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    AXL AXL receptor tyrosine kinase [ Homo sapiens (human) ]

    Gene ID: 558, updated on 19-May-2013
    Official Symbol
    AXLprovided by HGNC
    Official Full Name
    AXL receptor tyrosine kinaseprovided by HGNC
    Primary source
    HGNC:905
    See related
    Ensembl:ENSG00000167601; HPRD:00171; MIM:109135; Vega:OTTHUMG00000182727
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    UFO; JTK11
    Summary
    The protein encoded by this gene is a member of the receptor tyrosine kinase subfamily. Although it is similar to other receptor tyrosine kinases, this protein represents a unique structure of the extracellular region that juxtaposes IgL and FNIII repeats. It transduces signals from the extracellular matrix into the cytoplasm by binding growth factors like vitamin K-dependent protein growth-arrest-specific gene 6. It is involved in the stimulation of cell proliferation and can also mediate cell aggregation by homophilic binding. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
    Location :
    19q13.1
    Sequence :
    Chromosome: 19; NC_000019.9 (41725108..41767671)

    Chromosome 19 - NC_000019.9Genomic Context describing neighboring genes Neighboring gene cytochrome P450, family 2, subfamily A Neighboring gene ribosomal protein L36 pseudogene 16 Neighboring gene cytochrome P450, family 2, subfamily S, polypeptide 1 Neighboring gene transfer RNA lysine 38 (anticodon UUU) pseudogene Neighboring gene heterogeneous nuclear ribonucleoprotein U-like 1 Neighboring gene coiled-coil domain containing 97

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description
    NP_068713.2 NP_068713.2 AXL    BIND  PubMed Axl forms a homodimer. 
    NP_068713.2 GRB2    BIND  PubMed Axl interacts with an unspecified isoform of Grb2. 
    NP_068713.2 NCK2    BIND  PubMed Axl interacts with an unspecified isoform of Nck2. 
    NP_068713.2 PIK3R1    BIND  PubMed Axl interacts with an unspecified isoform of p85-alpha. 
    NP_068713.2 NP_005018.1 PIK3R2    BIND  PubMed Axl interacts with p85-beta. 
    NP_068713.2 NP_003620.2 PIK3R3    BIND  PubMed Axl interacts with p55-gamma. 
    NP_068713.2 NP_005484.2 RANBP9    BIND  PubMed Axl interacts with RanBPM. 
    NP_068713.2 NP_003020.2 SHC1    BIND  PubMed ShcA interacts with Axl. 
    NP_068713.2 NP_003736.1 SOCS1    BIND  PubMed Axl interacts with SOCS-1. 
    NP_068713.2 BAA83027.2 TENC1    BIND  PubMed Axl interacts with C1-TEN. 
    P30530 O14672 ADAM10    HPRD  PubMed  
    P30530 P30530 AXL    HPRD  PubMed  
    P30530 P22681 CBL    HPRD  PubMed  
    P30530 Q14393 GAS6    HPRD  PubMed  
    P30530 P62993 GRB2    HPRD  PubMed  
    P30530 P06239 LCK    HPRD  PubMed  
    P30530 O43639 NCK2    HPRD  PubMed  
    P30530 P27986 PIK3R1    HPRD  PubMed  
    P30530 O00459 PIK3R2    HPRD  PubMed  
    P30530 Q92569 PIK3R3    HPRD  PubMed  
    P30530 P19174 PLCG1    HPRD  PubMed  
    P30530 Q06124 PTPN11    HPRD  PubMed  
    P30530 Q96S59 RANBP9    HPRD  PubMed  
    P30530 P29353 SHC1    HPRD  PubMed  
    P30530 Q92529 SHC3    HPRD  PubMed  
    P30530 O15524 SOCS1    HPRD  PubMed  
    P30530 P12931 SRC    HPRD  PubMed  
    P30530 Tensin like C1 domain containing phosphatase (tensin 2) TENC1    HPRD  PubMed  
    BioGRID:107036 BioGRID:107315 CBL    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107036 BioGRID:108309 ELAVL1    BioGRID  PubMed Affinity Capture-RNA 
    BioGRID:107036 BioGRID:119923 ERRFI1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107036 BioGRID:108891 GAS6    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107036 BioGRID:109142 GRB2    BioGRID  PubMed Far Western 
    BioGRID:107036 BioGRID:109552 HSP90AA1    BioGRID  PubMed Affinity Capture-Luminescence 
    BioGRID:107036 BioGRID:110124 LCK    BioGRID  PubMed Far Western 
    BioGRID:107036 BioGRID:111313 PIK3R1    BioGRID  PubMed Biochemical Activity 
    BioGRID:107036 BioGRID:111314 PIK3R2    BioGRID  PubMed Biochemical Activity 
    BioGRID:107036 BioGRID:116982 SIRT3    BioGRID  PubMed Negative Genetic 
    BioGRID:107036 BioGRID:112592 SRC    BioGRID  PubMed Far Western 
    BioGRID:107036 BioGRID:116951 TENC1    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:107036 BioGRID:115485 TNK2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107036 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatidylserine binding IDA
    Inferred from Direct Assay
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    transmembrane receptor protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    apoptotic cell clearance IEA
    Inferred from Electronic Annotation
    more info
     
