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DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28 [ Homo sapiens (human) ]

Gene ID: 55794, updated on 7-Aug-2014
Official Symbol
DDX28provided by HGNC
Official Full Name
DEAD (Asp-Glu-Ala-Asp) box polypeptide 28provided by HGNC
Primary source
HGNC:17330
See related
Ensembl:ENSG00000182810; HPRD:06357; MIM:607618; Vega:OTTHUMG00000137549
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MDDX28
Summary
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene is intronless. It encodes an RNA-dependent ATPase. The encoded protein is localized in the mitochondria and the nucleus, and can be transported between the mitochondria and the nucleus. [provided by RefSeq, Jul 2008]
See DDX28 in Epigenomics, MapViewer
Location:
16q22.1
Exon count:
1
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 16 NC_000016.10 (68021274..68023867, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (68055177..68057770, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100131303 Neighboring gene lysyl-tRNA synthetase pseudogene 3 Neighboring gene dihydrouridine synthase 2 Neighboring gene nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 Neighboring gene ribosomal protein S12 pseudogene 27 Neighboring gene microRNA 6773 Neighboring gene epithelial splicing regulatory protein 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ11282

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
helicase activity IEA
Inferred from Electronic Annotation
more info
 
poly(A) RNA binding IDA
Inferred from Direct Assay
more info
 
Process Evidence Code Pubs
metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
mitochondrial nucleoid IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
probable ATP-dependent RNA helicase DDX28
Names
probable ATP-dependent RNA helicase DDX28
mitochondrial DEAD box protein 28
mitochondrial DEAD-box polypeptide 28
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 28
NP_060850.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018380.3NP_060850.2  probable ATP-dependent RNA helicase DDX28

    See proteins identical to NP_060850.2

    Status: REVIEWED

    Source sequence(s)
    AK002144, BM671594, CF993871, DA159162
    Consensus CDS
    CCDS10858.1
    UniProtKB/Swiss-Prot
    Q9NUL7
    Related
    ENSP00000332340, OTTHUMP00000174854, ENST00000332395, OTTHUMT00000268883
    Conserved Domains (3) summary
    PRK01297
    Location:27538
    Blast Score: 408
    PRK01297; ATP-dependent RNA helicase RhlB; Provisional
    cd00079
    Location:367502
    Blast Score: 266
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    cl17251
    Location:128343
    Blast Score: 373
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000016.10 

    Range
    68021274..68023867
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000148.1 

    Range
    53928754..53931347
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018927.2 

    Range
    69463195..69465788
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)