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    YY1AP1 YY1 associated protein 1 [ Homo sapiens ]

    Gene ID: 55249, updated on 11-May-2012
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    Summary

    Official Symbol
    YY1AP1provided by HGNC
    Official Full Name
    YY1 associated protein 1provided by HGNC
    Primary source
    HGNC:30935
    Locus tag
    RP11-243J18.1
    See related
    Ensembl:ENSG00000163374; HPRD:08485; MIM:607860; Vega:OTTHUMG00000035437
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    YAP; HCCA1; HCCA2; YY1AP; FLJ10875; FLJ13914
    Summary
    The encoded gene product presumably interacts with YY1 protein; however, its exact function is not known. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    1q22
    Sequence :
    Chromosome: 1; NC_000001.10 (155629233..155658823, complement)
    See YY1AP1 in Epigenomics, MapViewer

    Chromosome 1 - NC_000001.10Genomic Context describing neighboring genes Neighboring gene gon-4-like (C. elegans) pseudogene Neighboring gene gon-4-like (C. elegans) pseudogene Neighboring gene death associated protein 3 Neighboring gene uncharacterized LOC100505728 Neighboring gene misato homolog 2 pseudogene

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. A directed protein interaction network for investigating intracellular signal transduction. Vinayagam A, et al. Sci Signal, 2011 Sep 6. PMID 21900206.
    2. Comparative proteomic analysis identifies a role for SUMO in protein quality control. Tatham MH, et al. Sci Signal, 2011 Jun 21. PMID 21693764.
    3. Identification of a tumor suppressor relay between the FOXP3 and the Hippo pathways in breast and prostate cancers. Li W, et al. Cancer Res, 2011 Mar 15. PMID 21278236.
    4. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, et al. Mol Cell Proteomics, 2011 Mar. PMID 21139048.
    5. A human MAP kinase interactome. Bandyopadhyay S, et al. Nat Methods, 2010 Oct. PMID 20936779.

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Data suggest that defective expression of LATS2 is attributable to FOXP3 defects and may be a major independent determinant of YAP protein elevation in cancer.
      Title: Identification of a tumor suppressor relay between the FOXP3 and the Hippo pathways in breast and prostate cancers.
    2. HCCA2 may play a novel role in cell cycle regulation.
      Title: Hepatocellular carcinoma-associated gene 2 interacts with MAD2L2.
    3. YY1AP is a novel co-activator of YY1
      Title: YY1AP, a novel co-activator of YY1.
    4. human liver cancer associated gene
      Title: [Clone of a novel liver cancer associated gene and analysis of the secondary structures of the predicted protein].
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q9H869 P54253 ATXN1    HPRD  PubMed  
    Q9H869 Q01844 EWSR1    HPRD  PubMed  
    BioGRID:120540 BioGRID:108431 EWSR1    BioGRID  PubMed Two-hybrid 
    BioGRID:120540 BioGRID:107819 MAPK14    BioGRID  PubMed Two-hybrid 
    BioGRID:120540 BioGRID:117086 MAPK8IP2    BioGRID  PubMed Two-hybrid 
    BioGRID:120540 BioGRID:112497 SUMO2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:120540 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    regulation of cell cycle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    regulation of transcription, DNA-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    YY1-associated protein 1
    Names
    YY1-associated protein 1
    hepatocellular carcinoma-associated protein 2
    hepatocellular carcinoma susceptibility protein
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001198899.1 → NP_001185828.1  YY1-associated protein 1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) lacks 5' two exons but has an alternate 5' segment, resulting in a downstream AUG start codon, as compared to variant 10. The resulting isoform (1) has a shorter N-terminus, as compared to isoform 6. Variants 1, 6 and 7 encode the same isoform 1.
      Source sequence(s)
      AK303386, BC014906, DC346197
      UniProtKB/Swiss-Prot
      Q9H869
      Related
      ENSP00000437926, ENST00000535662

    2. NM_001198900.1 → NP_001185829.1  YY1-associated protein 1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) has an alternate 5' sequence, resulting in a downstream AUG start codon, as compared to variant 10. The resulting isoform (1) has a shorter N-terminus, as compared to isoform 6. Variants 1, 6 and 7 encode the same isoform 1.
      Source sequence(s)
      BC003500, BC009358, BC044887, DC399389
      UniProtKB/Swiss-Prot
      Q9H869
      Related
      ENSP00000352134, OTTHUMP00000033473, ENST00000359205, OTTHUMT00000086021

