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    PPP4C protein phosphatase 4, catalytic subunit [ Homo sapiens ]

    Gene ID: 5531, updated on 11-May-2012
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    Summary

    Official Symbol
    PPP4Cprovided by HGNC
    Official Full Name
    protein phosphatase 4, catalytic subunitprovided by HGNC
    Primary source
    HGNC:9319
    See related
    Ensembl:ENSG00000149923; HPRD:03615; MIM:602035; Vega:OTTHUMG00000132113
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PP4; PPX; PP4C; PPH3; PPP4
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    Genomic context

    Location :
    16p11.2
    Sequence :
    Chromosome: 16; NC_000016.9 (30087385..30096695)
    See PPP4C in Epigenomics, MapViewer

    Chromosome 16 - NC_000016.9Genomic Context describing neighboring genes Neighboring gene chromosome 16 open reading frame 92 Neighboring gene family with sequence similarity 57, member B Neighboring gene aldolase A, fructose-bisphosphate Neighboring gene T-box 6 Neighboring gene yippee-like 3 (Drosophila)

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. Lee KA, et al. J Biol Chem, 2011 Dec 2. PMID 21987572.
    2. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    3. A directed protein interaction network for investigating intracellular signal transduction. Vinayagam A, et al. Sci Signal, 2011 Sep 6. PMID 21900206.
    4. Smek promotes histone deacetylation to suppress transcription of Wnt target gene brachyury in pluripotent embryonic stem cells. Lyu J, et al. Cell Res, 2011 Jun. PMID 21423269.
    5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, et al. Mol Cell Proteomics, 2011 Mar. PMID 21139048.

    See all (35) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. PP4R2, a regulatory subunit of PP4, mediates the DNA damage-dependent association between RPA2 and the PP4C catalytic subunit.
      Title: A PP4 phosphatase complex dephosphorylates RPA2 to facilitate DNA repair via homologous recombination.
    2. PP4 activity significantly affects the mutation rate in leukemic T-cells, indicating that PP4 dysfunction may be important in the development and progression of leukemia
      Title: Protein phosphatase 4 regulates apoptosis in leukemic and primary human T-cells.
    3. A three-protein PP4 phosphatase complex in mammalian cells, containing PP4C, PP4R2, and PP4R3beta, specifically dephosphorylates ATR-mediated gamma-H2AX generated during DNA replication.
      Title: A PP4-phosphatase complex dephosphorylates gamma-H2AX generated during DNA replication.
    4. Observational study of gene-disease association. (HuGE Navigator)
      Title: Association and mutation analyses of 16p11.2 autism candidate genes.
    5. An evolutionarily conserved gamma histone 2AX phosphatase active on both DNA-damaged and undamaged chromatin.
      Title: PP4 is a gamma H2AX phosphatase required for recovery from the DNA damage checkpoint.
    6. PP4R4 forms a novel cytosolic complex with PP4c, independent from the complexes containing PP4R1, PP4R2.PP4R3, and alpha4, and the regulatory subunits of PP4c have evolved different modes of interaction with the catalytic subunit
      Title: PP4R4/KIAA1622 forms a novel stable cytosolic complex with phosphoprotein phosphatase 4.
    7. The results suggest that Ppp4c-R2-R3 complexes may co-ordinate centrosome maturation and cell migration via regulation of RhoGTPases.
      Title: Depletion of protein phosphatase 4 in human cells reveals essential roles in centrosome maturation, cell migration and the regulation of Rho GTPases.
    8. Analysis of the role of the serine/threonine protein phosphatase, protein phosphatase 4, in controlling the apoptosis of HEK 293 T cells, using the complementary techniques of gene over-expression and down regulation through RNA interference.
      Title: Protein phosphatase 4 regulates apoptosis, proliferation and mutation rate of human cells.
    9. Our work uncovers a unique regulatory mechanism of MT organization by PP4c through its targets Cdk1 and NDEL1 via regulation of katanin p60 distribution.
      Title: Protein phosphatase 4 catalytic subunit regulates Cdk1 activity and microtubule organization via NDEL1 dephosphorylation.
    10. IRS-4 is subject to regulation by TNF-alpha, and PP4 mediates TNF-alpha-induced degradation of IRS-4
      Title: Protein phosphatase 4 interacts with and down-regulates insulin receptor substrate 4 following tumor necrosis factor-alpha stimulation.
    Submit: New GeneRIF Correction See all (13)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_002711.1 NP_003874.2 HDAC3    BIND  PubMed PPP4C (PP4C) interacts with HDAC3. 
    P60510 Q16204 CCDC6    HPRD  PubMed  
    P60510 Q92620 DHX38    HPRD  PubMed  
    P60510 O15379 HDAC3    HPRD  PubMed  
    P60510 P78318 IGBP1    HPRD  PubMed  
    P60510 P19838 NFKB1    HPRD  PubMed  
    P60510 P30153 PPP2R1A    HPRD  PubMed  
    P60510 Q14738 PPP2R5D    HPRD  PubMed  
    P60510 Q8TF05 PPP4R1    HPRD  PubMed  
    P60510 Protein phosphatase 4, regulatory subunit 2 PPP4R2    HPRD  PubMed  
    P60510 KIAA1622 PPP4R4    HPRD  PubMed  
    P60510 Q04864 REL    HPRD  PubMed  
    P60510 Q04206 RELA    HPRD  PubMed  
    P60510 Q5MIZ7 SMEK2    HPRD  PubMed  
    P60510 P62328 TMSB4X    HPRD  PubMed  
    BioGRID:111523 BioGRID:120506 ATAD3A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111523 BioGRID:123774 ATAD3B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111523 BioGRID:113647 BAG6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111523 BioGRID:113725 CCDC6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111523 BioGRID:115827 CCT2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111523 BioGRID:113054 CCT3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111523 BioGRID:115826 CCT4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111523 BioGRID:116603 CCT5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111523 BioGRID:107346 CCT6A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111523 BioGRID:568623 CCT6P1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111523 BioGRID:115825 CCT7    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111523 BioGRID:115933 CCT8    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111523 BioGRID:115129 DHX38    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111523 BioGRID:108237 EEF1A1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111523 BioGRID:119102 GEMIN4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111523 BioGRID:133128 GLYATL3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111523 BioGRID:114368 HDAC3    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111523 BioGRID:109698 IGBP1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Two-hybrid 
    BioGRID:111523 BioGRID:109928 JUN    BioGRID  PubMed Reconstituted Complex 
    BioGRID:111523 BioGRID:116354 MAP4K1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:111523 BioGRID:110857 NFKB1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111523 BioGRID:114467 PLOD3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111523 BioGRID:119524 PPME1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111523 BioGRID:111508 PPP2CB    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111523 BioGRID:111510 PPP2R1A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111523 BioGRID:111513 PPP2R2B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111523 BioGRID:120946 PPP2R2D    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111523 BioGRID:111516 PPP2R4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111523 BioGRID:111520 PPP2R5D    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111523 BioGRID:115310 PPP4R1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:111523 BioGRID:127414 PPP4R2    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111523 BioGRID:121741 PPP4R4    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111523 BioGRID:111898 REL    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:111523 BioGRID:111902 RELA    BioGRID  PubMed Reconstituted Complex 
    BioGRID:111523 BioGRID:123649 SLC25A31    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111523 BioGRID:120803 SMEK1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111523 BioGRID:121459 SMEK2    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:111523 BioGRID:112490 SMN1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111523 BioGRID:117071 SRRM2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111523 BioGRID:112810 TCP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111523 BioGRID:129283 TIPRL    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:111523 BioGRID:112938 TK1    BioGRID  PubMed Two-hybrid 
    BioGRID:111523 BioGRID:112954 TLR4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111523 BioGRID:113010 TP53    BioGRID  PubMed Reconstituted Complex 
    BioGRID:111523 BioGRID:113041 TRAF6    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:111523 BioGRID:123562 TRMT1L    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111523 BioGRID:113129 TUBA3C    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111523 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111523 BioGRID:125911 WDR81    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    • Homologs of the PPP4C gene: The PPP4C gene is conserved in chimpanzee, , dog, cow, mouse, rat, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, , S.pombe, , N.crassa, A.thaliana, and rice.
    • Map Viewer (Mouse, Rat)

