My NCBISign In

Display Settings:

Format

Send to:

Choose Destination

    PPP2R5A protein phosphatase 2, regulatory subunit B', alpha [ Homo sapiens ]

    Gene ID: 5525, updated on 19-May-2012
    Help top of page

    Summary

    Official Symbol
    PPP2R5Aprovided by HGNC
    Official Full Name
    protein phosphatase 2, regulatory subunit B', alphaprovided by HGNC
    Primary source
    HGNC:9309
    See related
    Ensembl:ENSG00000066027; HPRD:03384; MIM:601643; Vega:OTTHUMG00000036750
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    B56A; PR61A; MGC131915
    Summary
    The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes an alpha isoform of the regulatory subunit B56 subfamily. Alternative transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Dec 2010]
    Help top of page

    Genomic context

    Location :
    1q32.2-q32.3
    Sequence :
    Chromosome: 1; NC_000001.10 (212458879..212535205)
    See PPP2R5A in Epigenomics, MapViewer

    Chromosome 1 - NC_000001.10Genomic Context describing neighboring genes Neighboring gene ribosomal protein L21 pseudogene 28 Neighboring gene denticleless E3 ubiquitin protein ligase homolog (Drosophila) Neighboring gene microRNA 3122 Neighboring gene ribosomal protein L23a pseudogene 18 Neighboring gene small nucleolar RNA, H/ACA box 16B Neighboring gene transmembrane protein 206 Neighboring gene neudesin neurotrophic factor

    Help top of page

    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
    Helptop of page

    Bibliography

    Related articles in PubMed

    1. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    2. The antagonistic action of B56-containing protein phosphatase 2As and casein kinase 2 controls the phosphorylation and Gli turnover function of Daz interacting protein 1. Jin Z, et al. J Biol Chem, 2011 Oct 21. PMID 21878643.
    3. Formation of stable attachments between kinetochores and microtubules depends on the B56-PP2A phosphatase. Foley EA, et al. Nat Cell Biol, 2011 Aug 28. PMID 21874008.
    4. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, et al. Mol Cell Proteomics, 2011 Mar. PMID 21139048.
    5. A critical role for the protein phosphatase 2A B'α regulatory subunit in dephosphorylation of sphingosine kinase 1. Pitman MR, et al. Int J Biochem Cell Biol, 2011 Mar. PMID 21075214.

    See all (59) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. reversible phosphorylation of Dzip1, which is controlled by the antagonistic action of CK2 and B56-containing PP2As, has an important impact on the stability of Gli transcription factors and Hh signaling.
      Title: The antagonistic action of B56-containing protein phosphatase 2As and casein kinase 2 controls the phosphorylation and Gli turnover function of Daz interacting protein 1.
    2. Reveal that PPP2R5A, an essential tumour suppressor, tunes the balance of phosphorylation to promote chromosome-spindle interactions during cell division.
      Title: Formation of stable attachments between kinetochores and microtubules depends on the B56-PP2A phosphatase.
    3. The PP2A-B'alpha holoenzyme appears to function as an important endogenous regulator of SK1.
      Title: A critical role for the protein phosphatase 2A B'α regulatory subunit in dephosphorylation of sphingosine kinase 1.
    4. Following TGF-beta1 treatment, recruitment of PP2A-Balpha by TbetaRI increased in benign cells, but not in malignant cells. Inhibition of PP2A in benign cells resulted in an increase in ERK activation and in TGF-beta1 auto-induction after TGF-beta1 tre...
      Title: Overexpression of transforming growth factor β1 in malignant prostate cells is partly caused by a runaway of TGF-β1 auto-induction mediated through a defective recruitment of protein phosphatase 2A by TGF-β type I receptor.
    5. B56alpha has a role in nuclear export of the catalytic subunit of PP2A
      Title: Nuclear export and centrosome targeting of the protein phosphatase 2A subunit B56alpha: role of B56alpha in nuclear export of the catalytic subunit.
    6. The B'alpha subunit of protein phosphatase 2A (PP 2A) as a CHK2 binding partner shows that their interaction is modulated by DNA damage.
      Title: Negative regulation of CHK2 activity by protein phosphatase 2A is modulated by DNA damage.
    7. these data indicate that the B subunits alpha and delta are essential for the interaction of PP2A with CaMKIV.
      Title: The Balpha and Bdelta regulatory subunits of PP2A are necessary for assembly of the CaMKIV.PP2A signaling complex.
    8. The B'alpha1 subunit of the serine/threonine protein phosphatase 2A, which binds to cyclin G1, can stabilize cyclin G1 under unstressed conditions and upon DNA damage, as well as inhibit the ability of cyclin G1 to be ubiquitinated.
      Title: Lysine-independent turnover of cyclin G1 can be stabilized by B'alpha subunits of protein phosphatase 2A.
    9. PKR regulates B56(alpha)-mediated BCL2 phosphatase activity in acute lymphoblastic leukemia-derived REH cells.
      Title: PKR regulates B56(alpha)-mediated BCL2 phosphatase activity in acute lymphoblastic leukemia-derived REH cells.
    Submit: New GeneRIF Correction
    Help top of page

