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    PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit [ Homo sapiens ]

    Gene ID: 5562, updated on 12-May-2012
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    Summary

    Official Symbol
    PRKAA1provided by HGNC
    Official Full Name
    protein kinase, AMP-activated, alpha 1 catalytic subunitprovided by HGNC
    Primary source
    HGNC:9376
    See related
    Ensembl:ENSG00000132356; HPRD:04115; MIM:602739; Vega:OTTHUMG00000162269
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AMPK; AMPKa1; MGC33776; MGC57364
    Summary
    The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    5p12
    Sequence :
    Chromosome: 5; NC_000005.9 (40759481..40798297, complement)
    See PRKAA1 in Epigenomics, MapViewer

    Chromosome 5 - NC_000005.9Genomic Context describing neighboring genes Neighboring gene prostaglandin E receptor 4 (subtype EP4) Neighboring gene tetratricopeptide repeat domain 33 Neighboring gene uncharacterized LOC100506548 Neighboring gene small nucleolar RNA, C/D box 72 Neighboring gene ribosomal protein L37

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Functional dissection of lysine deacetylases reveals that HDAC1 and p300 regulate AMPK. Lin YY, et al. Nature, 2012 Feb 8. PMID 22318606.
    2. Subunit and domain requirements for adenylate-mediated protection of Snf1 kinase activation loop from dephosphorylation. Chandrashekarappa DG, et al. J Biol Chem, 2011 Dec 30. PMID 22065577.
    3. A genome-wide association study identifies new susceptibility loci for non-cardia gastric cancer at 3q13.31 and 5p13.1. Shi Y, et al. Nat Genet, 2011 Oct 30. PMID 22037551.
    4. 5'-Adenosine monophosphate-activated protein kinase--mammalian target of rapamycin axis as therapeutic target for age-related macular degeneration. Hyttinen JM, et al. Rejuvenation Res, 2011 Dec. PMID 22007913.
    5. Curcumin differentially regulates endoplasmic reticulum stress through transcriptional corepressor SMILE (small heterodimer partner-interacting leucine zipper protein)-mediated inhibition of CREBH (cAMP responsive element-binding protein H). Misra J, et al. J Biol Chem, 2011 Dec 9. PMID 21994947.

