC105372401 Neighboring gene coiled-coil domain containing 97

Related articles in PubMed

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
capsid gag AXL inhibits the release of HIV-1 in terms of reduced levels of CA in virus particles and induces the accumulation of cell-associated CA PubMed

Go to the HIV-1, Human Interaction Database

  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by VEGF, organism-specific biosystem (from REACTOME)
    Signaling by VEGF, organism-specific biosystemIn normal development vascular endothelial growth factors (VEGFs) are crucial regulators of vascular development during embryogenesis (vasculogenesis) and blood-vessel formation in the adult (angioge...
  • VEGFA-VEGFR2 Pathway, organism-specific biosystem (from REACTOME)
    VEGFA-VEGFR2 Pathway, organism-specific biosystemAngiogenesis is the formation of new blood vessels from preexisting vasculature. One of the most important proangiogenic factors is vascular endothelial growth factor (VEGF). VEGF exerts its biologic...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
myosin heavy chain binding IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol 3-kinase binding IEA
Inferred from Electronic Annotation
more info
 
phosphatidylserine binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
protein tyrosine kinase activity EXP
Inferred from Experiment
more info
 
transmembrane receptor protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
apoptotic cell clearance IEA
Inferred from Electronic Annotation
more info
 
blood vessel remodeling IEA
Inferred from Electronic Annotation
more info
 
cell maturation IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to extracellular stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to hydrogen peroxide IEA
Inferred from Electronic Annotation
more info
 
cellular response to interferon-alpha IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to lipopolysaccharide IDA
Inferred from Direct Assay
more info
PubMed 
dendritic cell differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
erythrocyte homeostasis IEA
Inferred from Electronic Annotation
more info
 
forebrain cell migration IEA
Inferred from Electronic Annotation
more info
 
inflammatory response IEA
Inferred from Electronic Annotation
more info
 
innate immune response IEA
Inferred from Electronic Annotation
more info
 
natural killer cell differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of dendritic cell apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of interferon-gamma production IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of lymphocyte activation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of tumor necrosis factor production IEA
Inferred from Electronic Annotation
more info
 
neuron migration IEA
Inferred from Electronic Annotation
more info
 
organ regeneration IEA
Inferred from Electronic Annotation
more info
 
ovulation cycle IEA
Inferred from Electronic Annotation
more info
 
peptidyl-tyrosine phosphorylation EXP
Inferred from Experiment
more info
 
peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
peptidyl-tyrosine phosphorylation TAS
Traceable Author Statement
more info
PubMed 
phagocytosis IDA
Inferred from Direct Assay
more info
PubMed 
platelet activation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cytokine-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of natural killer cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of pinocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein kinase B signaling IEA
Inferred from Electronic Annotation
more info
 
protein kinase B signaling IEA
Inferred from Electronic Annotation
more info
 
secretion by cell IEA
Inferred from Electronic Annotation
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
substrate adhesion-dependent cell spreading IEA
Inferred from Electronic Annotation
more info
 
vagina development IEA
Inferred from Electronic Annotation
more info
 
vascular endothelial growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
 
viral entry into host cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
host cell surface IDA
Inferred from Direct Assay
more info
PubMed 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
tyrosine-protein kinase receptor UFO
Names
tyrosine-protein kinase receptor UFO
AXL oncogene
AXL transforming sequence/gene
NP_001265528.1
NP_001690.2
NP_068713.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001278599.1NP_001265528.1  tyrosine-protein kinase receptor UFO isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks four alternate exons in the 5' coding region and initiates translation at a downstream AUG, compared to variant 1. It encodes isoform 3 which has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AI300772, AI309979, AK309139, CA437238, X66029
    Consensus CDS
    CCDS62677.1
    UniProtKB/TrEMBL
    M0R0W6
    Conserved Domains (3) summary
    smart00221
    Location:270535
    STYKc; Protein kinase; unclassified specificity
    cd00063
    Location:67154
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05075
    Location:267543
    PTKc_Axl; Catalytic domain of the Protein Tyrosine Kinase, Axl
  2. NM_001699.5NP_001690.2  tyrosine-protein kinase receptor UFO isoform 2 precursor

    See identical proteins and their annotated locations for NP_001690.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. It encodes isoform 2, which lacks an internal segment and is shorter than isoform 1.
    Source sequence(s)
    AA021223, AI300772, AI309979, AK309139, AL556721, BC032229, CA437238, HY045208, M76125, X66029
    Consensus CDS
    CCDS12574.1
    UniProtKB/Swiss-Prot
    P30530
    Conserved Domains (7) summary
    cd00096
    Location:53126
    Ig; Immunoglobulin domain
    cd05749
    Location:141222
    Ig2_Tyro3_like; Second immunoglobulin (Ig)-like domain of Axl/Tyro3 receptor tyrosine kinases (RTKs)
    smart00221
    Location:529794
    STYKc; Protein kinase; unclassified specificity
    smart00409
    Location:41123
    IG; Immunoglobulin
    smart00410
    Location:145223
    IG_like; Immunoglobulin like
    cd00063
    Location:225328
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05075
    Location:526802
    PTKc_Axl; Catalytic domain of the Protein Tyrosine Kinase, Axl
  3. NM_021913.4NP_068713.2  tyrosine-protein kinase receptor UFO isoform 1 precursor

    See identical proteins and their annotated locations for NP_068713.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AA021223, AI300772, AI309979, AK309139, AL556721, BC032229, CA437238, HY045208, X66029
    Consensus CDS
    CCDS12575.1
    UniProtKB/Swiss-Prot
    P30530
    Related
    ENSP00000301178, OTTHUMP00000269992, ENST00000301178, OTTHUMT00000463323
    Conserved Domains (7) summary
    cd00096
    Location:53126
    Ig; Immunoglobulin domain
    cd05749
    Location:141222
    Ig2_Tyro3_like; Second immunoglobulin (Ig)-like domain of Axl/Tyro3 receptor tyrosine kinases (RTKs)
    smart00221
    Location:538803
    STYKc; Protein kinase; unclassified specificity
    smart00409
    Location:41123
    IG; Immunoglobulin
    smart00410
    Location:145223
    IG_like; Immunoglobulin like
    cd00063
    Location:225328
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05075
    Location:535811
    PTKc_Axl; Catalytic domain of the Protein Tyrosine Kinase, Axl

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p2 Primary Assembly

    Range
    41219199..41261767
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018930.2 Alternate CHM1_1.1

    Range
    41724837..41767370
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)