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    PPP3CB protein phosphatase 3, catalytic subunit, beta isozyme [ Homo sapiens ]

    Gene ID: 5532, updated on 19-May-2012
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    Summary

    Official Symbol
    PPP3CBprovided by HGNC
    Official Full Name
    protein phosphatase 3, catalytic subunit, beta isozymeprovided by HGNC
    Primary source
    HGNC:9315
    Locus tag
    RP11-345K20.1
    See related
    Ensembl:ENSG00000107758; HPRD:00235; MIM:114106; Vega:OTTHUMG00000018472
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CNA2; CALNB; CALNA2; PP2Bbeta
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    Genomic context

    Location :
    10q22.2
    Sequence :
    Chromosome: 10; NC_000010.10 (75196563..75255782, complement)
    See PPP3CB in Epigenomics, MapViewer

    Chromosome 10 - NC_000010.10Genomic Context describing neighboring genes Neighboring gene ribosomal protein L26 pseudogene 6 Neighboring gene MSS51 mitochondrial translational activator homolog (S. cerevisiae) Neighboring gene uncharacterized LOC100507259 Neighboring gene ubiquitin specific peptidase 54 Neighboring gene ribosomal protein S26 pseudogene 41 Neighboring gene myozenin 1

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Global identification of modular cullin-RING ligase substrates. Emanuele MJ, et al. Cell, 2011 Oct 14. PMID 21963094.
    2. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    3. Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. Li S, et al. Immunity, 2011 Sep 23. PMID 21903422.
    4. P43-dependent mitochondrial activity regulates myoblast differentiation and slow myosin isoform expression by control of Calcineurin expression. Seyer P, et al. Exp Cell Res, 2011 Aug 15. PMID 21664352.
    5. ANXA7, PPP3CB, DNAJC9, and ZMYND17 genes at chromosome 10q22 associated with the subgroup of schizophrenia with deficits in attention and executive function. Liu CM, et al. Biol Psychiatry, 2011 Jul 1. PMID 21531385.

