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POLR3E polymerase (RNA) III subunit E [ Homo sapiens (human) ]

Gene ID: 55718, updated on 9-Jun-2016
Official Symbol
POLR3Eprovided by HGNC
Official Full Name
polymerase (RNA) III subunit Eprovided by HGNC
Primary source
HGNC:HGNC:30347
See related
Ensembl:ENSG00000058600 HPRD:15155; Vega:OTTHUMG00000094779
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SIN; RPC5
Orthologs
Location:
16p12.2
Exon count:
22
Annotation release Status Assembly Chr Location
108 current GRCh38.p7 (GCF_000001405.33) 16 NC_000016.10 (22297366..22335103)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (22308696..22346424)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene eukaryotic elongation factor 2 kinase Neighboring gene transfer RNA-Leu (AAG) 2-4 Neighboring gene uncharacterized LOC107984846 Neighboring gene cerebellar degeneration related protein 2 Neighboring gene uncharacterized LOC440346

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat upregulates the transcription by RNA polymerase III of co-transfected or endogenous cellular Alu-repeated sequences by activating transcription factor TFIIIC PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to RNA polymerase III activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
defense response to virus IEA
Inferred from Electronic Annotation
more info
 
innate immune response IEA
Inferred from Electronic Annotation
more info
 
positive regulation of type I interferon production TAS
Traceable Author Statement
more info
 
transcription from RNA polymerase III promoter IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
DNA-directed RNA polymerase III complex IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
Preferred Names
DNA-directed RNA polymerase III subunit RPC5
Names
DNA-directed RNA polymerase III 80 kDa polypeptide
RNA polymerase III 80 kDa subunit RPC5
RNA polymerase III subunit C5
polymerase (RNA) III (DNA directed) polypeptide E (80kD)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001258033.1NP_001244962.1  DNA-directed RNA polymerase III subunit RPC5 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame acceptor splice site in the 3' coding region compared to variant 1. The resulting isoform (2) is shorter, missing an internal protein segment, compared to isoform 1.
    Source sequence(s)
    AA282721, AC092338, AK001371, AK026645, AK222671, AK300735, AL048627, AW205673, DB047155
    Consensus CDS
    CCDS58432.1
    UniProtKB/Swiss-Prot
    Q9NVU0
    Related
    ENSP00000456967, OTTHUMP00000253693, ENST00000564209, OTTHUMT00000430064
    Conserved Domains (1) summary
    pfam04801
    Location:4434
    Sin_N; Sin-like protein conserved region
  2. NM_001258034.1NP_001244963.1  DNA-directed RNA polymerase III subunit RPC5 isoform 4

    See identical proteins and their annotated locations for NP_001244963.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an exon and uses an alternate acceptor splice site in the 5' region compared to variant 1, However, it maintains the reading frame, and encodes an isoform (4) missing an internal protein segment compared to isoform 1.
    Source sequence(s)
    AA282721, AC092338, AK001371, AK222671, AK296813, AL048627, AW205673, DB047155
    Consensus CDS
    CCDS58434.1
    UniProtKB/Swiss-Prot
    Q9NVU0
    Related
    ENSP00000399254, OTTHUMP00000253695, ENST00000418581, OTTHUMT00000430066
    Conserved Domains (1) summary
    pfam04801
    Location:4398
    Sin_N; Sin-like protein conserved region
  3. NM_001258035.1NP_001244964.1  DNA-directed RNA polymerase III subunit RPC5 isoform 3

    See identical proteins and their annotated locations for NP_001244964.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an exon in the 5' region compared to variant 1, which results in translation initiation from an in-frame downstream AUG, and an isoform (3) with a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AA282721, AC092338, AK001371, AK023231, AK222671, AL048627, AW205673, DB047155
    Consensus CDS
    CCDS73845.1
    UniProtKB/Swiss-Prot
    Q9NVU0
    UniProtKB/TrEMBL
    A0A0C4DH01
    Related
    ENSP00000484648, ENST00000615879
    Conserved Domains (1) summary
    pfam04801
    Location:1398
    Sin_N; Sin-like protein conserved region
  4. NM_001258036.1NP_001244965.1  DNA-directed RNA polymerase III subunit RPC5 isoform 5

    See identical proteins and their annotated locations for NP_001244965.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an exon in the 3' coding region compared to variant 1. The resulting isoform (5) is shorter, missing an internal protein segment, compared to isoform 1.
    Source sequence(s)
    AA282721, AC092338, AK001371, AK026645, AK222671, AL048627, AW205673, DB047155
    Consensus CDS
    CCDS58433.1
    UniProtKB/Swiss-Prot
    Q9NVU0
    Related
    ENSP00000352140, OTTHUMP00000253697, ENST00000359210, OTTHUMT00000430068
    Conserved Domains (1) summary
    pfam04801
    Location:4434
    Sin_N; Sin-like protein conserved region
  5. NM_018119.3NP_060589.1  DNA-directed RNA polymerase III subunit RPC5 isoform 1

    See identical proteins and their annotated locations for NP_060589.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AA282721, AC092338, AK001371, AK026645, AK222671, AL048627, AW205673, DB047155
    Consensus CDS
    CCDS10605.1
    UniProtKB/Swiss-Prot
    Q9NVU0
    Related
    ENSP00000299853, OTTHUMP00000120008, ENST00000299853, OTTHUMT00000211590
    Conserved Domains (1) summary
    pfam04801
    Location:4434
    Sin_N; Sin-like protein conserved region

RNA

  1. NR_047581.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) uses an alternate acceptor splice site at an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most translational start codon (with a strong Kozak signal), as used in variant 1, renders this transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA282721, AC092338, AK001371, AK026645, AK222671, AK293300, AL048627, AW205673, DB047155

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p7 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p7 Primary Assembly

    Range
    22297366..22335103
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011545892.1XP_011544194.1  

    Conserved Domains (1) summary
    pfam04801
    Location:4433
    Sin_N; Sin-like protein conserved region
  2. XM_017023443.1XP_016878932.1  

  3. XM_011545893.2XP_011544195.1  

    Conserved Domains (1) summary
    pfam04801
    Location:4434
    Sin_N; Sin-like protein conserved region
  4. XM_006721063.2XP_006721126.1  

    See identical proteins and their annotated locations for XP_006721126.1

    UniProtKB/Swiss-Prot
    Q9NVU0
    Conserved Domains (1) summary
    pfam04801
    Location:4434
    Sin_N; Sin-like protein conserved region

Alternate CHM1_1.1

Genomic

  1. NC_018927.2 Alternate CHM1_1.1

    Range
    22044894..22082622 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)