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MNS1 meiosis-specific nuclear structural 1 [ Homo sapiens (human) ]

Gene ID: 55329, updated on 19-Jul-2014
Official Symbol
MNS1provided by HGNC
Official Full Name
meiosis-specific nuclear structural 1provided by HGNC
Primary source
HGNC:29636
See related
Ensembl:ENSG00000138587; HPRD:10967; MIM:610766; Vega:OTTHUMG00000132034
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SPATA40
Summary
This gene encodes a protein highly similar to the mouse meiosis-specific nuclear structural 1 protein. The mouse protein was shown to be expressed at the pachytene stage during spermatogenesis and may function as a nuclear skeletal protein to regulate nuclear morphology during meiosis. [provided by RefSeq, Oct 2008]
See MNS1 in Epigenomics, MapViewer
Location:
15q21.3
Exon count :
10
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 15 NC_000015.10 (56428731..56465137, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (56720929..56757335, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene regulatory factor X, 7 Neighboring gene hydroxyacyl-CoA dehydrogenase pseudogene Neighboring gene testis expressed 9 Neighboring gene high mobility group box 1 pseudogene 33 Neighboring gene zinc finger protein 280D Neighboring gene acyl-CoA binding domain containing 7 pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Common variants in left/right asymmetry genes and pathways are associated with relative hand skill.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif downregulates the expression of meiosis-specific nuclear structural 1 (MNS1) in Vif-expression T cells PubMed

Go to the HIV-1, Human Protein Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
identical protein binding IDA
Inferred from Direct Assay
more info
 
Process Evidence Code Pubs
cilium organization IEA
Inferred from Electronic Annotation
more info
 
left/right axis specification IEA
Inferred from Electronic Annotation
more info
 
meiotic nuclear division IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
axoneme IEA
Inferred from Electronic Annotation
more info
 
intermediate filament IEA
Inferred from Electronic Annotation
more info
 
nuclear envelope IEA
Inferred from Electronic Annotation
more info
 
sperm flagellum IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
meiosis-specific nuclear structural protein 1
Names
meiosis-specific nuclear structural protein 1
spermatogenesis associated 40

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018365.2NP_060835.1  meiosis-specific nuclear structural protein 1

    See proteins identical to NP_060835.1

    Status: REVIEWED

    Source sequence(s)
    AK002084, AK057542, BC034991
    Consensus CDS
    CCDS10158.1
    UniProtKB/TrEMBL
    B3KQ70
    UniProtKB/Swiss-Prot
    Q8NEH6
    Related
    ENSP00000260453, OTTHUMP00000162907, ENST00000260453, OTTHUMT00000255047
    Conserved Domains (1) summary
    pfam13868
    Location:116465
    Blast Score: 577
    Trichoplein; tumor suppressor, Mitostatin

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000015.10 

    Range
    56428731..56465137
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000147.1 

    Range
    33544043..33580471
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018926.2 

    Range
    56839205..56875585
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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