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    PRKAG1 protein kinase, AMP-activated, gamma 1 non-catalytic subunit [ Homo sapiens ]

    Gene ID: 5571, updated on 12-May-2012
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    Summary

    Official Symbol
    PRKAG1provided by HGNC
    Official Full Name
    protein kinase, AMP-activated, gamma 1 non-catalytic subunitprovided by HGNC
    Primary source
    HGNC:9385
    See related
    Ensembl:ENSG00000181929; HPRD:04118; MIM:602742; Vega:OTTHUMG00000170406
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AMPKG; MGC8666
    Summary
    The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit is one of the gamma regulatory subunits of AMPK. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    12q12-q14
    Sequence :
    Chromosome: 12; NC_000012.11 (49396055..49412629, complement)
    See PRKAG1 in Epigenomics, MapViewer

    Chromosome 12 - NC_000012.11Genomic Context describing neighboring genes Neighboring gene wingless-type MMTV integration site family, member 1 Neighboring gene uncharacterized LOC100652964 Neighboring gene dendrin Neighboring gene myeloid/lymphoid or mixed-lineage leukemia 2 Neighboring gene Ras homolog enriched in brain like 1

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. Lee KA, et al. J Biol Chem, 2011 Dec 2. PMID 21987572.
    2. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    3. The AMPK signalling pathway coordinates cell growth, autophagy and metabolism. Mihaylova MM, et al. Nat Cell Biol, 2011 Sep 2. PMID 21892142.
    4. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    5. Hypoxia triggers AMPK activation through reactive oxygen species-mediated activation of calcium release-activated calcium channels. Mungai PT, et al. Mol Cell Biol, 2011 Sep. PMID 21670147.