    blood vessel remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    cell maturation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to extracellular stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to interferon-alpha IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to lipopolysaccharide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dendritic cell differentiation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    enzyme linked receptor protein signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    erythrocyte homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    forebrain cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    natural killer cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of dendritic cell apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of interferon-gamma production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of lymphocyte activation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of neuron apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of tumor necrosis factor production IEA
    Inferred from Electronic Annotation
    more info
     
    neuron migration IEA
    Inferred from Electronic Annotation
    more info
     
    ovulation cycle IEA
    Inferred from Electronic Annotation
    more info
     
    phagocytosis IDA
    Inferred from Direct Assay
    more info
     
    platelet activation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cytokine-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of natural killer cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of protein kinase B signaling cascade IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase B signaling cascade IEA
    Inferred from Electronic Annotation
    more info
     
    secretion by cell IEA
    Inferred from Electronic Annotation
    more info
     
    signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    substrate adhesion-dependent cell spreading IEA
    Inferred from Electronic Annotation
    more info
     
    vagina development IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space IDA
    Inferred from Direct Assay
    more info
     
    integral to plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    Preferred Names
    tyrosine-protein kinase receptor UFO
    Names
    tyrosine-protein kinase receptor UFO
    AXL oncogene
    oncogene AXL
    AXL transforming sequence/gene
    NP_001690.2
    NP_068713.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001699.4NP_001690.2  tyrosine-protein kinase receptor UFO isoform 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an in-frame segment of the coding region, compared to variant 1. It encodes a shorter isoform (2), that is missing an internal segment compared to isoform 1.
      Source sequence(s)
      AC011510, AL556721, BC032229, DA478638, M76125, X66029
      Consensus CDS
      CCDS12574.1
      UniProtKB/Swiss-Prot
      P30530
      Conserved Domains (6) summary
      cd00063
      Location:225328
      Blast Score: 121
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:53126
      Blast Score: 118
      Ig; Immunoglobulin domain
      cd05749
      Location:141222
      Blast Score: 353
      Ig2_Tyro3_like; Second immunoglobulin (Ig)-like domain of Axl/Tyro3 receptor tyrosine kinases (RTKs)
      cd05075
      Location:527798
      Blast Score: 1503
      PTKc_Axl; Catalytic domain of the Protein Tyrosine Kinase, Axl
      pfam07679
      Location:139223
      Blast Score: 91
      I-set; Immunoglobulin I-set domain
      smart00221
      Location:529794
      Blast Score: 968
      STYKc; Protein kinase; unclassified specificity.
    2. NM_021913.3NP_068713.2  tyrosine-protein kinase receptor UFO isoform 1 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript, and encodes the longer isoform (1).
      Source sequence(s)
      AC011510, AL556721, BC032229, DA478638, M76125, X66029
      Consensus CDS
      CCDS12575.1
      UniProtKB/Swiss-Prot
      P30530
      Related
      ENSP00000301178, OTTHUMP00000269992, ENST00000301178, OTTHUMT00000463323
      Conserved Domains (6) summary
      cd00063
      Location:225328
      Blast Score: 121
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:53126
      Blast Score: 118
      Ig; Immunoglobulin domain
      cd05749
      Location:141222
      Blast Score: 353
      Ig2_Tyro3_like; Second immunoglobulin (Ig)-like domain of Axl/Tyro3 receptor tyrosine kinases (RTKs)
      cd05075
      Location:536807
      Blast Score: 1503
      PTKc_Axl; Catalytic domain of the Protein Tyrosine Kinase, Axl
      pfam07679
      Location:139223
      Blast Score: 91
      I-set; Immunoglobulin I-set domain
      smart00221
      Location:538803
      Blast Score: 969
      STYKc; Protein kinase; unclassified specificity.

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000019.9 Reference GRCh37.p10 Primary Assembly

      Range
      41725108..41767671
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000151.1 Alternate HuRef

      Range
      38157139..38200126
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018930.1 Alternate CHM1_1.0

      Range
      41913351..41955930
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

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