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    UBE2W ubiquitin-conjugating enzyme E2W (putative) [ Homo sapiens ]

    Gene ID: 55284, updated on 11-May-2012

    Summary

    Official Symbol
    UBE2Wprovided by HGNC
    Official Full Name
    ubiquitin-conjugating enzyme E2W (putative)provided by HGNC
    Primary source
    HGNC:25616
    See related
    Ensembl:ENSG00000104343; HPRD:07724; MIM:614277; Vega:OTTHUMG00000164517
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    UBC16; UBC-16; hUBC-16; FLJ11011

    Genomic context

    Location :
    8q21.11
    Sequence :
    Chromosome: 8; NC_000008.10 (74702840..74791110, complement)
    See UBE2W in Epigenomics, MapViewer

    Chromosome 8 - NC_000008.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100128126 Neighboring gene staufen, RNA binding protein, homolog 2 (Drosophila) Neighboring gene VENT homeobox pseudogene 6 Neighboring gene glycogenin 1 pseudogene 1 Neighboring gene transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q96B02 P42330 AKR1C3    HPRD  PubMed  
    Q96B02 P19387 POLR2C    HPRD  PubMed  
    BioGRID:120572 BioGRID:114196 AKR1C3    BioGRID  PubMed Two-hybrid 
    BioGRID:120572 BioGRID:106764 AMFR    BioGRID  PubMed Two-hybrid 
    BioGRID:120572 BioGRID:119435 BFAR    BioGRID  PubMed Two-hybrid 
    BioGRID:120572 BioGRID:106826 BIRC2    BioGRID  PubMed Two-hybrid 
    BioGRID:120572 BioGRID:125186 BIRC8    BioGRID  PubMed Two-hybrid 
    BioGRID:120572 BioGRID:107140 BRCA1    BioGRID  PubMed Co-crystal Structure; Reconstituted Complex; Two-hybrid 
    BioGRID:120572 BioGRID:125051 CADPS2    BioGRID  PubMed Two-hybrid 
    BioGRID:120572 BioGRID:120861 CHFR    BioGRID  PubMed Two-hybrid 
    BioGRID:120572 BioGRID:110912 CNOT4    BioGRID  PubMed Two-hybrid 
    BioGRID:120572 BioGRID:108126 DNMT3B    BioGRID  PubMed Two-hybrid 
    BioGRID:120572 BioGRID:128203 DTX3    BioGRID  PubMed Two-hybrid 
    BioGRID:120572 BioGRID:127392 DTX3L    BioGRID  PubMed Two-hybrid 
    BioGRID:120572 BioGRID:115021 DZIP3    BioGRID  PubMed Two-hybrid 
    BioGRID:120572 BioGRID:114265 EED    BioGRID  PubMed Two-hybrid 
    BioGRID:120572 BioGRID:120429 FANCL    BioGRID  PubMed PCA; Reconstituted Complex 
    BioGRID:120572 BioGRID:124754 LRSAM1    BioGRID  PubMed Two-hybrid 
    BioGRID:120572 BioGRID:110378 MAP3K1    BioGRID  PubMed Two-hybrid 
    BioGRID:120572 BioGRID:125416 MARCH3    BioGRID  PubMed Two-hybrid 
    BioGRID:120572 BioGRID:120105 MARCH5    BioGRID  PubMed Two-hybrid 
    BioGRID:120572 BioGRID:116890 MGRN1    BioGRID  PubMed Two-hybrid 
    BioGRID:120572 BioGRID:121593 MIB1    BioGRID  PubMed Two-hybrid 
    BioGRID:120572 BioGRID:110427 MID1    BioGRID  PubMed Two-hybrid 
    BioGRID:120572 BioGRID:117141 MKRN1    BioGRID  PubMed Two-hybrid 
    BioGRID:120572 BioGRID:113479 MKRN3    BioGRID  PubMed Two-hybrid 
