PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) [Homo sapiens] - Gene

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Summary

Official Symbol: PRG2provided by HGNC
Official Full Name: proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)provided by HGNC
Primary source: HGNC:9362
See related: Ensembl:ENSG00000186652; HPRD:09283; MIM:605601; Vega:OTTHUMG00000167027
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MBP; BMPG; MBP1; MGC14537
Summary: The protein encoded by this gene is the predominant constituent of the crystalline core of the eosinophil granule. High levels of the proform of this protein are also present in placenta and pregnancy serum, where it exists as a complex with several other proteins including pregnancy-associated plasma protein A (PAPPA), angiotensinogen (AGT), and C3dg. This protein may be involved in antiparasitic defense mechanisms as a cytotoxin and helminthotoxin, and in immune hypersensitivity reactions. It is directly implicated in epithelial cell damage, exfoliation, and bronchospasm in allergic diseases. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

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Genomic context

Location :: 11q12

Sequence :: Chromosome: 11; NC_000011.9 (57154834..57158130, complement)

See PRG2 in Epigenomics, MapViewer

Chromosome 11 - NC_000011.9 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Combinations of respiratory syncytial virus and MBP synergistically induced cell death in pulmonary alveolar epithelial cells (A549).
Title: Effects of respiratory syncytial virus infection and major basic protein derived from eosinophils in pulmonary alveolar epithelial cells (A549).
The expression of MBP in nasal mucus obtained from chronic rhinosinusitispatients was obviously higher than that of nasal mucus obtained from controls.
Title: [Expression and its significance of eosinophil major basic protein in chronic rhinosinusitis].
MBP and NE collaborated to cause the pathological effects of nasal polyps.
Title: [Expression of eosinophil major basic protein and neutrophil elastase in nasal polyp tissue and secretion].
novel transcript was alternatively transcribed from intron III of the ENO1 gene and was feasible for MBP-1 production
Title: MBP-1 is efficiently encoded by an alternative transcript of the ENO1 gene but post-translationally regulated by proteasome-dependent protein turnover.
Observational study of gene-disease association. (HuGE Navigator)
Title: New genetic associations detected in a host response study to hepatitis B vaccine.
The proMBP is a novel first trimester serum marker for adverse pregnancy outcome.
Title: The proform of eosinophil major basic protein: a new maternal serum marker for adverse pregnancy outcome.
addition to granule-stored MBP, even unstimulated eosinophils contained appreciable amounts of MBP within secretory vesicles
Title: Vesicle-mediated secretion of human eosinophil granule-derived major basic protein.
The significantly elevated levels of proMBP in myelofibrosis patients implies that proMBP could be an important stromal cytokine in bone marrow fibrosis.
Title: Clinical correlates of serum pro-major basic protein in a spectrum of eosinophilic disorders and myelofibrosis.
No variation in genes major basic protein for Atopic dermatitis pathogenesis in this German cohort
Title: Variation in genes encoding eosinophil granule proteins in atopic dermatitis patients from Germany.
knockdown of endogenous MBP-1 is involved in cellular senescence of HFF through p53-p21 pathway.
Title: Knockdown of MBP-1 in human foreskin fibroblasts induces p53-p21 dependent senescence.

