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ZNF446 zinc finger protein 446 [ Homo sapiens (human) ]

Gene ID: 55663, updated on 12-May-2016
Official Symbol
ZNF446provided by HGNC
Official Full Name
zinc finger protein 446provided by HGNC
Primary source
HGNC:HGNC:21036
See related
Ensembl:ENSG00000083838 HPRD:07934; Vega:OTTHUMG00000183541
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZSCAN30; ZSCAN52; ZKSCAN20
Orthologs
Location:
19q13.43
Exon count:
8
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 19 NC_000019.10 (58474543..58489533)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (58985910..58992601)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 324B Neighboring gene zinc finger protein 250 pseudogene Neighboring gene zinc finger protein 324 Neighboring gene uncharacterized LOC105372485 Neighboring gene solute carrier family 27 member 5 Neighboring gene uncharacterized LOC105372486 Neighboring gene zinc finger and BTB domain containing 45

NHGRI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog
  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
    Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ17426, FLJ20626

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
regulation of transcription from RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
Preferred Names
zinc finger protein 446
Names
zinc finger protein with KRAB and SCAN domains 20

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001304453.1NP_001291382.1  zinc finger protein 446 isoform 2

    See identical proteins and their annotated locations for NP_001291382.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has a shorter 5' UTR and differs in the 3' exon structure, compared to variant 1. The encoded isoform (2) has a distinct, shorter C-terminus compared to isoform 1.
    Source sequence(s)
    AL833955, BQ441187, DA162028
    UniProtKB/TrEMBL
    Q8NDK2
    Conserved Domains (3) summary
    smart00431
    Location:22137
    SCAN; leucine rich region
    cd07765
    Location:209237
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    cd07936
    Location:22106
    SCAN; SCAN oligomerization domain
  2. NM_017908.3NP_060378.1  zinc finger protein 446 isoform 1

    See identical proteins and their annotated locations for NP_060378.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK000633, AL122108, DA162028
    Consensus CDS
    CCDS12982.1
    UniProtKB/Swiss-Prot
    Q9NWS9
    UniProtKB/TrEMBL
    Q9UFF2
    Related
    ENSP00000472802, OTTHUMP00000271926, ENST00000594369, OTTHUMT00000467052
    Conserved Domains (6) summary
    smart00431
    Location:22137
    SCAN; leucine rich region
    cd07765
    Location:209237
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    cd07936
    Location:22106
    SCAN; SCAN oligomerization domain
    pfam00096
    Location:395417
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:410432
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:334354
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p2 Primary Assembly

    Range
    58474543..58489533
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006723266.2XP_006723329.1  

    See identical proteins and their annotated locations for XP_006723329.1

    Conserved Domains (3) summary
    smart00431
    Location:22137
    SCAN; leucine rich region
    cd07765
    Location:209237
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    cd07936
    Location:22106
    SCAN; SCAN oligomerization domain
  2. XM_005259052.3XP_005259109.1  

    See identical proteins and their annotated locations for XP_005259109.1

    UniProtKB/Swiss-Prot
    Q9NWS9
    Conserved Domains (6) summary
    smart00431
    Location:22137
    SCAN; leucine rich region
    cd07765
    Location:209237
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    cd07936
    Location:22106
    SCAN; SCAN oligomerization domain
    pfam00096
    Location:395417
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:410432
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:334354
    ZF_C2H2; C2H2 Zn finger [structural motif]
  3. XM_005259053.3XP_005259110.1  

    Related
    ENSP00000472219, OTTHUMP00000271924, ENST00000596341, OTTHUMT00000467048
    Conserved Domains (6) summary
    smart00431
    Location:22137
    SCAN; leucine rich region
    cd07765
    Location:209237
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    cd07936
    Location:22106
    SCAN; SCAN oligomerization domain
    pfam00096
    Location:356378
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:371393
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:295315
    ZF_C2H2; C2H2 Zn finger [structural motif]

Alternate CHM1_1.1

Genomic

  1. NC_018930.2 Alternate CHM1_1.1

    Range
    58981394..58994991
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)