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PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) [ Homo sapiens (human) ]

Gene ID: 5553, updated on 26-May-2016
Official Symbol
PRG2provided by HGNC
Official Full Name
proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)provided by HGNC
Primary source
HGNC:HGNC:9362
See related
Ensembl:ENSG00000186652 HPRD:09283; MIM:605601; Vega:OTTHUMG00000167027
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MBP; BMPG; MBP1
Summary
The protein encoded by this gene is the predominant constituent of the crystalline core of the eosinophil granule. High levels of the proform of this protein are also present in placenta and pregnancy serum, where it exists as a complex with several other proteins including pregnancy-associated plasma protein A (PAPPA), angiotensinogen (AGT), and C3dg. This protein may be involved in antiparasitic defense mechanisms as a cytotoxin and helminthotoxin, and in immune hypersensitivity reactions. The encoded protein contains a peptide that displays potent antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria, and fungi. It is directly implicated in epithelial cell damage, exfoliation, and bronchospasm in allergic diseases. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]
Orthologs
Location:
11q12
Exon count:
6
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 11 NC_000011.10 (57386787..57390657, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (57154834..57171420, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene purinergic receptor P2X 3 Neighboring gene proteoglycan 3 Neighboring gene uncharacterized LOC105369312 Neighboring gene solute carrier family 43 member 3

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-Tat peptide interferes with polyamine uptake via competition for proteoglycan binding sites rather than a putative downstream transporter in human carcinoma cells PubMed

Go to the HIV-1, Human Interaction Database

  • Asthma, organism-specific biosystem (from KEGG)
    Asthma, organism-specific biosystemAsthma is a complex syndrome with many clinical phenotypes in both adults and children. Its major characteristics include a variable degree of airflow obstruction, bronchial hyperresponsiveness, and ...
  • Asthma, conserved biosystem (from KEGG)
    Asthma, conserved biosystemAsthma is a complex syndrome with many clinical phenotypes in both adults and children. Its major characteristics include a variable degree of airflow obstruction, bronchial hyperresponsiveness, and ...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC14537

Gene Ontology Provided by GOA

Function Evidence Code Pubs
carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 
heparin binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
defense response to bacterium IEA
Inferred from Electronic Annotation
more info
 
defense response to nematode IEA
Inferred from Electronic Annotation
more info
 
immune response IEA
Inferred from Electronic Annotation
more info
 
negative regulation of interleukin-10 production IEA
Inferred from Electronic Annotation
more info
 
positive regulation of interleukin-4 production IEA
Inferred from Electronic Annotation
more info
 
regulation of cytokine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
PubMed 
transport vesicle IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
bone marrow proteoglycan
Names
bone-marrow proteoglycan
eosinophil granule major basic protein
eosinophil major basic protein
natural killer cell activator
proteoglycan 2 preproprotein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001243245.2NP_001230174.1  bone marrow proteoglycan isoform 2 preproprotein

    See identical proteins and their annotated locations for NP_001230174.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame donor splice site at an internal coding exon compared to variant 1. This results in a shorter isoform (2) missing a 11 aa protein segment compared to isoform 1.
    Source sequence(s)
    AP000781, BC005929, BX397850, BX454677, CB997424, X65787
    Consensus CDS
    CCDS58133.1
    UniProtKB/Swiss-Prot
    P13727
    Related
    ENSP00000433231, OTTHUMP00000234775, ENST00000533605, OTTHUMT00000392469
    Conserved Domains (1) summary
    cd03598
    Location:101211
    CLECT_EMBP_like; C-type lectin-like domain (CTLD) of the type found in the human proteins, eosinophil major basic protein (EMBP) and prepro major basic protein homolog (MBPH)
  2. NM_001302926.1NP_001289855.1  bone marrow proteoglycan isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_001289855.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 3, and 4 all encode the same isoform (1).
    Source sequence(s)
    AP000781, BC005929, BX397850, BX454677, DA841825, X65787
    Consensus CDS
    CCDS7955.1
    UniProtKB/Swiss-Prot
    P13727
    Conserved Domains (1) summary
    cd03598
    Location:106222
    CLECT_EMBP_like; C-type lectin-like domain (CTLD) of the type found in the human proteins, eosinophil major basic protein (EMBP) and prepro major basic protein homolog (MBPH)
  3. NM_001302927.1NP_001289856.1  bone marrow proteoglycan isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_001289856.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 3, and 4 all encode the same isoform (1).
    Source sequence(s)
    AP000781, AU135652, BC005929, BX397850, BX454677, X65787
    Consensus CDS
    CCDS7955.1
    UniProtKB/Swiss-Prot
    P13727
    Related
    ENSP00000433016, OTTHUMP00000234776, ENST00000525955, OTTHUMT00000392470
    Conserved Domains (1) summary
    cd03598
    Location:106222
    CLECT_EMBP_like; C-type lectin-like domain (CTLD) of the type found in the human proteins, eosinophil major basic protein (EMBP) and prepro major basic protein homolog (MBPH)
  4. NM_002728.5NP_002719.3  bone marrow proteoglycan isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_002719.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript and encodes the longer isoform (1). Variants 1, 3, and 4 all encode the same isoform (1).
    Source sequence(s)
    AP000781, BC005929, BX397850, BX454677, X65787
    Consensus CDS
    CCDS7955.1
    UniProtKB/Swiss-Prot
    P13727
    Related
    ENSP00000312134, OTTHUMP00000234774, ENST00000311862, OTTHUMT00000392468
    Conserved Domains (1) summary
    cd03598
    Location:106222
    CLECT_EMBP_like; C-type lectin-like domain (CTLD) of the type found in the human proteins, eosinophil major basic protein (EMBP) and prepro major basic protein homolog (MBPH)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p2 Primary Assembly

    Range
    57386787..57390657 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018922.2 Alternate CHM1_1.1

    Range
    57020279..57024149 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)