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UEVLD UEV and lactate/malate dehyrogenase domains [ Homo sapiens (human) ]

Gene ID: 55293, updated on 8-May-2016
Official Symbol
UEVLDprovided by HGNC
Official Full Name
UEV and lactate/malate dehyrogenase domainsprovided by HGNC
Primary source
HGNC:HGNC:30866
See related
Ensembl:ENSG00000151116 HPRD:15608; MIM:610985; Vega:OTTHUMG00000167729
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ATTP; UEV3
Orthologs
Location:
11p15.1
Exon count:
15
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 11 NC_000011.10 (18529609..18588938, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (18551156..18610293, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene lactate dehydrogenase A like 6A Neighboring gene tumor susceptibility 101 Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta pseudogene 2 Neighboring gene mitochondrial carrier 1 pseudogene Neighboring gene SPTY2D1 antisense RNA 1 Neighboring gene SPT2 chromatin protein domain containing 1

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ11068

Gene Ontology Provided by GOA

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
carboxylic acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
cellular protein modification process IEA
Inferred from Electronic Annotation
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
protein transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
ubiquitin-conjugating enzyme E2 variant 3
Names
EV and lactate/malate dehydrogenase domain-containing protein
UEV-3
UEVLD
signaling molecule ATTP

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001040697.2NP_001035787.1  ubiquitin-conjugating enzyme E2 variant 3 isoform a

    See identical proteins and their annotated locations for NP_001035787.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AC027544, AK314521, CF138618
    Consensus CDS
    CCDS41624.1
    UniProtKB/Swiss-Prot
    Q8IX04
    Related
    ENSP00000379500, OTTHUMP00000236665, ENST00000396197, OTTHUMT00000395923
    Conserved Domains (3) summary
    cd05293
    Location:180468
    LDH_1; A subgroup of L-lactate dehydrogenases
    PLN02602
    Location:161471
    PLN02602; lactate dehydrogenase
    pfam05743
    Location:21138
    UEV; UEV domain
  2. NM_001261382.1NP_001248311.1  ubiquitin-conjugating enzyme E2 variant 3 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon in the 5' coding region, compared to variant 1. The resulting isoform (c) lacks an internal segment, compared to isoform a.
    Source sequence(s)
    AC027544, AK296835, AK314521, CF138618
    Consensus CDS
    CCDS58124.1
    UniProtKB/Swiss-Prot
    Q8IX04
    Related
    ENSP00000368697, OTTHUMP00000236667, ENST00000379387, OTTHUMT00000395925
    Conserved Domains (3) summary
    cd05293
    Location:158446
    LDH_1; A subgroup of L-lactate dehydrogenases
    PLN02602
    Location:139449
    PLN02602; lactate dehydrogenase
    pfam05743
    Location:21116
    UEV; UEV domain
  3. NM_001261383.1NP_001248312.1  ubiquitin-conjugating enzyme E2 variant 3 isoform d

    See identical proteins and their annotated locations for NP_001248312.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an in-frame exon in the 5' coding region and an exon in the 3' coding region, which results in a frameshift and an early stop codon, compared to variant 1. The resulting isoform (d) is shorter; it lacks an internal segment and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AC027544, AK314521, BC064566
    Consensus CDS
    CCDS58123.1
    UniProtKB/Swiss-Prot
    Q8IX04
    Related
    ENSP00000323353, OTTHUMP00000236666, ENST00000320750, OTTHUMT00000395924
    Conserved Domains (2) summary
    pfam05743
    Location:21116
    UEV; UEV domain
    cl21454
    Location:158339
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  4. NM_001261384.1NP_001248313.1  ubiquitin-conjugating enzyme E2 variant 3 isoform e

    See identical proteins and their annotated locations for NP_001248313.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks two exons in the 5' coding region, which results in a downstream start codon, compared to variant 1. The resulting isoform (e) has a shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AC027544, AK295501, AK314521, CF138618
    UniProtKB/Swiss-Prot
    Q8IX04
    UniProtKB/TrEMBL
    B4DIA9
    Conserved Domains (2) summary
    cd05293
    Location:50338
    LDH_1; A subgroup of L-lactate dehydrogenases
    PLN02602
    Location:31341
    PLN02602; lactate dehydrogenase
  5. NM_001261385.1NP_001248314.1  ubiquitin-conjugating enzyme E2 variant 3 isoform f

