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    ATF7IP activating transcription factor 7 interacting protein [ Homo sapiens ]

    Gene ID: 55729, updated on 11-May-2012
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    Summary

    Official Symbol
    ATF7IPprovided by HGNC
    Official Full Name
    activating transcription factor 7 interacting proteinprovided by HGNC
    Primary source
    HGNC:20092
    See related
    Ensembl:ENSG00000171681; HPRD:09811; MIM:613644; Vega:OTTHUMG00000168656
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AM; MCAF; p621; MCAF1; FLJ10139; FLJ10688
    Summary
    ATF7IP is a multifunctional nuclear protein that associates with heterochromatin. It can act as a transcriptional coactivator or corepressor depending upon its binding partners (summary by Liu et al., 2009 [PubMed 19106100]).[supplied by OMIM, Nov 2010]
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    Genomic context

    Location :
    12p13.1
    Sequence :
    Chromosome: 12; NC_000012.11 (14518611..14651697)
    See ATF7IP in Epigenomics, MapViewer

    Chromosome 12 - NC_000012.11Genomic Context describing neighboring genes Neighboring gene guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 pseudogene 1 Neighboring gene ribosomal protein L30 pseudogene 11 Neighboring gene phospholipase B domain containing 1 Neighboring gene guanylate cyclase 2C (heat stable enterotoxin receptor)

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. Lee KA, et al. J Biol Chem, 2011 Dec 2. PMID 21987572.
    2. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    3. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    4. Comparative proteomic analysis identifies a role for SUMO in protein quality control. Tatham MH, et al. Sci Signal, 2011 Jun 21. PMID 21693764.
    5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, et al. Mol Cell Proteomics, 2011 Mar. PMID 21139048.

    See all (27) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Studies identified three new susceptibility loci DMRT1, TERT and ATF7IP associated with testicular germ cell cancer.
      Title: Variants near DMRT1, TERT and ATF7IP are associated with testicular germ cell cancer.
    2. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
      Title: Variants near DMRT1, TERT and ATF7IP are associated with testicular germ cell cancer.
    3. Two evolutionarily conserved domains of MCAF1 directly interact with Sp1 and the general transcriptional apparatus. Selective depletion of MCAF1 or Sp1 down-regulates TERT and TERC genes in cultured cells, which results in decreased telomerase activity.
      Title: MCAF1/AM is involved in Sp1-mediated maintenance of cancer-associated telomerase activity.
    4. the acidic stretch of the SIM of MCAF1 plays an important role in the binding to SUMO-3.
      Title: Structure of the small ubiquitin-like modifier (SUMO)-interacting motif of MBD1-containing chromatin-associated factor 1 bound to SUMO-3.
    5. mAM/hAM facilitates conversion of H3-K9 dimethyl to trimethyl by ESET/SETDB1
      Title: mAM facilitates conversion by ESET of dimethyl to trimethyl lysine 9 of histone H3 to cause transcriptional repression.
    6. These data suggest that MBD1.MCAF1.SETDB1 complex facilitates the formation of heterochromatic domains, emphasizing the role of MCAF/AM family proteins in epigenetic control, and describe a new family member, MCAF2.
      Title: Transcriptional repression and heterochromatin formation by MBD1 and MCAF/AM family proteins.
    7. MBD1- and MCAF1-mediated heterochromatin formation involves SUMO modification
      Title: Involvement of SUMO modification in MBD1- and MCAF1-mediated heterochromatin formation.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Variants near DMRT1, TERT and ATF7IP are associated with testicular germ cell cancer.

