My NCBISign In

Display Settings:

Format

Send to:

Choose Destination

    STRADB STE20-related kinase adaptor beta [ Homo sapiens ]

    Gene ID: 55437, updated on 11-May-2012
    Help top of page

    Summary

    Official Symbol
    STRADBprovided by HGNC
    Official Full Name
    STE20-related kinase adaptor betaprovided by HGNC
    Primary source
    HGNC:13205
    Locus tag
    PRO1038
    See related
    Ensembl:ENSG00000082146; HPRD:09546; MIM:607333; Vega:OTTHUMG00000132831
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PAPK; ILPIP; ILPIPA; ALS2CR2; CALS-21; PRO1038; MGC102916
    Summary
    This gene encodes a protein that belongs to the serine/threonine protein kinase STE20 subfamily. One of the active site residues in the protein kinase domain of this protein is altered, and it is thus a pseudokinase. This protein is a component of a complex involved in the activation of serine/threonine kinase 11, a master kinase that regulates cell polarity and energy-generating metabolism. This complex regulates the relocation of this kinase from the nucleus to the cytoplasm, and it is essential for G1 cell cycle arrest mediated by this kinase. The protein encoded by this gene can also interact with the X chromosome-linked inhibitor of apoptosis protein, and this interaction enhances the anti-apoptotic activity of this protein via the JNK1 signal transduction pathway. Two pseudogenes, located on chromosomes 1 and 7, have been found for this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]
    Help top of page

    Genomic context

    Location :
    2q33.1
    Sequence :
    Chromosome: 2; NC_000002.11 (202316392..202345574)
    See STRADB in Epigenomics, MapViewer

    Chromosome 2 - NC_000002.11Genomic Context describing neighboring genes Neighboring gene amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 12 Neighboring gene SCY1-like 2 (S. cerevisiae) pseudogene Neighboring gene trafficking protein, kinesin binding 2 Neighboring gene amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 11 Neighboring gene transmembrane protein 237

    Help top of page

    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
    Helptop of page

    Bibliography

    Related articles in PubMed

    1. Network organization of the human autophagy system. Behrends C, et al. Nature, 2010 Jul 1. PMID 20562859.
    2. Protein interaction data set highlighted with human Ras-MAPK/PI3K signaling pathways. Wang J, et al. J Proteome Res, 2008 Sep. PMID 18624398.
    3. Emerging roles of pseudokinases. Boudeau J, et al. Trends Cell Biol, 2006 Sep. PMID 16879967.
    4. LKB1-dependent signaling pathways. Alessi DR, et al. Annu Rev Biochem, 2006. PMID 16756488.
    5. AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism. Kahn BB, et al. Cell Metab, 2005 Jan. PMID 16054041.

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. a novel XIAP-interacting protein that acts as a co-factor enhancing XIAP-mediated activation of JNK1 and the caspase-independent protection of XIAP against apoptosis
      Title: ILPIP, a novel anti-apoptotic protein that enhances XIAP-mediated activation of JNK1 and protection against apoptosis.
    Submit: New GeneRIF Correction
    Help top of page

    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Help top of page

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_061041.2 NP_000446.1 STK11    BIND  PubMed LKB1 phosphorylates PAPK. 
    Q9C0K7 Q9Y376 CAB39    HPRD  PubMed  
    Q9C0K7 O43318 MAP3K7    HPRD  PubMed  
    Q9C0K7 Q15831 STK11    HPRD  PubMed  
    Q9C0K7 Q9Y4K3 TRAF6    HPRD  PubMed  
    Q9C0K7 P98170 XIAP    HPRD  PubMed  
    BioGRID:120668 BioGRID:109142 GRB2    BioGRID  PubMed Two-hybrid 
    BioGRID:120668 BioGRID:112748 MAP3K7    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:120668 BioGRID:112670 STK11    BioGRID  PubMed Affinity Capture-MS; Biochemical Activity 
    BioGRID:120668 BioGRID:113041 TRAF6    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:120668 BioGRID:106828 XIAP    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    Help top of page