    3. NM_001198901.1 → NP_001185830.1  YY1-associated protein 1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) has an alternate 5' sequence, resulting in a downstream AUG start codon, as compared to variant 10. The resulting isoform (3) has a shorter N-terminus, as compared to isoform 6. Variants 3, 8 and 9 encode the same isoform 3.
      Source sequence(s)
      AY604179, BC009358, DC300265
      Consensus CDS
      CCDS1116.1
      UniProtKB/Swiss-Prot
      Q9H869
      Related
      ENSP00000357314, OTTHUMP00000200831, ENST00000368330, OTTHUMT00000324531

    4. NM_001198902.1 → NP_001185831.1  YY1-associated protein 1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9) has an alternate 5' sequence, resulting in a downstream AUG start codon, as compared to variant 10. The resulting isoform (3) has a shorter N-terminus, as compared to isoform 6. Variants 3, 8 and 9 encode the same isoform 3.
      Source sequence(s)
      AF466401, BC009358, BG325066
      Consensus CDS
      CCDS1116.1
      UniProtKB/Swiss-Prot
      Q9H869
      Related
      ENSP00000316079, OTTHUMP00000033476, ENST00000347088, OTTHUMT00000086024

    5. NM_001198903.1 → NP_001185832.1  YY1-associated protein 1 isoform 6

      Status: VALIDATED

      Description
      Transcript Variant: This variant (10) encodes the longest isoform (6).
      Source sequence(s)
      AK297562, BC009358, BC025272, DC406177
      Consensus CDS
      CCDS55645.1
      UniProtKB/TrEMBL
      B4DMP2
      UniProtKB/TrEMBL
      H7BY62
      UniProtKB/Swiss-Prot
      Q9H869
      Related
      ENSP00000357323, ENST00000368339

    6. NM_001198904.1 → NP_001185833.1  YY1-associated protein 1 isoform 7

      Status: VALIDATED

      Description
      Transcript Variant: This variant (11) has an alternate splice site in the CDS, as compared to variant 10. The resulting isoform (7) lacks an internal segment, as compared to isoform 6.
      Source sequence(s)
      BC009358, BC025272, DC406177
      Consensus CDS
      CCDS55644.1
      UniProtKB/TrEMBL
      Q5VYZ1
      UniProtKB/Swiss-Prot
      Q9H869
      Related
      ENSP00000357324, OTTHUMP00000033478, ENST00000368340, OTTHUMT00000086026

    7. NM_001198905.1 → NP_001185834.1  YY1-associated protein 1 isoform 8

      Status: VALIDATED

      Description
      Transcript Variant: This variant (12) has an alternate 5' sequence, resulting in a downstream AUG start codon, and has an alternate splice site in the middle coding region, as compared to variant 10. The resulting isoform (8) has a shorter N-terminus and lacks an internal segment, as compared to isoform 6.
      Source sequence(s)
      BC008766, BC009358, DC399389
      Consensus CDS
      CCDS55643.1
      UniProtKB/Swiss-Prot
      Q9H869
      Related
      ENSP00000385390, OTTHUMP00000200833, ENST00000404643, OTTHUMT00000324533

    8. NM_001198906.1 → NP_001185835.1  YY1-associated protein 1 isoform 9

      Status: VALIDATED

      Description
      Transcript Variant: This variant (13) has an alternate 5' sequence and an alternate splice site in the 3' coding region, resulting in frame-shift, as compared to variant 10. The resulting isoform (9) has shorter and distinct N- and C-termini, as compared to isoform 6.
      Source sequence(s)
      AK298904, BC014906, DC388975
      UniProtKB/TrEMBL
      B4DQQ0
      UniProtKB/Swiss-Prot
      Q9H869

    9. NM_018253.3 → NP_060723.2  YY1-associated protein 1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) has an alternate 5' sequence and an additional exon in the 5' region, resulting in a downstream AUG start codon, as compared to variant 10. The resulting isoform (1) has a shorter N-terminus, as compared to isoform 6. Variants 1, 6 and 7 encode the same isoform 1.
      Source sequence(s)
      BC001655, BC014906, DC399389
      UniProtKB/Swiss-Prot
      Q9H869
      Related
      ENSP00000355298, OTTHUMP00000033477, ENST00000361831, OTTHUMT00000086025

