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    IARS2 isoleucyl-tRNA synthetase 2, mitochondrial [ Homo sapiens ]

    Gene ID: 55699, updated on 11-May-2012

    Summary

    Official Symbol
    IARS2provided by HGNC
    Official Full Name
    isoleucyl-tRNA synthetase 2, mitochondrialprovided by HGNC
    Primary source
    HGNC:29685
    See related
    Ensembl:ENSG00000067704; HPRD:13334; MIM:612801; Vega:OTTHUMG00000037287
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ILERS; FLJ10326

    Genomic context

    Location :
    1q41
    Sequence :
    Chromosome: 1; NC_000001.10 (220267455..220321383)
    See IARS2 in Epigenomics, MapViewer

    Chromosome 1 - NC_000001.10Genomic Context describing neighboring genes Neighboring gene glutamyl-prolyl-tRNA synthetase Neighboring gene 3'(2'), 5'-bisphosphate nucleotidase 1 Neighboring gene microRNA 194-1 Neighboring gene microRNA 215 Neighboring gene ribosomal protein S15a pseudogene 12 Neighboring gene RAB3 GTPase activating protein subunit 2 (non-catalytic) Neighboring gene small nucleolar RNA, H/ACA box 36B Neighboring gene microRNA 664 Neighboring gene sorting nexin 2 pseudogene 1

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:120824 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:120824 BioGRID:116168 YWHAQ    BioGRID  PubMed Affinity Capture-MS 

    General gene information

    Markers

    Homology

    • Homologs of the IARS2 gene: The IARS2 gene is conserved in chimpanzee, , dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, , S.pombe, , N.crassa, A.thaliana, and rice.
    • Map Viewer (Mouse, Rat)

    Pathways from BioSystems

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    isoleucine-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    gene expression TAS
    Traceable Author Statement
    more info
     
    isoleucyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
     
    tRNA aminoacylation for protein translation TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrial matrix TAS
    Traceable Author Statement
    more info
     
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    isoleucine--tRNA ligase, mitochondrial
    Names
    isoleucine--tRNA ligase, mitochondrial
    isoleucine tRNA ligase 2, mitochondrial
    isoleucyl-tRNA synthetase, mitochondrial
    mitochondrial isoleucine tRNA synthetase
    isoleucine-tRNA synthetase 2, mitochondrial
    NP_060530.3

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_018060.3NP_060530.3  isoleucine--tRNA ligase, mitochondrial precursor

      Status: VALIDATED

      Source sequence(s)
      BC040376, BI459732, BM149097
      Consensus CDS
      CCDS1523.1
      UniProtKB/Swiss-Prot
      Q9NSE4
      Related
      ENSP00000303279, ENST00000302637
      Conserved Domains (4) summary
      cd07960
      Location:711890
      Blast Score: 663
      Anticodon_Ia_Ile_BEm; Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases
      cd00818
      Location:472708
      Blast Score: 678
      IleRS_core; catalytic core domain of isoleucyl-tRNA synthetases
      PRK05743
      Location:601011
      Blast Score: 2830
      ileS; isoleucyl-tRNA synthetase; Reviewed
      pfam06827
      Location:9841008
      Blast Score: 105
      zf-FPG_IleRS; Zinc finger found in FPG and IleRS

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000001.10 Reference GRCh37.p5 Primary Assembly

      Range
      220267455..220321383
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000133.1 Alternate HuRef

      Range
      190941806..190995804
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC103590.2 (147075..201003) None
    genomic CH471100.2 EAW93305.1
    mRNA AK001188.1 BAA91544.1
    mRNA AK001726.1 None
    mRNA AK022665.1 BAB14164.1
    mRNA AK291432.1 BAF84121.1
    mRNA AY267462.1 AAP94033.1
    mRNA AY952883.1 None
    mRNA BC010218.1 AAH10218.2
    mRNA BC040376.1 AAH40376.2
    mRNA BC047880.1 AAH47880.3
    mRNA BC137438.1 AAI37439.1
    mRNA BI459732.1 None
    mRNA BM149097.1 None
    mRNA D28500.1 BAA95147.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NSE4.2 GenPept UniProtKB/Swiss-Prot:Q9NSE4

      Supplemental Content

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