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    RIOK2 RIO kinase 2 (yeast) [ Homo sapiens ]

    Gene ID: 55781, updated on 11-May-2012
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    Summary

    Official Symbol
    RIOK2provided by HGNC
    Official Full Name
    RIO kinase 2 (yeast)provided by HGNC
    Primary source
    HGNC:18999
    See related
    Ensembl:ENSG00000058729; HPRD:10193; Vega:OTTHUMG00000128723
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RIO2; FLJ11159
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    Genomic context

    Location :
    5q15
    Sequence :
    Chromosome: 5; NC_000005.9 (96496571..96519005, complement)
    See RIOK2 in Epigenomics, MapViewer

    Chromosome 5 - NC_000005.9Genomic Context describing neighboring genes Neighboring gene SET pseudogene 22 Neighboring gene Lix1 homolog (chicken) Neighboring gene YTH domain family, member 1 pseudogene 1 Neighboring gene NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae) pseudogene

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    2. Phosphorylation of right open reading frame 2 (Rio2) protein kinase by polo-like kinase 1 regulates mitotic progression. Liu T, et al. J Biol Chem, 2011 Oct 21. PMID 21880710.
    3. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, et al. Mol Cell Proteomics, 2011 Mar. PMID 21139048.
    4. The ERAP2 gene is associated with preeclampsia in Australian and Norwegian populations. Johnson MP, et al. Hum Genet, 2009 Nov. PMID 19578876.
    5. Distinct cytoplasmic maturation steps of 40S ribosomal subunit precursors require hRio2. Zemp I, et al. J Cell Biol, 2009 Jun 29. PMID 19564402.

    See all (13) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Plk1-mediated phosphorylation of Rio2 regulates metaphase-anaphase transition during mitotic progression.
      Title: Phosphorylation of right open reading frame 2 (Rio2) protein kinase by polo-like kinase 1 regulates mitotic progression.
    2. Observational study of gene-disease association. (HuGE Navigator)
      Title: The ERAP2 gene is associated with preeclampsia in Australian and Norwegian populations.
    3. Results show that the protein kinase human Rio2 (hRio2) is part of a late 40S preribosomal particle in human cells.
      Title: Distinct cytoplasmic maturation steps of 40S ribosomal subunit precursors require hRio2.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:120896 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    • Homologs of the RIOK2 gene: The RIOK2 gene is conserved in chimpanzee, , dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, , S.pombe, , N.crassa, A.thaliana, rice, and P.falciparum.
    • Map Viewer (Mouse, Rat)

    Pathways from BioSystems

    • Ribosome biogenesis in eukaryotes, organism-specific biosystem (from KEGG)
      Ribosome biogenesis in eukaryotes, organism-specific biosystemRibosomes are the cellular factories responsible for making proteins. In eukaryotes, ribosome biogenesis involves the production and correct assembly of four rRNAs and about 80 ribosomal proteins. It...
    • Ribosome biogenesis in eukaryotes, conserved biosystem (from KEGG)
      Ribosome biogenesis in eukaryotes, conserved biosystemRibosomes are the cellular factories responsible for making proteins. In eukaryotes, ribosome biogenesis involves the production and correct assembly of four rRNAs and about 80 ribosomal proteins. It...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    serine/threonine-protein kinase RIO2
    Names
    serine/threonine-protein kinase RIO2
    NP_001153221.1
    NP_060813.2
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159749.1 → NP_001153221.1  serine/threonine-protein kinase RIO2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK225348, DB240299
      Consensus CDS
      CCDS54884.1
      UniProtKB/TrEMBL
      D6RDI3
      Related
      ENSP00000420932, OTTHUMP00000222868, ENST00000508447, OTTHUMT00000370854
      Conserved Domains (3) summary
      COG0478
      Location:6 – 308
      Blast Score: 787
      COG0478; RIO-like serine/threonine protein kinase fused to N-terminal HTH domain [Signal transduction mechanisms]
      cd05144
      Location:79 – 276
      Blast Score: 880
      RIO2_C; RIO kinase family; RIO2, C-terminal catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), ...
      pfam09202
      Location:9 – 91
      Blast Score: 339
      Rio2_N; Rio2, N-terminal

    2. NM_018343.2 → NP_060813.2  serine/threonine-protein kinase RIO2 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC008865, AK002021, CA415109, DB240299
      Consensus CDS
      CCDS4089.1
      UniProtKB/Swiss-Prot
      Q9BVS4
      Related
      ENSP00000283109, OTTHUMP00000158911, ENST00000283109, OTTHUMT00000250628
      Conserved Domains (3) summary
      COG0478
      Location:6 – 308
      Blast Score: 795
      COG0478; RIO-like serine/threonine protein kinase fused to N-terminal HTH domain [Signal transduction mechanisms]
      cd05144
      Location:79 – 276
      Blast Score: 890
      RIO2_C; RIO kinase family; RIO2, C-terminal catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), ...
      pfam09202
      Location:9 – 91
      Blast Score: 343
      Rio2_N; Rio2, N-terminal

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000005.9 Reference GRCh37.p5 Primary Assembly

      Range
      96496571..96519005, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000137.1 Alternate HuRef

      Range
      91686274..91709022, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC008865.3 (174782..191161) None
    genomic AC008883.6 (17523..23514) None
    genomic CH471084.1 EAW96088.1
    mRNA AK001697.1 BAA91844.1
    mRNA AK002021.1 BAA92040.1
    mRNA AK225348.1 None
    mRNA BC000953.2 AAH00953.1
    mRNA CA415109.1 None
    mRNA DB240299.1 None
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9BVS4.2 GenPept UniProtKB/Swiss-Prot:Q9BVS4
    Q9NVB0 GenPept UniProtKB/TrEMBL:Q9NVB0
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

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