    See all (49) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. The C allele of protein phosphatase 3 subunit alpha rs3804358 polymorphism was overrepresented in athletes compared with controls, whereas the T allele of protein phosphatase 3 subunit beta rs3763679 polymorphism was underrepresented in athletes.
      Title: Are calcineurin genes associated with athletic status? A function, replication study.
    2. ANXA7, PPP3CB, DNAJC9, and ZMYND17 genes are potential candidate genes for schizophrenia, especially in patients with deficits in sustained attention and executive function.
      Title: ANXA7, PPP3CB, DNAJC9, and ZMYND17 genes at chromosome 10q22 associated with the subgroup of schizophrenia with deficits in attention and executive function.
    3. The expression of a constitutively active Calcineurin stimulates myoblast differentiation, whereas a Calcineurin antisense has the opposite effect.
      Title: P43-dependent mitochondrial activity regulates myoblast differentiation and slow myosin isoform expression by control of Calcineurin expression.
    4. A novel-splicing variant of calcineurin Ass CnAss-FK, which is encoded by an intron-retaining mRNA and is deficient in the autoinhibitory domain, is predominantly expressed in mature follicular keratinocytes.
      Title: Expression of a constitutively active calcineurin encoded by an intron-retaining mRNA in follicular keratinocytes.
    5. two new complementary roles for calcineurin in the regulation of the early UPR (Unfolded Protein Responses)
      Title: Calcineurin interacts with PERK and dephosphorylates calnexin to relieve ER stress in mammals and frogs.
    6. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: Using genetic and clinical factors to predict tacrolimus dose in renal transplant recipients.
    7. Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Polymorphisms in the calcineurin genes are associated with the training responsiveness of cardiac phenotypes in Chinese young adults.
    8. [review] The nuclear localization sequence, a region spanning amino acids 172-183 of calcineurin A beta, is essential for recognition and shuttling of calcineurin into the nucleus by importin beta.
      Title: Inhibition of the calcineurin-NFAT signalling cascade in the treatment of heart failure.
    9. Observational study and genome-wide association study of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Biological pathway-based genome-wide association analysis identified the vasoactive intestinal peptide (VIP) pathway important for obesity.
    10. Observational study of gene-disease association. (HuGE Navigator)
      Title: Are calcineurin genes associated with endurance phenotype traits?
    Submit: New GeneRIF Correction See all (19)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Tat tat Induction of TNF-alpha by HIV-1 Tat is inhibited by cyclosporin A, an inhibitor of calcineurin that acts by preventing the dephosphorylation of NF-AT, suggesting Tat activates calcineurin PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    P16298 Q9Y6J0 CABIN1    HPRD  PubMed  
    P16298 Q9NPC6 MYOZ2    HPRD  PubMed  
    P16298 Q8TDC0 MYOZ3    HPRD  PubMed  
    P16298 Q13469 NFATC2    HPRD  PubMed  
    P16298 P32418 SLC8A1    HPRD  PubMed  
    P16298 Q9UPR5 SLC8A2    HPRD  PubMed  
    P16298 P57103 SLC8A3    HPRD  PubMed  
    P16298 O14543 SOCS3    HPRD  PubMed  
    BioGRID:111524 BioGRID:109863 IRAK1    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:111524 BioGRID:109868 IRF2    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:111524 BioGRID:109928 JUN    BioGRID  PubMed FRET; Reconstituted Complex 
    BioGRID:111524 BioGRID:110438 MLH1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111524 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Alzheimer's disease, organism-specific biosystem (from KEGG)
      Alzheimer's disease, organism-specific biosystemAlzheimer's disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-b...
    • Alzheimer's disease, conserved biosystem (from KEGG)
      Alzheimer's disease, conserved biosystemAlzheimer's disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-b...
    • Amphetamine addiction, organism-specific biosystem (from KEGG)
      Amphetamine addiction, organism-specific biosystemAmphetamine is a psychostimulant drug that exerts persistent addictive effects. Most addictive drugs increase extracellular concentrations of dopamine (DA) in nucleus accumbens (NAc) and medial prefr...
    • Amphetamine addiction, conserved biosystem (from KEGG)
      Amphetamine addiction, conserved biosystemAmphetamine is a psychostimulant drug that exerts persistent addictive effects. Most addictive drugs increase extracellular concentrations of dopamine (DA) in nucleus accumbens (NAc) and medial prefr...
    • Amyotrophic lateral sclerosis (ALS), organism-specific biosystem (from KEGG)
      Amyotrophic lateral sclerosis (ALS), organism-specific biosystemAmyotrophic lateral sclerosis (ALS) is a progressive, lethal, degenerative disorder of motor neurons. The hallmark of this disease is the selective death of motor neurons in the brain and spinal cord...
    • Amyotrophic lateral sclerosis (ALS), conserved biosystem (from KEGG)
      Amyotrophic lateral sclerosis (ALS), conserved biosystemAmyotrophic lateral sclerosis (ALS) is a progressive, lethal, degenerative disorder of motor neurons. The hallmark of this disease is the selective death of motor neurons in the brain and spinal cord...
