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PI4K2B phosphatidylinositol 4-kinase type 2 beta [ Homo sapiens (human) ]

Gene ID: 55300, updated on 12-May-2016
Official Symbol
PI4K2Bprovided by HGNC
Official Full Name
phosphatidylinositol 4-kinase type 2 betaprovided by HGNC
Primary source
HGNC:HGNC:18215
See related
Ensembl:ENSG00000038210 Ensembl:ENSG00000281028 HPRD:15132; MIM:612101; Vega:OTTHUMG00000128564
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PIK42B; PI4KIIB
Summary
Phosphatidylinositol 4-kinases (PI4Ks) phosphorylate phosphatidylinositol to generate phosphatidylinositol 4-phosphate (PIP), an immediate precursor of several important signaling and scaffolding molecules. PIP itself may also have direct functional and structural roles. PI4K2B is a primarily cytosolic PI4K that is recruited to membranes, where it stimulates phosphatidylinositol 4,5-bisphosphate synthesis (Wei et al., 2002 [PubMed 12324459]).[supplied by OMIM, Jun 2008]
Orthologs
Location:
4p15.2
Exon count:
11
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 4 NC_000004.12 (25234031..25279209)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (25235653..25280831)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase Neighboring gene SEPSECS antisense RNA 1 (head to head) Neighboring gene uncharacterized LOC105374535 Neighboring gene zinc finger CCHC-type containing 4 Neighboring gene anaphase promoting complex subunit 4

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ11105

Gene Ontology Provided by GOA

Function Evidence Code Pubs
1-phosphatidylinositol 4-kinase activity TAS
Traceable Author Statement
more info
 
ATP binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
phosphatidylinositol biosynthetic process TAS
Traceable Author Statement
more info
 
phosphatidylinositol phosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
phosphatidylinositol 4-kinase type 2-beta
Names
PI4KII-BETA
phosphatidylinositol 4-kinase type II-beta
phosphatidylinositol 4-kinase type-II beta
NP_060793.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018323.3NP_060793.2  phosphatidylinositol 4-kinase type 2-beta

    See identical proteins and their annotated locations for NP_060793.2

    Status: VALIDATED

    Source sequence(s)
    AC108218, AY091514, BC051749
    Consensus CDS
    CCDS3433.1
    UniProtKB/Swiss-Prot
    Q8TCG2
    Related
    ENSP00000264864, OTTHUMP00000158714, ENST00000264864, OTTHUMT00000250415
    Conserved Domains (1) summary
    pfam00454
    Location:167415
    PI3_PI4_kinase; Phosphatidylinositol 3- and 4-kinase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p2 Primary Assembly

    Range
    25234031..25279209
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005248174.1XP_005248231.1  

    Conserved Domains (1) summary
    pfam00454
    Location:167410
    PI3_PI4_kinase; Phosphatidylinositol 3- and 4-kinase
  2. XM_011513855.1XP_011512157.1  

    Conserved Domains (1) summary
    cl21453
    Location:167241
    PKc_like; Protein Kinases, catalytic domain
  3. XM_005248175.3XP_005248232.1  

    See identical proteins and their annotated locations for XP_005248232.1

    UniProtKB/TrEMBL
    G5E9Z4
    Related
    ENSP00000423373, OTTHUMP00000278207, ENST00000512921, OTTHUMT00000479881
    Conserved Domains (1) summary
    pfam00454
    Location:71319
    PI3_PI4_kinase; Phosphatidylinositol 3- and 4-kinase

Alternate CHM1_1.1

Genomic

  1. NC_018915.2 Alternate CHM1_1.1

    Range
    25235255..25280463
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)