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    NPLOC4 nuclear protein localization 4 homolog (S. cerevisiae) [ Homo sapiens ]

    Gene ID: 55666, updated on 11-May-2012

    Summary

    Official Symbol
    NPLOC4provided by HGNC
    Official Full Name
    nuclear protein localization 4 homolog (S. cerevisiae)provided by HGNC
    Primary source
    HGNC:18261
    See related
    Ensembl:ENSG00000182446; HPRD:06975; MIM:606590
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NPL4; FLJ20657; FLJ23742; KIAA1499

    Genomic context

    Location :
    17qter
    Sequence :
    Chromosome: 17; NC_000017.10 (79523913..79604138, complement)
    See NPLOC4 in Epigenomics, MapViewer

    Chromosome 17 - NC_000017.10Genomic Context describing neighboring genes Neighboring gene fascin homolog 2, actin-bundling protein, retinal (Strongylocentrotus purpuratus) Neighboring gene chromosome 17 open reading frame 70 Neighboring gene tetraspanin 10 Neighboring gene phosphodiesterase 6G, cGMP-specific, rod, gamma

    Genomic regions, transcripts, and products

    Bibliography

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q8TAT6 Q92890 UFD1L    HPRD  PubMed  
    BioGRID:120798 BioGRID:122516 ASPSCR1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:120798 BioGRID:116298 FAF1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:120798 BioGRID:116806 FAF2    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:120798 BioGRID:121014 NSFL1C    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:120798 BioGRID:120934 SELS    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:120798 BioGRID:129222 SVIP    BioGRID  PubMed Affinity Capture-Western; Co-fractionation 
    BioGRID:120798 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:120798 BioGRID:113885 UBL4A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:120798 BioGRID:119239 UBXN1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:120798 BioGRID:126082 UBXN10    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:120798 BioGRID:124844 UBXN11    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:120798 BioGRID:117507 UBXN7    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:120798 BioGRID:113702 UBXN8    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:120798 BioGRID:113200 UFD1L    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:120798 BioGRID:114465 USP13    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:120798 BioGRID:113258 VCP    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:120798 BioGRID:123125 VCPIP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:120798 BioGRID:120666 YOD1    BioGRID  PubMed Two-hybrid 

    General gene information

    Markers

    Homology

    • Homologs of the NPLOC4 gene: The NPLOC4 gene is conserved in chimpanzee, , dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, , S.pombe, , and N.crassa.
    • Map Viewer (Mouse, Rat)

    Pathways from BioSystems

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    ER-associated protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Golgi organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    cellular membrane fusion ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    intracellular IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear outer membrane-endoplasmic reticulum membrane network ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    nuclear protein localization protein 4 homolog
    Names
    nuclear protein localization protein 4 homolog

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017921.2NP_060391.2  nuclear protein localization protein 4 homolog

      Status: VALIDATED

      Source sequence(s)
      AK000664, AK023046, BC013406, BC025930, DC322260
      Consensus CDS
      CCDS45812.1
      UniProtKB/Swiss-Prot
      Q8TAT6
      Related
      ENSP00000331487, ENST00000331134
      Conserved Domains (4) summary
      pfam05020
      Location:104246
      Blast Score: 625
      zf-NPL4; NPL4 family, putative zinc binding region
      cd08061
      Location:214513
      Blast Score: 1063
      MPN_NPL4; Mov34/MPN/PAD-1 family: nuclear protein localization-4 (Npl4) domain
      pfam05021
      Location:249556
      Blast Score: 1135
      NPL4; NPL4 family
      cl00155
      Location:180
      Blast Score: 342
      UBQ; Ubiquitin-like proteins

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000017.10 Reference GRCh37.p5 Primary Assembly

      Range
      79523913..79604138, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000149.1 Alternate HuRef

      Range
      74971514..75050623, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC137896.5 (51914..107288) None
    genomic AC139149.5 None
    genomic AC139530.3 (92630..106439) None
    genomic CH471099.1 EAW89661.1
      EAW89662.1
      EAW89663.1
    mRNA AB040932.1 BAA96023.1
    mRNA AK000664.1 BAA91314.1
    mRNA AK023046.1 BAB14372.1
    mRNA AK023272.1 BAB14499.1
    mRNA AK074322.1 None
    mRNA AK294473.1 BAG57700.1
    mRNA AK311741.1 None
    mRNA AL133629.1 None
    mRNA AL834300.1 CAD38971.1
    mRNA BC013406.2 None
    mRNA BC025930.1 AAH25930.1
    mRNA DC322260.1 None
    mRNA DQ587272.1 None
    mRNA DQ587568.1 None
    other-genetic DQ895356.2 ABM86282.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8TAT6.3 GenPept UniProtKB/Swiss-Prot:Q8TAT6

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