    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Help top of page

    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Tat tat Protein phosphatase-2A (PP2A) and protein phosphatase-1 (PP1) regulate HIV-1 Tat-activated transcription through dephosphorylation of CDK9 PubMed
    tat An increase in the amount of PP2A core enzyme with a concomitant decrease in the amount of PP2A holoenzyme inhibits HIV-1 Tat-stimulated transcription from the HIV-1 LTR promoter, indicating a role for PP2A in the modulation of HIV-1 gene expression PubMed
    Vpr vpr HIV-1 Vpr was reported to mediate G2 arrest by forming a complex with PP2A through binding to the B55 regulatory subunit, thereby targeting the complex to the nucleus and enhancing cdc25 dephosphorylation, however the paper was subsequently retracted PubMed
    vpr HIV-1 Vpr was found to upregulate PP2A in fission yeast PubMed
    vpr HIV-1 Vpr forms a complex with HIV-1 nucleocapsid that directly activates PP2A PubMed
    nucleocapsid gag HIV-1 Vpr forms a complex with HIV-1 nucleocapsid that directly activates PP2A PubMed

    Go to the HIV-1, Human Protein Interaction Database

    Help top of page

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q15172 P25054 APC    HPRD  PubMed  
    Q15172 P10415 BCL2    HPRD  PubMed  
    Q15172 O76090 BEST1    HPRD  PubMed  
    Q15172 O96017 CHEK2    HPRD  PubMed  
    Q15172 P48729 CSNK1A1    HPRD  PubMed  
    Q15172 P16410 CTLA4    HPRD  PubMed  
    Q15172 P19525 EIF2AK2    HPRD  PubMed  
    Q15172 Q9BVP2 GNL3    HPRD  PubMed  
    Q15172 O60674 JAK2    HPRD  PubMed  
    Q15172 P10636 MAPT    HPRD  PubMed  
    Q15172 Q96PY6 NEK1    HPRD  PubMed  
    Q15172 P29474 NOS3    HPRD  PubMed  
    Q15172 P30153 PPP2R1A    HPRD  PubMed  
    Q15172 Q5FBB7 SGOL1    HPRD  PubMed  
    Q15172 P29353 SHC1    HPRD  PubMed  
    Q15172 Q9H3D4 TP63    HPRD  PubMed  
    BioGRID:111517 BioGRID:236230 9830001H06Rik    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111517 BioGRID:106821 APC    BioGRID  PubMed Co-localization 
    BioGRID:111517 BioGRID:113909 AXIN1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111517 BioGRID:107068 BCL2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111517 BioGRID:116369 CHEK2    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:111517 BioGRID:107875 CTLA4    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:111517 BioGRID:111596 EIF2AK2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111517 BioGRID:110694 MYC    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111517 BioGRID:111507 PPP2CA    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-fractionation 
    BioGRID:111517 BioGRID:111510 PPP2R1A    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111517 BioGRID:111511 PPP2R1B    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-fractionation; Reconstituted Complex 
    BioGRID:111517 BioGRID:111519 PPP2R5C    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111517 BioGRID:206176 Ppp2r1a    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111517 BioGRID:215364 Sgol1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111517 BioGRID:212920 Sgol2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111517 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    Help top of page

