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    PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme [ Homo sapiens ]

    Gene ID: 5530, updated on 19-May-2012
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    Summary

    Official Symbol
    PPP3CAprovided by HGNC
    Official Full Name
    protein phosphatase 3, catalytic subunit, alpha isozymeprovided by HGNC
    Primary source
    HGNC:9314
    See related
    Ensembl:ENSG00000138814; HPRD:00234; MIM:114105; Vega:OTTHUMG00000133839
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CALN; CCN1; CNA1; CALNA; PPP2B; CALNA1
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    Genomic context

    Location :
    4q24
    Sequence :
    Chromosome: 4; NC_000004.11 (101944587..102268628, complement)
    See PPP3CA in Epigenomics, MapViewer

    Chromosome 4 - NC_000004.11Genomic Context describing neighboring genes Neighboring gene DNA-damage-inducible transcript 4-like Neighboring gene endomucin Neighboring gene microRNA 1255a Neighboring gene uncharacterized LOC90024 Neighboring gene B-cell scaffold protein with ankyrin repeats 1

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Investigation of two Wnt signalling pathway single nucleotide polymorphisms in a breast cancer-affected Australian population. Gabrovska PN, et al. Twin Res Hum Genet, 2011 Dec. PMID 22506312.
    2. Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration. Martins-de-Souza D, et al. J Proteome Res, 2012 Apr 6. PMID 22360420.
    3. Structural basis for activation of calcineurin by calmodulin. Rumi-Masante J, et al. J Mol Biol, 2012 Jan 13. PMID 22100452.
    4. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    5. Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. Li S, et al. Immunity, 2011 Sep 23. PMID 21903422.