    • Apoptosis, organism-specific biosystem (from KEGG)
      Apoptosis, organism-specific biosystemApoptosis is a genetically controlled mechanisms of cell death involved in the regulation of tissue homeostasis. The 2 major pathways of apoptosis are the extrinsic (Fas and other TNFR superfamily me...
    • Apoptosis, conserved biosystem (from KEGG)
      Apoptosis, conserved biosystemApoptosis is a genetically controlled mechanisms of cell death involved in the regulation of tissue homeostasis. The 2 major pathways of apoptosis are the extrinsic (Fas and other TNFR superfamily me...
    • Axon guidance, organism-specific biosystem (from KEGG)
      Axon guidance, organism-specific biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
    • Axon guidance, conserved biosystem (from KEGG)
      Axon guidance, conserved biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
    • B Cell Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      B Cell Receptor Signaling Pathway, organism-specific biosystemThe B cell receptor includes membrane ?? heavy chain molecules bound to a light chain and an Ig alpha (CD79A)/Ig beta (CD79B) heterodimer. Activation of the B cell receptor involves phosphorylation o...
    • B cell receptor signaling pathway, organism-specific biosystem (from KEGG)
      B cell receptor signaling pathway, organism-specific biosystemB cells are an important component of adaptive immunity. They produce and secrete millions of different antibody molecules, each of which recognizes a different (foreign) antigen. The B cell receptor...
    • B cell receptor signaling pathway, conserved biosystem (from KEGG)
      B cell receptor signaling pathway, conserved biosystemB cells are an important component of adaptive immunity. They produce and secrete millions of different antibody molecules, each of which recognizes a different (foreign) antigen. The B cell receptor...
    • BCR signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      BCR signaling pathway, organism-specific biosystem
      BCR signaling pathway
    • Calcium signaling pathway, organism-specific biosystem (from KEGG)
      Calcium signaling pathway, organism-specific biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
    • Calcium signaling pathway, conserved biosystem (from KEGG)
      Calcium signaling pathway, conserved biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
    • DARPP-32 events, organism-specific biosystem (from REACTOME)
      DARPP-32 events, organism-specific biosystemDopamine- and cAMP-regulated phosphoprotein, Mr 32 kDa (DARPP-32), was identified as a major target for dopamine and protein kinase A (PKA) in striatum. Recent advances now indicate that regulation D...
    • Dopaminergic synapse, organism-specific biosystem (from KEGG)
      Dopaminergic synapse, organism-specific biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
    • Dopaminergic synapse, conserved biosystem (from KEGG)
      Dopaminergic synapse, conserved biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
    • Energy Metabolism, organism-specific biosystem (from WikiPathways)
      Energy Metabolism, organism-specific biosystemThe PPARGC1A protein is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with the nuclear receptor PPARG, which permits the interaction of ...
    • ErbB2/ErbB3 signaling events, organism-specific biosystem (from Pathway Interaction Database)
      ErbB2/ErbB3 signaling events, organism-specific biosystem
      ErbB2/ErbB3 signaling events
    • Glutamatergic synapse, organism-specific biosystem (from KEGG)
      Glutamatergic synapse, organism-specific biosystemGlutamate is the major excitatory neurotransmitter in the mammalian central nervous system(CNS). Glutamate is packaged into synaptic vesicles in the presynaptic terminal. Once released into the synap...
    • Glutamatergic synapse, conserved biosystem (from KEGG)
      Glutamatergic synapse, conserved biosystemGlutamate is the major excitatory neurotransmitter in the mammalian central nervous system(CNS). Glutamate is packaged into synaptic vesicles in the presynaptic terminal. Once released into the synap...
    • HTLV-I infection, organism-specific biosystem (from KEGG)
      HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • HTLV-I infection, conserved biosystem (from KEGG)
      HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • Long-term potentiation, organism-specific biosystem (from KEGG)
      Long-term potentiation, organism-specific biosystemHippocampal long-term potentiation (LTP), a long-lasting increase in synaptic efficacy, is the molecular basis for learning and memory. Tetanic stimulation of afferents in the CA1 region of the hippo...
    • Long-term potentiation, conserved biosystem (from KEGG)
      Long-term potentiation, conserved biosystemHippocampal long-term potentiation (LTP), a long-lasting increase in synaptic efficacy, is the molecular basis for learning and memory. Tetanic stimulation of afferents in the CA1 region of the hippo...
    • MAPK signaling pathway, organism-specific biosystem (from WikiPathways)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, organism-specific biosystem (from KEGG)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, conserved biosystem (from KEGG)
      MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MicroRNAs in cardiomyocyte hypertrophy, organism-specific biosystem (from WikiPathways)
      MicroRNAs in cardiomyocyte hypertrophy, organism-specific biosystemThis pathway shows the role of microRNAs in the process of cardiac hypertrophy. MicroRNA targets were predicted by the TargetScan algorithm, and the predicted interactions are shown in red dashed lin...
    • Natural killer cell mediated cytotoxicity, organism-specific biosystem (from KEGG)
      Natural killer cell mediated cytotoxicity, organism-specific biosystemNatural killer (NK) cells are lymphocytes of the innate immune system that are involved in early defenses against both allogeneic (nonself) cells and autologous cells undergoing various forms of stre...
    • Natural killer cell mediated cytotoxicity, conserved biosystem (from KEGG)
      Natural killer cell mediated cytotoxicity, conserved biosystemNatural killer (NK) cells are lymphocytes of the innate immune system that are involved in early defenses against both allogeneic (nonself) cells and autologous cells undergoing various forms of stre...
    • Oocyte meiosis, organism-specific biosystem (from KEGG)
      Oocyte meiosis, organism-specific biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, homologous chromosomes recombine and then segrega...
    • Oocyte meiosis, conserved biosystem (from KEGG)
      Oocyte meiosis, conserved biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, homologous chromosomes recombine and then segrega...
    • Opioid Signalling, organism-specific biosystem (from REACTOME)
      Opioid Signalling, organism-specific biosystemOpioids are chemical substances similar to opiates, the active substances found in opium (morphine, codeine etc.). Opioid action is mediated by the receptors for endogenous opioids; peptides such as...
    • Osteoclast differentiation, organism-specific biosystem (from KEGG)
      Osteoclast differentiation, organism-specific biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
    • Osteoclast differentiation, conserved biosystem (from KEGG)
      Osteoclast differentiation, conserved biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by GPCR, organism-specific biosystem (from REACTOME)
      Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
    • T Cell Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      T Cell Receptor Signaling Pathway, organism-specific biosystem
      T Cell Receptor Signaling Pathway
    • T cell receptor signaling pathway, organism-specific biosystem (from KEGG)
      T cell receptor signaling pathway, organism-specific biosystemActivation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. En...
    • T cell receptor signaling pathway, conserved biosystem (from KEGG)
      T cell receptor signaling pathway, conserved biosystemActivation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. En...
    • Tuberculosis, organism-specific biosystem (from KEGG)
      Tuberculosis, organism-specific biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
    • Tuberculosis, conserved biosystem (from KEGG)
      Tuberculosis, conserved biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
    • VEGF signaling pathway, organism-specific biosystem (from KEGG)
      VEGF signaling pathway, organism-specific biosystemThere is now much evidence that VEGFR-2 is the major mediator of VEGF-driven responses in endothelial cells and it is considered to be a crucial signal transducer in both physiologic and pathologic a...
    • VEGF signaling pathway, conserved biosystem (from KEGG)
      VEGF signaling pathway, conserved biosystemThere is now much evidence that VEGFR-2 is the major mediator of VEGF-driven responses in endothelial cells and it is considered to be a crucial signal transducer in both physiologic and pathologic a...
    • Wnt signaling pathway, organism-specific biosystem (from KEGG)
      Wnt signaling pathway, organism-specific biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
    • Wnt signaling pathway, conserved biosystem (from KEGG)
      Wnt signaling pathway, conserved biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    calcium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    calcium-dependent protein serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    calmodulin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    calmodulin binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    calmodulin-dependent protein phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    calmodulin-dependent protein phosphatase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    drug binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enzyme binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein dimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein phosphatase 2B binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein serine/threonine phosphatase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    T cell activation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    T cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    T cell homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    T cell proliferation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    axon extension TAS
    Traceable Author Statement
    more info
    		  