Submit: New GeneRIF Correction See all (20)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
M34462.1	NP_005185.2	CEBPB	BIND	PubMed	The MBP-P2 promoter interacts with C/EBP-beta.
M34462.1	NP_001796.2	CEBPE	BIND	PubMed	The MBP-P2 promoter interacts with C/EBP-epsilon.
M34462.1	NP_002040.1	GATA1	BIND	PubMed	The MBP-P2 promoter interacts with GATA-1.
M34462.1	NP_003111.1	SPI1	BIND	PubMed	The MBP-P2 promoter interacts with PU.1.
P13727	P01019	AGT	HPRD	PubMed
P13727	P31749	AKT1	HPRD	PubMed
P13727	Q12873	CHD3	HPRD	PubMed
P13727	P04141	CSF2	HPRD	PubMed
P13727	Q13219	PAPPA	HPRD	PubMed
P13727	Q05513	PRKCZ	HPRD	PubMed
P13727	Hypothetical protein DKFZp564O0523	RBM48	HPRD	PubMed
BioGRID:111544	BioGRID:107532	CHD3	BioGRID	PubMed	Two-hybrid
BioGRID:111544	BioGRID:111104	PAPPA	BioGRID	PubMed	Co-purification
BioGRID:111544	BioGRID:123855	RBM48	BioGRID	PubMed	Two-hybrid
BioGRID:111544	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS

Function	Evidence Code	Pubs
binding	IEA Inferred from Electronic Annotation more info
heparin binding	IEA Inferred from Electronic Annotation more info
sugar binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
defense response to bacterium	IEA Inferred from Electronic Annotation more info
immune response	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
extracellular region	IEA Inferred from Electronic Annotation more info
intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info	PubMed
NOT nucleolus	IDA Inferred from Direct Assay more info	PubMed
nucleus	IDA Inferred from Direct Assay more info	PubMed
transport vesicle	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: bone marrow proteoglycan

Names: bone marrow proteoglycan; bone-marrow proteoglycan; proteoglycan 2 preproprotein; natural killer cell activator; eosinophil major basic protein; eosinophil granule major basic protein

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001243245.1 → NP_001230174.1 bone marrow proteoglycan isoform 2 preproprotein

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate in-frame donor splice site at an internal coding exon compared to variant 1. This results in a shorter isoform (2) missing a 11 aa protein segment compared to isoform 1.

Source sequence(s)

BQ445845, DQ846874, X65787

UniProtKB/TrEMBL

A6XMW0

UniProtKB/Swiss-Prot

P13727

Conserved Domains (1) summary

cd03598
Location:101 – 211
Blast Score: 440

CLECT_EMBP_like; C-type lectin-like domain (CTLD) of the type found in the human proteins, eosinophil major basic protein (EMBP) and prepro major basic protein homolog (MBPH)
NM_002728.4 → NP_002719.3 bone marrow proteoglycan isoform 1 preproprotein

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the predominant transcript, and encodes the longer isoform (1).

Source sequence(s)

BQ445845, DQ846874, X65787

Consensus CDS

CCDS7955.1

UniProtKB/TrEMBL

A6XMW0

UniProtKB/Swiss-Prot

P13727

Related

ENSP00000312134, OTTHUMP00000234774, ENST00000311862, OTTHUMT00000392468

Conserved Domains (1) summary

cd03598
Location:106 – 222
Blast Score: 479

CLECT_EMBP_like; C-type lectin-like domain (CTLD) of the type found in the human proteins, eosinophil major basic protein (EMBP) and prepro major basic protein homolog (MBPH)

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000011.9 Reference GRCh37.p5 Primary Assembly

Range

57154834..57158130, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000143.1 Alternate HuRef

Range

53504113..53507408, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AP000781.6 (142675..145971)	None
genomic	HC007226.1	CBH19418.1
genomic	M34462.1	AAA35796.1
mRNA	AK312195.1	BAG35128.1
mRNA	BC005929.1	AAH05929.1
mRNA	BQ445845.1	None
mRNA	BX395670.2	None
mRNA	CR450311.1	CAG29307.1
mRNA	DQ846874.1	ABI63361.1
mRNA	M35670.1	AAA35965.1
mRNA	M36805.1	AAA36203.1
mRNA	X14088.1	CAA32250.1
mRNA	X65787.1	CAA46670.1
mRNA	Y00809.1	CAA68751.1
mRNA	Z26248.1	CAA81207.1
other-genetic	DQ893180.2	ABM84106.1
other-genetic	DQ896482.2	ABM87481.1