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NOP10 NOP10 ribonucleoprotein [ Homo sapiens (human) ]

Gene ID: 55505, updated on 25-Jul-2014
Official Symbol
NOP10provided by HGNC
Official Full Name
NOP10 ribonucleoproteinprovided by HGNC
Primary source
HGNC:14378
See related
Ensembl:ENSG00000182117; HPRD:07571; MIM:606471; Vega:OTTHUMG00000129440
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DKCB1; NOLA3; NOP10P
Summary
This gene is a member of the H/ACA snoRNPs (small nucleolar ribonucleoproteins) gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been classified into two families: C/D and H/ACA. The H/ACA snoRNPs also include the DKC1, NOLA1 and NOLA2 proteins. These four H/ACA snoRNP proteins localize to the dense fibrillar components of nucleoli and to coiled (Cajal) bodies in the nucleus. Both 18S rRNA production and rRNA pseudouridylation are impaired if any one of the four proteins is depleted. The four H/ACA snoRNP proteins are also components of the telomerase complex. This gene encodes a protein related to Saccharomyces cerevisiae Nop10p. [provided by RefSeq, Jul 2008]
See NOP10 in Epigenomics, MapViewer
Location:
15q14-q15
Exon count:
2
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 15 NC_000015.10 (34341716..34343161, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (34633917..34635362, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene katanin p80 subunit B-like 1 Neighboring gene solute carrier family 12 (potassium/chloride transporter), member 6 Neighboring gene ER membrane protein complex subunit 4 Neighboring gene NUT midline carcinoma, family member 1 Neighboring gene lysophosphatidylcholine acyltransferase 4

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Tat tat Expression of HIV-1 Tat upregulates the abundance of NOP10 ribonucleoprotein (NOP10) in the nucleoli of Jurkat T-cells PubMed

Go to the HIV-1, Human Protein Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC70651

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
snoRNA binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
pseudouridine synthesis NAS
Non-traceable Author Statement
more info
PubMed 
rRNA processing IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Cajal body IEA
Inferred from Electronic Annotation
more info
 
box H/ACA RNP complex IEA
Inferred from Electronic Annotation
more info
 
nucleolus IEA
Inferred from Electronic Annotation
more info
 
small nucleolar ribonucleoprotein complex TAS
Traceable Author Statement
more info
PubMed 
Preferred Names
H/ACA ribonucleoprotein complex subunit 3
Names
H/ACA ribonucleoprotein complex subunit 3
nucleolar protein 10
snoRNP protein NOP10
homolog of yeast Nop10p
NOP10 ribonucleoprotein homolog
nucleolar protein family A member 3
nucleolar protein family A, member 3 (H/ACA small nucleolar RNPs)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011562.1 

    Range
    5001..6446
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_345

mRNA and Protein(s)

  1. NM_018648.3NP_061118.1  H/ACA ribonucleoprotein complex subunit 3

    See proteins identical to NP_061118.1

    Status: REVIEWED

    Source sequence(s)
    BM554889, BQ218536
    Consensus CDS
    CCDS10037.1
    UniProtKB/Swiss-Prot
    Q9NPE3
    Related
    ENSP00000332198, OTTHUMP00000159812, ENST00000328848, OTTHUMT00000251602
    Conserved Domains (1) summary
    pfam04135
    Location:353
    Blast Score: 186
    Nop10p; Nucleolar RNA-binding protein, Nop10p family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000015.10 

    Range
    34341716..34343161
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000147.1 

    Range
    11497261..11498790
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018926.2 

    Range
    34751973..34753418
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)