    See identical proteins and their annotated locations for NP_001248314.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) has an alternate 5' exon, which results in a downstream start codon, and also lacks an exon in the 3' coding region, which results in a frameshift and an early stop codon, compared to variant 1. The resulting isoform (f) is shorter and has a shorter N-terminus and a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AC027544, AK001930, BC064566
    Consensus CDS
    CCDS58122.1
    UniProtKB/Swiss-Prot
    Q8IX04
    Related
    ENSP00000441092, OTTHUMP00000236664, ENST00000535484, OTTHUMT00000395922
    Conserved Domains (2) summary
    pfam05743
    Location:1100
    UEV; UEV domain
    cl21454
    Location:142323
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  6. NM_001261386.1NP_001248315.1  ubiquitin-conjugating enzyme E2 variant 3 isoform g

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) has multiple differences in the coding region, compared to variant 1. The resulting isoform (g) lacks two internal segments and has a shorter and distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AC027544, AK314521, BC064566, CD109744
    Consensus CDS
    CCDS58125.1
    UniProtKB/Swiss-Prot
    Q8IX04
    Related
    ENSP00000437538, OTTHUMP00000236669, ENST00000541984, OTTHUMT00000395928
    Conserved Domains (2) summary
    cl00154
    Location:2167
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    cl21454
    Location:80196
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  7. NM_001297771.1NP_001284700.1  ubiquitin-conjugating enzyme E2 variant 3 isoform h

    See identical proteins and their annotated locations for NP_001284700.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) has an alternate 3'-most exon in place of the last six exons compared to variant 1. The resulting isoform (h) has a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AK314521, BC011011
    Consensus CDS
    CCDS73266.1
    UniProtKB/Swiss-Prot
    Q8IX04
    Related
    ENSP00000300038, OTTHUMP00000236670, ENST00000300038, OTTHUMT00000395930
    Conserved Domains (2) summary
    pfam05743
    Location:21138
    UEV; UEV domain
    cl21454
    Location:180204
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  8. NM_018314.4NP_060784.3  ubiquitin-conjugating enzyme E2 variant 3 isoform b

    See identical proteins and their annotated locations for NP_060784.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 3' coding region, which results in a frameshift and an early stop codon, compared to variant 1. The resulting isoform (b) is shorter and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AC027544, AK314521
    Consensus CDS
    CCDS7843.1
    UniProtKB/Swiss-Prot
    Q8IX04
    Related
    ENSP00000442974, OTTHUMP00000236663, ENST00000543987, OTTHUMT00000395920
    Conserved Domains (2) summary
    pfam05743
    Location:21138
    UEV; UEV domain
    cl21454
    Location:180361
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p2 Primary Assembly

    Range
    18529609..18588938 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011520198.1XP_011518500.1  

    Conserved Domains (3) summary
    cd05293
    Location:241529
    LDH_1; A subgroup of L-lactate dehydrogenases
    PLN02602
    Location:222532
    PLN02602; lactate dehydrogenase
    pfam05743
    Location:97199
    UEV; UEV domain
  2. XM_011520201.1XP_011518503.1  

    See identical proteins and their annotated locations for XP_011518503.1

    UniProtKB/TrEMBL
    B4DWH4
    Conserved Domains (1) summary
    cl21454
    Location:1245
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  3. XM_006718255.1XP_006718318.1  

    See identical proteins and their annotated locations for XP_006718318.1

    UniProtKB/TrEMBL
    B4DWH4
    Conserved Domains (1) summary
    cl21454
    Location:1245
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  4. XM_011520199.1XP_011518501.1  

    Conserved Domains (2) summary
    pfam05743
    Location:97199
    UEV; UEV domain
    cl21454
    Location:241422
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  5. XM_011520200.1XP_011518502.1  

    Conserved Domains (2) summary
    pfam05743
    Location:97199
    UEV; UEV domain
    cl21454
    Location:241417
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

Alternate CHM1_1.1

Genomic

  1. NC_018922.2 Alternate CHM1_1.1

    Range
    18552301..18609649 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001040698.1: Suppressed sequence

    Description
    NM_001040698.1: This RefSeq was permanently suppressed because its 3' coding region is highly similar to an Alu repeat and the C-terminus of its protein has no support from any other proteins in the database.