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    DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4 [ Homo sapiens ]

    Gene ID: 55466, updated on 11-May-2012

    Summary

    Official Symbol
    DNAJA4provided by HGNC
    Official Full Name
    DnaJ (Hsp40) homolog, subfamily A, member 4provided by HGNC
    Primary source
    HGNC:14885
    See related
    Ensembl:ENSG00000140403; HPRD:09920; Vega:OTTHUMG00000143733
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MST104; MSTP104; PRO1472

    Genomic context

    Location :
    15q25.1
    Sequence :
    Chromosome: 15; NC_000015.9 (78556487..78574538)
    See DNAJA4 in Epigenomics, MapViewer

    Chromosome 15 - NC_000015.9Genomic Context describing neighboring genes Neighboring gene isocitrate dehydrogenase 3 (NAD+) alpha Neighboring gene acyl-CoA synthetase bubblegum family member 1 Neighboring gene WD repeat domain 61 Neighboring gene cellular retinoic acid binding protein 1

    Genomic regions, transcripts, and products

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:120675 BioGRID:204381 Tubb5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:120675 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    heat shock protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    protein folding IEA
    Inferred from Electronic Annotation
    more info
     
    response to heat IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    dnaJ homolog subfamily A member 4
    Names
    dnaJ homolog subfamily A member 4

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130182.1NP_001123654.1  dnaJ homolog subfamily A member 4 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, compared to variant 1, which results in a protein (isoform 2) with a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC090607, AK096616, AL133096
      Consensus CDS
      CCDS45316.1
      UniProtKB/TrEMBL
      Q69YX3
      UniProtKB/Swiss-Prot
      Q8WW22
      Related
      ENSP00000378321, OTTHUMP00000184908, ENST00000394852, OTTHUMT00000289801
      Conserved Domains (5) summary
      cd06257
      Location:757
      Blast Score: 238
      DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
      PTZ00037
      Location:2394
      Blast Score: 874
      PTZ00037; DnaJ_C chaperone protein; Provisional
      cd10719
      Location:152201
      Blast Score: 144
      DnaJ_zf; Zinc finger domain of DnaJ and HSP40
      cd10747
      Location:202332
      Blast Score: 349
      DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
      cl03262
      Location:106134
      Blast Score: 91
      DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
    2. NM_001130183.1NP_001123655.1  dnaJ homolog subfamily A member 4 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region, compared to variant 1, which results in a protein (isoform 3) with a shorter and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AC090607, AK096616, AL133096, BC031044, DA561365
      Consensus CDS
      CCDS45317.1
      UniProtKB/TrEMBL
      E9PDM9
      UniProtKB/TrEMBL
      Q69YX3
      UniProtKB/TrEMBL
      Q8N5Z4
      UniProtKB/Swiss-Prot
      Q8WW22
      Related
      ENSP00000413499, OTTHUMP00000211600, ENST00000446172, OTTHUMT00000347701
      Conserved Domains (5) summary
      PRK14293
      Location:1766
      Blast Score: 113
      PRK14293; chaperone protein DnaJ; Provisional
      cd10719
      Location:125174
      Blast Score: 142
      DnaJ_zf; Zinc finger domain of DnaJ and HSP40
      cd10747
      Location:175305
      Blast Score: 352
      DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
      cl02542
      Location:938
      Blast Score: 105
      DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
      cl03262
      Location:79107
      Blast Score: 91
      DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
    3. NM_018602.3NP_061072.3  dnaJ homolog subfamily A member 4 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC090607, AK096616, AL133096, BC021720, DB047940
      Consensus CDS
      CCDS10299.2
      UniProtKB/TrEMBL
      Q69YX3
      UniProtKB/Swiss-Prot
      Q8WW22
      Related
      ENSP00000378324, OTTHUMP00000184907, ENST00000394855, OTTHUMT00000289800
      Conserved Domains (5) summary
      cd06257
      Location:3686
      Blast Score: 240
      DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
      PTZ00037
      Location:15423
      Blast Score: 885
      PTZ00037; DnaJ_C chaperone protein; Provisional
      cd10719
      Location:181230
      Blast Score: 143
      DnaJ_zf; Zinc finger domain of DnaJ and HSP40
      cd10747
      Location:231361
      Blast Score: 352
      DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
      cl03262
      Location:135163
      Blast Score: 91
      DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000015.9 Reference GRCh37.p5 Primary Assembly

      Range
      78556487..78574538
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000147.1 Alternate HuRef

      Range
      55314570..55332634
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

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