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NPY4R neuropeptide Y receptor Y4 [ Homo sapiens (human) ]

Gene ID: 5540, updated on 8-May-2016
Official Symbol
NPY4Rprovided by HGNC
Official Full Name
neuropeptide Y receptor Y4provided by HGNC
Primary source
HGNC:HGNC:9329
See related
Ensembl:ENSG00000204174 HPRD:03476; MIM:601790
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Y4; PP1; PPYR1; NPY4-R
Orthologs
Location:
10q11.2
Exon count:
8
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 10 NC_000010.11 (46458551..46470647, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (47083534..47088320)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene annexin A8-like 1 Neighboring gene long intergenic non-protein coding RNA 842 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 33 Neighboring gene G protein regulated inducer of neurite outgrowth 2 Neighboring gene uncharacterized LOC101927699 Neighboring gene synaptotagmin 15

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
    Class A/1 (Rhodopsin-like receptors), organism-specific biosystemRhodopsin-like receptors (class A/1) are the largest group of GPCRs and are the best studied group from a functional and structural point of view. They show great diversity at the sequence level and ...
  • G alpha (i) signalling events, organism-specific biosystem (from REACTOME)
    G alpha (i) signalling events, organism-specific biosystemThe classical signalling mechanism for G alpha (i) is inhibition of the cAMP dependent pathway through inhibition of adenylate cyclase. Decreased production of cAMP from ATP results in decreased act...
  • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
    GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
  • GPCR ligand binding, organism-specific biosystem (from REACTOME)
    GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
  • GPCRs, Class A Rhodopsin-like, organism-specific biosystem (from WikiPathways)
    GPCRs, Class A Rhodopsin-like, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.cmbi.kun.nl/7tm/. The groupings are based on the GPCR phylogenetic tree available from the GPCRDB and the training sets used ...
  • Neuroactive ligand-receptor interaction, organism-specific biosystem (from KEGG)
    Neuroactive ligand-receptor interaction, organism-specific biosystem
    Neuroactive ligand-receptor interaction
  • Neuroactive ligand-receptor interaction, conserved biosystem (from KEGG)
    Neuroactive ligand-receptor interaction, conserved biosystem
    Neuroactive ligand-receptor interaction
  • Peptide GPCRs, organism-specific biosystem (from WikiPathways)
    Peptide GPCRs, organism-specific biosystem
    Peptide GPCRs
  • Peptide ligand-binding receptors, organism-specific biosystem (from REACTOME)
    Peptide ligand-binding receptors, organism-specific biosystemThese receptors, a subset of the Class A/1 (Rhodopsin-like) family, all bind peptide ligands which include the chemokines, opioids and somatostatins.
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC116897

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G-protein coupled receptor activity TAS
Traceable Author Statement
more info
PubMed 
pancreatic polypeptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
peptide YY receptor activity IEA
Inferred from Electronic Annotation
more info
 
peptide binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G-protein coupled receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
blood circulation TAS
Traceable Author Statement
more info
PubMed 
cell surface receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
digestion TAS
Traceable Author Statement
more info
PubMed 
feeding behavior TAS
Traceable Author Statement
more info
PubMed 
neuropeptide signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
neuropeptide Y receptor type 4
Names
pancreatic polypeptide receptor 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001278794.1NP_001265723.1  neuropeptide Y receptor type 4

    See identical proteins and their annotated locations for NP_001265723.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC244230
    Consensus CDS
    CCDS73100.1
    UniProtKB/Swiss-Prot
    P50391
    Related
    ENSP00000480883, ENST00000612632
    Conserved Domains (1) summary
    pfam00001
    Location:64322
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  2. NM_005972.5NP_005963.4  neuropeptide Y receptor type 4

    See identical proteins and their annotated locations for NP_005963.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC244230
    Consensus CDS
    CCDS73100.1
    UniProtKB/Swiss-Prot
    P50391
    Related
    ENSP00000363431, ENST00000374312
    Conserved Domains (1) summary
    pfam00001
    Location:64322
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p2 Primary Assembly

    Range
    46458551..46470647 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011539933.1XP_011538235.1  

    See identical proteins and their annotated locations for XP_011538235.1

    UniProtKB/Swiss-Prot
    P50391
    Conserved Domains (1) summary
    pfam00001
    Location:64322
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  2. XM_011539937.1XP_011538239.1  

    See identical proteins and their annotated locations for XP_011538239.1

    UniProtKB/Swiss-Prot
    P50391
    Conserved Domains (1) summary
    pfam00001
    Location:64322
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  3. XM_011539932.1XP_011538234.1  

    See identical proteins and their annotated locations for XP_011538234.1

    UniProtKB/Swiss-Prot
    P50391
    Conserved Domains (1) summary
    pfam00001
    Location:64322
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  4. XM_011539936.1XP_011538238.1  

    See identical proteins and their annotated locations for XP_011538238.1

    UniProtKB/Swiss-Prot
    P50391
    Conserved Domains (1) summary
    pfam00001
    Location:64322
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  5. XM_011539934.1XP_011538236.1  

    See identical proteins and their annotated locations for XP_011538236.1

    UniProtKB/Swiss-Prot
    P50391
    Conserved Domains (1) summary
    pfam00001
    Location:64322
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  6. XM_011539935.1XP_011538237.1  

    See identical proteins and their annotated locations for XP_011538237.1

    UniProtKB/Swiss-Prot
    P50391
    Conserved Domains (1) summary
    pfam00001
    Location:64322
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  7. XM_011539931.1XP_011538233.1  

    See identical proteins and their annotated locations for XP_011538233.1

    UniProtKB/Swiss-Prot
    P50391
    Conserved Domains (1) summary
    pfam00001
    Location:64322
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  8. XM_011539929.1XP_011538231.1  

    See identical proteins and their annotated locations for XP_011538231.1

    UniProtKB/Swiss-Prot
    P50391
    Conserved Domains (1) summary
    pfam00001
    Location:64322
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  9. XM_011539930.1XP_011538232.1  

    See identical proteins and their annotated locations for XP_011538232.1

    UniProtKB/Swiss-Prot
    P50391
    Conserved Domains (1) summary
    pfam00001
    Location:64322
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  10. XM_011539928.1XP_011538230.1  

    Conserved Domains (1) summary
    pfam00001
    Location:101359
    7tm_1; 7 transmembrane receptor (rhodopsin family)

Alternate CHM1_1.1

Genomic

  1. NC_018921.2 Alternate CHM1_1.1

    Range
    47901251..47906033 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)