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IARS2 isoleucyl-tRNA synthetase 2, mitochondrial [ Homo sapiens (human) ]

Gene ID: 55699, updated on 8-May-2016
Official Symbol
IARS2provided by HGNC
Official Full Name
isoleucyl-tRNA synthetase 2, mitochondrialprovided by HGNC
Primary source
HGNC:HGNC:29685
See related
Ensembl:ENSG00000067704 HPRD:13334; MIM:612801; Vega:OTTHUMG00000037287
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ILERS; CAGSSS
Summary
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAS, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Two forms of isoleucine-tRNA synthetase exist, a cytoplasmic form and a mitochondrial form. This gene encodes the mitochondrial isoleucine-tRNA synthetase which belongs to the class-I aminoacyl-tRNA synthetase family. [provided by RefSeq, Dec 2014]
Orthologs
Location:
1q41
Exon count:
23
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 1 NC_000001.11 (220094113..220148041)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (220267455..220321383)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene glutamyl-prolyl-tRNA synthetase Neighboring gene 3'(2'), 5'-bisphosphate nucleotidase 1 Neighboring gene uncharacterized LOC105373475 Neighboring gene microRNA 194-1 Neighboring gene microRNA 215 Neighboring gene ribosomal protein S15a pseudogene 12 Neighboring gene RAB3 GTPase activating non-catalytic protein subunit 2 Neighboring gene small nucleolar RNA, H/ACA box 36B Neighboring gene microRNA 664a Neighboring gene sorting nexin 2 pseudogene 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ10326

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
aminoacyl-tRNA editing activity IEA
Inferred from Electronic Annotation
more info
 
isoleucine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
isoleucine-tRNA ligase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
isoleucyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
 
regulation of translational fidelity IEA
Inferred from Electronic Annotation
more info
 
tRNA aminoacylation for protein translation TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
mitochondrial matrix TAS
Traceable Author Statement
more info
 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
 
Preferred Names
isoleucine--tRNA ligase, mitochondrial
Names
isoleucine tRNA ligase 2, mitochondrial
isoleucine-tRNA synthetase 2, mitochondrial
isoleucyl-tRNA synthetase, mitochondrial
mitochondrial isoleucine tRNA synthetase
NP_060530.3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_041799.1 RefSeqGene

    Range
    5001..58929
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_018060.3NP_060530.3  isoleucine--tRNA ligase, mitochondrial precursor

    See identical proteins and their annotated locations for NP_060530.3

    Status: REVIEWED

    Source sequence(s)
    BC040376, BI459732, BM149097
    Consensus CDS
    CCDS1523.1
    UniProtKB/Swiss-Prot
    Q9NSE4
    Related
    ENSP00000355889, OTTHUMP00000035401, ENST00000366922, OTTHUMT00000090761
    Conserved Domains (6) summary
    cd07960
    Location:711890
    Anticodon_Ia_Ile_BEm; Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases
    cd00818
    Location:472708
    IleRS_core; catalytic core domain of isoleucyl-tRNA synthetases
    PRK05743
    Location:601011
    ileS; isoleucyl-tRNA synthetase; Reviewed
    pfam06827
    Location:9841008
    zf-FPG_IleRS; Zinc finger found in FPG and IleRS
    pfam13603
    Location:266412
    tRNA-synt_1_2; Leucyl-tRNA synthetase, Domain 2
    cl00015
    Location:107245
    nt_trans; nucleotidyl transferase superfamily

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p2 Primary Assembly

    Range
    220094113..220148041
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018912.2 Alternate CHM1_1.1

    Range
    221540260..221593871
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)