    calcium ion-dependent exocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    cellular response to drug IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    dephosphorylation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    heart development IEA
    Inferred from Electronic Annotation
    more info
    		  
    learning TAS
    Traceable Author Statement
    more info
    		  
    memory TAS
    Traceable Author Statement
    more info
    		  
    muscle cell homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of T cell mediated cytotoxicity IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of insulin secretion involved in cellular response to glucose stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    positive regulation of transcription, DNA-dependent NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein dephosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of insulin secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    regulation of synaptic plasticity TAS
    Traceable Author Statement
    more info
    		  
    response to amphetamine IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to cytokine stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    signal transduction NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    social behavior IEP
    Inferred from Expression Pattern
    more info
    		  
    Component Evidence Code Pubs
    calcineurin complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    insoluble fraction IEA
    Inferred from Electronic Annotation
    more info
    		  
    plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    protein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    soluble fraction IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    serine/threonine-protein phosphatase 2B catalytic subunit beta isoform
    Names
    serine/threonine-protein phosphatase 2B catalytic subunit beta isoform
    calcineurin A2
    calcineurin A beta
    CAM-PRP catalytic subunit
    protein phosphatase from PCR fragment H32
    calmodulin-dependent calcineurin A subunit beta isoform
    protein phosphatase 2B, catalytic subunit, beta isoform
    protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform
    NP_001135825.1
    NP_001135826.1
    NP_066955.1
    Help top of page

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001142353.1 → NP_001135825.1  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      BC028049, DA192735
      Consensus CDS
      CCDS44437.1
      UniProtKB/TrEMBL
      Q8N1F0
      Related
      ENSP00000378306, ENST00000394829
      Conserved Domains (2) summary
      cd07416
      Location:50 – 354
      Blast Score: 1737
      MPP_PP2B; PP2B, metallophosphatase domain
      smart00156
      Location:67 – 338
      Blast Score: 1031
      PP2Ac; Protein phosphatase 2A homologues, catalytic domain.

    2. NM_001142354.1 → NP_001135826.1  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an in-frame exon in the coding region, compared to variant 1. It encodes isoform c, which is shorter than isoform a.
      Source sequence(s)
      AJ488506, BU633160, DA192735
      Consensus CDS
      CCDS44436.1
      UniProtKB/Swiss-Prot
      P16298
      Related
      ENSP00000378305, ENST00000394828
      Conserved Domains (2) summary
      cd07416
      Location:50 – 354
      Blast Score: 1733
      MPP_PP2B; PP2B, metallophosphatase domain
      smart00156
      Location:67 – 338
      Blast Score: 1028
      PP2Ac; Protein phosphatase 2A homologues, catalytic domain.

    3. NM_021132.2 → NP_066955.1  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. It encodes isoform b which is shorter than isoform a.
      Source sequence(s)
      BU633160, DA192735, M29551
      Consensus CDS
      CCDS7328.1
      UniProtKB/Swiss-Prot
      P16298
      Related
      ENSP00000353881, OTTHUMP00000019823, ENST00000360663, OTTHUMT00000048669
      Conserved Domains (2) summary
      cd07416
      Location:50 – 354
      Blast Score: 1737
      MPP_PP2B; PP2B, metallophosphatase domain
      smart00156
      Location:67 – 338
      Blast Score: 1031
      PP2Ac; Protein phosphatase 2A homologues, catalytic domain.

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000010.10 Reference GRCh37.p5 Primary Assembly

      Range
      75196563..75255782, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000142.1 Alternate HuRef

      Range
      69190274..69249395, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL353731.15 CAI52482.1
      CAI52487.1
      CAI52488.1
    genomic AL359074.12 CAI52472.1
      CAI52473.1
      CAI52474.1
    genomic CH471083.1 EAW54496.1
      EAW54497.1
      EAW54498.1
      EAW54499.1
      EAW54500.1
    genomic S40012.1 AAB22473.1
    mRNA AJ488506.1 CAD32694.1
    mRNA AK300701.1 BAH13328.1
    mRNA AK301582.1 BAH13517.1
    mRNA BC028049.1 AAH28049.1
    mRNA BC035464.1 None
    mRNA BU633160.1 None
    mRNA DA192735.1 None
    mRNA M29550.1 AAA35705.1
    mRNA M29551.1 AAA35706.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P16298.2 GenPept UniProtKB/Swiss-Prot:P16298
    Q5F2F8 GenPept UniProtKB/TrEMBL:Q5F2F8
    Q5F2G0 GenPept UniProtKB/TrEMBL:Q5F2G0
    Q8N1F0 GenPept UniProtKB/TrEMBL:Q8N1F0
    Q9UMB2 GenPept UniProtKB/TrEMBL:Q9UMB2
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