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    G2E3 G2/M-phase specific E3 ubiquitin protein ligase [ Homo sapiens (human) ]

    Gene ID: 55632, updated on 5-May-2013
    Official Symbol
    G2E3provided by HGNC
    Official Full Name
    G2/M-phase specific E3 ubiquitin protein ligaseprovided by HGNC
    Primary source
    HGNC:20338
    See related
    Ensembl:ENSG00000092140; HPRD:13851; MIM:611299; Vega:OTTHUMG00000140204
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PHF7B; KIAA1333
    Location :
    14q12
    Sequence :
    Chromosome: 14; NC_000014.8 (31028329..31089046)
    See G2E3 in Epigenomics, MapViewer

    Chromosome 14 - NC_000014.8Genomic Context describing neighboring genes Neighboring gene ribosomal protein S6 pseudogene 24 Neighboring gene SYF2 homolog, RNA splicing factor (S. cerevisiae) pseudogene 1 Neighboring gene sec1 family domain containing 1 Neighboring gene ubiquitin-conjugating enzyme E2C pseudogene 1 Neighboring gene ribosomal protein L12 pseudogene 5

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. Povlsen LK, et al. Nat Cell Biol, 2012 Oct. PMID 23000965.
    2. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. Taipale M, et al. Cell, 2012 Aug 31. PMID 22939624.
    3. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    4. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, et al. Mol Cell Proteomics, 2011 Mar. PMID 21139048.
    5. G2E3 is a dual function ubiquitin ligase required for early embryonic development. Brooks WS, et al. J Biol Chem, 2008 Aug 8. PMID 18511420.

    See all (16) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Cell cycle phase-specific expression and highly regulated subcellular localization of G2E3 suggest a possible role in cell cycle regulation and the cellular response to DNA damage.
      Title: G2E3 is a nucleo-cytoplasmic shuttling protein with DNA damage responsive localization.
    Submit: New GeneRIF Correction

    Review eQTL and phenotype association data in this region using PheGenI

    Products Interactant Other Gene Complex Source Pubs Description
    Q7L622 O00453 LST1    HPRD  PubMed  
    Q7L622 Q9NNW5 WDR6    HPRD  PubMed  
    BioGRID:120771 BioGRID:109552 HSP90AA1    BioGRID  PubMed Affinity Capture-Luminescence 
    BioGRID:120771 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:120771 BioGRID:116350 WDR6    BioGRID  PubMed Two-hybrid 

    Markers

    Genotypes

    Homology

    Clone Names

    • FLJ20333, KIAA1333

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ubiquitin-protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    blastocyst development IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein polyubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		  
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    		  
    nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    Preferred Names
    G2/M phase-specific E3 ubiquitin-protein ligase
    Names
    G2/M phase-specific E3 ubiquitin-protein ligase
    PHD finger protein 7B
    G2/M-phase specific E3 ubiquitin ligase

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017769.3 → NP_060239.2  G2/M phase-specific E3 ubiquitin-protein ligase

      Status: VALIDATED

      Source sequence(s)
      AB037754, AI432917, DA491192
      Consensus CDS
      CCDS9638.1
      UniProtKB/Swiss-Prot
      Q7L622
      Related
      ENSP00000206595, OTTHUMP00000178787, ENST00000206595, OTTHUMT00000276613
      Conserved Domains (3) summary
      smart00119
      Location:411 – 692
      Blast Score: 125
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam13771
      Location:41 – 128
      Blast Score: 266
      zf-HC5HC2H; PHD-like zinc-binding domain
      cl00077
      Location:363 – 692
      Blast Score: 157
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000014.8 Reference GRCh37.p10 Primary Assembly

      Range
      31028329..31089046
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000146.1 Alternate HuRef

      Range
      11145937..11206602
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018925.1 Alternate CHM1_1.0

      Range
      12027766..12088474
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    genomic ABBA01061403.1 (18645..79310) None
    genomic AL117355.5 (75485..136154) None
    genomic AMYH01005636.1 (304066..364774) None
    genomic CH471078.2 EAW65969.1
    mRNA AB037754.1 BAA92571.1
    mRNA AI432917.1 None
    mRNA AK000340.1 BAA91095.1
    mRNA AK022867.1 BAB14280.1
    mRNA AK093536.1 None
    mRNA AK225346.1 None
    mRNA AK295571.1 BAG58471.1
    mRNA AK296872.1 BAG59435.1
    mRNA BC000973.2 AAH00973.2
    mRNA BC008436.1 None
    mRNA BC040179.1 AAH40179.1
    mRNA DA491192.1 None
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7L622.1 GenPept UniProtKB/Swiss-Prot:Q7L622

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Related information

      • Order cDNA clone
        Order cDNA clone
      • BioAssay
        Related PubChem BioAssays
      • BioProjects
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      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • dbVar
        Link from Gene to dbVar
      • EST
        Link to related EST entry
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • GAP
        GAP Links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • Nucleotide
        Link to related Nucleotide entry
      • OMIM
        Links between OMIM and Gene are calculated by Gene based on MIM numbers included in the summary and phenotype sections of the Gene record.
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed (OMIM)
        Links are provided when Gene has a link to a record in OMIM, and OMIM explicitly cites these publications in PubMed.
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • SNP
        Related SNP records
      • SNP: GeneView
        SNPs linked from GeneView
      • SNP: Genotype
        Gene Genotype Report
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

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