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PRR5-ARHGAP8 PRR5-ARHGAP8 readthrough [ Homo sapiens (human) ]

Gene ID: 553158, updated on 26-May-2016
Official Symbol
PRR5-ARHGAP8provided by HGNC
Official Full Name
PRR5-ARHGAP8 readthroughprovided by HGNC
Primary source
HGNC:HGNC:34512
See related
Ensembl:ENSG00000248405 HPRD:18688; Vega:OTTHUMG00000160954
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The PRR5-ARHGAP8 mRNA is an infrequent but naturally occurring read-through transcript of the neighboring proline rich 5, renal (PRR5) and Rho GTPase activating protein 8 (ARHGAP8) genes. The resulting fusion protein contains sequence identity with each individual gene product, and it includes domains characteristic of a RhoGAP protein. The significance of this read-through transcript and the function of its protein product have not yet been determined. [provided by RefSeq, Nov 2010]
Location:
22q13
Exon count:
15
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 22 NC_000022.11 (44702198..44862784)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (45098382..45258664)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 229 Neighboring gene uncharacterized LOC105373060 Neighboring gene acidic nuclear phosphoprotein 32 family member B pseudogene 2 Neighboring gene proline rich 5 Neighboring gene Rho GTPase activating protein 8 Neighboring gene uncharacterized LOC105373062 Neighboring gene PHD finger protein 21B Neighboring gene ribosomal protein L6 pseudogene 28 Neighboring gene uncharacterized LOC105373063

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

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Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Preferred Names
PRR5-ARHGAP8 fusion protein
Names
PRR5-ARHGAP8 fusion

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046967.1 RefSeqGene

    Range
    5001..165587
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_181334.5NP_851851.3  PRR5-ARHGAP8 fusion protein

    Status: REVIEWED

    Source sequence(s)
    AF195968, BX335168, Z83838, Z98743
    Consensus CDS
    CCDS54538.2
    UniProtKB/TrEMBL
    B1AHC3
    Related
    ENSP00000354732, OTTHUMP00000219407, ENST00000361473, OTTHUMT00000363126
    Conserved Domains (3) summary
    pfam08539
    Location:35108
    HbrB; HbrB-like
    cd00170
    Location:143288
    SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...
    cl02570
    Location:322512
    RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p2 Primary Assembly

    Range
    44702198..44862784
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018933.2 Alternate CHM1_1.1

    Range
    45056807..45217387
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)