Display Settings:

Format

Send to:

Choose Destination
We are sorry, but NCBI web applications do not support your browser and may not function properly. More information

POLR3E polymerase (RNA) III (DNA directed) polypeptide E (80kD) [ Homo sapiens (human) ]

Gene ID: 55718, updated on 6-Jul-2014
Official Symbol
POLR3Eprovided by HGNC
Official Full Name
polymerase (RNA) III (DNA directed) polypeptide E (80kD)provided by HGNC
Primary source
HGNC:30347
See related
Ensembl:ENSG00000058600; HPRD:15155; Vega:OTTHUMG00000094779
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SIN; RPC5
See POLR3E in Epigenomics, MapViewer
Location:
16p12.2
Exon count :
22
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 16 NC_000016.10 (22297375..22335103)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (22308696..22346424)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene eukaryotic elongation factor-2 kinase Neighboring gene transfer RNA-Leu (AAG) 2-2 Neighboring gene cerebellar degeneration-related protein 2, 62kDa Neighboring gene RNA polymerase I transcription factor homolog (S. cerevisiae) pseudogene 3 Neighboring gene SMG1 pseudogene 1

Protein interactions

Protein Gene Interaction Pubs
Tat, p14 tat HIV-1 Tat upregulates the transcription by RNA polymerase III of co-transfected or endogenous cellular Alu-repeated sequences by activating transcription factor TFIIIC PubMed

Go to the HIV-1, Human Protein Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to RNA polymerase III activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
defense response to virus IEA
Inferred from Electronic Annotation
more info
 
gene expression TAS
Traceable Author Statement
more info
 
innate immune response TAS
Traceable Author Statement
more info
 
positive regulation of type I interferon production TAS
Traceable Author Statement
more info
 
termination of RNA polymerase III transcription TAS
Traceable Author Statement
more info
 
transcription elongation from RNA polymerase III promoter TAS
Traceable Author Statement
more info
 
transcription from RNA polymerase III promoter TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
DNA-directed RNA polymerase III complex IBA
Inferred from Biological aspect of Ancestor
more info
 
DNA-directed RNA polymerase III complex IDA
Inferred from Direct Assay
more info
 
centrosome IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
NOT nucleolus IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 
Preferred Names
DNA-directed RNA polymerase III subunit RPC5
Names
DNA-directed RNA polymerase III subunit RPC5
RNA polymerase III subunit C5
RNA polymerase III 80 kDa subunit RPC5
DNA-directed RNA polymerase III 80 kDa polypeptide

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001258033.1NP_001244962.1  DNA-directed RNA polymerase III subunit RPC5 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame acceptor splice site in the 3' coding region compared to variant 1. The resulting isoform (2) is shorter, missing an internal protein segment, compared to isoform 1.
    Source sequence(s)
    AA282721, AC092338, AK001371, AK026645, AK222671, AK300735, AL048627, AW205673, DB047155
    Consensus CDS
    CCDS58432.1
    UniProtKB/Swiss-Prot
    Q9NVU0
    Conserved Domains (1) summary
    pfam04801
    Location:4434
    Blast Score: 1537
    Sin_N; Sin-like protein conserved region
  2. NM_001258034.1NP_001244963.1  DNA-directed RNA polymerase III subunit RPC5 isoform 4

    See proteins identical to NP_001244963.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an exon and uses an alternate acceptor splice site in the 5' region compared to variant 1, However, it maintains the reading frame, and encodes an isoform (4) missing an internal protein segment compared to isoform 1.
    Source sequence(s)
    AA282721, AC092338, AK001371, AK222671, AK296813, AL048627, AW205673, DB047155
    Consensus CDS
    CCDS58434.1
    UniProtKB/Swiss-Prot
    Q9NVU0
    Conserved Domains (1) summary
    pfam04801
    Location:4398
    Blast Score: 1337
    Sin_N; Sin-like protein conserved region
  3. NM_001258035.1NP_001244964.1  DNA-directed RNA polymerase III subunit RPC5 isoform 3

    See proteins identical to NP_001244964.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an exon in the 5' region compared to variant 1, which results in translation initiation from an in-frame downstream AUG, and an isoform (3) with a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AA282721, AC092338, AK001371, AK023231, AK222671, AL048627, AW205673, DB047155
    UniProtKB/Swiss-Prot
    Q9NVU0
    Conserved Domains (1) summary
    pfam04801
    Location:1398
    Blast Score: 1369
    Sin_N; Sin-like protein conserved region
  4. NM_001258036.1NP_001244965.1  DNA-directed RNA polymerase III subunit RPC5 isoform 5

    See proteins identical to NP_001244965.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an exon in the 3' coding region compared to variant 1. The resulting isoform (5) is shorter, missing an internal protein segment, compared to isoform 1.
    Source sequence(s)
    AA282721, AC092338, AK001371, AK026645, AK222671, AL048627, AW205673, DB047155
    Consensus CDS
    CCDS58433.1
    UniProtKB/Swiss-Prot
    Q9NVU0
    Conserved Domains (1) summary
    pfam04801
    Location:4434
    Blast Score: 1542
    Sin_N; Sin-like protein conserved region
  5. NM_018119.3NP_060589.1  DNA-directed RNA polymerase III subunit RPC5 isoform 1

    See proteins identical to NP_060589.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AA282721, AC092338, AK001371, AK026645, AK222671, AL048627, AW205673, DB047155
    Consensus CDS
    CCDS10605.1
    UniProtKB/Swiss-Prot
    Q9NVU0
    Related
    ENSP00000299853, OTTHUMP00000120008, ENST00000299853, OTTHUMT00000211590
    Conserved Domains (1) summary
    pfam04801
    Location:4434
    Blast Score: 1535
    Sin_N; Sin-like protein conserved region

RNA

  1. NR_047581.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) uses an alternate acceptor splice site at an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most translational start codon (with a strong Kozak signal), as used in variant 1, renders this transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA282721, AC092338, AK001371, AK026645, AK222671, AK293300, AL048627, AW205673, DB047155

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000016.10 

    Range
    22297375..22335103
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006721063.1XP_006721126.1  

    See proteins identical to XP_006721126.1

    UniProtKB/Swiss-Prot
    Q9NVU0
    Conserved Domains (1) summary
    pfam04801
    Location:4434
    Blast Score: 1535
    Sin_N; Sin-like protein conserved region

Alternate HuRef

Genomic

  1. AC_000148.1 

    Range
    20553291..20591117
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018927.2 

    Range
    22044894..22082622
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Supplemental Content

Recent activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...