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    H2AFY2 H2A histone family, member Y2 [ Homo sapiens ]

    Gene ID: 55506, updated on 12-May-2012
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    Summary

    Official Symbol
    H2AFY2provided by HGNC
    Official Full Name
    H2A histone family, member Y2provided by HGNC
    Primary source
    HGNC:14453
    Locus tag
    RP11-367H5.3
    See related
    Ensembl:ENSG00000099284; HPRD:13625; Vega:OTTHUMG00000018396
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    macroH2A2
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    Genomic context

    Location :
    10q22.1
    Sequence :
    Chromosome: 10; NC_000010.10 (71812357..71872040)
    See H2AFY2 in Epigenomics, MapViewer

    Chromosome 10 - NC_000010.10Genomic Context describing neighboring genes Neighboring gene ribosomal protein L5 pseudogene 26 Neighboring gene collagen, type XIII, alpha 1 Neighboring gene apoptosis-inducing factor, mitochondrion-associated, 2 Neighboring gene trypsin domain containing 1 Neighboring gene SAR1 homolog A (S. cerevisiae) Neighboring gene calmodulin 2 pseudogene 2

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Interactome study suggests multiple cellular functions of hepatoma-derived growth factor (HDGF). Zhao J, et al. J Proteomics, 2011 Dec 21. PMID 21907836.
    2. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    3. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    4. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, et al. Mol Cell Proteomics, 2011 Mar. PMID 21139048.
    5. Inherited genetic variant predisposes to aggressive but not indolent prostate cancer. Xu J, et al. Proc Natl Acad Sci U S A, 2010 Feb 2. PMID 20080650.

    See all (19) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Observational study of gene-disease association. (HuGE Navigator)
      Title: Inherited genetic variant predisposes to aggressive but not indolent prostate cancer.
    2. expression of histone macroH2A1.1 and macroH2A2 predicts lung cancer recurrence.
      Title: Histone macroH2A isoforms predict the risk of lung cancer recurrence.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat peptides bind core histones H2A, H2B, H3 and H4, and Tat protein recruits histone acetyltransferases to the HIV-1 LTR promoter leading to acetylation of histones H3 and H4, derepressing chromatin structure and increasing NFkappaB responsiveness PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:120686 BioGRID:109318 HDGF    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:120686 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:120686 BioGRID:1205541 tat    BioGRID  PubMed Protein-peptide 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Alcoholism, organism-specific biosystem (from KEGG)
      Alcoholism, organism-specific biosystemAlcoholism, also called dependence on alcohol (ethanol), is a chronic relapsing disorder that is progressive and has serious detrimental health outcomes. As one of the primary mediators of the reward...
    • Alcoholism, conserved biosystem (from KEGG)
      Alcoholism, conserved biosystemAlcoholism, also called dependence on alcohol (ethanol), is a chronic relapsing disorder that is progressive and has serious detrimental health outcomes. As one of the primary mediators of the reward...
    • Systemic lupus erythematosus, organism-specific biosystem (from KEGG)
      Systemic lupus erythematosus, organism-specific biosystemSystemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterised by the production of IgG autoantibodies that are specific for self-antigens, such as DNA, nuclear proteins and cert...
    • Systemic lupus erythematosus, conserved biosystem (from KEGG)
      Systemic lupus erythematosus, conserved biosystemSystemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterised by the production of IgG autoantibodies that are specific for self-antigens, such as DNA, nuclear proteins and cert...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    chromatin modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    dosage compensation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleosome assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    Barr body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    core histone macro-H2A.2
    Names
    core histone macro-H2A.2
    mH2A2
    histone macroH2A2
    core histone macroH2A2.2
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_018649.2 → NP_061119.1  core histone macro-H2A.2

      Status: VALIDATED

      Source sequence(s)
      BC016172, BF439798, CX752382
      Consensus CDS
      CCDS7296.1
      UniProtKB/Swiss-Prot
      Q9P0M6
      Related
      ENSP00000362352, OTTHUMP00000019735, ENST00000373255, OTTHUMT00000048480
      Conserved Domains (2) summary
      cd02904
      Location:178 – 364
      Blast Score: 777
      Macro_H2A_like; Macro domain, Macro_H2A_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose ...
      cd00074
      Location:17 – 117
      Blast Score: 418
      H2A; Histone 2A; H2A is a subunit of the nucleosome. The nucleosome is an octamer containing two H2A, H2B, H3, and H4 subunits. The H2A subunit performs essential roles in maintaining structural integrity of the nucleosome, chromatin condensation, and binding ...

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000010.10 Reference GRCh37.p5 Primary Assembly

      Range
      71812357..71872040
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000142.1 Alternate HuRef

      Range
      65804968..65864674
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC024601.9 None
    genomic AL731540.4 CAI13682.1
      CAI13683.1
    genomic AL731540.4 CAI13682.1
      CAI13683.1
    genomic CH471083.1 EAW54372.1
      EAW54373.1
      EAW54374.1
    mRNA AF151534.1 AAF72101.1
    mRNA AF336304.1 AAK52471.1
    mRNA AK022475.1 BAB14049.1
    mRNA AK022776.1 BAB14239.1
    mRNA AK131057.1 None
    mRNA BC016172.2 AAH16172.1
    mRNA BF439798.1 None
    mRNA CX752382.1 None
    other-genetic EU446956.1 ABZ92485.1
    other-genetic JF432444.1 ADZ15661.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9HA11 GenPept UniProtKB/TrEMBL:Q9HA11
    Q9P0M6.3 GenPept UniProtKB/Swiss-Prot:Q9P0M6
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Links

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