    See all (93) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Even though an association of the polymorphisms rs2850328 and rs2395 and breast cancer was not detected in our case-control study population, other variants within the PPP3CA and MARK4 genes may still be associated with breast cancer.
      Title: Investigation of two Wnt signalling pathway single nucleotide polymorphisms in a breast cancer-affected Australian population.
    2. A protein encoded by this locus was found to be differentially expressed in postmortem brains from patients with atypical frontotemporal lobar degeneration.
      Title: Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration.
    3. The authors demonstrate that the regulatory domain within calcineurin is unstructured and that it folds upon binding calmodulin, ousting the autoinhibitory domain from the catalytic site.
      Title: Structural basis for activation of calcineurin by calmodulin.
    4. High calcineurin A alpha protein is associated with bone metastasis in small-cell lung cancer.
      Title: The effect of down regulation of calcineurin Aα by lentiviral vector-mediated RNAi on the biological behavior of small-cell lung cancer and its bone metastasis.
    5. The C allele of protein phosphatase 3 subunit alpha rs3804358 polymorphism was overrepresented in athletes compared with controls, whereas the T allele of protein phosphatase 3 subunit beta rs3763679 polymorphism was underrepresented in athletes.
      Title: Are calcineurin genes associated with athletic status? A function, replication study.
    6. Findings demonstrate that CaN functions as a critical signaling molecule during Th cell activation, regulating Bcl-10 phosphorylation and NF-kappaB activation.
      Title: Dephosphorylation of Bcl-10 by calcineurin is essential for canonical NF-κB activation in Th cells.
    7. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
      Title: Schizophrenia and vitamin D related genes could have been subject to latitude-driven adaptation.
    8. calcineurin has a role in the heart and in cardiac disease
      Title: A salutary role for calcineurin in the heart.
    9. two new complementary roles for calcineurin in the regulation of the early UPR (Unfolded Protein Responses)
      Title: Calcineurin interacts with PERK and dephosphorylates calnexin to relieve ER stress in mammals and frogs.
    10. data underscore the importance of calcineurin gene in the molecular mechanism of addiction and Alzheimer's diseases
      Title: Fine mapping of calcineurin (PPP3CA) gene reveals novel alternative splicing patterns, association of 5'UTR trinucleotide repeat with addiction vulnerability, and differential isoform expression in Alzheimer's disease.
    Submit: New GeneRIF Correction See all (35)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Tat tat Induction of TNF-alpha by HIV-1 Tat is inhibited by cyclosporin A, an inhibitor of calcineurin that acts by preventing the dephosphorylation of NF-AT, suggesting Tat activates calcineurin PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_000935.1 NP_859066.1 CRTC2    BIND  PubMed TORC2 interacts with CnA. 
    Q08209 P24588 AKAP5    HPRD  PubMed  
    Q08209 P23634 ATP2B4    HPRD  PubMed  
    Q08209 Q92934 BAD    HPRD  PubMed  
    Q08209 P10415 BCL2    HPRD  PubMed  
    Q08209 Q96GX8 C16orf74    HPRD  PubMed  
    Q08209 Q9Y6J0 CABIN1    HPRD  PubMed  
    Q08209 P42574 CASP3    HPRD  PubMed  
    Q08209 Transducer of regulated cAMP response element binding protein 2 CRTC2    HPRD  PubMed  
    Q08209 P62942 FKBP1A    HPRD  PubMed  
    Q08209 Q14318 FKBP8    HPRD  PubMed  
    Q08209 P14867 GABRA1    HPRD  PubMed  
    Q08209 P47870 GABRB2    HPRD  PubMed  
    Q08209 P18507 GABRG2    HPRD  PubMed  
    Q08209 Q9NPC6 MYOZ2    HPRD  PubMed  
    Q08209 Q8TDC0 MYOZ3    HPRD  PubMed  
    Q08209 Q08209 PPP3CA    HPRD  PubMed  
    Q08209 P63098 PPP3R1    HPRD  PubMed  
    Q08209 Q05513 PRKCZ    HPRD  PubMed  
    Q08209 P53805 RCAN1    HPRD  PubMed  
    Q08209 Q14206 RCAN2    HPRD  PubMed  
    Q08209 P00441 SOD1    HPRD  PubMed  
    Q08209 O43426 SYNJ1    HPRD  PubMed  
    BioGRID:111522 BioGRID:106663 ADRB2    BioGRID  PubMed Co-fractionation 
    BioGRID:111522 BioGRID:114874 AKAP5    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:111522 BioGRID:106710 AKT1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111522 BioGRID:107068 BCL2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111522 BioGRID:135663 C16orf74    BioGRID  PubMed Two-hybrid 
    BioGRID:111522 BioGRID:117070 CABIN1    BioGRID  PubMed Two-hybrid 
    BioGRID:111522 BioGRID:212401 Fbxo32    BioGRID  PubMed Two-hybrid 
    BioGRID:111522 BioGRID:109142 GRB2    BioGRID  PubMed Two-hybrid 
    BioGRID:111522 BioGRID:109868 IRF2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111522 BioGRID:121849 MYOZ1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111522 BioGRID:119726 MYOZ2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111522 BioGRID:116674 PHLPP2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111522 BioGRID:111474 PPIA    BioGRID  PubMed Co-crystal Structure 
    BioGRID:111522 BioGRID:111700 PTEN    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111522 BioGRID:108161 RCAN1    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:111522 BioGRID:115525 RCAN2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:111522 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    • Homologs of the PPP3CA gene: The PPP3CA gene is conserved in chimpanzee, , dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, , S.pombe, , and N.crassa.
    • Map Viewer (Mouse, Rat)

