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CDCA7L cell division cycle associated 7 like [ Homo sapiens (human) ]

Gene ID: 55536, updated on 15-May-2016
Official Symbol
CDCA7Lprovided by HGNC
Official Full Name
cell division cycle associated 7 likeprovided by HGNC
Primary source
HGNC:HGNC:30777
See related
Ensembl:ENSG00000164649 HPRD:11481; MIM:609685; Vega:OTTHUMG00000128429
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
R1; JPO2; RAM2
Orthologs
Location:
7p15.3
Exon count:
11
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 7 NC_000007.14 (21900899..21945924, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (21940517..21985542, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene microRNA 1183 Neighboring gene Sp4 transcription factor Neighboring gene uncharacterized LOC105375183 Neighboring gene dynein axonemal heavy chain 11 Neighboring gene uncharacterized LOC102724143 Neighboring gene Rap guanine nucleotide exchange factor 5 Neighboring gene uncharacterized LOC105375184

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
A genome-wide association study in 19 633 Japanese subjects identified LHX3-QSOX2 and IGF1 as adult height loci.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat downregulates the expression of cell division cycle associated 7-like (CDCA7L; JPO2) in human primary T cells PubMed
tat HIV-1 Tat-mediated stimulation of the viral LTR is increased in the presence of JPO2 PubMed
integrase gag-pol Both HIV-1 IN and JPO2 proteins are present as oligomers and co-localize in the nucleus of HeLa cells PubMed
gag-pol HIV-1 IN and JPO2 bind mutually exclusively to LEDGF/p75. Two LEDGF/p75 mutants (I365A and D366N) abrogate interaction between LEDGF/p75 and IN but interact with JPO2 to the same extent as wild-type LEDGF/p75 PubMed

Go to the HIV-1, Human Interaction Database

  • SIDS Susceptibility Pathways, organism-specific biosystem (from WikiPathways)
    SIDS Susceptibility Pathways, organism-specific biosystemIn this model, we provide an integrated view of Sudden Infant Death Syndrome (SIDS) at the level of implicated tissues, signaling networks and genetics. The purpose of this model is to serve as an ov...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • DKFZp762L0311

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
positive regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
cell division cycle-associated 7-like protein
Names
cell division cycle associated 7-like
transcription factor RAM2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001127370.2NP_001120842.1  cell division cycle-associated 7-like protein isoform 2

    See identical proteins and their annotated locations for NP_001120842.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes an alternate exon in the 5' UTR which results in the use of a downstream start codon, compared to variant 1. Isoform 2 has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AA922229, AK022955, AK095965, AL576822, BC009352, BU753973, DA041070
    Consensus CDS
    CCDS47559.1
    UniProtKB/Swiss-Prot
    Q96GN5
    Related
    ENSP00000348523, OTTHUMP00000201868, ENST00000356195, OTTHUMT00000326585
    Conserved Domains (1) summary
    pfam10497
    Location:310410
    zf-4CXXC_R1; Zinc-finger domain of monoamine-oxidase A repressor R1
  2. NM_001127371.2NP_001120843.1  cell division cycle-associated 7-like protein isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame coding exon, compared to variant 1. The resulting protein (isoform 3) is shorter when it is compared to isoform 1.
    Source sequence(s)
    AA922229, AK022955, AK300781, AL576822, BU753973, BX422040, DC331792
    Consensus CDS
    CCDS47558.1
    UniProtKB/Swiss-Prot
    Q96GN5
    Related
    ENSP00000363045, OTTHUMP00000225272, ENST00000373934, OTTHUMT00000376196
    Conserved Domains (1) summary
    pfam10497
    Location:298398
    zf-4CXXC_R1; Zinc-finger domain of monoamine-oxidase A repressor R1
  3. NM_018719.4NP_061189.2  cell division cycle-associated 7-like protein isoform 1

    See identical proteins and their annotated locations for NP_061189.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the predominant and longest protein (isoform 1).
    Source sequence(s)
    AA922229, AK022955, AK292490, AL576822, BC009352, BU753973, DA041070
    Consensus CDS
    CCDS5374.1
    UniProtKB/Swiss-Prot
    Q96GN5
    UniProtKB/TrEMBL
    A0A024RA51, A8K8X5
    Related
    ENSP00000383986, OTTHUMP00000158537, ENST00000406877, OTTHUMT00000250218
    Conserved Domains (1) summary
    pfam10497
    Location:344444
    zf-4CXXC_R1; Zinc-finger domain of monoamine-oxidase A repressor R1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p2 Primary Assembly

    Range
    21900899..21945924 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018918.2 Alternate CHM1_1.1

    Range
    21941227..21986281 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)