    See all (135) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. the 5'-Adenosine monophosphate-activated protein kinase--mammalian target of rapamycin axis is a therapeutic target for age-related macular degeneration
      Title: 5'-Adenosine monophosphate-activated protein kinase--mammalian target of rapamycin axis as therapeutic target for age-related macular degeneration.
    2. findings provide new insights into previously underappreciated metabolic regulatory roles of HDAC1 in coordinating nutrient availability and cellular responses upstream of AMPK
      Title: Functional dissection of lysine deacetylases reveals that HDAC1 and p300 regulate AMPK.
    3. knockdown of AMPK during osteogenesis inhibited ERK phosphorylation, which is required for osteogenesis
      Title: Human mesenchymal stem cell differentiation to the osteogenic or adipogenic lineage is regulated by AMP-activated protein kinase.
    4. the curcumin/LKB1/AMPK/SMILE/PGC1alpha pathway differentially regulates ER stress-mediated gene transcription
      Title: Curcumin differentially regulates endoplasmic reticulum stress through transcriptional corepressor SMILE (small heterodimer partner-interacting leucine zipper protein)-mediated inhibition of CREBH (cAMP responsive element-binding protein H).
    5. We identified new susceptibility loci for non-cardia gastric cancer at 5p13.1: rs13361707 in the region including PTGER4 and PRKAA1
      Title: A genome-wide association study identifies new susceptibility loci for non-cardia gastric cancer at 3q13.31 and 5p13.1.
    6. the kinase domain of AMPKalpha1 is sufficient to interact with CaMKKbeta
      Title: Characterization of the CaMKKβ-AMPK signaling complex.
    7. These results suggest that regression in autism may be associated, in part, with decreased PKA-mediated phosphorylation of proteins and abnormalities in cellular signaling.
      Title: Brain region-specific decrease in the activity and expression of protein kinase A in the frontal cortex of regressive autism.
    8. Studies indicate that in most species, AMPK exists as an obligate heterotrimer, containing a catalytic subunit (alpha), and two regulatory subunits (beta and gamma).
      Title: The AMPK signalling pathway coordinates cell growth, autophagy and metabolism.
    9. Data indicate that co-administration perifosine with paclitaxel in ovarian cancer cells led to the inhibition of AKT, and a striking increase in the activation of pro-apoptosis pathways, including caspase 3, JNK1 and AMPKalpha1.
      Title: Co-administration of perifosine with paclitaxel synergistically induces apoptosis in ovarian cancer cells: more than just AKT inhibition.
    10. Findings reveal that hypoxia can trigger AMPK activation in the apparent absence of increased [AMP] through ROS-dependent CRAC channel activation, leading to increases in cytosolic calcium that activate the AMPK upstream kinase CaMKKbeta.
      Title: Hypoxia triggers AMPK activation through reactive oxygen species-mediated activation of calcium release-activated calcium channels.
    Submit: New GeneRIF Correction See all (68)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q13131 Q13085 ACACA    HPRD  PubMed  
    Q13131 Q9Y376 CAB39    HPRD  PubMed  
    Q13131 P13569 CFTR    HPRD  PubMed  
    Q13131 O00418 EEF2K    HPRD  PubMed  
    Q13131 Q13002 GRIK2    HPRD  PubMed  
    Q13131 P42345 MTOR    HPRD  PubMed  
    Q13131 O60825 PFKFB2    HPRD  PubMed  
    Q13131 Q9Y478 PRKAB1    HPRD  PubMed  
    Q13131 O43741 PRKAB2    HPRD  PubMed  
    Q13131 P54619 PRKAG1    HPRD  PubMed  
    Q13131 Q9UGI9 PRKAG3    HPRD  PubMed  
    Q13131 P04049 RAF1    HPRD  PubMed  
    Q13131 Q15785 TOMM34    HPRD  PubMed  
    BioGRID:111549 BioGRID:124084 BRSK1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111549 BioGRID:114491 BRSK2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111549 BioGRID:116312 CDC37    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111549 BioGRID:107506 CFTR    BioGRID  PubMed Biochemical Activity; Reconstituted Complex 
    BioGRID:111549 BioGRID:122485 DDA1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111549 BioGRID:115024 EIF5B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111549 BioGRID:108619 FMR1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111549 BioGRID:125175 FNIP1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:111549 BioGRID:114890 FXR2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111549 BioGRID:115448 G3BP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111549 BioGRID:109552 HSP90AA1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111549 BioGRID:109540 HSPA4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111549 BioGRID:110309 MARK1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111549 BioGRID:108326 MARK2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111549 BioGRID:110310 MARK3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111549 BioGRID:121760 MARK4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111549 BioGRID:108757 MTOR    BioGRID  PubMed Protein-peptide 
    BioGRID:111549 BioGRID:115221 NUAK1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111549 BioGRID:123581 NUAK2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111549 BioGRID:111075 PA2G4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111549 BioGRID:106652 PARP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111549 BioGRID:111507 PPP2CA    BioGRID  PubMed Affinity Capture-MS; Biochemical Activity 
    BioGRID:111549 BioGRID:111511 PPP2R1B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111549 BioGRID:111550 PRKAA2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111549 BioGRID:111551 PRKAB1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111549 BioGRID:111552 PRKAB2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111549 BioGRID:111558 PRKAG1    BioGRID  PubMed Affinity Capture-MS; Two-hybrid 
    BioGRID:111549 BioGRID:119531 PRKAG2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111549 BioGRID:116392 RPL35    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111549 BioGRID:127260 SIK1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111549 BioGRID:116840 SIK2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111549 BioGRID:116963 SIK3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111549 BioGRID:117974 SND1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111549 BioGRID:120211 SNRK    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111549 BioGRID:116367 SUPT16H    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111549 BioGRID:113100 TSC2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111549 BioGRID:113603 TUBA1A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111549 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111549 BioGRID:113996 ULK1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111549 BioGRID:114553 USP2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111549 BioGRID:113258 VCP    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111549 BioGRID:113363 YWHAE    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111549 BioGRID:113366 YWHAZ    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • AMPK signaling, organism-specific biosystem (from WikiPathways)