    BioGRID:120572 BioGRID:122734 MUL1    BioGRID  PubMed Two-hybrid 
    BioGRID:120572 BioGRID:115200 PJA2    BioGRID  PubMed Two-hybrid 
    BioGRID:120572 BioGRID:111428 POLR2C    BioGRID  PubMed Two-hybrid 
    BioGRID:120572 BioGRID:120460 RFWD3    BioGRID  PubMed Two-hybrid 
    BioGRID:120572 BioGRID:122287 RMND5B    BioGRID  PubMed Two-hybrid 
    BioGRID:120572 BioGRID:115249 RNF10    BioGRID  PubMed Two-hybrid 
    BioGRID:120572 BioGRID:113601 RNF103    BioGRID  PubMed Two-hybrid 
    BioGRID:120572 BioGRID:120146 RNF111    BioGRID  PubMed Two-hybrid 
    BioGRID:120572 BioGRID:120991 RNF114    BioGRID  PubMed Two-hybrid 
    BioGRID:120572 BioGRID:118094 RNF115    BioGRID  PubMed Two-hybrid 
    BioGRID:120572 BioGRID:120281 RNF125    BioGRID  PubMed Two-hybrid 
    BioGRID:120572 BioGRID:119545 RNF138    BioGRID  PubMed Two-hybrid 
    BioGRID:120572 BioGRID:114968 RNF14    BioGRID  PubMed Two-hybrid 
    BioGRID:120572 BioGRID:121553 RNF150    BioGRID  PubMed Two-hybrid 
    BioGRID:120572 BioGRID:128647 RNF152    BioGRID  PubMed Two-hybrid 
    BioGRID:120572 BioGRID:138966 RNF165    BioGRID  PubMed Two-hybrid 
    BioGRID:120572 BioGRID:125465 RNF166    BioGRID  PubMed Two-hybrid 
    BioGRID:120572 BioGRID:117477 RNF167    BioGRID  PubMed Two-hybrid 
    BioGRID:120572 BioGRID:124834 RNF185    BioGRID  PubMed Two-hybrid 
    BioGRID:120572 BioGRID:111972 RNF2    BioGRID  PubMed Two-hybrid 
    BioGRID:120572 BioGRID:122549 RNF26    BioGRID  PubMed Two-hybrid 
    BioGRID:120572 BioGRID:111974 RNF4    BioGRID  PubMed Two-hybrid 
    BioGRID:120572 BioGRID:111975 RNF5    BioGRID  PubMed Two-hybrid 
    BioGRID:120572 BioGRID:114492 RNF8    BioGRID  PubMed Two-hybrid 
    BioGRID:120572 BioGRID:115563 STUB1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:120572 BioGRID:115505 TOPORS    BioGRID  PubMed Two-hybrid 
    BioGRID:120572 BioGRID:119314 TRIM17    BioGRID  PubMed Two-hybrid 
    BioGRID:120572 BioGRID:116910 TRIM2    BioGRID  PubMed Two-hybrid 
    BioGRID:120572 BioGRID:111919 TRIM27    BioGRID  PubMed Two-hybrid 
    BioGRID:120572 BioGRID:116257 TRIM31    BioGRID  PubMed Two-hybrid 
    BioGRID:120572 BioGRID:116716 TRIM35    BioGRID  PubMed Two-hybrid 
    BioGRID:120572 BioGRID:121170 TRIM39    BioGRID  PubMed Two-hybrid 
    BioGRID:120572 BioGRID:123541 TRIM8    BioGRID  PubMed Two-hybrid 
    BioGRID:120572 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:120572 BioGRID:116554 UBOX5    BioGRID  PubMed Two-hybrid 
    BioGRID:120572 BioGRID:119616 UFM1    BioGRID  PubMed Two-hybrid 
    BioGRID:120572 BioGRID:125434 UHRF2    BioGRID  PubMed Two-hybrid 
    BioGRID:120572 BioGRID:106828 XIAP    BioGRID  PubMed Two-hybrid 
    BioGRID:120572 BioGRID:124371 ZNRF1    BioGRID  PubMed Two-hybrid 
    BioGRID:120572 BioGRID:127116 ZNRF4    BioGRID  PubMed Two-hybrid 