    10. NM_139118.2 → NP_620829.1  YY1-associated protein 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate 5' sequence and an alternate splice site in the middle coding region, as compared to variant 10. The resulting isoform (2) has a shorter and distinct N-terminus and lacks an internal segment, as compared to isoform 6.
      Source sequence(s)
      BC008766, BC014906, DC388975
      Consensus CDS
      CCDS1115.1
      UniProtKB/Swiss-Prot
      Q9H869
      Related
      ENSP00000295566, OTTHUMP00000033479, ENST00000295566, OTTHUMT00000086027

    11. NM_139119.2 → NP_620830.1  YY1-associated protein 1 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) has an alternate 5' sequence, resulting in a downstream AUG start codon, as compared to variant 10. The resulting isoform (3) has a shorter N-terminus, as compared to isoform 6. Variants 3, 8 and 9 encode the same isoform 3.
      Source sequence(s)
      BC014906, BC044887
      Consensus CDS
      CCDS1116.1
      UniProtKB/Swiss-Prot
      Q9H869
      Related
      ENSP00000347686, OTTHUMP00000033474, ENST00000355499, OTTHUMT00000086022

    12. NM_139121.2 → NP_620832.1  YY1-associated protein 1 isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) has alternate 5' sequence and an additional exon in the 5' region, resulting in a downstream AUG start codon, as compared to variant 10. The resulting isoform (5) has a shorter N-terminus, as compared to isoform 6.
      Source sequence(s)
      BC003500, BC009358
      UniProtKB/Swiss-Prot
      Q9H869

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000001.10 Reference GRCh37.p5 Primary Assembly

      Range
      155629233..155658823, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000133.1 Alternate HuRef

      Range
      126991183..127020680, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_139120.1: Suppressed sequence

      Description
      NM_139120.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL162734.15 CAH71642.1
      CAH71643.1
      CAH71644.1
      CAH71645.1
      CAH71646.1
      CAM45731.1
      CAM45732.2
      CAQ09422.1
      CAQ09423.1
    genomic AL162734.15 CAH71642.1
      CAH71643.1
      CAH71644.1
      CAH71645.1
      CAH71646.1
      CAM45731.1
      CAM45732.2
      CAQ09422.1
      CAQ09423.1
    genomic BX088689.8 CAH73350.1
      CAH73351.1
      CAH73352.1
      CAH73353.1
      CAH73354.1
      CAQ07661.1
    genomic BX088689.8 CAH73350.1
      CAH73351.1
      CAH73352.1
      CAH73353.1
      CAH73354.1
      CAQ07661.1
    genomic CH471121.2 EAW53052.1
      EAW53053.1
      EAW53054.1
      EAW53055.1
      EAW53056.1
      EAW53057.1
      EAW53058.1
      EAW53059.1
      EAW53060.1
    mRNA AF203474.1 AAO13249.1
    mRNA AF206328.1 AAL74055.1
    mRNA AF466401.1 AAL75971.1
    mRNA AK001737.1 BAA91871.1
    mRNA AK023976.1 BAB14748.1
    mRNA AK125590.1 None
    mRNA AK225883.1 None
    mRNA AK297562.1 BAG59954.1
    mRNA AK298904.1 BAG61012.1
    mRNA AK303046.1 BAG64166.1
    mRNA AK303386.1 BAG64442.1
    mRNA AK303944.1 BAG64872.1
    mRNA AK309701.1 None
    mRNA AK315049.1 None
    mRNA AY604179.1 AAT34990.1
    mRNA BC001655.2 AAH01655.2
    mRNA BC001843.2 AAH01843.2
    mRNA BC003500.1 None
    mRNA BC008766.2 AAH08766.2
    mRNA BC009358.2 AAH09358.2
    mRNA BC014906.2 AAH14906.1
    mRNA BC025272.1 None
    mRNA BC044887.1 AAH44887.1
    mRNA BG325066.1 None
    mRNA CR749789.1 CAH18650.1
    mRNA DC300265.1 None
    mRNA DC346197.1 None
    mRNA DC388975.1 None
    mRNA DC399389.1 None
    mRNA DC406177.1 None
    other-genetic AM393344.1 CAL38222.1
    other-genetic AM393852.1 CAL38727.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5VYZ1 GenPept UniProtKB/TrEMBL:Q5VYZ1
    Q68CT8 GenPept UniProtKB/TrEMBL:Q68CT8
    Q9H869.2 GenPept UniProtKB/Swiss-Prot:Q9H869
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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