      AMPK signaling, organism-specific biosystemAMPK signaling pathway, a fuel sensor and regulator, promotes ATP-producing and inhibits ATP-consuming pathways in various tissues. AMPK is a heterotrimer composed of alpha-catalytic and beta and gam...
    • Adipocytokine signaling pathway, organism-specific biosystem (from KEGG)
      Adipocytokine signaling pathway, organism-specific biosystemIncreased adipocyte volume and number are positively correlated with leptin production, and negatively correlated with production of adiponectin. Leptin is an important regulator of energy intake and...
    • Adipocytokine signaling pathway, conserved biosystem (from KEGG)
      Adipocytokine signaling pathway, conserved biosystemIncreased adipocyte volume and number are positively correlated with leptin production, and negatively correlated with production of adiponectin. Leptin is an important regulator of energy intake and...
    • Energy Metabolism, organism-specific biosystem (from WikiPathways)
      Energy Metabolism, organism-specific biosystemThe PPARGC1A protein is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with the nuclear receptor PPARG, which permits the interaction of ...
    • Energy dependent regulation of mTOR by LKB1-AMPK, organism-specific biosystem (from REACTOME)
      Energy dependent regulation of mTOR by LKB1-AMPK, organism-specific biosystemUpon formation of a trimeric LKB1:STRAD:MO25 complex, LKB1 phosphorylates and activates AMPK. If the AMP:ATP ratio rises, this activation is maintained and AMPK activates the TSC complex by phosphory...
    • Hypertrophic cardiomyopathy (HCM), organism-specific biosystem (from KEGG)
      Hypertrophic cardiomyopathy (HCM), organism-specific biosystemHypertrophic cardiomyopathy (HCM) is a primary myocardial disorder with an autosomal dominant pattern of inheritance that is characterized by hypertrophy of the left ventricles with histological feat...
    • Hypertrophic cardiomyopathy (HCM), conserved biosystem (from KEGG)
      Hypertrophic cardiomyopathy (HCM), conserved biosystemHypertrophic cardiomyopathy (HCM) is a primary myocardial disorder with an autosomal dominant pattern of inheritance that is characterized by hypertrophy of the left ventricles with histological feat...
    • IRS-mediated signalling, organism-specific biosystem (from REACTOME)
      IRS-mediated signalling, organism-specific biosystemRelease of phospho-IRS from the insulin receptor triggers a cascade of signalling events via PI3K, SOS, RAF and the MAP kinases.
    • IRS-related events, organism-specific biosystem (from REACTOME)
      IRS-related events, organism-specific biosystemIRS is one of the mediators of insulin signalling events. It is activated by phosphorylation and triggers a cascade of events involving PI3K, SOS, RAF and the MAP kinases. The proteins mentioned unde...
    • Insulin Signaling, organism-specific biosystem (from WikiPathways)
      Insulin Signaling, organism-specific biosystem
      Insulin Signaling
    • Insulin receptor signalling cascade, organism-specific biosystem (from REACTOME)
      Insulin receptor signalling cascade, organism-specific biosystemAutophosphorylation of the insulin receptor triggers a series of signalling events, mediated by SHC or IRS, and resulting in activation of the Ras/RAF and MAP kinase cascades. A second effect of the ...
    • Insulin signaling pathway, organism-specific biosystem (from KEGG)
      Insulin signaling pathway, organism-specific biosystemInsulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the r...
    • Insulin signaling pathway, conserved biosystem (from KEGG)
      Insulin signaling pathway, conserved biosystemInsulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the r...
    • PI3K Cascade, organism-specific biosystem (from REACTOME)
      PI3K Cascade, organism-specific biosystem
      PI3K Cascade
    • PKB-mediated events, organism-specific biosystem (from REACTOME)
      PKB-mediated events, organism-specific biosystemPKB and PDK1 are activated via membrane-bound PIP3. Activated PDK1 phosphorylates PKB, which in turn phosphorylates PDE3B. The latter hydrolyses cAMP to 5'AMP, depleting cAMP pools.
    • Regulation of AMPK activity via LKB1, organism-specific biosystem (from REACTOME)
      Regulation of AMPK activity via LKB1, organism-specific biosystemLKB1 forms a complex with STRAD and MO25 thereby attaining a higher activity towards its substrates belonging to the subfamily of AMPK like kinases. LKB1:STRAD:MO25 complex phosphorylates AMPK consta...
    • Regulation of Rheb GTPase activity by AMPK, organism-specific biosystem (from REACTOME)
      Regulation of Rheb GTPase activity by AMPK, organism-specific biosystemActivated AMPK phosphorylates TSC2 and activates the TSC complex. TSC2 functions as a GTPase-activating protein and stimulates the intrinsic GTPase activity of a small G-protein Rheb. This results in...
    • Regulation of autophagy, organism-specific biosystem (from KEGG)
      Regulation of autophagy, organism-specific biosystem
      Regulation of autophagy
    • Regulation of autophagy, conserved biosystem (from KEGG)
      Regulation of autophagy, conserved biosystem
      Regulation of autophagy
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by Insulin receptor, organism-specific biosystem (from REACTOME)
      Signaling by Insulin receptor, organism-specific biosystemInsulin binding to its receptor results in receptor autophosphorylation on tyrosine residues and the tyrosine phosphorylation of insulin receptor substrates (e.g. IRS and Shc) by the insulin receptor...
    • mTOR signaling pathway, organism-specific biosystem (from KEGG)
      mTOR signaling pathway, organism-specific biosystem
      mTOR signaling pathway
    • mTOR signaling pathway, conserved biosystem (from KEGG)
      mTOR signaling pathway, conserved biosystem
      mTOR signaling pathway
    • mTOR signalling, organism-specific biosystem (from REACTOME)
      mTOR signalling, organism-specific biosystem
      mTOR signalling

