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ASPDH aspartate dehydrogenase domain containing [ Homo sapiens (human) ]

Gene ID: 554235, updated on 26-May-2016
Official Symbol
ASPDHprovided by HGNC
Official Full Name
aspartate dehydrogenase domain containingprovided by HGNC
Primary source
HGNC:HGNC:33856
See related
Ensembl:ENSG00000204653 HPRD:18692; Vega:OTTHUMG00000183057
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Orthologs
Location:
19q13.33
Exon count:
8
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 19 NC_000019.10 (50511600..50514690, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (51014857..51018689, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100506114 Neighboring gene ER membrane protein complex subunit 10 Neighboring gene uncharacterized LOC105372438 Neighboring gene Josephin domain containing 2 Neighboring gene leucine rich repeat containing 4B Neighboring gene small ILF3/NF90-associated RNA F

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NADP binding IEA
Inferred from Electronic Annotation
more info
 
aspartate dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
NAD biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
NADP catabolic process IEA
Inferred from Electronic Annotation
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
putative L-aspartate dehydrogenase
Names
aspartate dehydrogenase domain-containing protein
NP_001019827.2
NP_001108070.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024656.2NP_001019827.2  putative L-aspartate dehydrogenase isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains a distinct 5' UTR and lacks several in-frame portions of the 5' coding region, compared to variant 1. The resulting isoform (2) has a shorter, distinct N-terminus when compared to isoform 1. Isoform 2 lacks an N-terminus NAD-binding-3 domain, compared to isoform 1.
    Source sequence(s)
    BC066359, BM695973, BU729215
    Consensus CDS
    CCDS33082.1
    UniProtKB/Swiss-Prot
    A6ND91
    Related
    ENSP00000366114, OTTHUMP00000270747, ENST00000376916, OTTHUMT00000464859
    Conserved Domains (2) summary
    pfam01958
    Location:62161
    DUF108; Domain of unknown function DUF108
    cl21454
    Location:1235
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  2. NM_001114598.1NP_001108070.1  putative L-aspartate dehydrogenase isoform 1

    See identical proteins and their annotated locations for NP_001108070.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BM924033, BU729215
    Consensus CDS
    CCDS46153.1
    UniProtKB/Swiss-Prot
    A6ND91
    Related
    ENSP00000373860, OTTHUMP00000270748, ENST00000389208, OTTHUMT00000464861
    Conserved Domains (2) summary
    pfam01958
    Location:167266
    DUF108; Domain of unknown function DUF108
    pfam03447
    Location:13123
    NAD_binding_3; Homoserine dehydrogenase, NAD binding domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p2 Primary Assembly

    Range
    50511600..50514690 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018930.2 Alternate CHM1_1.1

    Range
    51016693..51019806 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)