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YOD1 YOD1 deubiquitinase [ Homo sapiens (human) ]

Gene ID: 55432, updated on 12-May-2016
Official Symbol
YOD1provided by HGNC
Official Full Name
YOD1 deubiquitinaseprovided by HGNC
Primary source
HGNC:HGNC:25035
See related
Ensembl:ENSG00000180667 HPRD:10312; MIM:612023; Vega:OTTHUMG00000036032
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DUBA8; OTUD2; PRO0907
Summary
Protein ubiquitination controls many intracellular processes, including cell cycle progression, transcriptional activation, and signal transduction. This dynamic process, involving ubiquitin conjugating enzymes and deubiquitinating enzymes, adds and removes ubiquitin. Deubiquitinating enzymes are cysteine proteases that specifically cleave ubiquitin from ubiquitin-conjugated protein substrates. The protein encoded by this gene belongs to a DUB subfamily characterized by an ovarian tumor (OTU) domain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
Orthologs
Location:
1q32.2
Exon count:
5
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 1 NC_000001.11 (207043849..207053133, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (207217194..207226325, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene transfer RNA-Pro (TGG) 5-1 Neighboring gene chromosome 1 open reading frame 116 Neighboring gene 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 Neighboring gene complement component 4 binding protein beta Neighboring gene complement component 4 binding protein alpha

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Protein processing in endoplasmic reticulum, organism-specific biosystem (from KEGG)
    Protein processing in endoplasmic reticulum, organism-specific biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
  • Protein processing in endoplasmic reticulum, conserved biosystem (from KEGG)
    Protein processing in endoplasmic reticulum, conserved biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • DKFZp451J1719

Gene Ontology Provided by GOA

Preferred Names
ubiquitin thioesterase OTU1
Names
DUBA-8
HIN-7
HIV-1-induced protease 7
OTU domain containing 2
OTU domain-containing protein 2
YOD1 OTU deubiquinating enzyme 1 homolog ( yeast)
hsHIN7
NP_001263249.1
NP_061036.3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001276320.1NP_001263249.1  ubiquitin thioesterase OTU1 isoform 2

    See identical proteins and their annotated locations for NP_001263249.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains alternate exons in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AL445493
    Consensus CDS
    CCDS60402.1
    UniProtKB/Swiss-Prot
    Q5VVQ6
    Related
    ENSP00000356051, OTTHUMP00000034283, ENST00000367084, OTTHUMT00000087836
    Conserved Domains (2) summary
    COG5539
    Location:47303
    COG5539; Predicted cysteine protease (OTU family) [Posttranslational modification, protein turnover, chaperones]
    pfam02338
    Location:111224
    OTU; OTU-like cysteine protease
  2. NM_018566.3NP_061036.3  ubiquitin thioesterase OTU1 isoform 1

    See identical proteins and their annotated locations for NP_061036.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AL445493
    Consensus CDS
    CCDS31002.1
    UniProtKB/Swiss-Prot
    Q5VVQ6
    Related
    ENSP00000326813, OTTHUMP00000034284, ENST00000315927, OTTHUMT00000087837
    Conserved Domains (3) summary
    COG5539
    Location:91347
    COG5539; Predicted cysteine protease (OTU family) [Posttranslational modification, protein turnover, chaperones]
    pfam02338
    Location:155268
    OTU; OTU-like cysteine protease
    cl00155
    Location:4689
    UBQ; Ubiquitin-like proteins

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p2 Primary Assembly

    Range
    207043849..207053133 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011509725.1XP_011508027.1  

    See identical proteins and their annotated locations for XP_011508027.1

    UniProtKB/Swiss-Prot
    Q5VVQ6
    Conserved Domains (2) summary
    COG5539
    Location:47303
    COG5539; Predicted cysteine protease (OTU family) [Posttranslational modification, protein turnover, chaperones]
    pfam02338
    Location:111224
    OTU; OTU-like cysteine protease

RNA

  1. XR_247031.3 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018912.2 Alternate CHM1_1.1

    Range
    208489805..208498936 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)