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SRGN serglycin [ Homo sapiens (human) ]

Gene ID: 5552, updated on 8-May-2016
Official Symbol
SRGNprovided by HGNC
Official Full Name
serglycinprovided by HGNC
Primary source
HGNC:HGNC:9361
See related
Ensembl:ENSG00000122862 HPRD:01513; MIM:177040; Vega:OTTHUMG00000018369
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PPG; PRG; PRG1
Summary
This gene encodes a protein best known as a hematopoietic cell granule proteoglycan. Proteoglycans stored in the secretory granules of many hematopoietic cells also contain a protease-resistant peptide core, which may be important for neutralizing hydrolytic enzymes. This encoded protein was found to be associated with the macromolecular complex of granzymes and perforin, which may serve as a mediator of granule-mediated apoptosis. Two transcript variants, only one of them protein-coding, have been found for this gene. [provided by RefSeq, Jul 2010]
Orthologs
Location:
10q22.1
Exon count:
3
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 10 NC_000010.11 (69088072..69104811)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (70847828..70864567)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene actin, beta pseudogene 14 Neighboring gene uncharacterized LOC105378342 Neighboring gene VPS26 retromer complex component A Neighboring gene ribosomal protein S12 pseudogene 17 Neighboring gene Suv3 like RNA helicase

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Identification of HKDC1 and BACE2 as genes influencing glycemic traits during pregnancy through genome-wide association studies.
NHGRI GWA Catalog
  • Hemostasis, organism-specific biosystem (from REACTOME)
    Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
  • Platelet activation, signaling and aggregation, organism-specific biosystem (from REACTOME)
    Platelet activation, signaling and aggregation, organism-specific biosystemPlatelet activation begins with the initial binding of adhesive ligands and of the excitatory platelet agonists (released or generated at the sites of vascular trauma) to cognate receptors on the pla...
  • Platelet degranulation, organism-specific biosystem (from REACTOME)
    Platelet degranulation, organism-specific biosystemPlatelets function as exocytotic cells, secreting a plethora of effector molecules at sites of vascular injury. Platelets contain a number of distinguishable storage granules including alpha granules...
  • Response to elevated platelet cytosolic Ca2+, organism-specific biosystem (from REACTOME)
    Response to elevated platelet cytosolic Ca2+, organism-specific biosystemActivation of phospholipase C enzymes results in the generation of second messengers of the phosphatidylinositol pathway. The events resulting from this pathway are a rise in intracellular calcium an...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC9289, FLJ12930

Gene Ontology Provided by GOA

Function Evidence Code Pubs
collagen binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
T cell secretory granule organization ISS
Inferred from Sequence or Structural Similarity
more info
 
biomineral tissue development IEA
Inferred from Electronic Annotation
more info
 
granzyme-mediated apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
maintenance of granzyme B location in T cell secretory granule ISS
Inferred from Sequence or Structural Similarity
more info
 
maintenance of protease location in mast cell secretory granule ISS
Inferred from Sequence or Structural Similarity
more info
 
mast cell secretory granule organization ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of bone mineralization IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cytokine secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
platelet degranulation TAS
Traceable Author Statement
more info
 
protease localization to mast cell secretory granule IBA
Inferred from Biological aspect of Ancestor
more info
 
protein processing ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
mast cell granule ISS
Inferred from Sequence or Structural Similarity
more info
 
platelet alpha granule lumen TAS
Traceable Author Statement
more info
 
zymogen granule IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
serglycin
Names
hematopoetic proteoglycan core peptide
hematopoetic proteoglycan core protein
hematopoietic proteoglycan core protein
p.PG
platelet proteoglycan core protein
proteoglycan 1, secretory granule
proteoglycan protein core for mast cell secretory granule
secretory granule proteoglycan core peptide
secretory granule proteoglycan core protein
serglycin proteoglycan

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001321053.1NP_001307982.1  serglycin isoform 1 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longer isoform (1). Both variants 1 and 3 encode isoform 1.
    Source sequence(s)
    AI347627, AL442635, BC015516, BP363056
    Conserved Domains (1) summary
    pfam04360
    Location:3152
    Serglycin; Serglycin
  2. NM_001321054.1NP_001307983.1  serglycin isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate internal exon in the coding region resulting in a frameshift compared to variant 1. The encoded isoform (2) is shorter, has a distinct N-terminus, and lacks a predicted signal peptide compared to isoform 1.
    Source sequence(s)
    AI347627, AL442635, BC015516, BP335278, BQ051861, CD677686
    Conserved Domains (1) summary
    pfam04360
    Location:2196
    Serglycin; Serglycin
  3. NM_002727.3NP_002718.2  serglycin isoform 1 precursor

    See identical proteins and their annotated locations for NP_002718.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) lacks an exon in the 5' UTR compared to variant 2. Both variants 1 and 3 encode isoform 1.
    Source sequence(s)
    AI347627, AL442635, BC015516, BG057351, BG548665, CA308463, CB110512
    Consensus CDS
    CCDS7285.1
    UniProtKB/Swiss-Prot
    P10124
    Related
    ENSP00000242465, OTTHUMP00000019716, ENST00000242465, OTTHUMT00000048379
    Conserved Domains (1) summary
    pfam04360
    Location:3152
    Serglycin; Serglycin

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p2 Primary Assembly

    Range
    69088072..69104811
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018921.2 Alternate CHM1_1.1

    Range
    71129576..71146327
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)