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    CCAR1 cell division cycle and apoptosis regulator 1 [ Homo sapiens ]

    Gene ID: 55749, updated on 11-May-2012
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    Summary

    Official Symbol
    CCAR1provided by HGNC
    Official Full Name
    cell division cycle and apoptosis regulator 1provided by HGNC
    Primary source
    HGNC:24236
    See related
    Ensembl:ENSG00000060339; HPRD:10811; MIM:612569; Vega:OTTHUMG00000018361
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MGC44628; RP11-437A18.1
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    Genomic context

    Location :
    10q21.3
    Sequence :
    Chromosome: 10; NC_000010.10 (70480971..70551309)
    See CCAR1 in Epigenomics, MapViewer

    Chromosome 10 - NC_000010.10Genomic Context describing neighboring genes Neighboring gene tet methylcytosine dioxygenase 1 Neighboring gene COX20 Cox2 chaperone homolog (S. cerevisiae) pseudogene Neighboring gene ribosomal protein S3a pseudogene 37 Neighboring gene microRNA 1254-1 Neighboring gene small nucleolar RNA, C/D box 98 Neighboring gene storkhead box 1 Neighboring gene DEAD (Asp-Glu-Ala-Asp) box polypeptide 50

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. CCAR1 is required for Ngn3-mediated endocrine differentiation. Lu CK, et al. Biochem Biophys Res Commun, 2012 Feb 10. PMID 22266316.
    2. Antagonists of anaphase-promoting complex (APC)-2-cell cycle and apoptosis regulatory protein (CARP)-1 interaction are novel regulators of cell growth and apoptosis. Puliyappadamba VT, et al. J Biol Chem, 2011 Nov 4. PMID 21903591.
    3. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    4. Comparative proteomic analysis identifies a role for SUMO in protein quality control. Tatham MH, et al. Sci Signal, 2011 Jun 21. PMID 21693764.
    5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, et al. Mol Cell Proteomics, 2011 Mar. PMID 21139048.

    See all (30) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. CCAR1 is a novel partner of Ngn3 in mediating endocrine differentiation.
      Title: CCAR1 is required for Ngn3-mediated endocrine differentiation.
    2. anaphase-promoting complex (APC)-2-cell cycle and apoptosis regulatory protein (CARP)-1 interaction antagonists are novel regulators of cell growth and apoptosis
      Title: Antagonists of anaphase-promoting complex (APC)-2-cell cycle and apoptosis regulatory protein (CARP)-1 interaction are novel regulators of cell growth and apoptosis.
    3. Observational study of gene-disease association. (HuGE Navigator)
      Title: A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
    4. CCAR1 is a novel component of Wnt/beta-catenin signaling that plays an important role in transcriptional regulation by beta-catenin.
      Title: Requirement of cell cycle and apoptosis regulator 1 for target gene activation by Wnt and beta-catenin and for anchorage-independent growth of human colon carcinoma cells.
    5. These results provide the first evidence for the microtubule dependent association of AKAP350A and CCAR1 with RNA stress granules.
      Title: Microtubule-dependent association of AKAP350A and CCAR1 with RNA stress granules.
    6. CCAR1 regulates expression of key proliferation-inducing genes.
      Title: CCAR1, a key regulator of mediator complex recruitment to nuclear receptor transcription complexes.
    7. Damaging exercise induced the expression of capZalpha, MCIP1, CARP1, DNAJB2, c-myc, and junD, each of which are likely involved in skeletal muscle growth, remodeling, and stress management.
      Title: Gene expression profiling in human skeletal muscle during recovery from eccentric exercise.
    8. The study shows that tyrosine 192 of CARP-1 is a target of apoptosis signaling, and CARP-1, in turn, promotes apoptosis by activating p38 MAPK and caspase-9.
      Title: Cell cycle- and apoptosis-regulatory protein-1 is involved in apoptosis signaling by epidermal growth factor receptor.
    9. CARP-1 is a suppressor of breast cancer growth, and its expression is diminished in tumors, in part, by methylation-dependent silencing
      Title: Transactivator of transcription-tagged cell cycle and apoptosis regulatory protein-1 peptides suppress the growth of human breast cancer cells in vitro and in vivo.
    10. cell cycle and apoptosis regulatory protein-1 is a novel mediator of apoptosis signaling by retinoid CD437
      Title: Identification and characterization of a cell cycle and apoptosis regulatory protein-1 as a novel mediator of apoptosis signaling by retinoid CD437.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q8IX12 Q92851 CASP10    HPRD  PubMed  
    Q8IX12 P31947 SFN    HPRD  PubMed  
    BioGRID:120867 BioGRID:122669 FYCO1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:120867 BioGRID:214951 Kif23    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:120867 BioGRID:112497 SUMO2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:120867 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:120867 BioGRID:116168 YWHAQ    BioGRID  PubMed Affinity Capture-Western 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystem (from REACTOME)
      Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystemCo-transcriptional pre-mRNA splicing is not obligatory. Pre-mRNA splicing begins co-transcriptionally and often continues post-transcriptionally. Human genes contain an average of nine introns per ge...
    • mRNA Splicing, organism-specific biosystem (from REACTOME)
      mRNA Splicing, organism-specific biosystemThe process in which excision of introns from the primary transcript of messenger RNA (mRNA) is followed by ligation of the two exon termini exposed by removal of each intron, is called mRNA splicing...
    • mRNA Splicing - Major Pathway, organism-specific biosystem (from REACTOME)
      mRNA Splicing - Major Pathway, organism-specific biosystemThe splicing of pre-mRNA occurs within a large, very dynamic complex, designated the 'spliceosome'. The 50-60S spliceosomes are estimated to be 40-60 nm in diameter, and have molecular weights in the...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		  
    Process Evidence Code Pubs
    RNA splicing TAS
    Traceable Author Statement
    more info
    		  
