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TLR4 toll like receptor 4 [ Ovis aries (sheep) ]

Gene ID: 554263, updated on 5-Mar-2024

Summary

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Gene symbol
TLR4
Gene description
toll like receptor 4
See related
EnsemblRapid:ENSOARG00020004476
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Ovis aries
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Caprinae; Ovis
Orthologs
human mouse all
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Genomic context

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See TLR4 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2023_10 current ARS-UI_Ramb_v3.0 (GCF_016772045.2) 2 NC_056055.1 (5924822..5934668, complement)

Chromosome 2 - NC_056055.1Genomic Context describing neighboring genes Neighboring gene transfer RNA serine (anticodon GGA) Neighboring gene transfer RNA serine (anticodon GGA) Neighboring gene elongation factor 1-alpha 1 Neighboring gene astrotactin 2 Neighboring gene tripartite motif containing 32

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_056055.1 Chromosome 2 Reference ARS-UI_Ramb_v3.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Association between ovine Toll-like receptor 4 (TLR4) gene coding variants and presence of Eimeria spp. in naturally infected adult Turkish native sheep. Yaman Y, et al. Anim Biotechnol, 2021 Jun. PMID 32967565
  2. Effects of TLR4 overexpression on sperm quality, seminal plasma biomarkers, sperm DNA methylation and pregnancy rate in sheep. Fang Y, et al. Theriogenology, 2020 Jan 15. PMID 31711688
  3. Overexpression of Toll-like receptor 4 enhances LPS-induced inflammatory response and inhibits Salmonella Typhimurium growth in ovine macrophages. Wei S, et al. Eur J Cell Biol, 2019 Jan. PMID 30522781
  4. Lipopolysaccharides belonging to different Salmonella serovars are differentially capable of activating Toll-like receptor 4. Chessa D, et al. Infect Immun, 2014 Nov. PMID 25135686, Free PMC Article
  5. Up-regulation of Toll-like receptor 4/nuclear factor-kappaB signaling is associated with enhanced adipogenesis and insulin resistance in fetal skeletal muscle of obese sheep at late gestation. Yan X, et al. Endocrinology, 2010 Jan. PMID 19887565, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Association between ovine Toll-like receptor 4 (TLR4) gene coding variants and presence of Eimeria spp. in naturally infected adult Turkish native sheep.
    Title: Association between ovine Toll-like receptor 4 (TLR4) gene coding variants and presence of Eimeria spp. in naturally infected adult Turkish native sheep.
  2. There was no evidence that TLR4 overexpression altered the sperm quality, seminal plasma or sperm DNA of transgenic sheep.
    Title: Effects of TLR4 overexpression on sperm quality, seminal plasma biomarkers, sperm DNA methylation and pregnancy rate in sheep.
  3. overexpression of TLR4 could enhance innate inflammatory responses, initiate the innate antiviral immunity, and control effectively S. Typhimurium growth in ovine macrophages.
    Title: Overexpression of Toll-like receptor 4 enhances LPS-induced inflammatory response and inhibits Salmonella Typhimurium growth in ovine macrophages.
  4. This study describes the interaction between S. Abortusovis LPS and TLR4 from human and ovine sources.
    Title: Lipopolysaccharides belonging to different Salmonella serovars are differentially capable of activating Toll-like receptor 4.
  5. Toll-like receptor 4 expression was higher in obese than control fetal muscle.
    Title: Up-regulation of Toll-like receptor 4/nuclear factor-kappaB signaling is associated with enhanced adipogenesis and insulin resistance in fetal skeletal muscle of obese sheep at late gestation.
  6. TLR2 and TLR4 mRNAs increase through gestation and expression of TLR2 and TLR4 are induced by LPS in the fetal sheep lung.
    Title: Toll-like receptors and agonist responses in the developing fetal sheep lung.
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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables lipopolysaccharide binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables lipopolysaccharide immune receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in defense response to Gram-negative bacterium IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in toll-like receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
toll-like receptor 4
NP_001129402.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135930.1 → NP_001129402.1  toll-like receptor 4 precursor

    See identical proteins and their annotated locations for NP_001129402.1

    Status: PROVISIONAL

    Source sequence(s)
    AM981302
    UniProtKB/TrEMBL
    A0A6P3CX24, A0A836D655, B5DC89
    Related
    ENSOARP00020005662.1, ENSOART00020006855.2
    Conserved Domains (5) summary
    smart00255
    Location:673 → 815
    TIR; Toll - interleukin 1 - resistance
    cd00116
    Location:369 → 580
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00031
    Location:55 → 78
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:374 → 399
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:56 → 113
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_016772045.2-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UI_Ramb_v3.0 Primary Assembly

Genomic

  1. NC_056055.1 Reference ARS-UI_Ramb_v3.0 Primary Assembly

    Range
    5924822..5934668 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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