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Activating transcription factor 7 interacting protein P01023 A2M    HPRD  PubMed  
    Activating transcription factor 7 interacting protein P60709 ACTB    HPRD  PubMed  
    Activating transcription factor 7 interacting protein P63261 ACTG1    HPRD  PubMed  
    Activating transcription factor 7 interacting protein Q10567 AP1B1    HPRD  PubMed  
    Activating transcription factor 7 interacting protein Immunoglobulin superfamily member 4 CADM1    HPRD  PubMed  
    Activating transcription factor 7 interacting protein Q9BV73 CEP250    HPRD  PubMed  
    Activating transcription factor 7 interacting protein P08572 COL4A2    HPRD  PubMed  
    Activating transcription factor 7 interacting protein Q6UVK1 CSPG4    HPRD  PubMed  
    Activating transcription factor 7 interacting protein Q9NRI5 DISC1    HPRD  PubMed  
    Activating transcription factor 7 interacting protein Cyclin D binding myb like transcription factor 1 DMTF1    HPRD  PubMed  
    Activating transcription factor 7 interacting protein P50570 DNM2    HPRD  PubMed  
    Activating transcription factor 7 interacting protein KIAA1632 EPG5    HPRD  PubMed  
    Activating transcription factor 7 interacting protein O75369 FLNB    HPRD  PubMed  
    Activating transcription factor 7 interacting protein P35916 FLT4    HPRD  PubMed  
    Activating transcription factor 7 interacting protein Q9Y692 GMEB1    HPRD  PubMed  
    Activating transcription factor 7 interacting protein P29084 GTF2E2    HPRD  PubMed  
    Activating transcription factor 7 interacting protein P35269 GTF2F1    HPRD  PubMed  
    Activating transcription factor 7 interacting protein P32780 GTF2H1    HPRD  PubMed  
    Activating transcription factor 7 interacting protein Hairy/enhancer-of-split related with YRPW motif-like HEYL    HPRD  PubMed  
    Activating transcription factor 7 interacting protein P01889 HLA-B    HPRD  PubMed  
    Activating transcription factor 7 interacting protein P98160 HSPG2    HPRD  PubMed  
    Activating transcription factor 7 interacting protein Q9H1H9 KIF13A    HPRD  PubMed  
    Activating transcription factor 7 interacting protein P08729 KRT7    HPRD  PubMed  
    Activating transcription factor 7 interacting protein Q16363 LAMA4    HPRD  PubMed  
    Activating transcription factor 7 interacting protein O15230 LAMA5    HPRD  PubMed  
    Activating transcription factor 7 interacting protein P11047 LAMC1    HPRD  PubMed  
    Activating transcription factor 7 interacting protein Q9Y383 LUC7L2    HPRD  PubMed  
    Activating transcription factor 7 interacting protein Q96PK2 MACF1    HPRD  PubMed  
    Activating transcription factor 7 interacting protein Q9UIS9 MBD1    HPRD  PubMed  
    Activating transcription factor 7 interacting protein P43121 MCAM    HPRD  PubMed  
    Activating transcription factor 7 interacting protein Q9NPJ6 MED4    HPRD  PubMed  
    Activating transcription factor 7 interacting protein Hypothetical protein MGC3207 MRI1    HPRD  PubMed  
    Activating transcription factor 7 interacting protein P69849 NOMO3    HPRD  PubMed  
    Activating transcription factor 7 interacting protein P16066 NPR1    HPRD  PubMed  
    Activating transcription factor 7 interacting protein Q13219 PAPPA    HPRD  PubMed  
    Activating transcription factor 7 interacting protein Q9BXP8 PAPPA2    HPRD  PubMed  
    Activating transcription factor 7 interacting protein Q08174 PCDH1    HPRD  PubMed  
    Activating transcription factor 7 interacting protein Q13608 PEX6    HPRD  PubMed  
    Activating transcription factor 7 interacting protein Q9Y6X2 PIAS3    HPRD  PubMed  
    Activating transcription factor 7 interacting protein P98161 PKD1    HPRD  PubMed  
    Activating transcription factor 7 interacting protein Q96CS7 PLEKHB2    HPRD  PubMed  
    Activating transcription factor 7 interacting protein P19387 POLR2C    HPRD  PubMed  
    Activating transcription factor 7 interacting protein O15514 POLR2D    HPRD  PubMed  
    Activating transcription factor 7 interacting protein P62487 POLR2G    HPRD  PubMed  
    Activating transcription factor 7 interacting protein Q16651 PRSS8    HPRD  PubMed  
    Activating transcription factor 7 interacting protein Q16557 PSG3    HPRD  PubMed  
    Activating transcription factor 7 interacting protein Q2TAL8 QRICH1    HPRD  PubMed  
    Activating transcription factor 7 interacting protein P61247 RPS3A    HPRD  PubMed  
    Activating transcription factor 7 interacting protein Q9P2E9 RRBP1    HPRD  PubMed  
    Activating transcription factor 7 interacting protein Q9H4L4 SENP3    HPRD  PubMed  
    Activating transcription factor 7 interacting protein Q15047 SETDB1    HPRD  PubMed  
    Activating transcription factor 7 interacting protein Q9UP95 SLC12A4    HPRD  PubMed  
    Activating transcription factor 7 interacting protein Q13485 SMAD4    HPRD  PubMed  
    Activating transcription factor 7 interacting protein P08047 SP1    HPRD  PubMed  
    Activating transcription factor 7 interacting protein Q01082 SPTBN1    HPRD  PubMed  
    Activating transcription factor 7 interacting protein Genethonin 1 STBD1    HPRD  PubMed  
    Activating transcription factor 7 interacting protein O43815 STRN    HPRD  PubMed  
    Activating transcription factor 7 interacting protein Q6UWL2 SUSD1    HPRD  PubMed  
    Activating transcription factor 7 interacting protein Chromosome 9 open reading frame 13 SVEP1    HPRD  PubMed  
    Activating transcription factor 7 interacting protein Q14669 TRIP12    HPRD  PubMed  
    Activating transcription factor 7 interacting protein P53804 TTC3    HPRD  PubMed  
    Activating transcription factor 7 interacting protein Q15916 ZBTB6    HPRD  PubMed  
    Activating transcription factor 7 interacting protein Q9GZX5 ZNF350    HPRD  PubMed  
    Activating transcription factor 7 interacting protein Q6AHZ1 ZNF518A    HPRD  PubMed  
    NP_060649.3 NP_061132.1 DISC1    BIND  PubMed DISC-1 interacts with ATF7ip. 
    NP_060649.3 NP_056671.2 MBD1    BIND  PubMed MCAF1 interacts with MBD1. 
    NP_060649.3 NP_036564.2 SETDB1    BIND  PubMed MCAF1 interacts with SETDB1. 
    NP_060649.3 NP_612482.2 SP1    BIND  PubMed MCAF1 interacts with Sp1. 
    BioGRID:120849 BioGRID:971769 BRLF1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:120849 BioGRID:107775 CREB1    BioGRID  PubMed Two-hybrid 
    BioGRID:120849 BioGRID:118061 DISC1    BioGRID  PubMed Two-hybrid 
    BioGRID:120849 BioGRID:108380 ERCC2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:120849 BioGRID:108383 ERCC3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:120849 BioGRID:109215 GTF2E1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:120849 BioGRID:109216 GTF2E2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:120849 BioGRID:110322 MBD1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:120849 BioGRID:111426 POLR2A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:120849 BioGRID:115202 SETDB1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:120849 BioGRID:112550 SP1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:120849 BioGRID:112599 SREBF2    BioGRID  PubMed Two-hybrid 
    BioGRID:120849 BioGRID:112497 SUMO2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:120849 BioGRID:112496 SUMO3    BioGRID  PubMed Reconstituted Complex 
    BioGRID:120849 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:120849 BioGRID:113177 UBE2I    BioGRID  PubMed Two-hybrid 
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    General gene information