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    AMP-activated protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    AMP-activated protein kinase activity TAS
    Traceable Author Statement
    more info
    		  
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    cAMP-dependent protein kinase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    chromatin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    histone serine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein kinase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    tau-protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    Wnt receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    activation of MAPK activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    cell cycle arrest TAS
    Traceable Author Statement
    more info
    		  
    cellular response to glucose starvation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    cellular response to nutrient levels ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    chromatin modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    fatty acid homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    glucose homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    histone-serine phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    insulin receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    lipid biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    negative regulation of TOR signaling cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    negative regulation of apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    negative regulation of glucosylceramide biosynthetic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    negative regulation of lipid catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    positive regulation of anti-apoptosis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    positive regulation of autophagy ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    positive regulation of cholesterol biosynthetic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    positive regulation of glycolysis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    protein phosphorylation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    regulation of circadian rhythm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    regulation of energy homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    regulation of fatty acid oxidation TAS
    Traceable Author Statement
    more info
    		  
    regulation of transcription, DNA-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to hypoxia NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    response to stress ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    rhythmic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    AMP-activated protein kinase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytosol TAS
    Traceable Author Statement
    more info
    		  
    intracellular IC
    Inferred by Curator
    more info
    		 PubMed 
    nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
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    General protein information

    Preferred Names
    5'-AMP-activated protein kinase catalytic subunit alpha-1
    Names
    5'-AMP-activated protein kinase catalytic subunit alpha-1
    AMPK alpha 1
    AMPK subunit alpha-1
    tau-protein kinase PRKAA1
    AMP -activate kinase alpha 1 subunit
    AMP-activated protein kinase, catalytic, alpha-1
    5'-AMP-activated protein kinase, catalytic alpha-1 chain
    NP_006242.5
    NP_996790.3
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006251.5 → NP_006242.5  5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) appears to represent the more predominantly expressed transcript. It lacks an in-frame coding exon compared to variant 2. The resulting isoform (1) lacks an internal segment, as compared to isoform 2.
      Source sequence(s)
      AC008810, BC048980, DB236105
      Consensus CDS
      CCDS3932.2
      UniProtKB/Swiss-Prot
      Q13131
      Related
      ENSP00000380317, OTTHUMP00000161796, ENST00000397128, OTTHUMT00000253833
      Conserved Domains (2) summary
      cd05123
      Location:46 – 279
      Blast Score: 592
      STKc_AGC; Catalytic domain of AGC family Protein Serine/Threonine Kinases
      smart00220
      Location:27 – 279
      Blast Score: 761
      S_TKc; Serine/Threonine protein kinases, catalytic domain

    2. NM_206907.3 → NP_996790.3  5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) represents the longer transcript and encodes the longer isoform (2).
      Source sequence(s)
      AC008810, BC048980, DB236105
      Consensus CDS
      CCDS3933.2
      UniProtKB/Swiss-Prot
      Q13131
      Related
      ENSP00000346148, OTTHUMP00000161795, ENST00000354209, OTTHUMT00000253832
      Conserved Domains (2) summary
      cd05123
      Location:46 – 294
      Blast Score: 567
      STKc_AGC; Catalytic domain of AGC family Protein Serine/Threonine Kinases
      smart00220
      Location:27 – 294
      Blast Score: 738
      S_TKc; Serine/Threonine protein kinases, catalytic domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000005.9 Reference GRCh37.p5 Primary Assembly

      Range
      40759481..40798297, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000137.1 Alternate HuRef

      Range
      40711304..40750184, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC008810.8 (80996..84386) None
    genomic CH471119.1 EAW56000.1
      EAW56001.1
    mRNA AB022017.1 BAA36547.1
    mRNA AF100763.1 AAD43027.1
    mRNA AK024252.1 None
    mRNA AK307546.1 None
    mRNA AK312947.1 BAG35788.1
    mRNA BC012622.1 AAH12622.1
    mRNA BC037303.2 AAH37303.1
    mRNA BC048980.1 AAH48980.1
    mRNA BQ049192.1 None
    mRNA BQ716041.1 None
    mRNA BX494823.1 None
    mRNA CD512588.1 None
    mRNA DB236105.1 None
    mRNA U22456.1 AAA64850.1
    mRNA Y12856.1 CAA73361.1
    other-genetic JF432366.1 ADZ15583.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q13131.4 GenPept UniProtKB/Swiss-Prot:Q13131
    Q96E92 GenPept UniProtKB/TrEMBL:Q96E92
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

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