    See all (50) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Studies indicate that in most species, AMPK exists as an obligate heterotrimer, containing a catalytic subunit (alpha), and two regulatory subunits (beta and gamma).
      Title: The AMPK signalling pathway coordinates cell growth, autophagy and metabolism.
    2. Findings reveal that hypoxia can trigger AMPK activation in the apparent absence of increased [AMP] through ROS-dependent CRAC channel activation, leading to increases in cytosolic calcium that activate the AMPK upstream kinase CaMKKbeta.
      Title: Hypoxia triggers AMPK activation through reactive oxygen species-mediated activation of calcium release-activated calcium channels.
    3. Results suggest that AMPK association with ULK1 plays an important role in autophagy induction.
      Title: The association of AMPK with ULK1 regulates autophagy.
    4. Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Common variants in 40 genes assessed for diabetes incidence and response to metformin and lifestyle intervention in the diabetes prevention program.
    5. Observational study of gene-disease association. (HuGE Navigator)
      Title: Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.
    6. Observational study of gene-disease association, gene-gene interaction, gene-environment interaction, and genetic testing. (HuGE Navigator)
      Title: Integrative predictive model of coronary artery calcification in atherosclerosis.
    7. Inhibition of the KCa3.1 channels by AMP-activated protein kinase in human airway epithelial cells.
      Title: Inhibition of the KCa3.1 channels by AMP-activated protein kinase in human airway epithelial cells.
    8. AMP-activated protein kinase inhibits alkaline pH- and PKA-induced apical vacuolar H+-ATPase accumulation in epididymal clear cells.
      Title: AMP-activated protein kinase inhibits alkaline pH- and PKA-induced apical vacuolar H+-ATPase accumulation in epididymal clear cells.
    9. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: Association study of energy homeostasis genes and antipsychotic-induced weight gain in patients with schizophrenia.
    10. findings show that that a beta1(186-270)gamma1 complex can form in the absence of detectable alpha subunit and that beta1 Thr-263 and Tyr-267 are required for betagamma association but not alphabeta association
      Title: AMP-activated protein kinase subunit interactions: beta1:gamma1 association requires beta1 Thr-263 and Tyr-267.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat induces IL-6 and TNF-alpha expression through the activation of cAMP-dependent protein kinase pathways PubMed
    matrix gag HIV-1 Matrix impairs proliferation of normal lymphocytes in vitro by inducing the activity of the inhibitory protein kinase A (PKA) PubMed
    gag Protein kinase A (PKA) has been shown to phosphorylate HIV-1 Matrix in vitro PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    P54619 O15554 KCNN4    HPRD  PubMed  
    P54619 Q13131 PRKAA1    HPRD  PubMed  
    P54619 P54646 PRKAA2    HPRD  PubMed  
    P54619 Q9Y478 PRKAB1    HPRD  PubMed  
    P54619 O43741 PRKAB2    HPRD  PubMed  
    P54619 Q9UGJ0 PRKAG2    HPRD  PubMed  
    BioGRID:111558 BioGRID:118855 BABAM1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111558 BioGRID:115889 CAMKK2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111558 BioGRID:108578 FKBP4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111558 BioGRID:125175 FNIP1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:111558 BioGRID:110339 MCM2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111558 BioGRID:111075 PA2G4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111558 BioGRID:111251 PGK1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111558 BioGRID:111549 PRKAA1    BioGRID  PubMed Affinity Capture-MS; Two-hybrid 
    BioGRID:111558 BioGRID:111550 PRKAA2    BioGRID  PubMed Affinity Capture-MS; Two-hybrid 
    BioGRID:111558 BioGRID:111551 PRKAB1    BioGRID  PubMed Affinity Capture-MS; Two-hybrid 
    BioGRID:111558 BioGRID:111552 PRKAB2    BioGRID  PubMed Affinity Capture-MS; Two-hybrid 
    BioGRID:111558 BioGRID:119531 PRKAG2    BioGRID  PubMed Affinity Capture-MS; Two-hybrid 
    BioGRID:111558 BioGRID:112760 TARS    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111558 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111558 BioGRID:113996 ULK1    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • AMPK signaling, organism-specific biosystem (from WikiPathways)
      AMPK signaling, organism-specific biosystemAMPK signaling pathway, a fuel sensor and regulator, promotes ATP-producing and inhibits ATP-consuming pathways in various tissues. AMPK is a heterotrimer composed of alpha-catalytic and beta and gam...
    • Adipocytokine signaling pathway, organism-specific biosystem (from KEGG)