    General gene information

    Markers

    Homology

    • Homologs of the UBE2W gene: The UBE2W gene is conserved in chimpanzee, , dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, , N.crassa, A.thaliana, and P.falciparum.
    • Map Viewer (Mouse, Rat)

    Pathways from BioSystems

    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem (from REACTOME)
      Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystemIntracellular foreign or aberrant host proteins are cleaved into peptide fragments of a precise size, such that they can be loaded on to class I MHC molecules and presented externally to cytotoxic T ...
    • Class I MHC mediated antigen processing & presentation, organism-specific biosystem (from REACTOME)
      Class I MHC mediated antigen processing & presentation, organism-specific biosystemMajor histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular b...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Ubiquitin mediated proteolysis, organism-specific biosystem (from KEGG)
      Ubiquitin mediated proteolysis, organism-specific biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
    • Ubiquitin mediated proteolysis, conserved biosystem (from KEGG)
      Ubiquitin mediated proteolysis, conserved biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    acid-amino acid ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin-protein ligase activity IDA
    Inferred from Direct Assay
    more info
     
    ubiquitin-protein ligase activity IMP
    Inferred from Mutant Phenotype
    more info
     
    Process Evidence Code Pubs
    protein K11-linked ubiquitination IDA
    Inferred from Direct Assay
    more info
     
    protein monoubiquitination IDA
    Inferred from Direct Assay
    more info
     
    protein monoubiquitination IMP
    Inferred from Mutant Phenotype
    more info
     
    Component Evidence Code Pubs
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    ubiquitin-conjugating enzyme E2 W
    Names
    ubiquitin-conjugating enzyme E2 W
    ubiquitin-protein ligase W
    ubiquitin carrier protein W
    ubiquitin-conjugating enzyme 16
    probable ubiquitin-conjugating enzyme E2 W
    NP_001001481.1
    NP_060769.3

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001001481.1NP_001001481.1  ubiquitin-conjugating enzyme E2 W isoform 1

      Status: VALIDATED

      Source sequence(s)
      AK024050, BX538145, BX648427
      Consensus CDS
      CCDS47875.1
      UniProtKB/Swiss-Prot
      Q96B02
      Related
      ENSP00000397453, OTTHUMP00000226883, ENST00000419880, OTTHUMT00000379083
      Conserved Domains (1) summary
      cd00195
      Location:16130
      Blast Score: 275
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    2. NM_018299.3NP_060769.3  ubiquitin-conjugating enzyme E2 W isoform 2

      Status: VALIDATED

      Source sequence(s)
      AK024050, BC016326, BX538145, BX648427
      Consensus CDS
      CCDS47874.1
      UniProtKB/Swiss-Prot
      Q96B02
      Related
      ENSP00000428813, OTTHUMP00000226882, ENST00000517608, OTTHUMT00000379082
      Conserved Domains (1) summary
      cd00195
      Location:6119
      Blast Score: 275
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000008.10 Reference GRCh37.p5 Primary Assembly

      Range
      74702840..74791110, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000140.1 Alternate HuRef

      Range
      70193719..70282251, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001001482.1: Suppressed sequence

      Description
      NM_001001482.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC022826.12 (94095..168838) None
    genomic AC022868.10 (123569..137095) None
    genomic CH471068.1 EAW87009.1
      EAW87010.1
      EAW87011.1
      EAW87012.1
    mRNA AK001873.1 BAA91954.1
    mRNA AK021735.1 BAB13883.1
    mRNA AK024050.1 BAB14800.1
    mRNA AK225554.1 None
    mRNA AK295792.1 BAG58613.1
    mRNA AY948289.1 AAY24555.1
    mRNA BC010900.1 AAH10900.1
    mRNA BC016326.1 AAH16326.1
    mRNA BX538145.1 None
    mRNA BX648427.1 None
    mRNA CR457275.1 CAG33556.1
    other-genetic EU446497.1 ABZ92026.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96B02.1 GenPept UniProtKB/Swiss-Prot:Q96B02
    Q96FI0 GenPept UniProtKB/TrEMBL:Q96FI0

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