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TMEM55A transmembrane protein 55A [ Homo sapiens (human) ]

Gene ID: 55529, updated on 3-Apr-2016
Official Symbol
TMEM55Aprovided by HGNC
Official Full Name
transmembrane protein 55Aprovided by HGNC
Primary source
HGNC:HGNC:25452
See related
Ensembl:ENSG00000155099 HPRD:13233; MIM:609864; Vega:OTTHUMG00000164019
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
TMEM55A catalyzes the degradation of phosphatidylinositol 4,5-bisphosphate (PtdIns-4,5-P2) by removing the 4-phosphate (Ungewickell et al., 2005 [PubMed 16365287]).[supplied by OMIM, Mar 2008]
Orthologs
Location:
8q21.3
Exon count:
8
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 8 NC_000008.11 (90994271..91040975, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (92006499..92053203, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene N-terminal EF-hand calcium binding protein 1 Neighboring gene uncharacterized LOC105375634 Neighboring gene chromosome 8 open reading frame 88 Neighboring gene uncharacterized LOC105375636 Neighboring gene OTUD6B antisense RNA 1 (head to head) Neighboring gene OTU domain containing 6B

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • DKFZp762O076

Gene Ontology Provided by GOA

Function Evidence Code Pubs
phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
phosphatidylinositol dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
late endosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
lysosomal membrane IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase
Names
PtdIns-4,5-P(2) 4-phosphatase type II
ptdIns-4,5-P2 4-Ptase II
type 2 PtdIns-4,5-P2 4-Ptase
type II phosphatidylinositol 4,5-bisphosphate 4-phosphatase
type II phosphatidylinositol-4,5-bisphosphate 4-phosphatase
NP_061180.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018710.2NP_061180.1  type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase

    See identical proteins and their annotated locations for NP_061180.1

    Status: VALIDATED

    Source sequence(s)
    AC087439, AK313783, CR749733, DA171968
    Consensus CDS
    CCDS6252.1
    UniProtKB/Swiss-Prot
    Q8N4L2
    Related
    ENSP00000285419, OTTHUMP00000225591, ENST00000285419, OTTHUMT00000376778
    Conserved Domains (1) summary
    pfam09788
    Location:3250
    Tmemb_55A; Transmembrane protein 55A

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p2 Primary Assembly

    Range
    90994271..91040975 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011517152.1XP_011515454.1  

    Conserved Domains (1) summary
    pfam09788
    Location:3181
    Tmemb_55A; Transmembrane protein 55A

Alternate CHM1_1.1

Genomic

  1. NC_018919.2 Alternate CHM1_1.1

    Range
    92047148..92093868 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)