      Adipocytokine signaling pathway, organism-specific biosystemIncreased adipocyte volume and number are positively correlated with leptin production, and negatively correlated with production of adiponectin. Leptin is an important regulator of energy intake and...
    • Adipocytokine signaling pathway, conserved biosystem (from KEGG)
      Adipocytokine signaling pathway, conserved biosystemIncreased adipocyte volume and number are positively correlated with leptin production, and negatively correlated with production of adiponectin. Leptin is an important regulator of energy intake and...
    • Energy Metabolism, organism-specific biosystem (from WikiPathways)
      Energy Metabolism, organism-specific biosystemThe PPARGC1A protein is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with the nuclear receptor PPARG, which permits the interaction of ...
    • Energy dependent regulation of mTOR by LKB1-AMPK, organism-specific biosystem (from REACTOME)
      Energy dependent regulation of mTOR by LKB1-AMPK, organism-specific biosystemUpon formation of a trimeric LKB1:STRAD:MO25 complex, LKB1 phosphorylates and activates AMPK. If the AMP:ATP ratio rises, this activation is maintained and AMPK activates the TSC complex by phosphory...
    • Hypertrophic cardiomyopathy (HCM), organism-specific biosystem (from KEGG)
      Hypertrophic cardiomyopathy (HCM), organism-specific biosystemHypertrophic cardiomyopathy (HCM) is a primary myocardial disorder with an autosomal dominant pattern of inheritance that is characterized by hypertrophy of the left ventricles with histological feat...
    • Hypertrophic cardiomyopathy (HCM), conserved biosystem (from KEGG)
      Hypertrophic cardiomyopathy (HCM), conserved biosystemHypertrophic cardiomyopathy (HCM) is a primary myocardial disorder with an autosomal dominant pattern of inheritance that is characterized by hypertrophy of the left ventricles with histological feat...
    • IRS-mediated signalling, organism-specific biosystem (from REACTOME)
      IRS-mediated signalling, organism-specific biosystemRelease of phospho-IRS from the insulin receptor triggers a cascade of signalling events via PI3K, SOS, RAF and the MAP kinases.
    • IRS-related events, organism-specific biosystem (from REACTOME)
      IRS-related events, organism-specific biosystemIRS is one of the mediators of insulin signalling events. It is activated by phosphorylation and triggers a cascade of events involving PI3K, SOS, RAF and the MAP kinases. The proteins mentioned unde...
    • Insulin receptor signalling cascade, organism-specific biosystem (from REACTOME)
      Insulin receptor signalling cascade, organism-specific biosystemAutophosphorylation of the insulin receptor triggers a series of signalling events, mediated by SHC or IRS, and resulting in activation of the Ras/RAF and MAP kinase cascades. A second effect of the ...
    • Insulin signaling pathway, organism-specific biosystem (from KEGG)
      Insulin signaling pathway, organism-specific biosystemInsulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the r...
    • Insulin signaling pathway, conserved biosystem (from KEGG)
      Insulin signaling pathway, conserved biosystemInsulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the r...
    • PI3K Cascade, organism-specific biosystem (from REACTOME)
      PI3K Cascade, organism-specific biosystem
      PI3K Cascade
    • PKB-mediated events, organism-specific biosystem (from REACTOME)
      PKB-mediated events, organism-specific biosystemPKB and PDK1 are activated via membrane-bound PIP3. Activated PDK1 phosphorylates PKB, which in turn phosphorylates PDE3B. The latter hydrolyses cAMP to 5'AMP, depleting cAMP pools.
    • Regulation of AMPK activity via LKB1, organism-specific biosystem (from REACTOME)
      Regulation of AMPK activity via LKB1, organism-specific biosystemLKB1 forms a complex with STRAD and MO25 thereby attaining a higher activity towards its substrates belonging to the subfamily of AMPK like kinases. LKB1:STRAD:MO25 complex phosphorylates AMPK consta...
    • Regulation of Rheb GTPase activity by AMPK, organism-specific biosystem (from REACTOME)
      Regulation of Rheb GTPase activity by AMPK, organism-specific biosystemActivated AMPK phosphorylates TSC2 and activates the TSC complex. TSC2 functions as a GTPase-activating protein and stimulates the intrinsic GTPase activity of a small G-protein Rheb. This results in...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by Insulin receptor, organism-specific biosystem (from REACTOME)
      Signaling by Insulin receptor, organism-specific biosystemInsulin binding to its receptor results in receptor autophosphorylation on tyrosine residues and the tyrosine phosphorylation of insulin receptor substrates (e.g. IRS and Shc) by the insulin receptor...
    • mTOR signalling, organism-specific biosystem (from REACTOME)
      mTOR signalling, organism-specific biosystem
      mTOR signalling

