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    NECAP2 NECAP endocytosis associated 2 [ Homo sapiens ]

    Gene ID: 55707, updated on 11-May-2012
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    Summary

    Official Symbol
    NECAP2provided by HGNC
    Official Full Name
    NECAP endocytosis associated 2provided by HGNC
    Primary source
    HGNC:25528
    See related
    Ensembl:ENSG00000157191; HPRD:07674; MIM:611624; Vega:OTTHUMG00000002313
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FLJ10420
    Summary
    This gene likely encodes a member of the adaptin-ear-binding coat-associated protein family. Studies of a similar protein in rat suggest a role in clathrin-mediated endocytosis. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2009]
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    Genomic context

    Location :
    1p36.13
    Sequence :
    Chromosome: 1; NC_000001.10 (16767167..16786585)
    See NECAP2 in Epigenomics, MapViewer

    Chromosome 1 - NC_000001.10Genomic Context describing neighboring genes Neighboring gene chromosome 1 open reading frame 144 Neighboring gene ribosomal protein L22 pseudogene 3 Neighboring gene spermatogenesis associated 21 Neighboring gene ciliary rootlet coiled-coil, rootletin pseudogene 3 Neighboring gene RNA, U1 small nuclear 1

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, et al. Mol Cell Proteomics, 2011 Mar. PMID 21139048.
    2. The DNA sequence and biological annotation of human chromosome 1. Gregory SG, et al. Nature, 2006 May 18. PMID 16710414.
    3. The LIFEdb database in 2006. Mehrle A, et al. Nucleic Acids Res, 2006 Jan 1. PMID 16381901.
    4. Transcriptome analysis of human gastric cancer. Oh JH, et al. Mamm Genome, 2005 Dec. PMID 16341674.
    5. Towards a proteome-scale map of the human protein-protein interaction network. Rual JF, et al. Nature, 2005 Oct 20. PMID 16189514.

    See all (17) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Describes identification and characterization of rat NECAP1 and NECAP2 and their roles in endocytosis.
      Title: Identification of a family of endocytic proteins that define a new alpha-adaptin ear-binding motif.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q9NVZ3 P63010 AP2B1    HPRD  PubMed  
    Q9NVZ3 Q13287 NMI    HPRD  PubMed  
    Q9NVZ3 O15162 PLSCR1    HPRD  PubMed  
    Q9NVZ3 Q12933 TRAF2    HPRD  PubMed  
    BioGRID:120832 BioGRID:106673 AP1G1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:120832 BioGRID:106672 AP2B1    BioGRID  PubMed Two-hybrid 
    BioGRID:120832 BioGRID:117540 GGA1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:120832 BioGRID:116697 GGA2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:120832 BioGRID:114561 NMI    BioGRID  PubMed Two-hybrid 
    BioGRID:120832 BioGRID:111373 PLSCR1    BioGRID  PubMed Two-hybrid 
    BioGRID:120832 BioGRID:113038 TRAF2    BioGRID  PubMed Two-hybrid 
    BioGRID:120832 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    • Homologs of the NECAP2 gene: The NECAP2 gene is conserved in chimpanzee, , dog, cow, mouse, rat, chicken, zebrafish, C.elegans, , N.crassa, A.thaliana, and rice.
    • Map Viewer (Mouse, Rat)

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    endocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    clathrin vesicle coat ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    coated pit ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    intracellular IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    adaptin ear-binding coat-associated protein 2
    Names
    adaptin ear-binding coat-associated protein 2
    NECAP-2
    NECAP endocytosis-associated protein 2
    adaptin-ear-binding coat-associated protein 2
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145277.1 → NP_001138749.1  adaptin ear-binding coat-associated protein 2 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the 3' coding region compared to variant 1 that causes a frameshift. The resulting protein (isoform 2) has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AK023545, BC018914, BM751287, BQ005870, BU676615
      Consensus CDS
      CCDS44066.1
      UniProtKB/Swiss-Prot
      Q9NVZ3
      Related
      ENSP00000391942, OTTHUMP00000221693, ENST00000443980, OTTHUMT00000368120
      Conserved Domains (1) summary
      pfam07933
      Location:6 – 164
      Blast Score: 717
      DUF1681; Protein of unknown function (DUF1681)

    2. NM_001145278.1 → NP_001138750.1  adaptin ear-binding coat-associated protein 2 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. This results in a shorter protein (isoform 3) compared to isoform 1.
      Source sequence(s)
      AK302227, BC018914, BM751287, BQ005870, BU676615
      Consensus CDS
      CCDS44067.1
      UniProtKB/Swiss-Prot
      Q9NVZ3
      Related
      ENSP00000407091, OTTHUMP00000221692, ENST00000457722, OTTHUMT00000368119
      Conserved Domains (1) summary
      pfam07933
      Location:6 – 138
      Blast Score: 576
      DUF1681; Protein of unknown function (DUF1681)

    3. NM_018090.4 → NP_060560.1  adaptin ear-binding coat-associated protein 2 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
      Source sequence(s)
      BC018914, BM751287, BQ005870, BU676615
      Consensus CDS
      CCDS173.1
      UniProtKB/Swiss-Prot
      Q9NVZ3
      Related
      ENSP00000338746, OTTHUMP00000002441, ENST00000337132, OTTHUMT00000006680
      Conserved Domains (1) summary
      pfam07933
      Location:6 – 164
      Blast Score: 713
      DUF1681; Protein of unknown function (DUF1681)

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000001.10 Reference GRCh37.p5 Primary Assembly

      Range
      16767167..16786585
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000133.1 Alternate HuRef

      Range
      15284492..15303914
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL137802.7 CAI22843.1
    genomic AL669962.4 CAH71454.1
    genomic CH471167.1 EAW51780.1
      EAW51781.1
      EAW51782.1
      EAW51783.1
      EAW51784.1
    mRNA AK001282.1 BAA91598.1
    mRNA AK021938.1 None
    mRNA AK023545.1 BAB14605.1
    mRNA AK024468.1 BAB15758.1
    mRNA AK223344.1 BAD97064.1
    mRNA AK300764.1 BAG62429.1
    mRNA AK302227.1 BAG63581.1
    mRNA BC017014.1 AAH17014.1
    mRNA BC018914.2 AAH18914.1
    mRNA BM751287.1 None
    mRNA BQ005870.1 None
    mRNA BU676615.1 None
    other-genetic AM393342.1 CAL38220.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q53FE5 GenPept UniProtKB/TrEMBL:Q53FE5
    Q9NVZ3.1 GenPept UniProtKB/Swiss-Prot:Q9NVZ3
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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