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AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5 [ Homo sapiens (human) ]

Gene ID: 55326, updated on 26-May-2016
Official Symbol
AGPAT5provided by HGNC
Official Full Name
1-acylglycerol-3-phosphate O-acyltransferase 5provided by HGNC
Primary source
HGNC:HGNC:20886
See related
Ensembl:ENSG00000155189 HPRD:12438; MIM:614796
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LPAATE; 1AGPAT5
Summary
This gene encodes a member of the 1-acylglycerol-3-phosphate O-acyltransferase family. This integral membrane protein converts lysophosphatidic acid to phosphatidic acid, the second step in de novo phospholipid biosynthesis. A pseudogene of this gene is present on the Y chromosome. [provided by RefSeq, Aug 2014]
Orthologs
Location:
8p23.1
Exon count:
8
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 8 NC_000008.11 (6708357..6761503)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (6565878..6619024)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene microcephalin 1 Neighboring gene angiopoietin 2 Neighboring gene MCPH1 antisense RNA 1 Neighboring gene microRNA 8055 Neighboring gene protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte) pseudogene Neighboring gene microRNA 4659a Neighboring gene microRNA 4659b Neighboring gene uncharacterized LOC100652791 Neighboring gene uncharacterized LOC105377798 Neighboring gene XK related 5

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
1-acylglycerol-3-phosphate O-acyltransferase activity NAS
Non-traceable Author Statement
more info
PubMed 
1-acylglycerol-3-phosphate O-acyltransferase activity TAS
Traceable Author Statement
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
CDP-diacylglycerol biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
hematopoietic progenitor cell differentiation IEA
Inferred from Electronic Annotation
more info
 
phosphatidic acid biosynthetic process TAS
Traceable Author Statement
more info
 
phospholipid biosynthetic process NAS
Non-traceable Author Statement
more info
PubMed 
triglyceride biosynthetic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrial outer membrane TAS
Traceable Author Statement
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
 
nuclear envelope IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon
Names
1-AGP acyltransferase 5
1-AGPAT 5
1-acylglycerol-3-phosphate O-acyltransferase 5 (lysophosphatidic acid acyltransferase, epsilon)
lysophosphatidic acid acyltransferase epsilon
testicular tissue protein Li 144
NP_060831.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018361.3NP_060831.2  1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon

    See identical proteins and their annotated locations for NP_060831.2

    Status: REVIEWED

    Source sequence(s)
    AF287957, AK021722, AL136587, BM837881, CA414711
    Consensus CDS
    CCDS34796.1
    UniProtKB/Swiss-Prot
    Q9NUQ2
    UniProtKB/TrEMBL
    A0A024R640
    Related
    ENSP00000285518, OTTHUMP00000224507, ENST00000285518, OTTHUMT00000374684
    Conserved Domains (1) summary
    cd07990
    Location:63263
    LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p2 Primary Assembly

    Range
    6708357..6761503
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011534751.1XP_011533053.1  

    Conserved Domains (1) summary
    cd07990
    Location:63166
    LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like

Alternate CHM1_1.1

Genomic

  1. NC_018919.2 Alternate CHM1_1.1

    Range
    6655163..6708308
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)