    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • Beta-catenin phosphorylation cascade, organism-specific biosystem (from REACTOME)
      Beta-catenin phosphorylation cascade, organism-specific biosystemDegradation of beta-catenin is initiated following amino-terminal serine/threonine phosphorylation. Phosphorylation of B-catenin at S45 by CK1 alpha primes the subsequent sequential GSK-3-mediated p...
    • C-MYC pathway, organism-specific biosystem (from Pathway Interaction Database)
      C-MYC pathway, organism-specific biosystem
      C-MYC pathway
    • CTLA4 inhibitory signaling, organism-specific biosystem (from REACTOME)
      CTLA4 inhibitory signaling, organism-specific biosystemCTLA4 is one of the best studied inhibitory receptors of the CD28 superfamily. CTLA4 inhibits Tcell activation by reducing IL2 production and IL2 expression, and by arresting T cells at the G1 phase ...
    • Cell Cycle, organism-specific biosystem (from REACTOME)
      Cell Cycle, organism-specific biosystem
      Cell Cycle
    • Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
      Cell Cycle, Mitotic, organism-specific biosystemThe replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried o...
    • Costimulation by the CD28 family, organism-specific biosystem (from REACTOME)
      Costimulation by the CD28 family, organism-specific biosystemOptimal activation of T-lymphocytes requires at least two signals. A primary one is delivered by the T-cell receptor (TCR) complex after antigen recognition and additional costimulatory signals are d...
    • DNA Replication, organism-specific biosystem (from REACTOME)
      DNA Replication, organism-specific biosystemStudies in the past decade have suggested that the basic mechanism of DNA replication initiation is conserved in all kingdoms of life. Initiation in unicellular eukaryotes, in particular Saccharomyce...
    • Degradation of beta-catenin by the destruction complex, organism-specific biosystem (from REACTOME)
      Degradation of beta-catenin by the destruction complex, organism-specific biosystemThe beta-catenin destruction complex plays a key role in the canonical Wnt signaling pathway. In the absence of Wnt signaling, this complex controls the levels of cytoplamic beta-catenin. Beta-cateni...
    • Dopaminergic synapse, organism-specific biosystem (from KEGG)
      Dopaminergic synapse, organism-specific biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
    • Dopaminergic synapse, conserved biosystem (from KEGG)
      Dopaminergic synapse, conserved biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
    • Glycogen Metabolism, organism-specific biosystem (from WikiPathways)
      Glycogen Metabolism, organism-specific biosystemGlycogen is a very large, branched polymer of glucose residues. Within skeletal musle and liver glucose is stored as glycogen. In the liver, glycogen synthesis and degradation are regulated to mainta...
    • Hemostasis, organism-specific biosystem (from REACTOME)
      Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
    • IL-6 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-6 Signaling Pathway, organism-specific biosystemInterleukin-6 belongs to a family of cytokines which includes IL-11, ciliary neurotrophic factor (CNTF), cardiotropin-1, cardiotrophin-like cytokine, leukemia inhibitory factor (LIF) and Oncostatin M...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • M Phase, organism-specific biosystem (from REACTOME)
      M Phase, organism-specific biosystemMitosis, or the M phase, involves nuclear division and cytokinesis, where two identical daughter cells are produced. Mitosis involves prophase, prometaphase, metaphase, anaphase, and telophase. Fin...
    • Mitotic M-M/G1 phases, organism-specific biosystem (from REACTOME)
      Mitotic M-M/G1 phases, organism-specific biosystem
      Mitotic M-M/G1 phases
    • Mitotic Prometaphase, organism-specific biosystem (from REACTOME)
      Mitotic Prometaphase, organism-specific biosystemThe dissolution of the nuclear membrane marks the beginning of the prometaphase. Kinetochores are created when proteins attach to the centromeres. Microtubules then attach at the kinetochores, and ...
    • Oocyte meiosis, organism-specific biosystem (from KEGG)
      Oocyte meiosis, organism-specific biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, homologous chromosomes recombine and then segrega...
    • Oocyte meiosis, conserved biosystem (from KEGG)
      Oocyte meiosis, conserved biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, homologous chromosomes recombine and then segrega...
    • Platelet homeostasis, organism-specific biosystem (from REACTOME)
      Platelet homeostasis, organism-specific biosystemUnder normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhesion and activation, suppresses coagulation, enhances fibrin cleavage and is anti-inflammatory in charact...
    • Platelet sensitization by LDL, organism-specific biosystem (from REACTOME)
      Platelet sensitization by LDL, organism-specific biosystemPhysiological concentrations (1g/L) of Low density lipoprotein (LDL) enhance platelet aggregation responses initiated by thrombin, collagen, and ADP. This enhancement involves the rapid phosphorylati...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by Wnt, organism-specific biosystem (from REACTOME)
      Signaling by Wnt, organism-specific biosystemThe beta-catenin destruction complex plays a key role in the canonical Wnt signaling pathway. In the absence of Wnt signaling, this complex controls the levels of cytoplamic beta-catenin. Beta-cateni...
    • Wnt signaling pathway, organism-specific biosystem (from KEGG)
      Wnt signaling pathway, organism-specific biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
    • Wnt signaling pathway, conserved biosystem (from KEGG)
      Wnt signaling pathway, conserved biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
    • mRNA surveillance pathway, organism-specific biosystem (from KEGG)
      mRNA surveillance pathway, organism-specific biosystemThe mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go ...
    • mRNA surveillance pathway, conserved biosystem (from KEGG)
      mRNA surveillance pathway, conserved biosystemThe mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go ...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    kinase binding IPI
    Inferred from Physical Interaction
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein phosphatase type 2A regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    negative regulation of establishment of protein localization in plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		  
    negative regulation of lipid kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		  
    positive regulation of protein dephosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    		  
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    colocalizes_with membrane fraction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein phosphatase type 2A complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Help top of page