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    transcription corepressor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    DNA methylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    interspecies interaction between organisms IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of transcription from RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of transcription, DNA-dependent IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of transcription, DNA-dependent IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    regulation of RNA polymerase II transcriptional preinitiation complex assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    transcription factor complex IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    activating transcription factor 7-interacting protein 1
    Names
    activating transcription factor 7-interacting protein 1
    hAM
    ATF-IP
    ATF-interacting protein
    ATF7-interacting protein
    ATFa-associated modulator
    MBD1-containing chromatin associated factor
    MBD1-containing chromatin-associated factor 1
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_018179.3 → NP_060649.3  activating transcription factor 7-interacting protein 1

      Status: VALIDATED

      Source sequence(s)
      AK025060, AK027575, AK074868, BX648096
      Consensus CDS
      CCDS8663.1
      UniProtKB/TrEMBL
      B3KNI7
      UniProtKB/TrEMBL
      B3KQF8
      UniProtKB/Swiss-Prot
      Q6VMQ6
      Related
      ENSP00000261168, ENST00000261168
      Conserved Domains (1) summary
      COG5271
      Location:298 – 435
      Blast Score: 102
      MDN1; AAA ATPase containing von Willebrand factor type A (vWA) domain [General function prediction only]

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000012.11 Reference GRCh37.p5 Primary Assembly

      Range
      14518611..14651697
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000144.1 Alternate HuRef

      Range
      14287849..14420834
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC007782.20 (70973..166081) None
    genomic AC008114.25 (2001..21058) None
    genomic AC124892.8 (2005..20924) None
    genomic CH471094.1 EAW96314.1
      EAW96315.1
      EAW96316.1
      EAW96317.1
      EAW96318.1
      EAW96319.1
      EAW96320.1
    mRNA AF425650.1 AAO91864.1
    mRNA AJ242978.1 CAB45135.1
    mRNA AK001001.1 None
    mRNA AK001550.1 BAA91751.1
    mRNA AK021569.1 None
    mRNA AK025060.1 None
    mRNA AK027575.1 BAG51349.1
    mRNA AK074868.1 BAG52020.1
    mRNA AK299320.1 BAG61328.1
    mRNA AK304184.1 BAG65064.1
    mRNA AY337596.1 AAQ92978.1
    mRNA BC037312.2 AAH37312.1
    mRNA BC053625.1 None
    mRNA BC063855.1 AAH63855.1
    mRNA BX648096.1 None
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6VMQ6.3 GenPept UniProtKB/Swiss-Prot:Q6VMQ6
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
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