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CDC42BPG CDC42 binding protein kinase gamma [ Homo sapiens (human) ]

Gene ID: 55561, updated on 8-May-2016
Official Symbol
CDC42BPGprovided by HGNC
Official Full Name
CDC42 binding protein kinase gammaprovided by HGNC
Primary source
HGNC:HGNC:29829
See related
Ensembl:ENSG00000171219 HPRD:13013; MIM:613991; Vega:OTTHUMG00000045365
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DMPK2; MRCKG; HSMDPKIN; KAPPA-200; MRCKgamma
Orthologs
Location:
11q13.1
Exon count:
40
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 11 NC_000011.10 (64823809..64844673, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (64591661..64612041, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase kinase kinase kinase 2 Neighboring gene menin 1 Neighboring gene EH domain containing 1 Neighboring gene ribosomal protein S16 pseudogene 6

NHGRI GWAS Catalog

Description
Genome-wide association study for serum urate concentrations and gout among African Americans identifies genomic risk loci and a novel URAT1 loss-of-function allele.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
ATP binding NAS
Non-traceable Author Statement
more info
PubMed 
magnesium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
actin cytoskeleton reorganization ISS
Inferred from Sequence or Structural Similarity
more info
 
intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cell leading edge IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
serine/threonine-protein kinase MRCK gamma
Names
CDC42 binding protein kinase gamma (DMPK-like)
CDC42-binding protein kinase gamma
CDC42BPG
DMPK-like gamma
MRCK gamma
myotonic dystrophy kinase-related CDC42-binding kinase gamma
myotonic dystrophy protein kinase like protein
myotonic dystrophy protein kinase-like alpha
myotonic dystrophy protein kinase-like gamma
NP_059995.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017525.2NP_059995.2  serine/threonine-protein kinase MRCK gamma

    See identical proteins and their annotated locations for NP_059995.2

    Status: VALIDATED

    Source sequence(s)
    AP001187, AY648038, BI793270
    Consensus CDS
    CCDS31601.1
    UniProtKB/Swiss-Prot
    Q6DT37
    Related
    ENSP00000345133, OTTHUMP00000042866, ENST00000342711, OTTHUMT00000105352
    Conserved Domains (8) summary
    pfam08826
    Location:744801
    DMPK_coil; DMPK coiled coil domain like
    smart00220
    Location:71337
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00029
    Location:879921
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    pfam00780
    Location:10971363
    CNH; CNH domain
    pfam15035
    Location:524714
    Rootletin; Ciliary rootlet component, centrosome cohesion
    cd01243
    Location:9381070
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05597
    Location:69399
    STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
    cl21477
    Location:444562
    FliJ; Flagellar FliJ protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p2 Primary Assembly

    Range
    64823809..64844673 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011545156.1XP_011543458.1  

    Conserved Domains (8) summary
    pfam08826
    Location:737794
    DMPK_coil; DMPK coiled coil domain like
    smart00220
    Location:71337
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00029
    Location:890932
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    pfam00780
    Location:11081374
    CNH; CNH domain
    pfam13868
    Location:410791
    Trichoplein; tumor suppressor, Mitostatin
    cd01243
    Location:9491081
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05597
    Location:69399
    STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
    cl21477
    Location:431555
    FliJ; Flagellar FliJ protein
  2. XM_011545158.1XP_011543460.1  

    Conserved Domains (8) summary
    pfam08826
    Location:744801
    DMPK_coil; DMPK coiled coil domain like
    smart00220
    Location:71337
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00029
    Location:897939
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    pfam15035
    Location:524714
    Rootletin; Ciliary rootlet component, centrosome cohesion
    cl02434
    Location:11151340
    CNH; CNH domain
    cd01243
    Location:9561088
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05597
    Location:69399
    STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
    cl21477
    Location:444562
    FliJ; Flagellar FliJ protein
  3. XM_011545157.1XP_011543459.1  

    Conserved Domains (8) summary
    pfam08826
    Location:744801
    DMPK_coil; DMPK coiled coil domain like
    smart00220
    Location:71337
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00029
    Location:897939
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    pfam15035
    Location:524714
    Rootletin; Ciliary rootlet component, centrosome cohesion
    cl02434
    Location:11151340
    CNH; CNH domain
    cd01243
    Location:9561088
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05597
    Location:69399
    STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
    cl21477
    Location:444562
    FliJ; Flagellar FliJ protein
  4. XM_011545155.1XP_011543457.1  

    See identical proteins and their annotated locations for XP_011543457.1

    Conserved Domains (8) summary
    pfam08826
    Location:744801
    DMPK_coil; DMPK coiled coil domain like
    smart00220
    Location:71337
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00029
    Location:897939
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    pfam00780
    Location:11151381
    CNH; CNH domain
    pfam15035
    Location:524714
    Rootletin; Ciliary rootlet component, centrosome cohesion
    cd01243
    Location:9561088
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05597
    Location:69399
    STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
    cl21477
    Location:444562
    FliJ; Flagellar FliJ protein
  5. XM_011545160.1XP_011543462.1  

    Conserved Domains (9) summary
    pfam08826
    Location:646703
    DMPK_coil; DMPK coiled coil domain like
    smart00220
    Location:1239
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00029
    Location:799841
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    pfam00780
    Location:10171283
    CNH; CNH domain
    pfam12795
    Location:556703
    MscS_porin; Mechanosensitive ion channel porin domain
    pfam15035
    Location:426616
    Rootletin; Ciliary rootlet component, centrosome cohesion
    cd01243
    Location:858990
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05597
    Location:1301
    STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
    cl21477
    Location:346464
    FliJ; Flagellar FliJ protein
  6. XM_011545159.1XP_011543461.1  

    Conserved Domains (8) summary
    pfam08826
    Location:744801
    DMPK_coil; DMPK coiled coil domain like
    smart00220
    Location:71337
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00029
    Location:897939
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    pfam00780
    Location:11151381
    CNH; CNH domain
    pfam15035
    Location:524714
    Rootletin; Ciliary rootlet component, centrosome cohesion
    cd01243
    Location:9561088
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05597
    Location:69399
    STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
    cl21477
    Location:444562
    FliJ; Flagellar FliJ protein
  7. XM_011545161.1XP_011543463.1  

    Conserved Domains (7) summary
    pfam08826
    Location:744801
    DMPK_coil; DMPK coiled coil domain like
    smart00220
    Location:71337
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00029
    Location:897939
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    pfam06818
    Location:482672
    Fez1; Fez1
    cd01243
    Location:9561088
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05597
    Location:69399
    STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
    cl21477
    Location:444562
    FliJ; Flagellar FliJ protein

RNA

  1. XR_949988.1 RNA Sequence

  2. XR_949989.1 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018922.2 Alternate CHM1_1.1

    Range
    64475451..64495843 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)