Display Settings:

Format

Send to:

Choose Destination

DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4 [ Homo sapiens (human) ]

Gene ID: 55466, updated on 21-Oct-2014
Official Symbol
DNAJA4provided by HGNC
Official Full Name
DnaJ (Hsp40) homolog, subfamily A, member 4provided by HGNC
Primary source
HGNC:HGNC:14885
See related
Ensembl:ENSG00000140403; HPRD:09920; Vega:OTTHUMG00000143733
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MST104; MSTP104; PRO1472
See DNAJA4 in Epigenomics, MapViewer
Location:
15q25.1
Exon count:
10
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 15 NC_000015.10 (78264145..78282196)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (78556487..78574538)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene isocitrate dehydrogenase 3 (NAD+) alpha Neighboring gene acyl-CoA synthetase bubblegum family member 1 Neighboring gene WD repeat domain 61 Neighboring gene cellular retinoic acid binding protein 1

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
chaperone binding IPI
Inferred from Physical Interaction
more info
 
heat shock protein binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
 
unfolded protein binding IDA
Inferred from Direct Assay
more info
 
Process Evidence Code Pubs
negative regulation of inclusion body assembly IDA
Inferred from Direct Assay
more info
 
protein refolding IDA
Inferred from Direct Assay
more info
 
response to heat IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
membrane IDA
Inferred from Direct Assay
more info
 
Preferred Names
dnaJ homolog subfamily A member 4
Names
dnaJ homolog subfamily A member 4

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130182.1NP_001123654.1  dnaJ homolog subfamily A member 4 isoform 2

    See proteins identical to NP_001123654.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, compared to variant 1, which results in a protein (isoform 2) with a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC090607, AK096616, AL133096
    Consensus CDS
    CCDS45316.1
    UniProtKB/TrEMBL
    Q69YX3
    UniProtKB/Swiss-Prot
    Q8WW22
    Related
    ENSP00000378321, OTTHUMP00000184908, ENST00000394852, OTTHUMT00000289801
    Conserved Domains (4) summary
    cd06257
    Location:757
    DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
    cd10719
    Location:135201
    DnaJ_zf; Zinc finger domain of DnaJ and HSP40
    cd10747
    Location:106332
    DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
    PTZ00037
    Location:2394
    PTZ00037; DnaJ_C chaperone protein; Provisional
  2. NM_001130183.1NP_001123655.1  dnaJ homolog subfamily A member 4 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region, compared to variant 1, which results in a protein (isoform 3) with a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC090607, AK096616, AL133096, BC031044, DA561365
    Consensus CDS
    CCDS45317.1
    UniProtKB/TrEMBL
    Q69YX3
    UniProtKB/Swiss-Prot
    Q8WW22
    Conserved Domains (4) summary
    PRK14277
    Location:7354
    PRK14277; chaperone protein DnaJ; Provisional
    cd10719
    Location:108174
    DnaJ_zf; Zinc finger domain of DnaJ and HSP40
    cd10747
    Location:79305
    DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
    pfam00226
    Location:938
    DnaJ; DnaJ domain
  3. NM_018602.3NP_061072.3  dnaJ homolog subfamily A member 4 isoform 1

    See proteins identical to NP_061072.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC090607, AK096616, AL133096, BC021720, DB047940
    Consensus CDS
    CCDS10299.2
    UniProtKB/TrEMBL
    Q69YX3
    UniProtKB/Swiss-Prot
    Q8WW22
    Related
    ENSP00000378324, OTTHUMP00000184907, ENST00000394855, OTTHUMT00000289800
    Conserved Domains (4) summary
    cd06257
    Location:3686
    DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
    cd10719
    Location:164230
    DnaJ_zf; Zinc finger domain of DnaJ and HSP40
    cd10747
    Location:135361
    DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
    PTZ00037
    Location:15423
    PTZ00037; DnaJ_C chaperone protein; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000015.10 

    Range
    78264145..78282196
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006720601.1XP_006720664.1  

    See proteins identical to XP_006720664.1

    UniProtKB/Swiss-Prot
    Q8WW22
    Related
    ENSP00000339581, OTTHUMP00000211598, ENST00000343789, OTTHUMT00000347698
    Conserved Domains (4) summary
    cd06257
    Location:757
    DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
    cd10719
    Location:135201
    DnaJ_zf; Zinc finger domain of DnaJ and HSP40
    cd10747
    Location:106332
    DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
    PTZ00037
    Location:2394
    PTZ00037; DnaJ_C chaperone protein; Provisional
  2. XM_005254535.1XP_005254592.1  

    See proteins identical to XP_005254592.1

    UniProtKB/Swiss-Prot
    Q8WW22
    Conserved Domains (4) summary
    cd06257
    Location:757
    DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
    cd10719
    Location:135201
    DnaJ_zf; Zinc finger domain of DnaJ and HSP40
    cd10747
    Location:106332
    DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
    PTZ00037
    Location:2394
    PTZ00037; DnaJ_C chaperone protein; Provisional

Alternate HuRef

Genomic

  1. AC_000147.1 

    Range
    55314570..55332634
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018926.2 

    Range
    78674451..78692505
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)