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ADP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    AMP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    contributes_to AMP-activated protein kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    AMP-activated protein kinase activity TAS
    Traceable Author Statement
    more info
    		  
    ATP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    cAMP-dependent protein kinase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    cAMP-dependent protein kinase regulator activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		  
    protein kinase binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    cell cycle arrest TAS
    Traceable Author Statement
    more info
    		  
    fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    insulin receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    positive regulation of protein kinase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    protein heterooligomerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein phosphorylation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    regulation of catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of fatty acid oxidation TAS
    Traceable Author Statement
    more info
    		  
    regulation of glycolysis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    spermatogenesis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    AMP-activated protein kinase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    cytosol TAS
    Traceable Author Statement
    more info
    		  
    nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    5'-AMP-activated protein kinase subunit gamma-1
    Names
    5'-AMP-activated protein kinase subunit gamma-1
    AMPK gamma1
    AMPK gamma-1 chain
    5'-AMP-activated protein kinase, gamma-1 subunit
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001206709.1 → NP_001193638.1  5'-AMP-activated protein kinase subunit gamma-1 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site in the central coding region, compared to variant 1, resulting in an isoform (3) that is longer than isoform 1.
      Source sequence(s)
      AK097606, BC000358, BM667691, DB020277
      Consensus CDS
      CCDS55825.1
      UniProtKB/Swiss-Prot
      P54619
      UniProtKB/TrEMBL
      Q8N7V9
      Related
      ENSP00000323867, OTTHUMP00000243708, ENST00000316299, OTTHUMT00000408945
      Conserved Domains (3) summary
      COG0517
      Location:212 – 328
      Blast Score: 109
      COG0517; FOG: CBS domain [General function prediction only]
      cd04618
      Location:46 – 184
      Blast Score: 295
      CBS_pair_5; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
      cd04641
      Location:211 – 330
      Blast Score: 416
      CBS_pair_28; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...

    2. NM_001206710.1 → NP_001193639.1  5'-AMP-activated protein kinase subunit gamma-1 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (4) is shorter at the N-terminus, compared to isoform 1.
      Source sequence(s)
      AK293332, BC000358, BM667691
      Consensus CDS
      CCDS55824.1
      UniProtKB/TrEMBL
      B4DDT7
      UniProtKB/Swiss-Prot
      P54619
      Related
      ENSP00000448972, OTTHUMP00000243712, ENST00000552212, OTTHUMT00000408949
      Conserved Domains (3) summary
      COG0517
      Location:171 – 287
      Blast Score: 107
      COG0517; FOG: CBS domain [General function prediction only]
      cd04618
      Location:14 – 143
      Blast Score: 312
      CBS_pair_5; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
      cd04641
      Location:170 – 289
      Blast Score: 415
      CBS_pair_28; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...

    3. NM_002733.4 → NP_002724.1  5'-AMP-activated protein kinase subunit gamma-1 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      BC000358, BM667691, DB020277
      Consensus CDS
      CCDS8777.1
      UniProtKB/Swiss-Prot
      P54619
      Related
      ENSP00000447433, OTTHUMP00000243709, ENST00000548065, OTTHUMT00000408946
      Conserved Domains (3) summary
      COG0517
      Location:203 – 319
      Blast Score: 109
      COG0517; FOG: CBS domain [General function prediction only]
      cd04618
      Location:46 – 175
      Blast Score: 316
      CBS_pair_5; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
      cd04641
      Location:202 – 321
      Blast Score: 416
      CBS_pair_28; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000012.11 Reference GRCh37.p5 Primary Assembly

      Range
      49396055..49412629, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000144.1 Alternate HuRef

      Range
      46427570..46444145, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_212461.1: Suppressed sequence

      Description
      NM_212461.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC011603.37 (140109..156646) None
    genomic CH471111.1 EAW58032.1
      EAW58033.1
    mRNA AK097606.1 BAC05117.1
    mRNA AK293332.1 BAG56848.1
    mRNA AK303276.1 BAG64356.1
    mRNA AK307994.1 None
    mRNA AK310250.1 None
    mRNA BC000358.2 AAH00358.1
    mRNA BG772337.1 None
    mRNA BG772412.1 None
    mRNA BI757340.1 None
    mRNA BM667691.1 None
    mRNA BM972308.1 None
    mRNA BT007345.1 AAP36009.1
    mRNA CB124830.1 None
    mRNA DB020277.1 None
    Protein Accession Links
    GenPept Link UniProtKB Link
    P54619.1 GenPept UniProtKB/Swiss-Prot:P54619
    Q8N7V9 GenPept UniProtKB/TrEMBL:Q8N7V9
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
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