    Pathways from BioSystems

    • Alzheimer's disease, organism-specific biosystem (from KEGG)
      Alzheimer's disease, organism-specific biosystemAlzheimer's disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-b...
    • Alzheimer's disease, conserved biosystem (from KEGG)
      Alzheimer's disease, conserved biosystemAlzheimer's disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-b...
    • Amphetamine addiction, organism-specific biosystem (from KEGG)
      Amphetamine addiction, organism-specific biosystemAmphetamine is a psychostimulant drug that exerts persistent addictive effects. Most addictive drugs increase extracellular concentrations of dopamine (DA) in nucleus accumbens (NAc) and medial prefr...
    • Amphetamine addiction, conserved biosystem (from KEGG)
      Amphetamine addiction, conserved biosystemAmphetamine is a psychostimulant drug that exerts persistent addictive effects. Most addictive drugs increase extracellular concentrations of dopamine (DA) in nucleus accumbens (NAc) and medial prefr...
    • Amyotrophic lateral sclerosis (ALS), organism-specific biosystem (from KEGG)
      Amyotrophic lateral sclerosis (ALS), organism-specific biosystemAmyotrophic lateral sclerosis (ALS) is a progressive, lethal, degenerative disorder of motor neurons. The hallmark of this disease is the selective death of motor neurons in the brain and spinal cord...
    • Amyotrophic lateral sclerosis (ALS), conserved biosystem (from KEGG)
      Amyotrophic lateral sclerosis (ALS), conserved biosystemAmyotrophic lateral sclerosis (ALS) is a progressive, lethal, degenerative disorder of motor neurons. The hallmark of this disease is the selective death of motor neurons in the brain and spinal cord...
    • Apoptosis, organism-specific biosystem (from KEGG)
      Apoptosis, organism-specific biosystemApoptosis is a genetically controlled mechanisms of cell death involved in the regulation of tissue homeostasis. The 2 major pathways of apoptosis are the extrinsic (Fas and other TNFR superfamily me...
    • Apoptosis, conserved biosystem (from KEGG)
      Apoptosis, conserved biosystemApoptosis is a genetically controlled mechanisms of cell death involved in the regulation of tissue homeostasis. The 2 major pathways of apoptosis are the extrinsic (Fas and other TNFR superfamily me...
    • Axon guidance, organism-specific biosystem (from KEGG)
      Axon guidance, organism-specific biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
    • Axon guidance, conserved biosystem (from KEGG)
      Axon guidance, conserved biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
    • B Cell Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      B Cell Receptor Signaling Pathway, organism-specific biosystemThe B cell receptor includes membrane ?? heavy chain molecules bound to a light chain and an Ig alpha (CD79A)/Ig beta (CD79B) heterodimer. Activation of the B cell receptor involves phosphorylation o...
    • B cell receptor signaling pathway, organism-specific biosystem (from KEGG)
      B cell receptor signaling pathway, organism-specific biosystemB cells are an important component of adaptive immunity. They produce and secrete millions of different antibody molecules, each of which recognizes a different (foreign) antigen. The B cell receptor...
    • B cell receptor signaling pathway, conserved biosystem (from KEGG)
      B cell receptor signaling pathway, conserved biosystemB cells are an important component of adaptive immunity. They produce and secrete millions of different antibody molecules, each of which recognizes a different (foreign) antigen. The B cell receptor...
    • BCR signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      BCR signaling pathway, organism-specific biosystem
      BCR signaling pathway
    • C-MYB transcription factor network, organism-specific biosystem (from Pathway Interaction Database)
      C-MYB transcription factor network, organism-specific biosystem
      C-MYB transcription factor network
    • Calcium signaling pathway, organism-specific biosystem (from KEGG)
      Calcium signaling pathway, organism-specific biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
    • Calcium signaling pathway, conserved biosystem (from KEGG)
      Calcium signaling pathway, conserved biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
    • DARPP-32 events, organism-specific biosystem (from REACTOME)
      DARPP-32 events, organism-specific biosystemDopamine- and cAMP-regulated phosphoprotein, Mr 32 kDa (DARPP-32), was identified as a major target for dopamine and protein kinase A (PKA) in striatum. Recent advances now indicate that regulation D...
    • Dopaminergic synapse, organism-specific biosystem (from KEGG)
      Dopaminergic synapse, organism-specific biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
    • Dopaminergic synapse, conserved biosystem (from KEGG)
      Dopaminergic synapse, conserved biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
    • Energy Metabolism, organism-specific biosystem (from WikiPathways)
      Energy Metabolism, organism-specific biosystemThe PPARGC1A protein is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with the nuclear receptor PPARG, which permits the interaction of ...
    • G Protein Signaling Pathways, organism-specific biosystem (from WikiPathways)
      G Protein Signaling Pathways, organism-specific biosystemG proteins, short for guanine nucleotide-binding proteins, are a family of proteins involved in second messenger cascades. G proteins are so called because they function as "molecular switches". They...
    • Glutamatergic synapse, organism-specific biosystem (from KEGG)
      Glutamatergic synapse, organism-specific biosystemGlutamate is the major excitatory neurotransmitter in the mammalian central nervous system(CNS). Glutamate is packaged into synaptic vesicles in the presynaptic terminal. Once released into the synap...
    • Glutamatergic synapse, conserved biosystem (from KEGG)
      Glutamatergic synapse, conserved biosystemGlutamate is the major excitatory neurotransmitter in the mammalian central nervous system(CNS). Glutamate is packaged into synaptic vesicles in the presynaptic terminal. Once released into the synap...
    • HTLV-I infection, organism-specific biosystem (from KEGG)
      HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • HTLV-I infection, conserved biosystem (from KEGG)
      HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • Long-term potentiation, organism-specific biosystem (from KEGG)
