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NECAP2 NECAP endocytosis associated 2 [ Homo sapiens (human) ]

Gene ID: 55707, updated on 12-May-2016
Official Symbol
NECAP2provided by HGNC
Official Full Name
NECAP endocytosis associated 2provided by HGNC
Primary source
HGNC:HGNC:25528
See related
Ensembl:ENSG00000157191 HPRD:07674; MIM:611624; Vega:OTTHUMG00000002313
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene likely encodes a member of the adaptin-ear-binding coat-associated protein family. Studies of a similar protein in rat suggest a role in clathrin-mediated endocytosis. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2009]
Orthologs
Location:
1p36.13
Exon count:
9
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 1 NC_000001.11 (16440672..16460090)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (16767167..16786585)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L22 pseudogene 3 Neighboring gene SUZ RNA binding domain containing 1 Neighboring gene spermatogenesis associated 21 Neighboring gene ciliary rootlet coiled-coil, rootletin pseudogene 3 Neighboring gene RNA, U1 small nuclear 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ10420

Gene Ontology Provided by GOA

Process Evidence Code Pubs
endocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 
protein transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
clathrin vesicle coat ISS
Inferred from Sequence or Structural Similarity
more info
 
coated pit ISS
Inferred from Sequence or Structural Similarity
more info
 
intracellular IDA
Inferred from Direct Assay
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
adaptin ear-binding coat-associated protein 2
Names
adaptin-ear-binding coat-associated protein 2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047165.1 RefSeqGene

    Range
    5001..24419
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001145277.1NP_001138749.1  adaptin ear-binding coat-associated protein 2 isoform 2

    See identical proteins and their annotated locations for NP_001138749.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 3' coding region compared to variant 1 that causes a frameshift. The resulting protein (isoform 2) has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK023545, BC018914, BM751287, BQ005870, BU676615
    Consensus CDS
    CCDS44066.1
    UniProtKB/Swiss-Prot
    Q9NVZ3
    Related
    ENSP00000391942, OTTHUMP00000221693, ENST00000443980, OTTHUMT00000368120
    Conserved Domains (1) summary
    cd13228
    Location:8127
    PHear_NECAP; NECAP (adaptin-ear-binding coat-associated protein) Plextrin Homology (PH) fold with ear-like function (PHear) domain
  2. NM_001145278.1NP_001138750.1  adaptin ear-binding coat-associated protein 2 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. This results in a shorter protein (isoform 3) compared to isoform 1.
    Source sequence(s)
    AK302227, BC018914, BM751287, BQ005870, BU676615
    Consensus CDS
    CCDS44067.1
    UniProtKB/Swiss-Prot
    Q9NVZ3
    Related
    ENSP00000407091, OTTHUMP00000221692, ENST00000457722, OTTHUMT00000368119
    Conserved Domains (1) summary
    cd13228
    Location:6101
    PHear_NECAP; NECAP (adaptin-ear-binding coat-associated protein) Plextrin Homology (PH) fold with ear-like function (PHear) domain
  3. NM_018090.4NP_060560.1  adaptin ear-binding coat-associated protein 2 isoform 1

    See identical proteins and their annotated locations for NP_060560.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
    Source sequence(s)
    BC018914, BM751287, BQ005870, BU676615
    Consensus CDS
    CCDS173.1
    UniProtKB/Swiss-Prot
    Q9NVZ3
    UniProtKB/TrEMBL
    A0A024QZ81
    Related
    ENSP00000338746, OTTHUMP00000002441, ENST00000337132, OTTHUMT00000006680
    Conserved Domains (1) summary
    cd13228
    Location:8127
    PHear_NECAP; NECAP (adaptin-ear-binding coat-associated protein) Plextrin Homology (PH) fold with ear-like function (PHear) domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p2 Primary Assembly

    Range
    16440672..16460090
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011541767.1XP_011540069.1  

    Conserved Domains (1) summary
    cd13228
    Location:274
    PHear_NECAP; NECAP (adaptin-ear-binding coat-associated protein) Plextrin Homology (PH) fold with ear-like function (PHear) domain

Alternate CHM1_1.1

Genomic

  1. NC_018912.2 Alternate CHM1_1.1

    Range
    16565964..16585382
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)