    General protein information

    Preferred Names
    serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform
    Names
    serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform
    PR61alpha
    PP2A B subunit isoform B'-alpha
    PP2A B subunit isoform R5-alpha
    PP2A B subunit isoform B56-alpha
    PP2A B subunit isoform PR61-alpha
    PP2A, B subunit, B' alpha isoform
    PP2A, B subunit, R5 alpha isoform
    PP2A, B subunit, B56 alpha isoform
    PP2A, B subunit, PR61 alpha isoform
    protein phosphatase 2, regulatory subunit B', alpha isoform
    protein phosphatase 2, regulatory subunit B (B56), alpha isoform
    serine/threonine protein phosphatase 2A, 56 kDa regulatory subunit, alpha isoform
    Help top of page

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001199756.1 → NP_001186685.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has an alternate 5' exon, as compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus, as compared to isoform 1.
      Source sequence(s)
      AA425592, AK302202, BP326450, L42373
      Consensus CDS
      CCDS55686.1
      UniProtKB/Swiss-Prot
      Q15172
      Related
      ENSP00000442866, ENST00000537030
      Conserved Domains (1) summary
      cl03277
      Location:4 – 380
      Blast Score: 1322
      B56; Protein phosphatase 2A regulatory B subunit (B56 family)

    2. NM_006243.3 → NP_006234.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AA425592, AL451060, L42373
      Consensus CDS
      CCDS1503.1
      UniProtKB/Swiss-Prot
      Q15172
      Related
      ENSP00000261461, OTTHUMP00000034891, ENST00000261461, OTTHUMT00000089302
      Conserved Domains (1) summary
      cl03277
      Location:59 – 437
      Blast Score: 1341
      B56; Protein phosphatase 2A regulatory B subunit (B56 family)

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000001.10 Reference GRCh37.p5 Primary Assembly

      Range
      212458879..212535205
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000133.1 Alternate HuRef

      Range
      183135716..183210570
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL360091.28 CAH73229.1
    genomic AL451060.13 CAH71821.1
    genomic CH471100.2 EAW93392.1
      EAW93393.1
    mRNA AA425592.1 None
    mRNA AK302202.1 BAH13648.1
    mRNA AK312530.1 BAG35429.1
    mRNA BC022474.1 AAH22474.1
    mRNA BC110883.1 AAI10884.1
    mRNA BM974076.1 None
    mRNA BP326450.1 None
    mRNA L42373.1 AAC37601.1
    other-genetic DQ892361.2 ABM83287.1
    other-genetic DQ895568.2 ABM86494.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q15172.1 GenPept UniProtKB/Swiss-Prot:Q15172
    Help top of page

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Links

      Links to other resources

      General information

      Related sites

      Feedback

      Subscription

      Recent activity

      Clear Turn Off Turn On

      Your browsing activity is empty.

      Activity recording is turned off.

      Turn recording back on

      See more...