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AXL AXL receptor tyrosine kinase [ Homo sapiens (human) ]

Gene ID: 558, updated on 8-Apr-2014
Official Symbol
AXLprovided by HGNC
Official Full Name
AXL receptor tyrosine kinaseprovided by HGNC
Primary source
HGNC:905
See related
Ensembl:ENSG00000167601; HPRD:00171; MIM:109135; Vega:OTTHUMG00000182727
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UFO; JTK11
Summary
The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]
Location :
19q13.1
Sequence :
Chromosome: 19; NC_000019.10 (41219199..41261767)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ribosomal protein L36 pseudogene 16 Neighboring gene cytochrome P450, family 2, subfamily S, polypeptide 1 Neighboring gene transfer RNA lysine 38 (anticodon UUU) pseudogene Neighboring gene heterogeneous nuclear ribonucleoprotein U-like 1 Neighboring gene coiled-coil domain containing 97

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
myosin heavy chain binding IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol 3-kinase binding IEA
Inferred from Electronic Annotation
more info
 
phosphatidylserine binding IDA
Inferred from Direct Assay
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
transmembrane receptor protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
apoptotic cell clearance IEA
Inferred from Electronic Annotation
more info
 
blood vessel remodeling IEA
Inferred from Electronic Annotation
more info
 
cell maturation IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to extracellular stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to hydrogen peroxide IEA
Inferred from Electronic Annotation
more info
 
cellular response to interferon-alpha IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to lipopolysaccharide IDA
Inferred from Direct Assay
more info
PubMed 
dendritic cell differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
enzyme linked receptor protein signaling pathway IEA
Inferred from Electronic Annotation
more info
 
erythrocyte homeostasis IEA
Inferred from Electronic Annotation
more info
 
forebrain cell migration IEA
Inferred from Electronic Annotation
more info
 
inflammatory response IEA
Inferred from Electronic Annotation
more info
 
innate immune response IEA
Inferred from Electronic Annotation
more info
 
natural killer cell differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of dendritic cell apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of interferon-gamma production IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of lymphocyte activation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of tumor necrosis factor production IEA
Inferred from Electronic Annotation
more info
 
neuron migration IEA
Inferred from Electronic Annotation
more info
 
organ regeneration IEA
Inferred from Electronic Annotation
more info
 
ovulation cycle IEA
Inferred from Electronic Annotation
more info
 
peptidyl-tyrosine phosphorylation TAS
Traceable Author Statement
more info
PubMed 
phagocytosis IDA
Inferred from Direct Assay
more info
 
platelet activation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cytokine-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of natural killer cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein kinase B signaling IEA
Inferred from Electronic Annotation
more info
 
protein kinase B signaling IEA
Inferred from Electronic Annotation
more info
 
secretion by cell IEA
Inferred from Electronic Annotation
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
substrate adhesion-dependent cell spreading IEA
Inferred from Electronic Annotation
more info
 
vagina development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
Preferred Names
tyrosine-protein kinase receptor UFO
Names
tyrosine-protein kinase receptor UFO
AXL oncogene
AXL transforming sequence/gene
NP_001265528.1
NP_001690.2
NP_068713.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001278599.1NP_001265528.1  tyrosine-protein kinase receptor UFO isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks four alternate exons in the 5' coding region and initiates translation at a downstream AUG, compared to variant 1. It encodes isoform 3 which has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AI300772, AI309979, AK309139, CA437238, X66029
    Consensus CDS
    CCDS62677.1
    UniProtKB/TrEMBL
    M0R0W6
    Conserved Domains (4) summary
    cd05075
    Location:268539
    Blast Score: 1562
    PTKc_Axl; Catalytic domain of the Protein Tyrosine Kinase, Axl
    smart00221
    Location:270535
    Blast Score: 976
    STYKc; Protein kinase; unclassified specificity
    cd00063
    Location:67154
    Blast Score: 105
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam14316
    Location:162213
    Blast Score: 90
    DUF4381; Domain of unknown function (DUF4381)
  2. NM_001699.5NP_001690.2  tyrosine-protein kinase receptor UFO isoform 2 precursor

    See proteins identical to NP_001690.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. It encodes isoform 2, which lacks an internal segment and is shorter than isoform 1.
    Source sequence(s)
    AA021223, AI300772, AI309979, AK309139, AL556721, BC032229, CA437238, HY045208, M76125, X66029
    Consensus CDS
    CCDS12574.1
    UniProtKB/Swiss-Prot
    P30530
    Conserved Domains (8) summary
    cd00096
    Location:53126
    Blast Score: 121
    Ig; Immunoglobulin domain
    cd05749
    Location:141222
    Blast Score: 379
    Ig2_Tyro3_like; Second immunoglobulin (Ig)-like domain of Axl/Tyro3 receptor tyrosine kinases (RTKs)
    cd05075
    Location:527798
    Blast Score: 1562
    PTKc_Axl; Catalytic domain of the Protein Tyrosine Kinase, Axl
    smart00221
    Location:529794
    Blast Score: 976
    STYKc; Protein kinase; unclassified specificity
    smart00409
    Location:41123
    Blast Score: 115
    IG; Immunoglobulin
    smart00410
    Location:145223
    Blast Score: 94
    IG_like; Immunoglobulin like
    cd00063
    Location:225328
    Blast Score: 133
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam14316
    Location:422472
    Blast Score: 95
    DUF4381; Domain of unknown function (DUF4381)
  3. NM_021913.4NP_068713.2  tyrosine-protein kinase receptor UFO isoform 1 precursor

    See proteins identical to NP_068713.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AA021223, AI300772, AI309979, AK309139, AL556721, BC032229, CA437238, HY045208, X66029
    Consensus CDS
    CCDS12575.1
    UniProtKB/Swiss-Prot
    P30530
    Related
    ENSP00000301178, OTTHUMP00000269992, ENST00000301178, OTTHUMT00000463323
    Conserved Domains (8) summary
    cd00096
    Location:53126
    Blast Score: 121
    Ig; Immunoglobulin domain
    cd05749
    Location:141222
    Blast Score: 379
    Ig2_Tyro3_like; Second immunoglobulin (Ig)-like domain of Axl/Tyro3 receptor tyrosine kinases (RTKs)
    cd05075
    Location:536807
    Blast Score: 1562
    PTKc_Axl; Catalytic domain of the Protein Tyrosine Kinase, Axl
    smart00221
    Location:538803
    Blast Score: 976
    STYKc; Protein kinase; unclassified specificity
    smart00409
    Location:41123
    Blast Score: 115
    IG; Immunoglobulin
    smart00410
    Location:145223
    Blast Score: 94
    IG_like; Immunoglobulin like
    cd00063
    Location:225328
    Blast Score: 134
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam14316
    Location:430481
    Blast Score: 88
    DUF4381; Domain of unknown function (DUF4381)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38 Primary Assembly

    Range
    41219199..41261767
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000151.1 Alternate HuRef

    Range
    38157135..38200127
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018930.2 Alternate CHM1_1.1

    Range
    41724837..41767370
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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