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    PPP6C protein phosphatase 6, catalytic subunit [ Homo sapiens ]

    Gene ID: 5537, updated on 11-May-2012
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    Summary

    Official Symbol
    PPP6Cprovided by HGNC
    Official Full Name
    protein phosphatase 6, catalytic subunitprovided by HGNC
    Primary source
    HGNC:9323
    Locus tag
    RP11-366O20.1
    See related
    Ensembl:ENSG00000119414; HPRD:02141; MIM:612725; Vega:OTTHUMG00000020671
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PP6; PP6C; FLJ92648; MGC12249
    Summary
    This gene encodes the catalytic subunit of protein phosphatase, a component of a signaling pathway regulating cell cycle progression. Splice variants encoding different protein isoforms exist. The pseudogene of this gene is located on chromosome X. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    9q33.3
    Sequence :
    Chromosome: 9; NC_000009.11 (127908852..127952218, complement)
    See PPP6C in Epigenomics, MapViewer

    Chromosome 9 - NC_000009.11Genomic Context describing neighboring genes Neighboring gene golgin A1 Neighboring gene frataxin pseudogene Neighboring gene suppressor of cancer cell invasion Neighboring gene phosphoribosyl pyrophosphate synthetase 1 pseudogene 2 Neighboring gene NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa pseudogene 2 Neighboring gene Rab9 effector protein with kelch motifs Neighboring gene heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. Lee KA, et al. J Biol Chem, 2011 Dec 2. PMID 21987572.
    2. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    3. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    4. MicroRNA-373, a new regulator of protein phosphatase 6, functions as an oncogene in hepatocellular carcinoma. Wu N, et al. FEBS J, 2011 Jun. PMID 21481188.
    5. Protein phosphatase PP6 is required for homology-directed repair of DNA double-strand breaks. Zhong J, et al. Cell Cycle, 2011 May 1. PMID 21451261.

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. miR-373 can regulate cell cycle progression by targeting PPP6C transcripts and promotes the growth activity of HCC cells in vitro. The downregulation of PPP6C by miR-373 may explain why the expression of miR-373 can promote HCC cell proliferation.
      Title: MicroRNA-373, a new regulator of protein phosphatase 6, functions as an oncogene in hepatocellular carcinoma.
    2. PP6 is required for non-homologous end joining repair; its expression may harbor a protective role during the development of breast cancer tissues.
      Title: Protein phosphatase PP6 is required for homology-directed repair of DNA double-strand breaks.
    3. Results demonstrate a role for PP6 as the T-loop phosphatase regulating Aurora A activity bound to its activator TPX2 during mitotic spindle formation.
      Title: Protein phosphatase 6 regulates mitotic spindle formation by controlling the T-loop phosphorylation state of Aurora A bound to its activator TPX2.
    4. A novel function of DNA-PKcs is to recruit PP6 to sites of DNA damage and that PP6 contributes to the dephosphorylation of gamma-H2AX, the dissolution of ionizing radiation-induced foci, and release from the G(2)/M checkpoint in vivo.
      Title: Protein phosphatase 6 interacts with the DNA-dependent protein kinase catalytic subunit and dephosphorylates gamma-H2AX.
    5. our results seem to discard the role of the previously described polymorphisms in SERPINE2, PPP6C and PBX3 in celiac disease susceptibility.
      Title: Lack of replication of celiac disease risk variants reported in a Spanish population using an independent Spanish sample.
    6. results illustrate that the human PP6-associated proteins are capable of providing distinct rapamycin-sensitive and Sit4-dependent Sap functions in the heterologous context of the yeast cell
      Title: Human protein phosphatase PP6 regulatory subunits provide Sit4-dependent and rapamycin-sensitive sap function in Saccharomyces cerevisiae.
    7. Observational study of gene-disease association. (HuGE Navigator)
      Title: Lack of replication of celiac disease risk variants reported in a Spanish population using an independent Spanish sample.
    8. Our data demonstrate that protein phosphatase-6 associates with and activates DNA-PK in response to ionizing radiation.
      Title: Activation of DNA-PK by ionizing radiation is mediated by protein phosphatase 6.
    9. PP6 regulates cell cycle progression in human cells at least in part through control of cyclin D1 and the function of PP6 is distinct from its homolog Sit4 in yeast.
      Title: Protein phosphatase PP6 N terminal domain restricts G1 to S phase progression in human cancer cells.
    10. Protein phosphatase 6 subunit with conserved Sit4-associated protein domain targets IkappaBepsilon
      Title: Protein phosphatase 6 subunit with conserved Sit4-associated protein domain targets IkappaBepsilon.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    O00743 P78318 IGBP1    HPRD  PubMed  
    O00743 O00221 NFKBIE    HPRD  PubMed  
    O00743 P36897 TGFBR1    HPRD  PubMed  
    BioGRID:111529 BioGRID:116847 ANKRD28    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111529 BioGRID:124841 ANKRD44    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111529 BioGRID:129540 ANKRD52    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111529 BioGRID:109698 IGBP1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:111529 BioGRID:112748 MAP3K7    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111529 BioGRID:110694 MYC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111529 BioGRID:120645 PIDD    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111529 BioGRID:116537 PPP6R1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111529 BioGRID:115053 PPP6R2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111529 BioGRID:120579 PPP6R3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111529 BioGRID:111577 PRKDC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111529 BioGRID:116740 TAB2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111529 BioGRID:118878 TBK1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111529 BioGRID:129283 TIPRL    BioGRID  PubMed Reconstituted Complex 
    BioGRID:111529 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
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    General gene information

