C20orf20 chromosome 20 open reading frame 20 [Homo sapiens] - Gene

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Summary

Official Symbol: C20orf20provided by HGNC
Official Full Name: chromosome 20 open reading frame 20provided by HGNC
Primary source: HGNC:15866
See related: Ensembl:ENSG00000101189; HPRD:16646; MIM:611157; Vega:OTTHUMG00000032940
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: Eaf7; MRGBP; URCC4; MRG15BP; FLJ10914

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Genomic context

Location :: 20q13.33

Sequence :: Chromosome: 20; NC_000020.10 (61427805..61431945)

See C20orf20 in Epigenomics, MapViewer

Chromosome 20 - NC_000020.10 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

role in tumorogenesis of cutaneous squamous cell carcinoma
Title: Integrative mRNA profiling comparing cultured primary cells with clinical samples reveals PLK1 and C20orf20 as therapeutic targets in cutaneous squamous cell carcinoma.
MRGBP contributes to colorectal carcinogenesis through rendering advantages in cell proliferation and/or division of cancer cells.
Title: MRG-binding protein contributes to colorectal cancer development.
These results suggest that C20orf20 protein has an important function in proliferation of cancer cells through the regulation of BRD8 protein.
Title: C20orf20 (MRG-binding protein) as a potential therapeutic target for colorectal cancer.
MRGBP is encoded by the FLJ10914 ORF and is a new component of the TRRAP/TIP60 HAT complex
Title: Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
Q9NV56	P60709	ACTB	HPRD	PubMed
Q9NV56	O96019	ACTL6A	HPRD	PubMed
Q9NV56	Q9H0E9	BRD8	HPRD	PubMed
Q9NV56	Q9NPF5	DMAP1	HPRD	PubMed
Q9NV56	Q9UK53	ING1	HPRD	PubMed
Q9NV56	Q9HAF1	MEAF6	HPRD	PubMed
Q9NV56	Q9UBU8	MORF4L1	HPRD	PubMed
Q9NV56	Q15014	MORF4L2	HPRD	PubMed
Q9NV56	Q9Y265	RUVBL1	HPRD	PubMed
Q9NV56	Q9Y4A5	TRRAP	HPRD	PubMed
Q9NV56	P07437	TUBB	HPRD	PubMed
Q9NV56	O95619	YEATS4	HPRD	PubMed
BioGRID:120548	BioGRID:106573	ACTA1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:120548	BioGRID:106575	ACTB	BioGRID	PubMed	Affinity Capture-MS
BioGRID:120548	BioGRID:106586	ACTG1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:120548	BioGRID:106601	ACTL6A	BioGRID	PubMed	Affinity Capture-MS
BioGRID:120548	BioGRID:116108	BRD8	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western; Two-hybrid
BioGRID:120548	BioGRID:120548	C20orf20	BioGRID	PubMed	Affinity Capture-MS
BioGRID:120548	BioGRID:116793	DIP2A	BioGRID	PubMed	Affinity Capture-Western
BioGRID:120548	BioGRID:121004	DMAP1	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:120548	BioGRID:123227	EPC1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:120548	BioGRID:117564	EPC2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:120548	BioGRID:125150	H2AFV	BioGRID	PubMed	Affinity Capture-MS
BioGRID:120548	BioGRID:113945	HIST2H2BE	BioGRID	PubMed	Affinity Capture-MS
BioGRID:120548	BioGRID:109431	HNRNPK	BioGRID	PubMed	Affinity Capture-MS
BioGRID:120548	BioGRID:110751	HNRNPM	BioGRID	PubMed	Affinity Capture-MS
BioGRID:120548	BioGRID:109433	HNRNPU	BioGRID	PubMed	Affinity Capture-MS
BioGRID:120548	BioGRID:109540	HSPA4	BioGRID	PubMed	Affinity Capture-MS
BioGRID:120548	BioGRID:109833	ING1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:120548	BioGRID:115779	KAT5	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:120548	BioGRID:110036	KPNA2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:120548	BioGRID:110035	KPNB1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:120548	BioGRID:110186	LMNA	BioGRID	PubMed	Affinity Capture-MS
BioGRID:120548	BioGRID:120158	MBTD1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:120548	BioGRID:122280	MEAF6	BioGRID	PubMed	Affinity Capture-MS
BioGRID:120548	BioGRID:116134	MORF4L1	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:120548	BioGRID:115001	MORF4L2	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:120548	BioGRID:125039	MRFAP1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:120548	BioGRID:111866	RBBP7	BioGRID	PubMed	Affinity Capture-MS
BioGRID:120548	BioGRID:117587	RSL1D1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:120548	BioGRID:114166	RUVBL1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:120548	BioGRID:116067	RUVBL2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:120548	BioGRID:116901	SIN3B	BioGRID	PubMed	Affinity Capture-Western
BioGRID:120548	BioGRID:116058	SRCAP	BioGRID	PubMed	Affinity Capture-MS
BioGRID:120548	BioGRID:113900	TRRAP	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:120548	BioGRID:113603	TUBA1A	BioGRID	PubMed	Affinity Capture-MS
BioGRID:120548	BioGRID:113131	TUBB2A	BioGRID	PubMed	Affinity Capture-MS
BioGRID:120548	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS
BioGRID:120548	BioGRID:112804	VPS72	BioGRID	PubMed	Affinity Capture-Western
BioGRID:120548	BioGRID:113761	YEATS4	BioGRID	PubMed	Affinity Capture-MS

Process	Evidence Code	Pubs
chromatin modification	IEA Inferred from Electronic Annotation more info
regulation of growth	IEA Inferred from Electronic Annotation more info
regulation of transcription, DNA-dependent	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
H4/H2A histone acetyltransferase complex	IEA Inferred from Electronic Annotation more info
nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

Preferred Names: MRG-binding protein

Names: MRG-binding protein; MRG(MORF4-related gene)-binding protein

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_018270.4 → NP_060740.1 MRG-binding protein

Status: VALIDATED

Source sequence(s)

AK001776, BC014235

Consensus CDS

CCDS13503.1

UniProtKB/TrEMBL

A8C4L5

UniProtKB/Swiss-Prot

Q9NV56

Related

ENSP00000359518, OTTHUMP00000031512, ENST00000370487, OTTHUMT00000080080

Conserved Domains (1) summary

pfam07904
Location:34 – 114
Blast Score: 295

Eaf7; Chromatin modification-related protein EAF7

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000020.10 Reference GRCh37.p5 Primary Assembly

Range

61427805..61431945

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000152.1 Alternate HuRef

Range

58146494..58149978

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AL035669.43	CAC12748.1
genomic	CH471077.2	EAW75342.1
		EAW75343.1
genomic	CS348926.1	CAL23011.1
mRNA	AB085682.1	BAF80630.1
mRNA	AK001776.1	BAA91902.1
mRNA	BC009889.2	AAH09889.1
mRNA	BC014235.2	AAH14235.1
mRNA	BC018841.2	AAH18841.1
other-genetic	JF432751.1	ADZ15968.1