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SLC30A10 solute carrier family 30, member 10 [ Homo sapiens (human) ]

Gene ID: 55532, updated on 19-Jul-2014
Official Symbol
SLC30A10provided by HGNC
Official Full Name
solute carrier family 30, member 10provided by HGNC
Primary source
HGNC:25355
See related
HPRD:15367; MIM:611146
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNT8; ZRC1; HMDPC; ZNT10; ZnT-10
Summary
This gene is highly expressed in the liver and is inducible by manganese. Its protein product appears to be critical in maintaining manganese levels, and has higher specificity for manganese than zinc. Loss of function mutations appear to result in a pleomorphic phenotype, including dystonia and adult-onset parkinsonism. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Mar 2012]
See SLC30A10 in Epigenomics, MapViewer
Location:
1q41
Exon count:
6
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 1 NC_000001.11 (219913919..219958910, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (220087606..220101993, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene zinc finger CCCH-type containing 11B pseudogene Neighboring gene RNA, 5S ribosomal pseudogene 76 Neighboring gene glutamyl-prolyl-tRNA synthetase Neighboring gene 3'(2'), 5'-bisphosphate nucleotidase 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits.
NHGRI GWA Catalog

Markers

Homology

Clone Names

  • DKFZp547M236

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cation transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
zinc ion transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
zinc transporter 10
Names
zinc transporter 10
zinc transporter 8

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032153.1 

    Range
    5001..19388
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_018713.2NP_061183.2  zinc transporter 10

    See proteins identical to NP_061183.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is protein-coding.
    Source sequence(s)
    AK090806, AL359609, AY212919, BG564297
    Consensus CDS
    CCDS31026.1
    UniProtKB/TrEMBL
    B3KR19
    UniProtKB/Swiss-Prot
    Q6XR72
    Conserved Domains (1) summary
    COG1230
    Location:10383
    Blast Score: 557
    CzcD; Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]

RNA

  1. NR_046437.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK090806, AL359609, BC036078, CB999545

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000001.11 

    Range
    219913919..219958910
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006711437.1XP_006711500.1  

    Conserved Domains (1) summary
    COG1230
    Location:1270
    Blast Score: 437
    CzcD; Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]
  2. XM_006711438.1XP_006711501.1  

    Conserved Domains (1) summary
    COG1230
    Location:20171
    Blast Score: 334
    CzcD; Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]
  3. XM_006711439.1XP_006711502.1  

    See proteins identical to XP_006711502.1

    UniProtKB/TrEMBL
    B3KR19
    Conserved Domains (1) summary
    COG1230
    Location:7158
    Blast Score: 329
    CzcD; Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]

Alternate HuRef

Genomic

  1. AC_000133.1 

    Range
    190762978..190777364
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018912.2 

    Range
    221360934..221375280
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001004433.1: Suppressed sequence

    Description
    NM_001004433.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.