DOCK10 dedicator of cytokinesis 10 [Homo sapiens] - Gene

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Summary

Official Symbol: DOCK10provided by HGNC
Official Full Name: dedicator of cytokinesis 10provided by HGNC
Primary source: HGNC:23479
See related: Ensembl:ENSG00000135905; HPRD:10919; MIM:611518; Vega:OTTHUMG00000153428
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ZIZ3; DRIP2; Nbla10300; DKFZp781A1532

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Genomic context

Location :: 2q36.2

Sequence :: Chromosome: 2; NC_000002.11 (225629807..225907330, complement)

See DOCK10 in Epigenomics, MapViewer

Chromosome 2 - NC_000002.11 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

T cells and B cells exhibited inverse expression patterns of the DOCK10 isoforms
Title: Human and mouse DOCK10 splicing isoforms with alternative first coding exon usage are differentially expressed in T and B lymphocytes.
Silencing DOCK10 expression in melanoma promotes conversion to mesenchymal migration and is associated with decreased MLC2 phosphorylation and increased Rac1 activation.
Title: DOCK10-mediated Cdc42 activation is necessary for amoeboid invasion of melanoma cells.
Dock10 could represent a point of convergence for interleukin 4 signalling and small Rho GTPase function in B cells.
Title: Dock10, a novel CZH protein selectively induced by interleukin-4 in human B lymphocytes.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
Q96BY6	Q96LR2	LURAP1	HPRD	PubMed
Q96BY6	Q9H4E5	RHOJ	HPRD	PubMed
BioGRID:120758	BioGRID:139071	LURAP1	BioGRID	PubMed	Two-hybrid
BioGRID:120758	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS

Function	Evidence Code	Pubs
GTP binding	IEA Inferred from Electronic Annotation more info
GTPase binding	IEA Inferred from Electronic Annotation more info
Rho GTPase binding	IEA Inferred from Electronic Annotation more info
Rho guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info
guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
regulation of catalytic activity	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: dedicator of cytokinesis protein 10

Names: dedicator of cytokinesis protein 10; zizimin3; zizimin-3; protein zizimin 3; dopamine receptor interacting protein 2

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_014689.2 → NP_055504.2 dedicator of cytokinesis protein 10

Status: VALIDATED

Source sequence(s)

AB014594, AC011739, AC017095, CR749492, DN991477, EG328193, EG328223, EG328495, EG328518, EG328531, EG328562

Consensus CDS

CCDS46528.1

UniProtKB/TrEMBL

Q68DA4

UniProtKB/Swiss-Prot

Q96BY6

Related

ENSP00000258390, OTTHUMP00000203922, ENST00000258390, OTTHUMT00000331246

Conserved Domains (4) summary

pfam11878
Location:59 – 153
Blast Score: 323

DUF3398; Domain of unknown function (DUF3398)

cd08697
Location:671 – 860
Blast Score: 801

C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins

cd00821
Location:204 – 287
Blast Score: 152

PH; Pleckstrin homology (PH) domain

pfam06920
Location:1966 – 2142
Blast Score: 647

Ded_cyto; Dedicator of cytokinesis

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000002.11 Reference GRCh37.p5 Primary Assembly

Range

225629807..225907330, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000134.1 Alternate HuRef

Range

217481808..217758286, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_017718.1: Suppressed sequence

Description

NM_017718.1: This RefSeq was permanently suppressed because it is a a nonsense-mediated mRNA decay (NMD) candidate.

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC011739.7	AAX88891.1
genomic	AC017095.7 (1999..59419)	None
genomic	AC093806.2	None
genomic	CH471063.1	EAW70832.1
		EAW70833.1
		EAW70834.1
		EAW70835.1
mRNA	AB014594.2	BAA31669.2
mRNA	AB074179.1	BAE45740.1
mRNA	AF250396.1	AAQ14262.1
mRNA	AK000227.1	BAA91022.1
mRNA	AK001253.1	BAA91583.1
mRNA	AK293847.1	BAG57245.1
mRNA	AK293879.1	BAG57268.1
mRNA	AK307914.1	None
mRNA	BC015018.1	AAH15018.1
mRNA	CR749492.1	CAH18316.1
mRNA	DN991477.1	None
mRNA	EG328193.1	None
mRNA	EG328223.1	None
mRNA	EG328495.1	None
mRNA	EG328518.1	None
mRNA	EG328531.1	None
mRNA	EG328562.1	None
mRNA	EU236710.2	ABY70713.2
other-genetic	JF432282.1	ADZ15499.1

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
Q3LIC8	GenPept	UniProtKB/TrEMBL:Q3LIC8
Q4W4X9	GenPept	UniProtKB/TrEMBL:Q4W4X9
Q4ZG60	GenPept	UniProtKB/TrEMBL:Q4ZG60
Q68DA4	GenPept	UniProtKB/TrEMBL:Q68DA4
Q96BY6.3	GenPept	UniProtKB/Swiss-Prot:Q96BY6