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    DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4 [ Homo sapiens (human) ]

    Gene ID: 55466, updated on 9-Jun-2013
    Official Symbol
    DNAJA4provided by HGNC
    Official Full Name
    DnaJ (Hsp40) homolog, subfamily A, member 4provided by HGNC
    Primary source
    HGNC:14885
    See related
    Ensembl:ENSG00000140403; HPRD:09920; Vega:OTTHUMG00000143733
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MST104; MSTP104; PRO1472
    Location :
    15q25.1
    Sequence :
    Chromosome: 15; NC_000015.9 (78556487..78574538)
    See DNAJA4 in Epigenomics, MapViewer

    Chromosome 15 - NC_000015.9Genomic Context describing neighboring genes Neighboring gene isocitrate dehydrogenase 3 (NAD+) alpha Neighboring gene acyl-CoA synthetase bubblegum family member 1 Neighboring gene WD repeat domain 61 Neighboring gene cellular retinoic acid binding protein 1

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. Povlsen LK, et al. Nat Cell Biol, 2012 Oct. PMID 23000965.
    2. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    3. Identification of SUMOylated proteins in neuroblastoma cells after treatment with hydrogen peroxide or ascorbate. Grant MM. BMB Rep, 2010 Nov. PMID 21110914.
    4. Systematic analysis of human protein complexes identifies chromosome segregation proteins. Hutchins JR, et al. Science, 2010 Apr 30. PMID 20360068.
    5. Hsp40 chaperones promote degradation of the HERG potassium channel. Walker VE, et al. J Biol Chem, 2010 Jan 29. PMID 19940115.

    See all (12) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Submit: New GeneRIF Correction

    Review eQTL and phenotype association data in this region using PheGenI

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:120675 BioGRID:108389 ERG    BioGRID  PubMed Reconstituted Complex 
    BioGRID:120675 BioGRID:117194 SH3BP4    BioGRID  PubMed Two-hybrid 
    BioGRID:120675 BioGRID:113188 SUMO1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:120675 BioGRID:204381 Tubb5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:120675 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    heat shock protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to heat IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    Preferred Names
    dnaJ homolog subfamily A member 4
    Names
    dnaJ homolog subfamily A member 4

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130182.1 → NP_001123654.1  dnaJ homolog subfamily A member 4 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, compared to variant 1, which results in a protein (isoform 2) with a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC090607, AK096616, AL133096
      Consensus CDS
      CCDS45316.1
      UniProtKB/TrEMBL
      Q69YX3
      UniProtKB/Swiss-Prot
      Q8WW22
      Related
      ENSP00000378321, OTTHUMP00000184908, ENST00000394852, OTTHUMT00000289801
      Conserved Domains (5) summary
      cd06257
      Location:7 – 57
      Blast Score: 238
      DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
      PTZ00037
      Location:2 – 394
      Blast Score: 874
      PTZ00037; DnaJ_C chaperone protein; Provisional
      cd10719
      Location:152 – 201
      Blast Score: 144
      DnaJ_zf; Zinc finger domain of DnaJ and HSP40
      cd10747
      Location:202 – 332
      Blast Score: 349
      DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
      cl03262
      Location:106 – 134
      Blast Score: 91
      DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40

    2. NM_001130183.1 → NP_001123655.1  dnaJ homolog subfamily A member 4 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region, compared to variant 1, which results in a protein (isoform 3) with a shorter and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AC090607, AK096616, AL133096, BC031044, DA561365
      Consensus CDS
      CCDS45317.1
      UniProtKB/TrEMBL
      Q69YX3
      UniProtKB/Swiss-Prot
      Q8WW22
      Conserved Domains (4) summary
      cd10719
      Location:125 – 174
      Blast Score: 142
      DnaJ_zf; Zinc finger domain of DnaJ and HSP40
      cd10747
      Location:175 – 305
      Blast Score: 352
      DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
      pfam00226
      Location:9 – 38
      Blast Score: 105
      DnaJ; DnaJ domain
      cl03262
      Location:79 – 107
      Blast Score: 91
      DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40

    3. NM_018602.3 → NP_061072.3  dnaJ homolog subfamily A member 4 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC090607, AK096616, AL133096, BC021720, DB047940
      Consensus CDS
      CCDS10299.2
      UniProtKB/TrEMBL
      Q69YX3
      UniProtKB/Swiss-Prot
      Q8WW22
      Related
      ENSP00000378324, OTTHUMP00000184907, ENST00000394855, OTTHUMT00000289800
      Conserved Domains (5) summary
      cd06257
      Location:36 – 86
      Blast Score: 240
      DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
      PTZ00037
      Location:15 – 423
      Blast Score: 885
      PTZ00037; DnaJ_C chaperone protein; Provisional
      cd10719
      Location:181 – 230
      Blast Score: 143
      DnaJ_zf; Zinc finger domain of DnaJ and HSP40
      cd10747
      Location:231 – 361
      Blast Score: 352
      DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
      cl03262
      Location:135 – 163
      Blast Score: 91
      DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000015.9 Reference GRCh37.p10 Primary Assembly

      Range
      78556487..78574538
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000147.1 Alternate HuRef

      Range
      55314570..55332634
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018926.1 Alternate CHM1_1.0

      Range
      58595569..58613623
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    genomic ABBA01060582.1 (37421..55485) None
    genomic AC090607.6 (80541..98581) None
    genomic AMYH01006832.1 (7436..25490) None
    genomic CH471136.2 EAW99176.1
      EAW99177.1
      EAW99178.1
      EAW99179.1
    mRNA AF116663.1 AAF71083.1
    mRNA AF173388.1 AAQ13629.1
    mRNA AK025069.1 None
    mRNA AK090898.1 BAC03540.1
    mRNA AK096616.1 BAC04828.1
    mRNA AK098079.1 BAC05229.1
    mRNA AL133096.1 CAH10713.1
    mRNA AL133431.1 None
    mRNA AL133432.1 None
    mRNA AL133433.1 None
    mRNA AL133434.1 None
    mRNA BC021720.2 AAH21720.1
    mRNA BC031044.1 AAH31044.2
    mRNA BX648710.1 CAH10558.1
    mRNA DA561365.1 None
    mRNA DB047940.1 None
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8WW22.1 GenPept UniProtKB/Swiss-Prot:Q8WW22

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Related information

      • Order cDNA clone
        Order cDNA clone
      • BioAssay
        Related PubChem BioAssays
      • BioProjects
        BioProjects related to a gene
      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • dbVar
        Link from Gene to dbVar
      • EST
        Link to related EST entry
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • Nucleotide
        Link to related Nucleotide entry
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • SNP
        Related SNP records
      • SNP: GeneView
        SNPs linked from GeneView
      • SNP: Genotype
        Gene Genotype Report
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

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