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PRH2 proline-rich protein HaeIII subfamily 2 [ Homo sapiens (human) ]

Gene ID: 5555, updated on 26-May-2016
Official Symbol
PRH2provided by HGNC
Official Full Name
proline-rich protein HaeIII subfamily 2provided by HGNC
Primary source
HGNC:HGNC:9367
See related
Ensembl:ENSG00000134551 HPRD:01350; MIM:168790
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Pr; pr1/Pr2; PRP-1/PRP-2
Summary
This gene encodes a member of the heterogeneous family of proline-rich salivary glycoproteins. The encoded preproprotein undergoes proteolytic processing to generate one or more mature isoforms before secretion from the parotid and submandibular/sublingual glands. In western population this locus is commonly biallelic and encodes proline-rich protein (PRP) isoforms, PRP-1 and PRP-2. The reference genome encodes the PRP-1 allele. Certain alleles of this gene are associated with susceptibility to dental caries. This gene is located in a cluster of closely related salivary proline-rich proteins on chromosome 12. [provided by RefSeq, Oct 2015]
Orthologs
Location:
12p13.2
Exon count:
4
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 12 NC_000012.12 (10929235..10934845)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (11081834..11087444)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene PRH1-PRR4 readthrough Neighboring gene taste 2 receptor member 12 pseudogene Neighboring gene proline-rich protein HaeIII subfamily 1 Neighboring gene taste 2 receptor member 13 Neighboring gene taste 2 receptor member 14 Neighboring gene taste 2 receptor member 15 pseudogene

  • Salivary secretion, organism-specific biosystem (from KEGG)
    Salivary secretion, organism-specific biosystemSaliva has manifold functions in maintaining the integrity of the oral tissues, in protecting teeth from caries, in the tasting and ingestion of food, in speech and in the tolerance of tenures, for e...
  • Salivary secretion, conserved biosystem (from KEGG)
    Salivary secretion, conserved biosystemSaliva has manifold functions in maintaining the integrity of the oral tissues, in protecting teeth from caries, in the tasting and ingestion of food, in speech and in the tolerance of tenures, for e...

Markers

Clone Names

  • DKFZp686B01256, DKFZp686F14256, DKFZp686I11251, DKFZp686J06255, DKFZp686L01253, DKFZp686L16244, DKFZp686M04243, DKFZp686N24248

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
extracellular space TAS
Traceable Author Statement
more info
PubMed 
Preferred Names
salivary acidic proline-rich phosphoprotein 1/2
Names
acidic salivary proline-rich protein, HaeIII type, 2
parotid acidic protein
parotid double-band protein
parotid proline-rich protein 1/2
protein C

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001110213.1NP_001103683.1  salivary acidic proline-rich phosphoprotein 1/2 preproprotein

    See identical proteins and their annotated locations for NP_001103683.1

    Status: REVIEWED

    Source sequence(s)
    AC006518, BC095488, BX648656
    Consensus CDS
    CCDS8636.1
    UniProtKB/Swiss-Prot
    P02810
    Related
    ENSP00000379682, OTTHUMP00000239039, ENST00000396400, OTTHUMT00000400231
    Conserved Domains (1) summary
    pfam15240
    Location:1276
    Pro-rich; Proline-rich

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p2 Primary Assembly

    Range
    10929235..10934845
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p2 ALT_REF_LOCI_1

Genomic

  1. NW_003571050.1 Reference GRCh38.p2 ALT_REF_LOCI_1

    Range
    127941..133551
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p2 ALT_REF_LOCI_2

Genomic

  1. NT_187658.1 Reference GRCh38.p2 ALT_REF_LOCI_2

    Range
    127941..133551
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018923.2 Alternate CHM1_1.1

    Range
    11051143..11056753
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_005042.4: Suppressed sequence

    Description
    NM_005042.4: This RefSeq was removed because currently there is insufficient support for the transcript.