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    PKIB protein kinase (cAMP-dependent, catalytic) inhibitor beta [ Homo sapiens ]

    Gene ID: 5570, updated on 11-May-2012
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    Summary

    Official Symbol
    PKIBprovided by HGNC
    Official Full Name
    protein kinase (cAMP-dependent, catalytic) inhibitor betaprovided by HGNC
    Primary source
    HGNC:9018
    Locus tag
    RP11-95G17.1
    See related
    Ensembl:ENSG00000135549; HPRD:06075; MIM:606914; Vega:OTTHUMG00000015488
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PRKACN2; FLJ23817
    Summary
    The protein encoded by this gene is a member of the cAMP-dependent protein kinase inhibitor family. Studies of a similar protein in rat suggest that this protein may interact with the catalytic subunit of cAMP-dependent protein kinase and act as a competitive inhibitor. At least three alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    6q22.31
    Sequence :
    Chromosome: 6; NC_000006.11 (122793062..123047518)
    See PKIB in Epigenomics, MapViewer

    Chromosome 6 - NC_000006.11Genomic Context describing neighboring genes Neighboring gene heat shock transcription factor 2 Neighboring gene serine incorporator 1 Neighboring gene sphingomyelin phosphodiesterase, acid-like 3A Neighboring gene fatty acid binding protein 7, brain

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    2. Overexpressing PKIB in prostate cancer promotes its aggressiveness by linking between PKA and Akt pathways. Chung S, et al. Oncogene, 2009 Aug 13. PMID 19483721.
    3. [Expression and characterizations of a novel full-length gene PKIbeta related to human glioma]. Qi ZY, et al. Zhonghua Yi Xue Za Zhi, 2008 Jul 1. PMID 19035091.
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334.
    5. The DNA sequence and analysis of human chromosome 6. Mungall AJ, et al. Nature, 2003 Oct 23. PMID 14574404.

    See all (12) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Findings show that PKIB and PKA-C kinase can have critical functions of aggressive phenotype of PCs through Akt phosphorylation and that they should be a promising molecular target for PC treatment.
      Title: Overexpressing PKIB in prostate cancer promotes its aggressiveness by linking between PKA and Akt pathways.
    2. PKIbeta may be a novel full-length gene related to human glioma and may provide a new way to gene therapy of glioma.
      Title: [Expression and characterizations of a novel full-length gene PKIbeta related to human glioma].
    3. human PKIbeta gene (clone 436F11, GenBank with accession number: AF225513) was over-expressed in normal brain tissues
      Title: Isolation of novel differentially expressed genes related to human glioma using cDNA microarray and characterizations of two novel full-length genes.
    4. Functional studies of the rat homolog
      Title: Molecular cloning of a rat testis form of the inhibitor protein of cAMP-dependent protein kinase.
    5. Functional studies of the mouse homolog
      Title: Evidence for two additional isoforms of the endogenous protein kinase inhibitor of cAMP-dependent protein kinase in mouse.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_861460.1 NP_003737.1 DYNLL1    BIND  PubMed PIN interacts with PKIB. 
    Q9C010 P63167 DYNLL1    HPRD  PubMed  
    Q9C010 P22694 PRKACB    HPRD  PubMed  
    BioGRID:111557 BioGRID:108201 E2F1    BioGRID  PubMed Two-hybrid 
    BioGRID:111557 BioGRID:108203 E2F3    BioGRID  PubMed Two-hybrid 
    BioGRID:111557 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Calcium Regulation in the Cardiac Cell, organism-specific biosystem (from WikiPathways)
      Calcium Regulation in the Cardiac Cell, organism-specific biosystemCalcium is a common signaling mechanism, as once it enters the cytoplasm it exerts allosteric regulatory affects on many enzymes and proteins. Calcium can act in signal transduction after influx resu...
    • Myometrial Relaxation and Contraction Pathways, organism-specific biosystem (from WikiPathways)
      Myometrial Relaxation and Contraction Pathways, organism-specific biosystemThis pathway illustrates signaling networks implicated in uterine muscle contraction at labor and quiescence throughout gestation (pregnancy). The muscle of the uterus, responsible for contractile ac...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    cAMP-dependent protein kinase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein kinase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    negative regulation of protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    cAMP-dependent protein kinase inhibitor beta
    Names
    cAMP-dependent protein kinase inhibitor beta
    PKI-beta
    cAMP-dependent protein kinase inhibitor 2
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_032471.4 → NP_115860.1  cAMP-dependent protein kinase inhibitor beta

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks a segment within the 5' UTR, as compared to variant 1. Both variants encode the same protein.
      Source sequence(s)
      BC036011, BG572417
      Consensus CDS
      CCDS5126.1
      UniProtKB/Swiss-Prot
      Q9C010
      Related
      ENSP00000376280, ENST00000392490
      Conserved Domains (1) summary
      pfam02827
      Location:9 – 77
      Blast Score: 168
      PKI; cAMP-dependent protein kinase inhibitor

    2. NM_181794.1 → NP_861459.1  cAMP-dependent protein kinase inhibitor beta

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, as compared to variant 1. Both variants encode the same protein.
      Source sequence(s)
      AJ420562, BC036011, BG507119
      Consensus CDS
      CCDS5126.1
      UniProtKB/Swiss-Prot
      Q9C010
      Related
      ENSP00000376281, ENST00000392491
      Conserved Domains (1) summary
      pfam02827
      Location:9 – 77
      Blast Score: 168
      PKI; cAMP-dependent protein kinase inhibitor

    3. NM_181795.1 → NP_861460.1  cAMP-dependent protein kinase inhibitor beta

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. It differs in the 5' UTR and encodes the same protein, as compared to variant 2 and 3.
      Source sequence(s)
      AF087873, BC036011, BG572417
      Consensus CDS
      CCDS5126.1
      UniProtKB/Swiss-Prot
      Q9C010
      Related
      ENSP00000357437, OTTHUMP00000017114, ENST00000368452, OTTHUMT00000042033
      Conserved Domains (1) summary
      pfam02827
      Location:9 – 77
      Blast Score: 168
      PKI; cAMP-dependent protein kinase inhibitor

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000006.11 Reference GRCh37.p5 Primary Assembly

      Range
      122793062..123047518
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000138.1 Alternate HuRef

      Range
      120370063..120624394
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL512283.12 CAI17093.1
      CAI17094.1
      CAI17095.1
    genomic AL513481.3 (100..26522) None
    genomic CH471051.2 EAW48168.1
      EAW48169.1
      EAW48170.1
      EAW48171.1
    mRNA AF087873.1 AAM10501.1
    mRNA AF225513.1 AAK00638.1
    mRNA AJ420562.1 None
    mRNA AK074397.1 None
    mRNA AK315151.1 BAG37599.1
    mRNA BC036011.1 AAH36011.1
    mRNA BC093027.1 AAH93027.1
    mRNA BG507119.1 None
    mRNA BG572417.1 None
    other-genetic HQ257931.1 ADR82685.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5T0Z6 GenPept UniProtKB/TrEMBL:Q5T0Z6
    Q5T0Z7 GenPept UniProtKB/TrEMBL:Q5T0Z7
    Q9C010.1 GenPept UniProtKB/Swiss-Prot:Q9C010
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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