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    NF-kappaB-inducing kinase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    metal ion binding NAS
    Non-traceable Author Statement
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein serine/threonine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		  
    protein serine/threonine phosphatase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    NIK/NF-kappaB cascade NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    microtubule cytoskeleton organization NAS
    Non-traceable Author Statement
    more info
    		  
    regulation of double-strand break repair via homologous recombination IMP
    Inferred from Mutant Phenotype
    more info
    		  
    Component Evidence Code Pubs
    centrosome NAS
    Non-traceable Author Statement
    more info
    		  
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleus NAS
    Non-traceable Author Statement
    more info
    		  
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    General protein information

    Preferred Names
    serine/threonine-protein phosphatase 4 catalytic subunit
    Names
    serine/threonine-protein phosphatase 4 catalytic subunit
    PP-X
    protein phosphatase X, catalytic subunit
    protein phosphatase 4 (formerly X), catalytic subunit
    NP_002711.1
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002720.1 → NP_002711.1  serine/threonine-protein phosphatase 4 catalytic subunit

      Status: PROVISIONAL

      Source sequence(s)
      AF097996
      Consensus CDS
      CCDS10669.1
      UniProtKB/Swiss-Prot
      P60510
      Related
      ENSP00000279387, OTTHUMP00000162993, ENST00000279387, OTTHUMT00000255155
      Conserved Domains (2) summary
      cd07415
      Location:6 – 290
      Blast Score: 1652
      MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain
      PTZ00239
      Location:6 – 307
      Blast Score: 1207
      PTZ00239; serine/threonine protein phosphatase 2A; Provisional

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000016.9 Reference GRCh37.p5 Primary Assembly

      Range
      30087385..30096695
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000148.1 Alternate HuRef

      Range
      27748654..27757965
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC093512.2 (144112..153422) None
    genomic CH471238.1 EAW79928.1
      EAW79929.1
      EAW79930.1
      EAW79931.1
    mRNA AF097996.1 AAC96318.1
    mRNA BC001416.2 AAH01416.1
    mRNA BT019746.1 AAV38551.1
    mRNA X70218.1 CAA49753.1
    other-genetic DQ891947.2 ABM82873.1
    other-genetic DQ895134.2 ABM86060.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P60510.1 GenPept UniProtKB/Swiss-Prot:P60510
    Q5U086 GenPept UniProtKB/TrEMBL:Q5U086
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

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