      Long-term potentiation, organism-specific biosystemHippocampal long-term potentiation (LTP), a long-lasting increase in synaptic efficacy, is the molecular basis for learning and memory. Tetanic stimulation of afferents in the CA1 region of the hippo...
    • Long-term potentiation, conserved biosystem (from KEGG)
      Long-term potentiation, conserved biosystemHippocampal long-term potentiation (LTP), a long-lasting increase in synaptic efficacy, is the molecular basis for learning and memory. Tetanic stimulation of afferents in the CA1 region of the hippo...
    • MAPK signaling pathway, organism-specific biosystem (from WikiPathways)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, organism-specific biosystem (from KEGG)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, conserved biosystem (from KEGG)
      MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MicroRNAs in cardiomyocyte hypertrophy, organism-specific biosystem (from WikiPathways)
      MicroRNAs in cardiomyocyte hypertrophy, organism-specific biosystemThis pathway shows the role of microRNAs in the process of cardiac hypertrophy. MicroRNA targets were predicted by the TargetScan algorithm, and the predicted interactions are shown in red dashed lin...
    • Natural killer cell mediated cytotoxicity, organism-specific biosystem (from KEGG)
      Natural killer cell mediated cytotoxicity, organism-specific biosystemNatural killer (NK) cells are lymphocytes of the innate immune system that are involved in early defenses against both allogeneic (nonself) cells and autologous cells undergoing various forms of stre...
    • Natural killer cell mediated cytotoxicity, conserved biosystem (from KEGG)
      Natural killer cell mediated cytotoxicity, conserved biosystemNatural killer (NK) cells are lymphocytes of the innate immune system that are involved in early defenses against both allogeneic (nonself) cells and autologous cells undergoing various forms of stre...
    • Oocyte meiosis, organism-specific biosystem (from KEGG)
      Oocyte meiosis, organism-specific biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, homologous chromosomes recombine and then segrega...
    • Oocyte meiosis, conserved biosystem (from KEGG)
      Oocyte meiosis, conserved biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, homologous chromosomes recombine and then segrega...
    • Opioid Signalling, organism-specific biosystem (from REACTOME)
      Opioid Signalling, organism-specific biosystemOpioids are chemical substances similar to opiates, the active substances found in opium (morphine, codeine etc.). Opioid action is mediated by the receptors for endogenous opioids; peptides such as...
    • Osteoclast differentiation, organism-specific biosystem (from KEGG)
      Osteoclast differentiation, organism-specific biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
    • Osteoclast differentiation, conserved biosystem (from KEGG)
      Osteoclast differentiation, conserved biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by GPCR, organism-specific biosystem (from REACTOME)
      Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
    • T cell receptor signaling pathway, organism-specific biosystem (from KEGG)
      T cell receptor signaling pathway, organism-specific biosystemActivation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. En...
    • T cell receptor signaling pathway, conserved biosystem (from KEGG)
      T cell receptor signaling pathway, conserved biosystemActivation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. En...
    • Tuberculosis, organism-specific biosystem (from KEGG)
      Tuberculosis, organism-specific biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
    • Tuberculosis, conserved biosystem (from KEGG)
      Tuberculosis, conserved biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
    • VEGF signaling pathway, organism-specific biosystem (from KEGG)
      VEGF signaling pathway, organism-specific biosystemThere is now much evidence that VEGFR-2 is the major mediator of VEGF-driven responses in endothelial cells and it is considered to be a crucial signal transducer in both physiologic and pathologic a...
    • VEGF signaling pathway, conserved biosystem (from KEGG)
      VEGF signaling pathway, conserved biosystemThere is now much evidence that VEGFR-2 is the major mediator of VEGF-driven responses in endothelial cells and it is considered to be a crucial signal transducer in both physiologic and pathologic a...
    • Wnt signaling pathway, organism-specific biosystem (from KEGG)
      Wnt signaling pathway, organism-specific biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
    • Wnt signaling pathway, conserved biosystem (from KEGG)
      Wnt signaling pathway, conserved biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    calcium ion binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    calmodulin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    calmodulin binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    calmodulin-dependent protein phosphatase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    drug binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enzyme binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein dimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein serine/threonine phosphatase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    G1/S transition of mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    T cell activation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    calcium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    cellular response to drug IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cellular response to glucose stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    dephosphorylation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    negative regulation of insulin secretion IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of transcription from RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein dephosphorylation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    protein import into nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of excitatory postsynaptic membrane potential IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to amphetamine IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to stress IEA
    Inferred from Electronic Annotation
    more info
    		  
