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G2E3 G2/M-phase specific E3 ubiquitin protein ligase [ Homo sapiens (human) ]

Gene ID: 55632, updated on 26-May-2016
Official Symbol
G2E3provided by HGNC
Official Full Name
G2/M-phase specific E3 ubiquitin protein ligaseprovided by HGNC
Primary source
HGNC:HGNC:20338
See related
Ensembl:ENSG00000092140 HPRD:13851; MIM:611299; Vega:OTTHUMG00000140204
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PHF7B; KIAA1333
Orthologs
Location:
14q12
Exon count:
16
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 14 NC_000014.9 (30559123..30619840)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (31028329..31089046)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370431 Neighboring gene uncharacterized LOC105370432 Neighboring gene uncharacterized LOC105370434 Neighboring gene SYF2 pre-mRNA splicing factor pseudogene 1 Neighboring gene sec1 family domain containing 1 Neighboring gene ubiquitin conjugating enzyme E2 C pseudogene 1 Neighboring gene ribosomal protein L12 pseudogene 5

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ20333, KIAA1333

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ligase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin-protein transferase activity IEA
Inferred from Electronic Annotation
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleolus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
G2/M phase-specific E3 ubiquitin-protein ligase
Names
G2/M-phase specific E3 ubiquitin ligase
PHD finger protein 7B
NP_060239.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308097.1NP_001295026.1  G2/M phase-specific E3 ubiquitin-protein ligase isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks an exon in the 5' coding region, which results in use of a downstream start codon compared to variant 1. It encodes isoform 2, which has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AB037754, AK296872, AW963891, BC008436, BC040179, BM993069, DA491192
    Consensus CDS
    CCDS76669.1
    UniProtKB/Swiss-Prot
    Q7L622
    UniProtKB/TrEMBL
    B4DL73, F5GX24, Q49AD9
    Conserved Domains (4) summary
    smart00119
    Location:365646
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cl00077
    Location:389646
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd15496
    Location:186239
    PHD_PHF7_G2E3_like; PHD finger found in PHD finger protein 7 (PHF7) and G2/M phase-specific E3 ubiquitin-protein ligase (G2E3)
    cd15669
    Location:181
    ePHD_PHF7_G2E3_like; Extended PHD finger found in PHD finger protein 7 (PHF7) and G2/M phase-specific E3 ubiquitin-protein ligase (G2E3)
  2. NM_017769.4NP_060239.2  G2/M phase-specific E3 ubiquitin-protein ligase isoform 1

    See identical proteins and their annotated locations for NP_060239.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AB037754, AI432917, BM993069, DA491192
    Consensus CDS
    CCDS9638.1
    UniProtKB/Swiss-Prot
    Q7L622
    Related
    ENSP00000206595, OTTHUMP00000178787, ENST00000206595, OTTHUMT00000276613
    Conserved Domains (4) summary
    smart00119
    Location:411692
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cl00077
    Location:435692
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd15496
    Location:232285
    PHD_PHF7_G2E3_like; PHD finger found in PHD finger protein 7 (PHF7) and G2/M phase-specific E3 ubiquitin-protein ligase (G2E3)
    cd15669
    Location:14127
    ePHD_PHF7_G2E3_like; Extended PHD finger found in PHD finger protein 7 (PHF7) and G2/M phase-specific E3 ubiquitin-protein ligase (G2E3)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p2 Primary Assembly

    Range
    30559123..30619840
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011536926.1XP_011535228.1  

    Conserved Domains (4) summary
    smart00119
    Location:372653
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cl00077
    Location:396653
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd15669
    Location:14127
    ePHD_PHF7_G2E3_like; Extended PHD finger found in PHD finger protein 7 (PHF7) and G2/M phase-specific E3 ubiquitin-protein ligase (G2E3)
    cl22851
    Location:210246
    PHD_SF; PHD finger superfamily
  2. XM_005267836.2XP_005267893.1  

    Conserved Domains (2) summary
    cd15496
    Location:232285
    PHD_PHF7_G2E3_like; PHD finger found in PHD finger protein 7 (PHF7) and G2/M phase-specific E3 ubiquitin-protein ligase (G2E3)
    cd15669
    Location:14127
    ePHD_PHF7_G2E3_like; Extended PHD finger found in PHD finger protein 7 (PHF7) and G2/M phase-specific E3 ubiquitin-protein ligase (G2E3)
  3. XM_011536928.1XP_011535230.1  

    Conserved Domains (2) summary
    cd15669
    Location:14127
    ePHD_PHF7_G2E3_like; Extended PHD finger found in PHD finger protein 7 (PHF7) and G2/M phase-specific E3 ubiquitin-protein ligase (G2E3)
    cl22851
    Location:210246
    PHD_SF; PHD finger superfamily
  4. XM_011536927.1XP_011535229.1  

    Related
    ENSP00000391068, OTTHUMP00000243941, ENST00000438909, OTTHUMT00000409442
    Conserved Domains (4) summary
    smart00119
    Location:365646
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cl00077
    Location:389646
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd15496
    Location:186239
    PHD_PHF7_G2E3_like; PHD finger found in PHD finger protein 7 (PHF7) and G2/M phase-specific E3 ubiquitin-protein ligase (G2E3)
    cd15669
    Location:181
    ePHD_PHF7_G2E3_like; Extended PHD finger found in PHD finger protein 7 (PHF7) and G2/M phase-specific E3 ubiquitin-protein ligase (G2E3)
  5. XM_011536929.1XP_011535231.1  

    See identical proteins and their annotated locations for XP_011535231.1

    UniProtKB/TrEMBL
    B4DIF9
    Conserved Domains (2) summary
    cd15669
    Location:181
    ePHD_PHF7_G2E3_like; Extended PHD finger found in PHD finger protein 7 (PHF7) and G2/M phase-specific E3 ubiquitin-protein ligase (G2E3)
    cl22851
    Location:164200
    PHD_SF; PHD finger superfamily
  6. XM_011536925.1XP_011535227.1  

    See identical proteins and their annotated locations for XP_011535227.1

    UniProtKB/Swiss-Prot
    Q7L622
    Related
    ENSP00000451653, OTTHUMP00000244055, ENST00000553504, OTTHUMT00000409675
    Conserved Domains (4) summary
    smart00119
    Location:411692
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cl00077
    Location:435692
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd15496
    Location:232285
    PHD_PHF7_G2E3_like; PHD finger found in PHD finger protein 7 (PHF7) and G2/M phase-specific E3 ubiquitin-protein ligase (G2E3)
    cd15669
    Location:14127
    ePHD_PHF7_G2E3_like; Extended PHD finger found in PHD finger protein 7 (PHF7) and G2/M phase-specific E3 ubiquitin-protein ligase (G2E3)

Alternate CHM1_1.1

Genomic

  1. NC_018925.2 Alternate CHM1_1.1

    Range
    31027850..31088578
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)