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    MNS1 meiosis-specific nuclear structural 1 [ Homo sapiens ]

    Gene ID: 55329, updated on 11-May-2012
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    Summary

    Official Symbol
    MNS1provided by HGNC
    Official Full Name
    meiosis-specific nuclear structural 1provided by HGNC
    Primary source
    HGNC:29636
    See related
    Ensembl:ENSG00000138587; HPRD:10967; MIM:610766; Vega:OTTHUMG00000132034
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FLJ11222; FLJ26051
    Summary
    This gene encodes a protein highly similar to the mouse meiosis-specific nuclear structural 1 protein. The mouse protein was shown to be expressed at the pachytene stage during spermatogenesis and may function as a nuclear skeletal protein to regulate nuclear morphology during meiosis. [provided by RefSeq, Oct 2008]
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    Genomic context

    Location :
    15q21.3
    Sequence :
    Chromosome: 15; NC_000015.9 (56720929..56757335, complement)
    See MNS1 in Epigenomics, MapViewer

    Chromosome 15 - NC_000015.9Genomic Context describing neighboring genes Neighboring gene CD24 molecule pseudogene 2 Neighboring gene regulatory factor X, 7 Neighboring gene hydroxyacyl-CoA dehydrogenase pseudogene Neighboring gene testis expressed 9 Neighboring gene zinc finger protein 280D Neighboring gene acyl-CoA binding domain containing 7 pseudogene

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Towards a proteome-scale map of the human protein-protein interaction network. Rual JF, et al. Nature, 2005 Oct 20. PMID 16189514.
    2. Proteomics profiling of nuclear proteins for kidney fibroblasts suggests hypoxia, meiosis, and cancer may meet in the nucleus. Shakib K, et al. Proteomics, 2005 Jul. PMID 15942958.
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039.
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932.
    5. cDNA cloning and functional characterization of a meiosis-specific protein (MNS1) with apparent nuclear association. Furukawa K, et al. Chromosome Res, 1994 Mar. PMID 8032679.

    See all (6) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Cloning and functional characterization of a highly similar gene in mouse.
      Title: cDNA cloning and functional characterization of a meiosis-specific protein (MNS1) with apparent nuclear association.
    2. A rat homologous protein was among the the nuclear proteins that change in abundance or form in response to prolonged hypoxia in the rat kidney fibroblasts.
      Title: Proteomics profiling of nuclear proteins for kidney fibroblasts suggests hypoxia, meiosis, and cancer may meet in the nucleus.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    MNS1 Q01844 EWSR1    HPRD  PubMed  
    BioGRID:120610 BioGRID:108431 EWSR1    BioGRID  PubMed Two-hybrid 
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    General gene information

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    meiosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    intermediate filament IEA
    Inferred from Electronic Annotation
    more info
    		  
    nuclear envelope IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    meiosis-specific nuclear structural protein 1
    Names
    meiosis-specific nuclear structural protein 1
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_018365.2 → NP_060835.1  meiosis-specific nuclear structural protein 1

      Status: REVIEWED

      Source sequence(s)
      AK002084, AK057542, BC034991
      Consensus CDS
      CCDS10158.1
      UniProtKB/TrEMBL
      B3KQ70
      UniProtKB/Swiss-Prot
      Q8NEH6
      Related
      ENSP00000260453, OTTHUMP00000162907, ENST00000260453, OTTHUMT00000255047
      Conserved Domains (1) summary
      pfam13868
      Location:116 – 423
      Blast Score: 119
      Trichoplein; Tumour suppressor, Mitostatin

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000015.9 Reference GRCh37.p5 Primary Assembly

      Range
      56720929..56757335, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000147.1 Alternate HuRef

      Range
      33544043..33580471, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC068713.8 (46184..48191) None
    genomic AC084782.2 (143541..177861) None
    genomic CH471082.1 EAW77501.1
      EAW77502.1
    mRNA AK002084.1 BAA92077.1
    mRNA AK057542.1 BAG51932.1
    mRNA BC012554.1 None
    mRNA BC031046.1 AAH31046.1
    mRNA BC034991.2 AAH34991.1
    other-genetic EU176292.1 ABW03743.1
    other-genetic EU176801.1 ABW03602.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8NEH6.2 GenPept UniProtKB/Swiss-Prot:Q8NEH6
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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