    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Energy dependent regulation of mTOR by LKB1-AMPK, organism-specific biosystem (from REACTOME)
      Energy dependent regulation of mTOR by LKB1-AMPK, organism-specific biosystemUpon formation of a trimeric LKB1:STRAD:MO25 complex, LKB1 phosphorylates and activates AMPK. If the AMP:ATP ratio rises, this activation is maintained and AMPK activates the TSC complex by phosphory...
    • IRS-mediated signalling, organism-specific biosystem (from REACTOME)
      IRS-mediated signalling, organism-specific biosystemRelease of phospho-IRS from the insulin receptor triggers a cascade of signalling events via PI3K, SOS, RAF and the MAP kinases.
    • IRS-related events, organism-specific biosystem (from REACTOME)
      IRS-related events, organism-specific biosystemIRS is one of the mediators of insulin signalling events. It is activated by phosphorylation and triggers a cascade of events involving PI3K, SOS, RAF and the MAP kinases. The proteins mentioned unde...
    • Insulin receptor signalling cascade, organism-specific biosystem (from REACTOME)
      Insulin receptor signalling cascade, organism-specific biosystemAutophosphorylation of the insulin receptor triggers a series of signalling events, mediated by SHC or IRS, and resulting in activation of the Ras/RAF and MAP kinase cascades. A second effect of the ...
    • LKB1 signaling events, organism-specific biosystem (from Pathway Interaction Database)
      LKB1 signaling events, organism-specific biosystem
      LKB1 signaling events
    • PI3K Cascade, organism-specific biosystem (from REACTOME)
      PI3K Cascade, organism-specific biosystem
      PI3K Cascade
    • PKB-mediated events, organism-specific biosystem (from REACTOME)
      PKB-mediated events, organism-specific biosystemPKB and PDK1 are activated via membrane-bound PIP3. Activated PDK1 phosphorylates PKB, which in turn phosphorylates PDE3B. The latter hydrolyses cAMP to 5'AMP, depleting cAMP pools.
    • Regulation of AMPK activity via LKB1, organism-specific biosystem (from REACTOME)
      Regulation of AMPK activity via LKB1, organism-specific biosystemLKB1 forms a complex with STRAD and MO25 thereby attaining a higher activity towards its substrates belonging to the subfamily of AMPK like kinases. LKB1:STRAD:MO25 complex phosphorylates AMPK consta...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by Insulin receptor, organism-specific biosystem (from REACTOME)
      Signaling by Insulin receptor, organism-specific biosystemInsulin binding to its receptor results in receptor autophosphorylation on tyrosine residues and the tyrosine phosphorylation of insulin receptor substrates (e.g. IRS and Shc) by the insulin receptor...
    • mTOR signalling, organism-specific biosystem (from REACTOME)
      mTOR signalling, organism-specific biosystem
      mTOR signalling

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding NAS
    Non-traceable Author Statement
    more info
    		  
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    NOT protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
    		  
    transferase activity, transferring phosphorus-containing groups IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    JNK cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    activation of protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    anti-apoptosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    cell cycle arrest TAS
    Traceable Author Statement
    more info
    		  
    cell morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    insulin receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    protein export from nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    regulation of fatty acid oxidation TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
    		  
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Help top of page

    General protein information

    Preferred Names
    STE20-related kinase adapter protein beta
    Names
    STE20-related kinase adapter protein beta
    STRAD beta
    pseudokinase ALS2CR2
    ILP-interacting protein ILPIPA
    amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 2
    amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein
    Help top of page

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029572.1 RefSeqGene

      Range
      5001..34183
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001206864.1 → NP_001193793.1  STE20-related kinase adapter protein beta isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has an alternate splice site in the 3' coding region, resulting in a longer transcript and a reading frame-shift, compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK027637, BC090871, BG110753
      Consensus CDS
      CCDS56161.1
      UniProtKB/Swiss-Prot
      Q9C0K7
      Related
      ENSP00000376080, OTTHUMP00000206592, ENST00000392249, OTTHUMT00000336914
      Conserved Domains (2) summary
      cd08226
      Location:59 – 371
      Blast Score: 1592
      PK_STRAD_beta; Pseudokinase domain of STE20-related kinase adapter protein beta
      smart00220
      Location:58 – 369
      Blast Score: 443
      S_TKc; Serine/Threonine protein kinases, catalytic domain

    2. NM_018571.5 → NP_061041.2  STE20-related kinase adapter protein beta isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK027637, W74591
      Consensus CDS
      CCDS2348.1
      UniProtKB/Swiss-Prot
      Q9C0K7
      Related
      ENSP00000194530, OTTHUMP00000163729, ENST00000194530, OTTHUMT00000256297
      Conserved Domains (2) summary
      cd08226
      Location:59 – 386
      Blast Score: 1663
      PK_STRAD_beta; Pseudokinase domain of STE20-related kinase adapter protein beta
      smart00220
      Location:58 – 369
      Blast Score: 444
      S_TKc; Serine/Threonine protein kinases, catalytic domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000002.11 Reference GRCh37.p5 Primary Assembly

      Range
      202316392..202345574
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000134.1 Alternate HuRef

      Range
      194164497..194193482
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC007282.4 AAY14692.1
    genomic CH471063.1 EAW70273.1
      EAW70274.1
      EAW70275.1
      EAW70276.1
    mRNA AB038950.1 BAB32500.1
    mRNA AK024720.1 None
    mRNA AK027637.1 BAB55254.1
    mRNA AK290457.1 BAF83146.1
    mRNA AY093697.1 AAM19143.1
    mRNA BC008302.1 AAH08302.1
    mRNA BC090871.1 AAH90871.1
    mRNA BG110753.1 None
    mRNA W74591.1 None
    other-genetic DQ893688.2 ABM84614.1
    other-genetic DQ893689.2 ABM84615.1
    other-genetic DQ896519.2 ABM87518.1
    other-genetic DQ896865.2 ABM87864.1
    other-genetic EU176785.1 ABW03586.1
    other-genetic EU176786.1 ABW03587.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9C0K7.1 GenPept UniProtKB/Swiss-Prot:Q9C0K7
    Help top of page

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Links

      Links to other resources

      General information

      Related sites

      Feedback

      Subscription

      Recent activity

      Clear Turn Off Turn On

      Your browsing activity is empty.

      Activity recording is turned off.

      Turn recording back on

      See more...