GALNT10 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 10 (GalNAc-T10) [Homo sapiens] - Gene

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Summary

Official Symbol: GALNT10provided by HGNC
Official Full Name: UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 10 (GalNAc-T10)provided by HGNC
Primary source: HGNC:19873
See related: Ensembl:ENSG00000164574; HPRD:12157; MIM:608043; Vega:OTTHUMG00000130145
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: GALNACT10; PPGALNACT10; PPGANTASE10; FLJ00205; FLJ11715; DKFZp586H0623
Summary: This gene encodes a member of the GalNAc polypeptide N-acetylgalactosaminyltransferases. These enzymes catalyze the first step in the synthesis of mucin-type oligosaccharides. These proteins transfer GalNAc from UDP-GalNAc to either serine or threonine residues of polypeptide acceptors. The protein encoded by this locus may have increased catalytic activity toward glycosylated peptides compared to activity toward non-glycosylated peptides.[provided by RefSeq, Apr 2010]

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Genomic context

Location :: 5q33.2

Sequence :: Chromosome: 5; NC_000005.9 (153570295..153800544)

See GALNT10 in Epigenomics, MapViewer

Chromosome 5 - NC_000005.9 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
GalNAc T10 has a large and pronounced glycopeptide preference for Ser/Thr-O-GalNAc only at the +1 position from the acceptor site, whereas T1 and T2 have significantly reduced and variable preferences for Ser/Thr-O-GalNAc.
Title: Glycopeptide-preferring polypeptide GalNAc transferase 10 (ppGalNAc T10), involved in mucin-type O-glycosylation, has a unique GalNAc-O-Ser/Thr-binding site in its catalytic domain not found in ppGalNAc T1 or T2.
sequence recognition by the catalytic domain differs between hT2 and hT10 in that hT10 requires a pre-existing GalNAc residue while hT2 does not
Title: The catalytic and lectin domains of UDP-GalNAc:polypeptide alpha-N-Acetylgalactosaminyltransferase function in concert to direct glycosylation site selection.
Molecular cloning and characterization of pp-GalNAc-T10 as a UDP-GalNAc transferase.
Title: Characterization of a novel human UDP-GalNAc transferase, pp-GalNAc-T10.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

Genome-Wide Association of BMI in African Americans.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description
Q86SR1	P15941	MUC1		HPRD	PubMed
Q86SR1	Q8TAX7	MUC7		HPRD	PubMed

Function	Evidence Code	Pubs
metal ion binding	IEA Inferred from Electronic Annotation more info
polypeptide N-acetylgalactosaminyltransferase activity	IEA Inferred from Electronic Annotation more info
sugar binding	IEA Inferred from Electronic Annotation more info
transferase activity, transferring glycosyl groups	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
O-glycan processing	TAS Traceable Author Statement more info
cellular protein metabolic process	TAS Traceable Author Statement more info
post-translational protein modification	TAS Traceable Author Statement more info

Component	Evidence Code	Pubs
Golgi apparatus	IEA Inferred from Electronic Annotation more info
Golgi membrane	TAS Traceable Author Statement more info
integral to membrane	IEA Inferred from Electronic Annotation more info
membrane	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: polypeptide N-acetylgalactosaminyltransferase 10

Names: polypeptide N-acetylgalactosaminyltransferase 10; GalNAc transferase 10; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 10

NP_938080.1

EC 2.4.1.41

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_198321.3 → NP_938080.1 polypeptide N-acetylgalactosaminyltransferase 10

Status: REVIEWED

Source sequence(s)

AC008625, AJ505950, BC050333, BQ549377

Consensus CDS

CCDS4325.1

UniProtKB/Swiss-Prot

Q86SR1

Related

ENSP00000297107, OTTHUMP00000160640, ENST00000297107, OTTHUMT00000252453

Conserved Domains (4) summary

cd00161
Location:461 – 589
Blast Score: 231

RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...

COG1216
Location:145 – 449
Blast Score: 154

COG1216; Predicted glycosyltransferases [General function prediction only]

cd02510
Location:148 – 443
Blast Score: 1354

pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans.

smart00458
Location:463 – 590
Blast Score: 273

RICIN; Ricin-type beta-trefoil

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000005.9 Reference GRCh37.p5 Primary Assembly

Range

153570295..153800544

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000137.1 Alternate HuRef

Range

148711113..148941366

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_017540.3: Suppressed sequence

Description

NM_017540.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
NM_024564.1: Suppressed sequence

Description

NM_024564.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC008625.5 (39295..134113)	None
genomic	AC008672.5	None
genomic	AC008675.5 (87250..185419)	None
genomic	AC010295.7	None
genomic	CH471062.2	EAW61639.1
		EAW61640.1
		EAW61641.1
		EAW61642.1
		EAW61643.1
		EAW61644.1
mRNA	AB078145.1	BAC56890.1
mRNA	AF086521.1	None
mRNA	AJ505950.1	CAD44532.1
mRNA	AK023782.1	BAB14676.1
mRNA	AK023815.1	None
mRNA	AK024931.1	None
mRNA	AK074132.1	BAB84958.1
mRNA	AK127135.1	BAG54441.1
mRNA	AL096739.1	CAB46378.1
mRNA	BC007224.1	AAH07224.2
mRNA	BC050333.1	None
mRNA	BC072450.1	AAH72450.1
mRNA	BC098444.1	AAH98444.1
mRNA	BE875528.1	None
mRNA	BG743249.1	None
mRNA	BQ549377.1	None
mRNA	BU661066.1	None
other-genetic	BC148615.1	AAI48616.1
other-genetic	BC153181.1	AAI53182.1