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein serine/threonine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    G1/S transition of mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		 PubMed 
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein dephosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    serine/threonine-protein phosphatase 6 catalytic subunit
    Names
    serine/threonine-protein phosphatase 6 catalytic subunit
    serine/threonine protein phosphatase catalytic subunit
    NP_001116827.1
    NP_001116841.1
    NP_002712.1
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001123355.1 → NP_001116827.1  serine/threonine-protein phosphatase 6 catalytic subunit isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) is the longest transcript; it encodes the longest isoform (a).
      Source sequence(s)
      AA251321, AL445930, BC006990, CB250498, DB037210, DC334216
      Consensus CDS
      CCDS48018.1
      UniProtKB/Swiss-Prot
      O00743
      Related
      ENSP00000392147, ENST00000451402
      Conserved Domains (2) summary
      cd07415
      Location:5 – 326
      Blast Score: 1378
      MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain
      PTZ00239
      Location:58 – 342
      Blast Score: 1221
      PTZ00239; serine/threonine protein phosphatase 2A; Provisional

    2. NM_001123369.1 → NP_001116841.1  serine/threonine-protein phosphatase 6 catalytic subunit isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks one coding exon compared to variant 1 and encodes isoform c, which is shorter than isoform a.
      Source sequence(s)
      AA251321, AL445930, BC006990, CB250498, DB037210, DC307002, DC369815
      Consensus CDS
      CCDS48019.1
      UniProtKB/Swiss-Prot
      O00743
      Related
      ENSP00000411744, ENST00000415905
      Conserved Domains (2) summary
      cd07415
      Location:5 – 267
      Blast Score: 1277
      MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain
      PTZ00239
      Location:4 – 283
      Blast Score: 1136
      PTZ00239; serine/threonine protein phosphatase 2A; Provisional

    3. NM_002721.4 → NP_002712.1  serine/threonine-protein phosphatase 6 catalytic subunit isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site and lacks an exon in the coding region, compared to variant 1; it encodes a shorter isoform (b).
      Source sequence(s)
      AA251321, AL445930, BC006990, CB250498, DB037210
      Consensus CDS
      CCDS6861.1
      UniProtKB/Swiss-Prot
      O00743
      Related
      ENSP00000362648, OTTHUMP00000022122, ENST00000373547, OTTHUMT00000054060
      Conserved Domains (2) summary
      cd07415
      Location:5 – 289
      Blast Score: 1420
      MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain
      PTZ00239
      Location:4 – 305
      Blast Score: 1262
      PTZ00239; serine/threonine protein phosphatase 2A; Provisional

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000009.11 Reference GRCh37.p5 Primary Assembly

      Range
      127908852..127952218, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000141.1 Alternate HuRef

      Range
      97520985..97564821, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL445930.11 CAI13676.1
      CAI13677.1
    genomic CH471090.1 EAW87611.1
      EAW87612.1
      EAW87613.1
    mRNA AA251321.1 None
    mRNA AF035158.2 AAD45400.2
    mRNA AK295190.1 BAH12005.1
    mRNA AK295752.1 BAH12178.1
    mRNA AK299087.1 BAH12945.1
    mRNA AK312332.1 BAG35253.1
    mRNA AK316527.1 BAH14898.1
    mRNA BC006990.1 AAH06990.1
    mRNA BT019708.1 AAV38514.1
    mRNA CB250498.1 None
    mRNA DB037210.1 None
    mRNA DC307002.1 None
    mRNA DC334216.1 None
    mRNA DC369815.1 None
    mRNA X92972.2 CAA63549.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    O00743.1 GenPept UniProtKB/Swiss-Prot:O00743
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
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