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    BRIX1 BRX1, biogenesis of ribosomes, homolog (S. cerevisiae) [ Homo sapiens ]

    Gene ID: 55299, updated on 11-May-2012
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    Summary

    Official Symbol
    BRIX1provided by HGNC
    Official Full Name
    BRX1, biogenesis of ribosomes, homolog (S. cerevisiae)provided by HGNC
    Primary source
    HGNC:24170
    See related
    Ensembl:ENSG00000113460; HPRD:16563; Vega:OTTHUMG00000162021
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BRIX; BXDC2; FLJ11100
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    Genomic context

    Location :
    5p13.2
    Sequence :
    Chromosome: 5; NC_000005.9 (34915820..34925787)
    See BRIX1 in Epigenomics, MapViewer

    Chromosome 5 - NC_000005.9Genomic Context describing neighboring genes Neighboring gene tetratricopeptide repeat domain 23-like Neighboring gene ribosomal protein L21 pseudogene 54 Neighboring gene RAD1 homolog (S. pombe) Neighboring gene DnaJ (Hsp40) homolog, subfamily C, member 21 Neighboring gene alanine--glyoxylate aminotransferase 2

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Interactome study suggests multiple cellular functions of hepatoma-derived growth factor (HDGF). Zhao J, et al. J Proteomics, 2011 Dec 21. PMID 21907836.
    2. A directed protein interaction network for investigating intracellular signal transduction. Vinayagam A, et al. Sci Signal, 2011 Sep 6. PMID 21900206.
    3. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, et al. Mol Cell Proteomics, 2011 Mar. PMID 21139048.
    4. In vitro nuclear interactome of the HIV-1 Tat protein. Gautier VW, et al. Retrovirology, 2009 May 19. PMID 19454010.
    5. Toward a confocal subcellular atlas of the human proteome. Barbe L, et al. Mol Cell Proteomics, 2008 Mar. PMID 18029348.

    See all (13) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q8TDN6 P09326 CD48    HPRD  PubMed  
    Q8TDN6 Q15047 SETDB1    HPRD  PubMed  
    Q8TDN6 Q9UBT2 UBA2    HPRD  PubMed  
    Q8TDN6 Q13432 UNC119    HPRD  PubMed  
    BioGRID:120586 BioGRID:107400 CD48    BioGRID  PubMed Two-hybrid 
    BioGRID:120586 BioGRID:114947 CDC42BPB    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:120586 BioGRID:113387 CNBP    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:120586 BioGRID:109187 GSK3B    BioGRID  PubMed Two-hybrid 
    BioGRID:120586 BioGRID:109318 HDGF    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:120586 BioGRID:120780 LYAR    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:120586 BioGRID:115783 NOP56    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:120586 BioGRID:115202 SETDB1    BioGRID  PubMed Two-hybrid 
    BioGRID:120586 BioGRID:115365 UBA2    BioGRID  PubMed Two-hybrid 
    BioGRID:120586 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:120586 BioGRID:114548 UNC119    BioGRID  PubMed Two-hybrid 
    BioGRID:120586 BioGRID:1205541 tat    BioGRID  PubMed Reconstituted Complex 
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    General gene information

    Markers

    Genotypes

    Homology

    • Homologs of the BRIX1 gene: The BRIX1 gene is conserved in chimpanzee, , dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, , S.pombe, , N.crassa, A.thaliana, and rice.
    • Map Viewer (Mouse, Rat)

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    ribosome biogenesis protein BRX1 homolog
    Names
    ribosome biogenesis protein BRX1 homolog
    brix domain containing 2
    brix domain-containing protein 2
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_018321.3 → NP_060791.3  ribosome biogenesis protein BRX1 homolog

      Status: VALIDATED

      Source sequence(s)
      BC001546
      Consensus CDS
      CCDS34143.1
      UniProtKB/Swiss-Prot
      Q8TDN6
      Related
      ENSP00000338862, OTTHUMP00000221047, ENST00000336767, OTTHUMT00000366826
      Conserved Domains (1) summary
      cl00935
      Location:58 – 307
      Blast Score: 675
      Brix; Brix domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000005.9 Reference GRCh37.p5 Primary Assembly

      Range
      34915820..34925787
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000137.1 Alternate HuRef

      Range
      34864475..34874444
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC026801.7 (157851..167818) None
    genomic CH471119.1 EAW55909.1
      EAW55910.1
    mRNA AF347667.1 AAL83818.1
    mRNA AK001962.1 BAA92003.1
    mRNA AK289610.1 BAF82299.1
    mRNA AK303311.1 BAG64380.1
    mRNA AK307492.1 None
    mRNA AY364243.1 AAQ76802.1
    mRNA AY364244.1 AAQ76803.1
    mRNA BC001546.1 AAH01546.2
    mRNA BC006014.1 AAH06014.1
    mRNA BC036741.1 AAH36741.1
    mRNA BX648902.1 None
    other-genetic DQ892108.2 ABM83034.1
    other-genetic DQ895302.2 ABM86228.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8TDN6.2 GenPept UniProtKB/Swiss-Prot:Q8TDN6
    Q9NUW4 GenPept UniProtKB/TrEMBL:Q9NUW4
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

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      Links

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