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    gene expression TAS
    Traceable Author Statement
    more info
    		  
    nuclear mRNA splicing, via spliceosome TAS
    Traceable Author Statement
    more info
    		  
    regulation of transcription, DNA-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    cell division cycle and apoptosis regulator protein 1
    Names
    cell division cycle and apoptosis regulator protein 1
    death inducer with SAP domain
    cell cycle and apoptosis regulatory protein 1
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_018237.2 → NP_060707.2  cell division cycle and apoptosis regulator protein 1

      Status: VALIDATED

      Source sequence(s)
      AK023438, AY249140, BM786237, BM905703, BU181074, CB136079
      Consensus CDS
      CCDS7282.1
      UniProtKB/Swiss-Prot
      Q8IX12
      Related
      ENSP00000265872, OTTHUMP00000019709, ENST00000265872, OTTHUMT00000048356
      Conserved Domains (3) summary
      pfam14443
      Location:478 – 603
      Blast Score: 562
      DBC1; DBC1
      pfam14444
      Location:149 – 204
      Blast Score: 318
      S1-like; S1-like
      cl02640
      Location:637 – 667
      Blast Score: 107
      SAP; SAP domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000010.10 Reference GRCh37.p5 Primary Assembly

      Range
      70480971..70551309
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000142.1 Alternate HuRef

      Range
      64482373..64552734
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL391539.27 CAH73835.1
    genomic AL513534.17 CAH70221.1
    genomic CH471083.1 EAW54300.1
      EAW54301.1
      EAW54302.1
    genomic HI574014.1 CBX47496.1
    mRNA AF465616.1 AAO17319.1
    mRNA AK000741.1 BAA91354.1
    mRNA AK001701.1 BAA91847.1
    mRNA AK023438.1 BAB14574.1
    mRNA AK122871.1 None
    mRNA AK292649.1 BAF85338.1
    mRNA AK298004.1 BAG60310.1
    mRNA AK299307.1 BAG61320.1
    mRNA AK307550.1 None
    mRNA AK307671.1 None
    mRNA AK307704.1 None
    mRNA AY249140.1 AAP82002.1
    mRNA BC015475.1 AAH15475.1
    mRNA BC026036.2 AAH26036.1
    mRNA BC058846.1 None
    mRNA BC089420.1 AAH89420.1
    mRNA BC108682.1 AAI08683.1
    mRNA BC130626.1 AAI30627.1
    mRNA BC132725.1 AAI32726.1
    mRNA BC144118.1 None
    mRNA BM786237.1 None
    mRNA BM905703.1 None
    mRNA BU181074.1 None
    mRNA BX647943.1 None
    mRNA CB136079.1 None
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IX12.2 GenPept UniProtKB/Swiss-Prot:Q8IX12
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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