    skeletal muscle fiber development IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    Z disc IEA
    Inferred from Electronic Annotation
    more info
    		  
    calcineurin complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    insoluble fraction IEA
    Inferred from Electronic Annotation
    more info
    		  
    membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    microsome IEA
    Inferred from Electronic Annotation
    more info
    		  
    mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    soluble fraction IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
    Names
    serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
    calcineurin A alpha
    CAM-PRP catalytic subunit
    calmodulin-dependent calcineurin A subunit alpha isoform
    protein phosphatase 2B, catalytic subunit, alpha isoform
    protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform
    NP_000935.1
    NP_001124163.1
    NP_001124164.1
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_000944.4 → NP_000935.1  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AL353950, AW973358, EU192652
      Consensus CDS
      CCDS34037.1
      UniProtKB/Swiss-Prot
      Q08209
      Related
      ENSP00000378323, OTTHUMP00000165327, ENST00000394854, OTTHUMT00000258379
      Conserved Domains (2) summary
      cd07416
      Location:41 – 345
      Blast Score: 1774
      MPP_PP2B; PP2B, metallophosphatase domain
      smart00156
      Location:58 – 329
      Blast Score: 1042
      PP2Ac; Protein phosphatase 2A homologues, catalytic domain.

    2. NM_001130691.1 → NP_001124163.1  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the 3' coding region, compared to variant 1, and encodes a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AW973358, BC025714, EU192652
      Consensus CDS
      CCDS47114.1
      UniProtKB/Swiss-Prot
      Q08209
      Related
      ENSP00000378322, OTTHUMP00000165328, ENST00000394853, OTTHUMT00000258380
      Conserved Domains (2) summary
      cd07416
      Location:41 – 345
      Blast Score: 1771
      MPP_PP2B; PP2B, metallophosphatase domain
      smart00156
      Location:58 – 329
      Blast Score: 1039
      PP2Ac; Protein phosphatase 2A homologues, catalytic domain.

    3. NM_001130692.1 → NP_001124164.1  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks multiple in-frame exons in the 3' coding region, compared to variant 1, and encodes a shorter protein (isoform 3), compared to isoform 1.
      Source sequence(s)
      AW973358, EU192652
      Consensus CDS
      CCDS47113.1
      Related
      ENSP00000320580, OTTHUMP00000219549, ENST00000323055, OTTHUMT00000363384
      Conserved Domains (2) summary
      cd07416
      Location:41 – 329
      Blast Score: 1601
      MPP_PP2B; PP2B, metallophosphatase domain
      smart00156
      Location:58 – 318
      Blast Score: 1005
      PP2Ac; Protein phosphatase 2A homologues, catalytic domain.

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000004.11 Reference GRCh37.p5 Primary Assembly

      Range
      101944587..102268628, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000136.1 Alternate HuRef

      Range
      97682764..98006594, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC092671.2 (38217..164228) None
    genomic AP001816.2 (45064..109553) None
    genomic AP001870.2 None
    genomic AP001939.3 (28480..147113) None
    genomic CH471057.1 EAX06123.1
      EAX06124.1
      EAX06125.1
    mRNA AB451338.1 BAG70152.1
    mRNA AB451487.1 BAG70301.1
    mRNA AK290532.1 BAF83221.1
    mRNA AL353950.1 CAB89253.1
    mRNA AW973358.1 None
    mRNA AY904364.1 AAY17314.1
    mRNA BC025714.1 AAH25714.1
    mRNA BC098424.1 None
    mRNA EU192652.1 ABW74484.1
    mRNA EU192653.1 ABW74485.1
    mRNA J05480.1 AAA35634.1
    mRNA L14778.1 AAA02631.1
    other-genetic AM393486.1 CAL38363.1
    other-genetic AM393713.1 CAL38589.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08209.1 GenPept UniProtKB/Swiss-Prot:Q08209
    Q9UMM5 GenPept UniProtKB/TrEMBL:Q9UMM5
    Help top of page

    Additional Links

    Gene LinkOut

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